Medicina-Lithuania最新文献

{"title":"The Effects of Methylprednisolone and Hyaluronic Acid on the Endometrium in Experimentally Induced Asherman Syndrome Rat Models: A Prospective Laboratory Study.","authors":"Mehmet Genco, Merve Genco, Fisun Vural, Nermin Koç","doi":"10.3390/medicina61030482","DOIUrl":"10.3390/medicina61030482","url":null,"abstract":"<p><p><i>Background and Objectives</i>: The current study was designed as a prospective laboratory investigation to evaluate the histopathological effects and VEGF (vascular endothelial growth factor) expression in uterine tissue following treatment with a combination of methylprednisolone and hyaluronic acid in a rat model of experimentally induced Asherman Syndrome. <i>Materials and Methods</i>: Twenty-six female Sprague-Dawley rats were used. Trichloroacetic acid was applied to the right uterine horns of all the groups to induce adhesion formation. First, we induced the Asherman model in two rats (Group 1). The remaining rats were divided into the following three groups: Group 2 received intrauterine hyaluronic acid treatment, Group 3 received oral methylprednisolone treatment, and Group 4 received both treatments. Inflammation, gland count, and fibrosis levels were assessed histopathologically. VEGF levels were analyzed immunohistochemically. <i>Results</i>: Hyaluronic acid treatment increased the uterine lumen diameter and vascularization. Methylprednisolone treatment increased the gland count and uterine wall thickness while decreasing the inflammation and fibrosis scores. Combined treatment provided a statistically significant advantage over single treatments. In particular, the combined treatment group exhibited significantly lower fibrosis (<i>p</i> = 0.184) and inflammation scores (<i>p</i> = 0.071), as well as higher gland counts (<i>p</i> = 0.849) and VEGF expression (<i>p</i> = 0.114), compared to the groups receiving only methylprednisolone or hyaluronic acid. These differences indicate that the synergistic effect of the two agents results in more effective endometrial healing than when either treatment is applied alone. <i>Conclusions</i>: Methylprednisolone treatment significantly prevented adhesion formation and reduced the inflammation and fibrosis scores compared to hyaluronic acid treatment alone. The combined treatment adds to the effects of the hyaluronic acid treatment alone and provides better healing.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Utilization and Resistance According to the WHO AWaRe Classification in Intensive Care Units After COVID-19 Third Wave in Pakistan: Findings and Implications.","authors":"Muhammad Shahid Iqbal, Mohd Faiyaz Khan, Sadaf Farooqui, Salah-Ud-Din Khan, Saeed Vohra, Shahzad Rasheed, Muhammad Zahid Iqbal, Shafqat Qamer","doi":"10.3390/medicina61030481","DOIUrl":"10.3390/medicina61030481","url":null,"abstract":"<p><p><i>Background and Objective:</i> Irrational use and overuse of antibiotics is considered a major cause of antimicrobial resistance (AMR) among patients admitted to hospitals, especially in intensive care units (ICUs). ICUs are the most critical wards in healthcare settings, where the use of antibiotics is much higher compared to other wards. Therefore, the appropriate administration and monitoring of antibiotic usage in these units is a matter of concern. <i>Materials and Methods:</i> This retrospective study evaluated the types, utilization patterns, sensitivity, and resistance of various antibiotics used among patients admitted to the ICUs of different hospitals after the third wave of the coronavirus disease in 2019 (COVID-19) in Pakistan. <i>Results:</i> It was observed that more than 40% of the patients were given two antibiotics and 54.3% were given at least one antibiotic each day. A total of 768 antibiotics from different groups, based on the World Health Organization (WHO) Access, Watch, and Reserve (AWaRe) classification, were prescribed to 313 patients admitted to ICUs between April and August 2021. Among the types of antibiotics, amoxicillin/clavulanic acid was the most frequently used antibiotic (75 prescriptions). It was also observed that the majority of the bacterial isolates were more sensitive to carbapenems than the other antibiotics. The current study showed that antibiotic usage according to the AWaRe classifications was 31.8% in the Access category, 59.5% in the Watch category, and 8.7% in the Reserve category in ICUs of the studied hospitals after the third wave of COVID-19. <i>Conclusions:</i> The findings of the study also highlight the importance and continuous need for the implementation of antibiotic stewardship programs to optimize the appropriate utilization of antibiotics in the ICUs of the studied hospitals.