A Polysaccharide-Based Fluorescent Polymer Carrier for Natural Product Delivery and Gastric Cancer Inhibition

IF 3 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2025-06-13 DOI:10.1002/bio.70235

Minghan Bai, Yupeng Yang, Yuan Wen

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Abstract

In this study, we designed and synthesized a novel polysaccharide-based fluorescent nanocarrier system, HPMC-AuNPs@1, for the delivery of plant extract compound 1. The HPMC-AuNPs@1 system was synthesized by functionalizing gold nanoparticles (AuNPs) with hydroxypropyl methylcellulose (HPMC) and loading Compound 1 into the system. The resulting nanocarrier exhibited a typical aggregation-induced emission (AIE) effect in aqueous media, showing strong green fluorescence in a DMSO-H₂O (5:95) solution. Host-guest sensing experiments revealed that HPMC-AuNPs@1 demonstrated high selectivity for detecting carcinoembryonic antigen (CEA) among 14 different metallic ions and antigen molecules. A noticeable fluorescence shift occurred upon binding with CEA, and the detection limit for CEA was as low as 2.56 × 10⁻⁶ M. Additionally, we explored the potential therapeutic applications of HPMC-AuNPs@1 in cancer treatment, particularly in inducing pyroptosis, a form of programmed cell death. In vitro experiments with SNU-16 cells showed that HPMC-AuNPs@1 nanoparticles inhibited cancer cell proliferation by inducing pyroptosis. These findings suggest that HPMC-AuNPs@1 holds great promise as a therapeutic platform for cancer treatment, particularly in targeting cell proliferation pathways via pyroptosis induction.

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天然产物传递和胃癌抑制的多糖基荧光聚合物载体

在这项研究中，我们设计并合成了一种新的基于多糖的荧光纳米载体系统HPMC-AuNPs@1，用于传递植物提取物化合物1。以羟丙基甲基纤维素（HPMC）功能化金纳米粒子（AuNPs），并将化合物1加载到体系中，合成了HPMC-AuNPs@1体系。所得纳米载体在水介质中表现出典型的聚集诱导发射（AIE）效应，在DMSO-H2O（5:95）溶液中表现出强烈的绿色荧光。主-客体传感实验表明，HPMC-AuNPs@1对14种不同金属离子和抗原分子的癌胚抗原（CEA）具有较高的选择性。与CEA结合后出现明显的荧光位移，对CEA的检出限低至2.56 × 10−6 M。此外，我们探索了HPMC-AuNPs@1在癌症治疗中的潜在治疗应用，特别是在诱导焦亡（一种程序性细胞死亡形式）方面。体外SNU-16细胞实验表明HPMC-AuNPs@1纳米颗粒通过诱导细胞焦亡抑制癌细胞增殖。这些发现表明HPMC-AuNPs@1作为癌症治疗的治疗平台具有很大的前景，特别是通过焦亡诱导靶向细胞增殖途径。

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.