Medical Engineering & Physics最新文献

{"title":"Study on the properties of capsule shell prepared by multi-type HPMC mixed system","authors":"Jun Wu ,&nbsp;Qingyang Meng ,&nbsp;Ruihe Zhao ,&nbsp;Yingling Zhu ,&nbsp;Jianhua Huang ,&nbsp;Yuan Zhang ,&nbsp;Jingrou Wang ,&nbsp;Jun Gong","doi":"10.1016/j.medengphy.2025.104362","DOIUrl":"10.1016/j.medengphy.2025.104362","url":null,"abstract":"<div><div>The objective of this study is to develop a viable formulation strategy aimed at minimizing the gel content in HPMC capsules and avoiding the issue of variable drug release rates in the different media environments attributed to the excessive gel content within the capsules. Through mixing various types of HPMC with different gel temperatures, the formulation facilitates reaching the staged gelation upon the mold as the temperature decreases, which effectively reduces the requisite amount of gelling agent. Consequently, the decrease in gel agent content ensures that the dissolution of the capsule shell is unaffected by the pH of the medium and the type of ions in the medium. This property allows for uniform drug release rates across diverse media, with complete drug release occurring within approximately 20 min. This improved formula not only reduces the gelling agent content in conventional HPMC formulations but also is characterized by the absence of any organic solvents and the simplicity of operation, thus providing a dependable and widely applicable method for the synthesis of HPMC capsules.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104362"},"PeriodicalIF":1.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we identify stroke sub-type without imaging? A multidimensional analysis","authors":"Abdulaziz Alshehri ,&nbsp;Ronney B. Panerai ,&nbsp;Man Yee Lam ,&nbsp;Osian Llwyd ,&nbsp;Thompson G. Robinson ,&nbsp;Jatinder S. Minhas","doi":"10.1016/j.medengphy.2025.104364","DOIUrl":"10.1016/j.medengphy.2025.104364","url":null,"abstract":"<div><div>Stroke is a major cause of mortality and disability worldwide, with ischemic stroke (AIS) and intracerebral haemorrhage (ICH) requiring distinct management approaches. Accurate early detection and differentiation of these subtypes is crucial for targeted treatment and improved patient outcomes. Traditionally, imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) are required to distinguish between AIS and ICH. However, this study explores a non-imaging approach to differentiate between stroke subtypes. Using a retrospective dataset of 80 mild-to-moderate patients suffering stroke (68 AIS and 12 ICH), we employed principal component analysis (PCA) combined with logistic regression (LR) to evaluate 67 parameters. These parameters include baroreceptor sensitivity, and cerebral and peripheral hemodynamic variables. The PCA-LR model, validated through two-fold and six-fold cross-validation methods, effectively differentiated between AIS and ICH. BRS parameters and cerebral hemodynamic factors contributed significantly to the model’s accuracy. The two-fold cross-validation approach achieved an area under the curve (AUC) of ≥0.92, while the six-fold method maintained a consistent variance explanation (AUC ≥0.79). Results suggest that this multidimensional approach may facilitate early stroke subtype identification (AIS vs ICH) without reliance on imaging, offering a promising tool for ultra-acute stroke care in prehospital settings. However, it is important to note that the model has been tested in confirmed stroke cases, and its ability to distinguish between stroke and stroke mimics remains an important limitation for broader clinical application. Future research with larger datasets is warranted to refine the model and validate its clinical applicability.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104364"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-uniform assignment method for skeletal materials based on slope difference distribution and experimental validation","authors":"Yafeng Li ,&nbsp;Zichun Zou ,&nbsp;Fengyuan Lu ,&nbsp;Bopeng Zhang ,&nbsp;Zhifeng Tian ,&nbsp;Xi Zhang ,&nbsp;Jing Zhang","doi":"10.1016/j.medengphy.2025.104359","DOIUrl":"10.1016/j.medengphy.2025.104359","url":null,"abstract":"<div><div>A modeling method of non-uniform material assignment based on Slope Difference Distribution (SDD) is proposed to establish a complete and effective finite element (FE) model of the lower limb tibia. The validity and accuracy of the model based on <em>in vitro</em> mechanical experiments are verified. An initial tibia model was established based on Computed Tomography (CT) images. The numerical distribution of the extracted Hounsfield Unit histograms of the tibia mesh elements was fitted as a smooth curve. The critical point of the slope difference distribution curve was computed and selected to establish a tibia FE model with non-uniform material properties through numerical variations. The composite tibia's area of interest was subjected to data acquisition and analysis of displacement and strain at three gaits through a Digital Image Correlation (DIC) device. The slopes of the stress-strain straight fitting lines for slope difference distribution and structural FE models are 47.17 and 36.45. A comparison of the results of the previous experiments revealed that the FE model based on the material assignment method of slope difference distribution is more accurate. The assignment method is not limited to tibia models but also provides a method for modeling other human bones and reduces the cost of mechanical testing for accurate prediction in the simulation of bone biomechanics.