Medicina-Lithuania最新文献

{"title":"Effect of Preoperative Oral Antibiotics for Prevention of Incisional Surgical Site Infection After Colorectal Surgery: A Propensity Score Matching Study.","authors":"Ryo Nakanishi, Heita Ozawa, Naoyuki Toyota, Minori Mise, Shin Fujita","doi":"10.3390/medicina60121970","DOIUrl":"https://doi.org/10.3390/medicina60121970","url":null,"abstract":"<p><p><i>Background and Objectives:</i> Recent findings suggest that combining mechanical bowel preparation (MBP) and preoperative oral antibiotics (OAs) decreases the risk of incisional surgical site infections (iSSIs) in colorectal surgery; however, this finding remains controversial. This study examined the efficacy of OAs and MBP in colorectal surgery using propensity score matching (PSM). <i>Materials and Methods</i>: Between January 2015 and December 2020, 559 patients with colorectal tumors underwent MBP followed by colorectal surgery. The multivariate analysis used a COX proportional hazards model to extract risk factors for iSSI. PSM was performed to balance the impact of potential co-factors of OAs with MBP (OA) and MBP alone (non-OA) on superficial SSI incidence. <i>Results</i>: The multivariate analysis identified non-OA use as an independent risk factor for iSSIs (odds ratio [OR]: 2.44, 95% confidence interval [CI]: 1.22-4.88, <i>p</i> = 0.0112). After matching the cohort, both OA and non-OA groups were divided into 217 cases each. The incisional SSI rate was significantly lower in the OA group (<i>n</i> = 338) than in the non-OA group (1.61% vs. 5.07%; OR 3.4; 95% CI; 0.123-0.707; <i>p</i> = 0.0062). <i>Conclusions</i>: This study revealed that OAs with MBP markedly reduced SSI rates. OAs with MBP should be adopted in colorectal surgery.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Schemata Revealed by the Critical View of Safety Approach: A Proposal of the Hellenic Task Force on the Typology of Safe Laparoscopic Cholecystectomy (HETALCHO).","authors":"Dimitris Papagoras, Gerasimos Douridas, Dimitrios Panagiotou, Konstantinos Toutouzas, Panagis Lykoudis, Alexandros Charalabopoulos, Dimitrios Korkolis, Konstantinos Alexiou, Nikolaos Sikalias, Dimitrios Lytras, Theodosios Papavramidis, Konstantinos Tepetes, Konstantinos Avgerinos, Spyridon Arnaoutos, Konstantinos Stamou, Evangelos Lolis, Dimitrios Zacharoulis, Georgios Zografos, Georgios Glantzounis","doi":"10.3390/medicina60121968","DOIUrl":"https://doi.org/10.3390/medicina60121968","url":null,"abstract":"<p><p><i>Background and objectives</i>: Laparoscopic cholecystectomy (LC) is the most commonly performed operation in general surgery in the Western World. Gallbladder surgery, although most of the time simple, always offers the possibility of unpleasant surprises. Despite progress, the incidence of common bile duct injury is 0.2-0.4%, causing devastating implications for the patient and the surgeon. This is mainly due to the failure to identify the normal anatomy properly. The literature review reveals a lack of structured knowledge in the surgical anatomy of cholecystectomy. The aim of this study was to develop a framework with a common anatomical language for safe laparoscopic and open cholecystectomy. <i>Materials and Methods:</i> The Hellenic Task Force group on the typology for Safe Laparoscopic Cholecystectomy performed a critical review of the literature on the laparoscopic anatomy of cholecystectomy. The results were compared with those of a clinical study of 279 patients undergoing LC for uncomplicated symptomatic gallstone disease. <i>Results:</i> Fourteen elements encountered during LC under the critical view of safety (CVS) approach were determined. The typical vascular-biliary pedicle with one cystic duct distributed laterally (or caudally) and one cystic artery medially (or cranially) lying at any point of the hepatocystic space was found in 66% of the cases studied. Anatomical schemata were formulated corresponding to the norm and four variations. <i>Conclusions:</i> The proposed cognitive anatomical schemata summarize simply what one can expect in terms of deviation from the norm. We believe that the synergy between the correct application of the CVS and the structured knowledge of the surgical anatomy in cholecystectomy helps the surgeon to handle non-typical structures safely and to complete the laparoscopic or open cholecystectomy without vascular-biliary injuries.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Indocyanine Green Dosage for Repetitive Angiography for Laparoscopic Colorectal Surgery.","authors":"Gyung Mo Son, Sang-Ho Park, Nam Su Kim, Mi Sook Yun, In Young Lee, Myeong-Sook Kwon, Tae Kyun Kim, Eun Hwa Lee, Eun Jung Hwang, Kwang-Ryul Baek","doi":"10.3390/medicina60121966","DOIUrl":"https://doi.org/10.3390/medicina60121966","url":null,"abstract":"<p><p><i>Background and Objectives</i>: This study aimed to determine the minimal effective dose of indocyanine green (ICG) required for accurately assessing colonic perfusion during laparoscopic colorectal surgery using a laser-assisted laparoscopic near-infrared (NIR) camera system. <i>Materials and Methods</i>: In 15 patients with colorectal cancer undergoing right hemicolectomy, the left branch of the middle colic artery was preserved, and ICG angiography was performed in the transverse colon. To determine the optimal ICG dose, experimental doses of 0.01, 0.02, 0.03, 0.04, and 0.05 mg of ICG per patient's body weight (kg) were