Luminescence最新文献

{"title":"Fluorescence Assisted Investigation of ERK1/2 Signaling in the Regulation of ATG3 and ATG5 Under Glutamine and Glucose Deprivation in Breast Cancer Cells","authors":"G. Gokulapriya,&nbsp;B. S. Lakshmi","doi":"10.1002/bio.70132","DOIUrl":"https://doi.org/10.1002/bio.70132","url":null,"abstract":"<div>\u0000 \u0000 <p>Extracellular signal–regulated kinases (ERKs) belong to the family of mitogen-activated protein kinases and transmit extracellular signals. The present study investigates ERK-mediated control of ATG3 and ATG5 as an adaptive response to glutamine and glucose deprivation, with the ERK–CREB axis implicated in this regulatory mechanism. Hyperactivation of ERKs plays a major role in tumor progression and differentiation. Phosphorylation of ERK1/2 at Thr202/Tyr204 residues was higher during glutamine and glucose starvation. Inhibition of ERK1/2 reduced cell viability, increased the presence of acidic vesicular organelle as observed by acridine orange fluorescence staining, and enhanced the expression levels of ATG3 and ATG5 proteins, signifying the protective role of ERK1/2 through control of ATG3 and ATG5 during starvation. The transcription factor CREB is activated by various kinases, including ERKs. Phosphorylation at Serine133 enables CREB to carry out transcriptional activation. Inhibition of ERK1/2 decreased CREB expression, suggesting that ERK1/2-dependent activation of CREB contributes to a reduction in cell viability and upregulation of ATG3 and ATG5 during glutamine and glucose starvation. Our findings collectively suggest that the ERK-mediated control of ATG3 and ATG5, in association with CREB, is essential for maintaining cell viability, serving as a stress adaptive strategy during glutamine and glucose starvation.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent Sensing of Fe3+ in Acidic Environment by Carbon Dots Derived From Empty Fruit Bunch Biochar: Central Composite Design Optimization","authors":"Mohammed Abdullah Issa,&nbsp;Zaid H. Jabbar,&nbsp;Hamid Zentou,&nbsp;Reham Basim Khalaf","doi":"10.1002/bio.70127","DOIUrl":"https://doi.org/10.1002/bio.70127","url":null,"abstract":"<div>\u0000 \u0000 <p>A rapid, eco-friendly, and selective monitoring of Fe(III) in real media utilizing carbon dots (CDs) as a luminescence detector has been reported. CDs were fabricated by a hydrothermal route from empty fruit bunch biochar. The as-synthesized CDs were analyzed using various analytical tools. The results reveal that CDs have spherical shapes with a narrow particle size distribution and are enriched with multiple active sites, which impart excellent hydrophilicity and photostability. The CDs displayed bright blue emission under UV light with emission/excitation maxima at 452/350 nm, respectively, and a QY of 7.54%. The CDs exhibited high resistance to photobleaching and high salt conditions and pose a long lifetime of up to 6 months with no agglomeration. The detection variables, including pH, temperature, and CDs concentration, were optimized via response surface methodology. The statistical data verified the precision of the quadratic model for predicting the sensing performance of the nanoprobe. Under optimal environments, a linear range from 0 to 50 μM and a detection limit of 0.17 μM was obtained. The turn-off process includes the strong coordination between Fe(III) and electron-donating oxygen species on the edge of CDs. The rapid luminescence recognition using acid-free materials renders CDs a promising option for water treatment.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Eosin Y as a Probe for Spectroscopic Determination of Aripiprazole in Human Plasma","authors":"Mohamed A. Saeed,&nbsp;Noha S. Mostafa,&nbsp;Amr M. Mahmoud,&nbsp;Mohamed Ahmed Elsayed","doi":"10.1002/bio.70131","DOIUrl":"https://doi.org/10.1002/bio.70131","url":null,"abstract":"<div>\u0000 \u0000 <p>This work presents the development of new, rapid, and sensitive spectrophotometric and spectrofluorimetric methods for the determination of Aripiprazole in different dosage forms and human plasma. Both methods are based on the formation of an ion-pair complex between Eosin Y and the studied drug in an acidic medium. In the spectrophotometric method, the absorbance of the formed complex was estimated at 551 nm, showing a linear range from 1.0 to 13.0 μg mL⁻¹ with