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104359"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel STA-EEGNet combined with channel selection for classification of EEG evoked in 2D and 3D virtual reality","authors":"MingLiang Zuo ,&nbsp;XiaoYu Chen ,&nbsp;Li Sui","doi":"10.1016/j.medengphy.2025.104363","DOIUrl":"10.1016/j.medengphy.2025.104363","url":null,"abstract":"<div><div>Virtual reality (VR), particularly through 3D presentations, significantly boosts user engagement and task efficiency in fields such as gaming, education, and healthcare, offering more immersive and interactive experiences than traditional 2D formats. This study investigates EEG classification in response to 2D and 3D VR stimuli to deepen our understanding of the neural mechanisms driving VR interactions, with implications for brain-computer interfaces (BCIs). We introduce STA-EEGNet, an innovative model that enhances EEGNet by incorporating spatial-temporal attention (STA), improving EEG signal classification from VR environments. A one-way analysis of variance (ANOVA) was utilized to optimize channel selection, enhancing model accuracy. Comparative experiments showed that STA-EEGNet surpassed traditional EEGNet, achieving a peak accuracy of 99.78 % with channel selection. These findings highlight the benefits of spatial-temporal attention and optimal channel selection in classifying VR-evoked EEG data. This study underscores the importance of integrating spatial-temporal attention with compact convolutional neural networks like EEGNet, not only improving EEG signal classification but also advancing neural decoding and optimizing BCI applications.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104363"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfonated polyetheretherketone enriched with MXene V2C promotes bone formation via WNT/β-catenin signaling in bone marrow mesenchymal stem cells","authors":"Shengjie Wang ,&nbsp;Wei Liu ,&nbsp;Chao Yang ,&nbsp;Xianlong Zhang ,&nbsp;Chunming Lyu","doi":"10.1016/j.medengphy.2025.104361","DOIUrl":"10.1016/j.medengphy.2025.104361","url":null,"abstract":"<div><div>Prosthetic loosening represents a catastrophic postoperative complication in artificial joint replacement, resulting in severe patient morbidity and substantial healthcare costs. This investigation aimed to develop a novel strategy for preventing prosthetic loosening. Two-dimensional MXene V₂C nanosheets were synthesized and subsequently immobilized onto three-dimensional porous sulfonated polyetheretherketone (SPEEK) surfaces with polydopamine (PDA) to form V₂C-PDA@SPEEK (Abbrev. V₂C-PS). The biocompatibility was systematically evaluated using rat bone marrow mesenchymal stem cells (rBMSCs) and murine models. The osteogenic differentiation potential of V₂C-PS was assessed through real-time PCR analysis, Alkaline phosphatase (ALP) staining, and Alizarin Red staining. The in vivo osteogenic capacity of V₂C-PS surrounding the implant material was evaluated in rat femoral models using micro-CT analysis, biomechanical pull-out testing, sequential fluorescent labeling of newly formed bone, and Van Gieson staining. The molecular mechanisms underlying V₂C-PS -mediated osteogenic differentiation of rBMSCs were investigated both in vitro and in vivo using chemical inhibitors, β-catenin shRNA lentiviral silencing, and β-catenin mRNA lentiviral overexpression. The results demonstrated that V₂C-PS exhibited excellent biocompatibility. Quantitative analysis revealed substantial upregulation (p &lt; 0.05) of critical osteogenic markers, including RUNX2 (4.4-fold), COL-1 (5.7-fold), OCN (3.3-fold), BMP-2 (4.4-fold), OPN (3.1-fold), BSP (3.3-fold), ON (4.3-fold), and OSX (2.83-fold), in the 25V₂C-PS treatment group compared to PS group. The bone parameters were also remarkably enhanced in the 25V₂C-PS group (BMD increased by 241 %, bone-implant contact by 159 %, BV/TV by 225 %, Tb.N by 281 %, Tb.Th by 214 %, maximum pull-out force by 250 %, and Tp.Sp decreased by 33 %). Furthermore, V₂C-PS were found to enhance rBMSC osteogenic differentiation through activation of the Wnt/β-catenin signaling pathway. This study presents a promising approach for preventing orthopedic prosthetic loosening and demonstrates significant potential for clinical translation.