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Control Trial Comparing Common Errors Made by Women During Three Different Methods of Pelvic Floor Muscle Contraction Training: By Verbal Education vs. Vaginal PalpationTraining vs. Perineometer Training.","authors":"Duygu Sultan Öge, Fatma Kılıç Hamzaoğlu, Hanife Doğan, Türkan Akbayrak","doi":"10.3390/medicina61030477","DOIUrl":"10.3390/medicina61030477","url":null,"abstract":"<p><p><i>Background and Objectives</i>: The aim of this study was to compare the effects of pelvic floor muscle contraction training (PFMCT) using verbal education, digital vaginal palpation (DVP), or perineometer on the common errors made during pelvic floor muscle contraction (PFMC) in women. <i>Materials and Methods</i>: A total of 48 women participated, and they were randomly assigned to three groups (Group I: PFMCT with verbal education, <i>n</i> = 16; Group II: PFMCT with DVP, <i>n</i> = 16; and Group III: PFMCT with perineometer, <i>n</i> = 16). Participants who had not previously received PFMCT were evaluated for pelvic floor muscle strength using the Modified Oxford Scale (MOS), and pelvic floor muscle activation was assessed with electromyographic biofeedback (EMG-BF). Possible errors during pelvic floor muscle contraction (gluteal, adductor and/or abdominal muscle contractions, stop breathing (breath holding), enhanced inhaling, and straining) were evaluated through inspection, palpation, or EMG-BF. After pre-training evaluations, all participants received training on pelvic floor. After this general training, each group received PFMCT using the specific training method for their group. After the training, the same evaluations were repeated. The sessions were conducted one-on-one and lasted for an average of one hour. <i>Results</i>: After the training, MOS values increased in Group II and Group III, while EMG-BF values only increased in Group II (<i>p</i> < 0.05). The number of incorrect movements during PFMC decreased after the training in all three groups (<i>p</i> < 0.05). The abdominal muscle contraction value monitored by EMG-BF only decreased in Group II (<i>p</i> < 0.05). <i>Conclusions</i>: Our study demonstrated that the PFMCT applied using the DVP method was more effective in creating more accurate and stronger muscle contractions and reducing common errors when compared to pre- and post-training values. Significant differences were observed between the groups in terms of performance improvements, with Group II showing the most notable progress. These results support the potential for DVP to yield better outcomes when used in PFMT.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Adherence in Hypertensive Patients-Pilot Study with Self-Efficacy for Appropriate Medication Use Scale in Bulgaria.","authors":"Zornitsa Mitkova, Elena Dimitrova, Velislava Kazakova, Nikolay Gerasimov, Diyan Gospodinov, Javor Mitkov, Stamen Pishev, Guenka Petrova","doi":"10.3390/medicina61030478","DOIUrl":"10.3390/medicina61030478","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Hypertension is found as the leading cardiovascular disease in Bulgaria and the most frequent lifelong condition with a high risk of non-adherence. The aim of this study is to assess the hypertension patients' adherence to medication therapy in Bulgaria by using the self-efficacy for appropriate medication use scale (SEAMS). <i>Materials and Methods</i>: A cross-sectional study was conducted in the major cardiology settings in the capital Sofia and in Burgas, the fourth largest city in Bulgaria. Data were collected from January 2024 to July 2024. The SEAMS was validated in Bulgarian in a sample of patients with hypertension that made it extremely suitable for our study. We applied 19 questions. Additionally, we used Cronbach's α, ANOVA analysis, Pearson correlation, and covariance tests for statistical significance. <i>Results</i>: A total of 232 patients completed the study. Both genders are almost equally distributed (49.6% male and 50.4% female). The results reveal that the increase in the number of diseases and prescribed medicinal products leads to a worsening adherence level. Advancing age negatively affects the adherence scores. The study showed that in half of the age groups studied (patients' age: 40-49, 60-69, and 70-79), adherence in patients treated with FDCs was better or almost the same (patients' age: 50-59) as those treated with several mono-products. <i>Conclusions</i>: Measuring adherence with SEAMS in the hypertensive Bulgarian population in two regions reveals a good level of adherence. Factors negatively affecting adherence were older age, polypharmacy, co-morbidity, and therapy with monoproducts.