detection and quantification limits of 0.20 and 0.60 μg mL⁻¹, respectively. The spectrofluorimetric method measured the fluorescence emission of the formed complex at 545 nm upon excitation at 255 nm. This method exhibited a good linear range from 0.1 to 2.0 μg mL⁻¹ with detection and quantification limits of 0.03 and 0.09 μg mL⁻¹, respectively. The developed techniques offer several benefits, such as simplicity, cost-effectiveness, and high sensitivity. The proposed methods were validated in accordance with ICH guidelines, permitting precise analysis of the studied drug in its tablets and spiked human plasma samples with a high percent recovery. Moreover, the eco-friendly characteristics of the proposed methods were evaluated using two greenness assessment tools: AGREE and GAPI.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and Computational Optoelectrochemical Investigation of Quinoxaline Based Charge Transfer Derivatives: Green-Orange Emissive, AIEE Active Materials","authors":"Pooja S. Singh,&nbsp;Sandeep E. Jadhav,&nbsp;Balaji R. Madje,&nbsp;Sajeev Chacko,&nbsp;Rajesh M. Kamble","doi":"10.1002/bio.70130","DOIUrl":"https://doi.org/10.1002/bio.70130","url":null,"abstract":"<div>\u0000 \u0000 <p>2,3-Diphenylquinoxalin-6-yl based dyes were synthesized and characterized using ¹H, ¹³C, HRMS and NOSEY spectroscopic technique. The comprehensive photophysical, aggregation-induced emission enhancement (AIEE) activity, electrochemical and theoretical studies of dyes explored. The intramolecular charge transfer transition (ICT) at 380–386 nm in absorption spectra suggest weak push-pull feature of dyes. Dyes show emission in green to orange region (λ_max: 561–588 nm) in solvent as well as solid state. The Stokes shift of dyes is 7979–9167 cm⁻¹. The minimal positive solvatochromism (slight variation in λ_emi) own by dyes, suggest environment stability of dyes in various solvent polarity. AIEE activity with good emission at solid-state make the dyes suitable candidature for solid state OLED's application. Further Dynamic Light Scattering (DLS) studies of dye <b>1</b> validate reverse correlation of emission behavior of nanoaggregate formed at high water fraction of THF–H₂O mixture with its particle size. The good thermal stability of dyes reflected by decomposition temperature i.e., 221°C–357°C (292°C–372°C) for 5(10)% weight loss. The LUMO (−3.68 to −3.83 eV) of derivatives are lower than LUMO of reported n-type materials (−3.0 to −3.30 eV). Thus, photophysical with AIEE activity and electrochemical properties obtained for dyes signify suitability of it in organic electronics.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Photoluminescence Properties of Eu3+-Activated Ba2Cd(BO3)2 Red-Emitting Phosphors for Near-Ultraviolet Excited White Light-Emitting Diodes","authors":"S. B. Töreli,&nbsp;V. E. Kafadar,&nbsp;F. M. Emen,&nbsp;E. Öztürk,&nbsp;R. Altınkaya","doi":"10.1002/bio.70135","DOIUrl":"https://doi.org/10.1002/bio.70135","url":null,"abstract":"<p>A new class of rare-earth doped borate phosphors, Ba₂Cd(BO₃)₂: <i>x</i>Eu³⁺ (<i>x</i> = 2, 3, 4, 5, and 6 mol%), was synthesized using the high-temperature solid-state reaction technique in air. X-ray diffraction (XRD) confirmed the phase formation of Ba₂Cd(BO₃)₂, while Fourier transform infrared spectroscopy (FT-IR) revealed the presence of trigonal [BO₃] units. The surface morphology was studied using field emission scanning electron microscopy (FE-SEM), and energy dispersive spectroscopy (EDS) identified the elements. Photoluminescence (PL) analysis showed that the phosphors emitted at 592, 613, 652, and 701 nm, corresponding to the ⁵D₀ → ⁷F₁, ⁵D₀ → ⁷F₂, ⁵D₀ → ⁷F₃, and ⁵D₀ → ⁷F₄ transition of Eu³⁺ ions, respectively. The 613 nm red emission, from the ⁵D₀ → ⁷F₂ transition, was strongest for the 6 mol% Eu³⁺ sample. The emission intensity increased with Eu³⁺ concentration, peaking at 6 mol%. CIE chromaticity, correlated color temperature (CCT), and color purity calculations showed acceptable color coordinates (0.6426 and 0.3548), a low CCT value (2355 K), and high purity (91.34%), making the 6 mol% Eu³⁺-doped phosphor ideal for red light in white light-emitting diodes (WLEDs).</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bio.