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104361"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of heterotopic ossification on the cervical spine with offset of the artificial disc – A finite element study","authors":"Balaji Harinathan ,&nbsp;Davidson Jebaseelan ,&nbsp;Hemkar Sharma ,&nbsp;Lenin Babu ,&nbsp;Rajasekaran Shanmuganathan ,&nbsp;Narayan Yoganandan","doi":"10.1016/j.medengphy.2025.104356","DOIUrl":"10.1016/j.medengphy.2025.104356","url":null,"abstract":"<div><div>Heterotopic ossification (HO) is a significant complication of cervical total disc replacement (TDR), often leading to fusion and negating the intended benefits of motion preservation. Although clinical factors associated with HO formation are known, the exact biomechanical mechanism remains unclear. This study aims to predict HO formation after Mobi-C disc replacement at the C5-C6 level using a validated finite element model (FEM) of the cervical spine (C2-T1) under physiological loading. The results revealed that the Mobi-C disc increased the range of motion (ROM) at the implanted level by 52 % under flexion and extension, while adjacent levels exhibited a 2–5 % reduction. Following HO formation, ROM at the implanted level decreased by 67–76 % in flexion and extension, respectively, while adjacent levels showed a moderate increase of 5–8 %. Additionally, intradiscal pressure at the adjacent levels increased by up to 60 % in extension, mimicking fusion-like behavior. HO volume was 678 mm³ for the ideal implant position, to 760 mm³ (+12 %) for a 0.5 mm offset and 800 mm³ (+17 %) for a 1 mm offset. This study highlights the importance of Mobi-C placement to minimize HO formation, preserve motion, and mitigate complications, providing insights for clinical practice.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104356"},"PeriodicalIF":1.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of skin color change for image-based tactile sensing","authors":"Seitaro Kaneko ,&nbsp;Hiroki Ishizuka ,&nbsp;Hidenori Yoshimura ,&nbsp;Hiroyuki Kajimoto","doi":"10.1016/j.medengphy.2025.104357","DOIUrl":"10.1016/j.medengphy.2025.104357","url":null,"abstract":"<div><div>Measurement of pressure distribution applied to a fingertip is crucial for the teleoperation of robots and human computer interface. Previous studies have acquired pressure distribution by affixing a sensor array to the fingertip or by optically recording the deformation of an object. However, these existing methods inhibit the fingertip from directly contacting the texture, and the pressure applied to the fingertip is measured indirectly. In this study, we propose a method to measure pressure distribution by directly touching a transparent object, focusing on the change in skin color induced by the applied pressure, caused by blood flow. We evaluated the relationship between pressure and skin color change when local pressure is applied, and found a correlation between the pressure and the color change. However, the contact area and the color change area did not align perfectly. We further explored the factor causing the spatial non-uniformity of the color change, by accounting for the stress distribution using finite element analysis. These results suggest that the proposed measurement method can be utilized to measure the internal stress distribution, and it is anticipated to serve as a simple sensor in the field of human computer interface.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"140 ","pages":"Article 104357"},"PeriodicalIF":1.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring properties of surgical mask modified by iodine-doped cellulose film with 2D reduced graphene oxide decorated with TiO2 nanocomposite","authors":"Bansod Sneha Bharat,&nbsp;Anju R Babu","doi":"10.1016/j.medengphy.2025.104360","DOIUrl":"10.1016/j.medengphy.2025.104360","url":null,"abstract":"<div><div>The surgical mask protects against respiratory infectious diseases and prevents the risk of secondary infection due to the lack of inactivation of viruses or pathogenic bacteria. This study aims to evaluate the properties of surgical masks after the modification with a nanocomposite of titanium oxide decorated on 2D reduced graphene oxide and iodine-carboxymethyl cellulose (TIRC). The titanium oxide decorated on 2D reduced graphene oxide was prepared by the hydrothermal method. Then, TIRC was synthesized by the solution-cast method, and the nanocomposite was spray-coated on the surgical mask. Further, chemical, structural, and morphological characterization was performed for TIRC-coated masks. The antibacterial properties of the TIRC-coated mask were evaluated using the disc diffusion method. Furthermore, the photocatalytic properties of the TIRC-coated mask were determined towards methylene blue (MB) dye. The Ti-O-Ti (624 cm⁻¹) bonds and <em>C</em> = <em>C</em> (1637 cm⁻¹) bonds of the TIRC-coated mask were confirmed by Fourier transform infrared spectroscopy. Raman spectra for TIRC nanocomposite also confirmed the presence of O-Ti-O bonds at peak 142 cm⁻¹, iodine molecules at peak 72 cm⁻¹, D band at 1354 cm⁻¹, and G band<del>s</del> at 1593 cm⁻¹. The TIRC coating improved the antibacterial properties of the mask with a zone of inhibition of 13.97 ± 0.14 mm and 13.12 ± 1.58 mm towards <em>S. aureus</em> and <em>Escherichia coli</em> bacteria, respectively. Moreover, the TIRC-coated mask exhibited 92.20 % methylene blue dye degradation efficiency under visible light. The TIRC exhibits effective photocatalyst properties, making it a promising candidate for a self-sterilizing coated mask.