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up.","authors":"Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia","doi":"10.3390/medicina61030476","DOIUrl":"10.3390/medicina61030476","url":null,"abstract":"<p><p><i>Background and Objectives</i>: To date, the gold standard of care for bone sarcomas is limb salvage surgical resection. In cases where the tumor arises in the distal femur or proximal tibia near the joint line, knee-sacrificing surgery is typically performed, followed by reconstruction with oncological megaprostheses. This study aims to evaluate the effectiveness of a precise 3D-based surgical approach for knee-sparing tumor resections, assessing its feasibility and its impact on surgical, oncological, and functional outcomes. <i>Materials and Methods</i>: This single-center retrospective study presents the surgical and oncological outcomes of knee-sparing surgeries following bone sarcoma resections. All patients underwent either intercalary or geographic resection, and reconstruction was tailored to each patient, using either an allograft or a titanium alloy Ti64 implant, depending on the specific requirements of the case. <i>Results</i>: A total of 23 patients (average age 21.04 years, 14 males) were included, with an average postoperative follow-up of 58 months (range: 12-102 months). Clear surgical margins were achieved in all patients, with 16 patients (69.5%) showing wide negative margins (R0) and the rest showing close negative margins (R1). Resections were primarily intercalary (17 patients, 73.9%), with 6 patients (26.1%) undergoing geographic resections. Reconstruction methods included allografts (9 patients, 39.3%), vascularized fibula and allograft (8 patients, 34.7%), and printed Ti64 cage reconstructions (6 patients, 26.0%). At the last follow-up, 19 patients (82.6%) were disease-free, 3 patients (13.4%) were alive with evidence of disease, and 1 patient (4%) was dead of disease. Complications included four cases of non-union that required revision surgery, as well as two local recurrences, which necessitated revision surgery to a modular endoprosthesis and above-knee amputation. The average MSTS at the final follow-up was 23.16 ± 5.91. <i>Conclusions</i>: The use of 3D-printed PSIs for knee-sparing bone tumor resections has emerged as the gold standard, enhancing both surgical and oncological outcomes. A future challenge lies in improving reconstruction techniques, shifting from traditional allografts to customized Ti64 printed lattice implants. As personalized healthcare and additive manufacturing continue to advance, the future of orthopedic oncology will likely see more precise, durable, and biologically integrated implants, further improving patient outcomes.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis.","authors":"Jeongmin Choi, Jongwan Kim, Yong Wook Jung, Jong Ho Park, Jae-Ho Lee","doi":"10.3390/medicina61030474","DOIUrl":"10.3390/medicina61030474","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Neurotrophic receptor tyrosine kinase 3 (<i>NTRK3</i>) is a member of the tropomyosin receptor kinase family of receptor tyrosine kinases, which play a crucial role in neural development. However, owing to the limited number of studies about <i>NTRK3</i> and cancer, we aimed to investigate <i>NTRK3</i> as a potential prognostic marker for breast cancer (BC). <i>Materials and Methods</i>: We conducted a comprehensive analysis of <i>NTRK3</i> expression in BC using the Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis 2, and Kaplan-Meier Plotter databases. We also explored the association between <i>NTRK3</i> expression and tumor-infiltrating immune cells. <i>Results</i>: Low <i>NTRK3</i> expression showed poorer prognosis in BC, as well as with T stage, pathology, and the Luminal subtype. In BC (BRCA), <i>NTRK3</i> was positively correlated with CD4+ T cell, CD8+ T cell, macrophage, and neutrophil infiltration. <i>Conclusions</i>: These results suggest that <i>NTRK3</i> may serve as a prognostic biomarker and provide novel insights into tumor immunology in BC. Therefore, <i>NTRK3</i> represents a potential diagnostic and therapeutic target for BC treatment.