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Novel Donor-π-Acceptor Benzothiazole-Thiazolidinone Fluorescent Chromophores With Enhanced Biological Activity","authors":"Haifa Alharbi,&nbsp;Hatun H. Alsharief,&nbsp;Abdulmajeed F. Alrefaei,&nbsp;Abdulrhman M. Alsharari,&nbsp;S. A. Al-Ghamdi,&nbsp;F. M. Aldosari,&nbsp;Ibrahim S. S. Alatawi,&nbsp;Nashwa M. El-Metwaly","doi":"10.1002/bio.70125","DOIUrl":"https://doi.org/10.1002/bio.70125","url":null,"abstract":"<div>\u0000 \u0000 <p>Four benzothiazole-thiazolidine-4-one derivatives <b>6</b> and <b>7a–c</b> were prepared, and their chemical constructions were proved by IR, NMR, UV–Vis absorption, and emission spectra. The absorption spectra of the synthesized derivatives showed that extending the conjugated system through the insertion of a substituted benzylidene group led to a red shift of λ_max, where the nitro derivative <b>7c</b> displayed the longer wavelength. Likewise, the emission spectra presented the same effect, where the Stock shift displayed a reversed order in which the parent <b>6</b> has the highest value. The synthesized derivatives exhibited cytotoxic effectiveness against several tumor cell lines, where compound <b>7b</b> displayed significant cytotoxicity towards MCF-7 cells (IC₅₀ = 8.73 ± 0.41 μM). The in vitro VEGFR-2 kinase inhibitory activity of synthetic benzothiazole-thiazolidin-4-one derivatives has been assessed, where derivative <b>7c</b> had the strongest inhibition (IC₅₀ = 0.20 ± 0.10 μM), followed by derivatives <b>7b</b> and <b>7a</b>, respectively. However, the molecular docking showed that derivatives <b>7b</b> and <b>7c</b> have higher binding affinity than Sorafenib due to unique molecular interactions with target residues. Moreover, the pharmacokinetic parameters of the newly synthesized derivatives showed that derivative <b>7b</b> revealed moderate lipophilicity and a lack of Lipinski violations, making it a viable lead contender.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerium-Decorated Reduced Graphene Oxide Nanostructure for Enhanced Biomedical Applications","authors":"Manoj Jayan,&nbsp; Anjumol Joy,&nbsp;J. Vinoth Kumar,&nbsp; Megha M.,&nbsp; Carlin R. J.,&nbsp;Mohammed F. Albeshr,&nbsp; Angel S. L.,&nbsp; R. Sathyalakshmi,&nbsp; A. Dhayal Raj,&nbsp;R. Mythili,&nbsp; Senthilkumar Muthuswamy,&nbsp; S. John Sundaram,&nbsp;M. Sherlin Nivetha","doi":"10.1002/bio.70123","DOIUrl":"https://doi.org/10.1002/bio.70123","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of multifunctional biomaterials holds paramount importance in advancing biomedical research and applications. This investigation focuses on synthesizing cerium/reduced graphene oxide (Ce/RGO) nanocomposites using a hydrothermal approach. Structural evaluations via XRD and Raman spectroscopy confirm the successful conversion of graphene oxide (GO) to rGO and the integration of cerium nanoparticles onto the rGO surface. FTIR spectroscopy further validates structural alterations and the successful adhesion of cerium nanoparticles. Morphological and elemental analyses performed using FE-SEM and EDAX demonstrate the attachment of cerium nanoparticles onto rGO sheets. Enhanced hardness in Ce/rGO samples, compared with pure rGO, as indicated by Vickers hardness testing, suggests improved mechanical properties because of the existence of cerium nanoparticles. Measurements of the water contact angle show reduced hydrophobicity in Ce-rGO samples, implying enhanced wettability upon cerium nanoparticle integration. Additionally, porosity analysis reveals increased porosity in Ce/rGO samples, facilitating enhanced nutrient transfer within the system. Biocompatibility assessments, including hemolytic activity testing and Vero cell viability tests demonstrate favorable biocompatibility and improved cell viability in Ce/rGO samples compared with pure rGO. Antibacterial studies unveil increased efficacy against <i>S. aureus</i> and <i>E. coli</i> in Ce/rGO samples, attributed to the synergistic effects of rGO's antimicrobial properties and cerium nanoparticles' activity. This study highlights the encouraging potential of Ce/rGO nanostructures for biomedical applications, offering distinct mechanical properties, hydrophilicity, favorable biological interactions, and enhanced antibacterial performance.