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104360"},"PeriodicalIF":1.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated step analysis algorithm for CMAP scan study","authors":"N. Tuğrul Artuğ ,&nbsp;Nermin Gorkem Sirin ,&nbsp;Sezin Alpaydın Baslo ,&nbsp;Elif Kocasoy Orhan ,&nbsp;M. Baris Baslo ,&nbsp;A. Emre Oge","doi":"10.1016/j.medengphy.2025.104353","DOIUrl":"10.1016/j.medengphy.2025.104353","url":null,"abstract":"<div><h3>Objective</h3><div>To create an automated method for step analysis in compound muscle action potential (CMAP) scan curves and compare the step parameters calculated using the conventional semi-automated and the new automated method between patients with amyotrophic lateral sclerosis (ALS) and controls.</div></div><div><h3>Methods</h3><div>Twenty ALS patients and fifteen controls were enrolled into the study. Median nerve was stimulated at the wrist to record CMAP scans from abductor pollisis brevis muscle. Automated step analysis software revealed gaps on CMAP scan graphics by using new parameters indicating the steps. New parameters were calculated and compared with the conventional semi-automated step analysis. Intra-class correlation coefficients (ICC) were measured for reliability between methods.</div></div><div><h3>Results</h3><div>Step parameters calculated by two methods showed no significant difference in patients with ALS, except step%, but their similarities were less favorable in controls. The reliability of parameters between two methods was good-to-excellent in patient group, but controls did not show a significant ICC for any of the parameters.</div></div><div><h3>Conclusion</h3><div>A completely new automated step analysis software was developed. Analyses were done within 5 s. New step parameters were presented with supporting graphics. Results of automated step analysis were in concordance with semi-automated one for ALS patients, but not in controls.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104353"},"PeriodicalIF":1.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance and usability of an intraoperative registration paste frame for a spine surgical navigation system","authors":"Wen-Shuo Chang ,&nbsp;Tsung-Mu Wu ,&nbsp;Chung-Han Ho ,&nbsp;Chi-Ming Huang ,&nbsp;Chi-Sheng Chien ,&nbsp;Kin Weng Wong","doi":"10.1016/j.medengphy.2025.104358","DOIUrl":"10.1016/j.medengphy.2025.104358","url":null,"abstract":"<div><h3>Study design</h3><div>Experimental and observational study</div></div><div><h3>Objectives</h3><div>Despite the rapid development of various spine surgical navigation systems, they are not yet widespread. The possible explanation is that navigation accuracy is not guaranteed and user errors still occur. Therefore, we develop four different intraoperative registration paste frames and conducted simulated spine surgery in a hybrid room environment. Through performance and usability tests, we aim to evaluate the proper registration tool for spine surgical navigation system.</div></div><div><h3>Methods</h3><div>Five spine surgeons used the spine surgical navigation system and a robotic 3D C-arm to execute performance and usability tests for four different intraoperative registration paste frames. In performance test, we measured the registration and navigation accuracies. As for usability test, three observers recorded the user errors during operation and surgeons filled out a questionnaire after the procedure. Statistical analysis was performed to evaluate the test result between different paste frame designs.</div></div><div><h3>Results</h3><div>L-type intraoperative registration paste frame made by PEEK achieved small registration error (0.060 ± 0.014 mm) and small navigation error (1.30 ± 0.69 mm). The usability test showed that the L-type design not only reduced the operational risk, but also increased satisfaction.</div></div><div><h3>Conclusion</h3><div>Through the performance and usability tests, we identified the L-type intraoperative registration paste frame made by PEEK as a promising registration tool in spine surgical navigation system. Further study in the clinical setting with more case numbers is necessary to consolidate this finding.</div></div>","PeriodicalId":49836,"journal":{"name":"Medical Engineering & Physics","volume":"141 ","pages":"Article 104358"},"PeriodicalIF":1.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}