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of microRNA in Overactive Bladder: Relationship and Clinical Correlation.","authors":"Kürşat Küçüker, Hülya Aybek, Hakan Akça, Ege Rıza Karagür, Elif Fırat, Yusuf Özlülerden, Sinan Çelen, Zafer Aybek","doi":"10.3390/medicina61030475","DOIUrl":"10.3390/medicina61030475","url":null,"abstract":"<p><p><i>Background and Objectives</i>: This study aimed to determine the relationship between miRNAs and overactive bladder (OAB). We also aimed to reveal the diagnostic properties of miRNAs and their potential to predict responses to therapy. <i>Materials and Methods:</i> The study included 60 patients with OAB as the treatment group and 60 healthy individuals as the control group. The blood levels of 15 miRNAs in both groups were determined using PCR. Also, miRNAs with high diagnostic values were identified with receiver operating characteristic (ROC) curves. Finally, the Turkish-validated OAB questionnaire form was filled out before and after the treatment by the participants in the treatment group. In this way, the relationship between OAB score changes and miRNA levels was examined. <i>Results:</i> The let-7a, let-7c, let-7e, let-7f, and let-7g miRNA molecules in the treatment group were higher, with a high level of significance (<i>p</i> = 0.0001). Additionally, the miR-135b, miR-300, miR-372, miR-373, miR-381, miR-520a, miR-520d, and miR-520e miRNA molecules were found to be statistically higher in the control group (<i>p</i> = 0.0001). In addition, let-7c (area under curve [AUC] = 0.985) and the let-7c + miR-381 combination (area under curve [AUC] = 1) were the highest values in the ROC analysis. Finally, after treatment in the patient group, a significant difference was detected in both miRNAs (let-7f and miR-135b) in patients with clinical improvements of 50% and above in the OAB score. <i>Conclusions:</i> miRNAs may help elucidate the pathophysiology of OAB. They may shed light on diagnosis and evaluation of treatment effectiveness.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility-Sparing Treatments in Endometrial Cancer: A Comprehensive Review on Efficacy, Oncological Outcomes, and Reproductive Potential.","authors":"Carlo Ronsini, Paola Romeo, Giada Andreoli, Vittorio Palmara, Marco Palumbo, Giuseppe Caruso, Pasquale De Franciscis, Giuseppe Vizzielli, Stefano Restaino, Vito Chiantera, Stefano Cianci","doi":"10.3390/medicina61030471","DOIUrl":"10.3390/medicina61030471","url":null,"abstract":"<p><p>Endometrial cancer (EC) affects 3-14% of women under 40 who wish to preserve their fertility. The standard treatment for EC is a hysterectomy with salpingo-oophorectomy. However, for those desiring fertility preservation, oral progestogens such as medroxy-progesterone acetate (MPA) or megestrol acetate (MA) are the most common therapies in Fertility-Sparing Treatment (FST). Other treatments include gonadotropin-releasing hormone agonist (GnRHa), levonorgestrel-releasing intrauterine system (LNG-IUS), and metformin plus progestin. This comprehensive review evaluates the best FST options for women with reproductive potential. PubMed, EMBASE, and Scopus were searched in June 2023 using specific keywords. Studies included in the review focused on patients with EC undergoing FST, with outcomes such as complete response rate (CRR), recurrence rate (RR), pregnancy rate (PR), and live birth rate. Eighteen studies met the inclusion criteria, involving 23,976 patients. In only-oral progestin trials, CRR ranged from 18% to 100%; RR ranged from 0% to 81.8%; Death Rate ranged from 0% to 3.6%. In studies combining oral progestin with LNG-IUS, CRR ranged from 55% to 87.5%; RR ranged from 0% to 41.7%; Death Rate was 0%. Most patients with Stage IA EC received MPA or MA. Fertility-related outcomes were reported in 15 studies. PR ranged from 4 to 44 patients in trials involving only oral progestins. When combining oral progestin with LNG-IUS, PR ranged from 1 to 46 patients. Progestin therapy, including oral MPA and MA, is considered safe and effective, with limited evidence supporting the use of LNG-IUS.