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Coumarin-Based Fluorescent Chemosensor for Selection Detection of Zinc Ions in Aqueous Ethanol","authors":"Wensheng Yang,&nbsp;Wan Yang,&nbsp;Yajun Ma,&nbsp;Long Yan","doi":"10.1002/bio.70122","DOIUrl":"https://doi.org/10.1002/bio.70122","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, a coumarin-based Schiff base (<b>1</b>) was designed and synthesized as a Zn²⁺-selective fluorescent chemosensor based on the PET mechanism. The structure of compound <b>1</b> was characterized by ¹H NMR and ¹³C NMR. The fluorescence properties of this chemosensor toward various metal ions were explored by fluorescence and UV–vis spectra. The results indicated that the chemosensor had high selectivity toward Zn²⁺ over other coexisting metal ions. The binding stoichiometry of <b>1</b> toward Zn²⁺ was determined to be 1:1 by Job's plot. Furthermore, the chemosensor was reversible for Zn²⁺ in an ethanol/H₂O (7:3, V/V) solution by the addition of Na₂ EDTA. The above experimental results demonstrate that <b>1</b> can be used as a fluorescent chemosensor for the real-time detection of Zn²⁺ in biological species and environmental systems.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorometric Innovations for Ultrasensitive Trace Element Analysis in Environmental Matrices","authors":"Y. Pragathi,&nbsp;K. Naga Prashant,&nbsp;Yenduri Suvarna","doi":"10.1002/bio.70109","DOIUrl":"https://doi.org/10.1002/bio.70109","url":null,"abstract":"<div>\u0000 \u0000 <p>Trace elements in environmental matrices and their potential harm to humans and the ecosystem are causing growing concern. For environmental monitoring and assessment, trace element analysis in water, soil, and air must be precise. Due to its selectivity and sensitivity, fluorometric analysis has grown in popularity. This review covers the latest fluorometric approaches for trace element measurement in environmental samples. This review discusses sensitive and selective fluorometric probes. A significant increase in fluorescence intensity makes this probe better for trace element research. Various parameters like pH, temperature, and reaction time were carefully optimized in each approach to increase sensitivity and accuracy. The current study sheds light on this analytical approach's concepts, applications, and difficulties. In general, fluorometric analysis is important for environmental studies. For researchers, it allows them to use fluorometric technology with other methods and focus on real-time analysis to solve environmental challenges.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Liver Health","authors":"Sukirtha Raman,&nbsp;Suguna Kasirajan,&nbsp;Bharathiraja Chinnapandi,&nbsp;Kandasamy Karthikeyan,&nbsp;Arjun Pandian,&nbsp;Kumar Chandrasekaran,&nbsp;Mysoon M. Al-Ansari,&nbsp;Vimal Sugumar,&nbsp;P. Srinivasan","doi":"10.1002/bio.70101","DOIUrl":"https://doi.org/10.1002/bio.70101","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Indigofera aspalathoides</i> is a medicinal plant with significant traditional importance, known for its anti-inflammatory, antimicrobial, and hepatoprotective properties. In this study, the green synthesis of selenium nanoparticles (SeNPs) was performed using <i>I</i>. <i>aspalathoides</i> ethanolic extract and characterized through Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), x-ray diffraction (XRD), and dynamic light scattering (DLS) analytical techniques. The synthesized SeNPs were evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging assays, cytotoxicity using the MTT assay against the MCF-7 breast cancer cell line, and hepatoprotective potential against the HepG2 liver cancer cell line. Characterization confirmed that the SeNPs possessed a stable, spherical structure with an optimal size range of 50–80 nm, enhancing their bioavailability and biological interactions. The SeNPs demonstrated remarkable antioxidant activity, achieving 70.32% DPPH scavenging and 73.68% hydroxyl radical scavenging, significantly surpassing the activity of the plant extract alone. The hepatoprotective effects were dose dependent, with maximum protection of HepG2 liver cells observed at 88 μg/mL (100% viability), but higher concentrations (100 μg/mL) showed some cytotoxicity. These results underscore the potential of <i>I. aspalathoides</i>-derived SeNPs as innovative nanomedicine solutions for addressing oxidative stress, hepatic disorders, and infections.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}