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced ECG Analysis to Evaluate Multimodal Exercise Effects on Cardiovascular Health.","authors":"Ruta Brazdzionyte, Deivydas Velicka, Kristina Motiejunaite, Kristina Poderiene, Zivile Kairiukstiene","doi":"10.3390/medicina61030473","DOIUrl":"10.3390/medicina61030473","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Cardiovascular diseases (CVD) are the primary causes of death throughout the world. Engaging in physical activity (PA) is crucial for the prevention of CVD, as a lack of exercise significantly impacts global health. For health promotion purposes, it is important to optimize PA and develop the main physical components. Multimodal exercise program (MEP) interventions cause unique cardiac changes that can be systematically analyzed using advanced ECG techniques. Using algebraic co-integration methods, this study examined the physiological cardiac adaptations of a 6-week MEP compared to sedentary control subjects. <i>Materials and Methods</i>: A total of 50 physically inactive males, aged 20-35 years, were recruited for a 6-week MEP. The intervention group (IG) consisted of 28 participants, while the control group (CG) included 22 participants. The MEP included balance, endurance, muscle strength, and flexibility exercises in one session. The cardiovascular system (CVS) was assessed using electrocardiography (ECG) and arterial blood pressure during an incremental cycle ergometer test, both before and after the 6-week period. <i>Results</i>: After the post-MEP, the IG's resting HR showed a slight but insignificant decrease, from 84.5 to 82 bpm, with improved recovery rates at minute 1 (113.1-104.7 bpm). The CG showed a similar trend. pBP in IG significantly increased post-MEP during recovery at minute 1 (73-81) and minute 2 (65-72), where the CG showed a slight but significant difference. DskJT-QRS in IG post-MEP increased significantly during recovery in minutes 1-4, with all values showing <i>p</i> < 0.05. CG showed significance only at minute 3. <i>Conclusions</i>: Both the 6-week MEP and control had a positive impact on the CVS. The statement refers to changes in dynamic interactions between ECG parameters registered during the incremental exercise test and especially during the recovery after workload. Algebraic data co-integration analysis of ECG parameters demonstrated a sensitive assessment of the influence of exercising on the cardiovascular system.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pain and Anxiety Levels After Periodontal Treatment.","authors":"Ebru Sarıbaş, Mehmet Cudi Tuncer","doi":"10.3390/medicina61030464","DOIUrl":"10.3390/medicina61030464","url":null,"abstract":"<p><p><i>Background and Objectives:</i> Nowadays, dental anxiety is one of the most common problems among the masses globally, causing individuals to avoid seeking dental treatment, which in turn leads to deterioration of quality of life related to oral health. Despite the technological advances in dentistry such that less pain is felt and high comfort performance is maintained, dental anxiety is still seen in individuals. Non-surgical periodontal therapy can be the cause of tension, anxiety, and stress. The aim of this study is to evaluate the possible relationships between pain perception and dental anxiety in individuals who underwent supragingival scaling. <i>Materials and Methods:</i> In our study, 226 individuals (114 female and 112 male) who were referred to the Dicle University Faculty of Dentistry, Department of Periodontology and who underwent supragingival scaling treatment were included. Participants were asked to complete the Modified Dental Anxiety Scale (M-DAS) and the Visual Analog Scale (VAS) to determine anxiety and pain levels and questionnaires containing information on gender, age, education level, previous dental visits, and complications. <i>Results:</i> The M-DAS score for females was significantly higher compared to males (<i>p</i> < 0.05). However, there was no statistically significant difference between genders regarding VAS scores. No statistically significant difference existed between M-DAS and VAS scores and education levels. There was a statistically significant relationship between M-DAS and VAS scores in females (<i>p</i> < 0.05). <i>Conclusions:</i> M-DAS and VAS scores in male patients did not show any statistically significant difference. Female patients exhibited higher levels of dental anxiety, and VAS scores were increased in females; M-DAS scores were also increased.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}