administered intravenously in each group. Additionally, a conventional dose of 0.2 mg/kg was administered in the same patients more than 30 min after the initial dose. For quantitative analysis, the fluorescent expression region was extracted, and fluorescence intensity was analyzed using automatic image processing. Analysis accessibility, T_1/2MAX, perfusion time ratio, slope, artificial intelligence (AI)-based perfusion pattern analysis, and washout time were measured in 150 detailed regions of interest in each image. <i>Results</i>: Group 1 (0.01 mg/kg) showed significantly lower accessibility rates for quantitative analysis (48.0%) compared with Groups 2-5 (84.7-100%). The mean slope value in Group 1 was 3.7, which fell below the acceptable threshold (>4) and was significantly lower than that of the other groups (<i>p</i> < 0.001). An acceptable AI-based perfusion pattern was 14.2% in Group 1, significantly lower than in Groups 2-5 (66.4-100%). Washout time was significantly faster with minimal doses compared with conventional doses (39.0 ± 15.8 s vs. 117.5 ± 4.9 s, respectively, <i>p</i> < 0.001). <i>Conclusions</i>: This study supports the use of minimal ICG doses, ranging from 0.02 to 0.05 mg/kg, to optimize repetitive ICG angiography using a laser-assisted laparoscopic NIR camera.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Enciu et al. Is Complete Excision Always Enough? A Quality of Sexual Life Assessment in Patients with Deep Endometriosis. <i>Medicina</i> 2024, <i>60</i>, 1534.","authors":"Raluca Gabriela Enciu, Octavian Enciu, Dragoș Eugen Georgescu, Adrian Tulin, Adrian Miron","doi":"10.3390/medicina60121965","DOIUrl":"https://doi.org/10.3390/medicina60121965","url":null,"abstract":"<p><p>In the original publication [...].</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of Plant Nutrition in the Creation of the Intestinal Microbiota-Prevention of Chronic Diseases: A Narrative Review.","authors":"Miljana Z Jovandaric, Kristina Jovanović, Misela Raus, Sandra Babic, Tamara Igic, Boba Kotlica, Srboljub Milicevic","doi":"10.3390/medicina60121969","DOIUrl":"10.3390/medicina60121969","url":null,"abstract":"<p><p>Dysbiosis of the gastrointestinal tract is the most common cause of disease in childhood and adulthood. The formation of the intestinal microbiome begins in utero, and composition modification during life depends mainly on various genetic, nutritional, and environmental factors. The main cause of intestinal dysbiosis is improper nutrition due to a short period of breastfeeding, insufficient intake of fresh fruits and vegetables, and/or consumption of a large amount of processed food. The benefits of a diet based on grains, legumes, fruits, and vegetables are reflected in reducing the risk of cancer, cardiovascular diseases, myocardial infarction, stroke, rheumatoid arthritis, high blood pressure, asthma, allergies, and kidney stones. Anaerobic fermentation of fibers produces short-chain fatty acids (SCFA) that have an anti-inflammatory role and great importance in shaping the intestinal microbiota. Factors associated with high fiber in a plant-based diet promote increased insulin sensitivity. Insulin and insulin-like growth factor 1 (IGF-I) act as promoters of most normal and pre-neoplastic tissues. Conclusion: A plant-based diet high in fiber prevents disease by creating metabolites in the gut that reduce oxidative stress.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Risk Factors in Idiopathic and Non-Idiopathic Interstitial Lung Disease: Similarities and Differences.","authors":"Stefania Cerri, Elisa Manzini, Ottavia Nori, Lucia Pacchetti, Laura Rossi, Maria Giulia Turchiano, Anna Valeria Samarelli, Giulia Raineri, Dario Andrisani, Filippo Gozzi, Bianca Beghè, Enrico Clini, Roberto Tonelli","doi":"10.3390/medicina60121967","DOIUrl":"https://doi.org/10.3390/medicina60121967","url":null,"abstract":"<p><p>Recent advances in genetics and epigenetics have provided critical insights into the pathogenesis of both idiopathic and non-idiopathic interstitial lung diseases (ILDs). Mutations in telomere-related genes and surfactant proteins have been linked to familial pulmonary fibrosis, while variants in MUC5B and TOLLIP increase the risk of ILD, including idiopathic pulmonary fibrosis and rheumatoid arthritis-associated ILD. Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs such as miR-21 and miR-29, regulate fibrotic pathways, influencing disease onset and progression. Although no standardized genetic panel for ILD exists, understanding the interplay of genetic mutations and epigenetic alterations could aid in the development of personalized therapeutic approaches. This review highlights the genetic and epigenetic factors driving ILD, emphasizing their potential for refining diagnosis and treatment.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Hirasawa et al. Comparative Analysis of Muscle Activity and Circulatory Dynamics: A Crossover Study Using Leg Exercise Apparatus and Ergometer. <i>Medicina</i> 2024, <i>60</i>, 1260.","authors":"Nobuhiro Hirasawa, Yukiyo Shimizu, Ayumu Haginoya, Yuichiro Soma, Gaku Watanabe, Kei Takehara, Kayo Tokeji, Yuki Mataki, Ryota Ishii, Yasushi Hada","doi":"10.3390/medicina60121958","DOIUrl":"https://doi.org/10.3390/medicina60121958","url":null,"abstract":"<p><p>In the original publication [...].</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Higher Charlson Comorbidity Index Is a Risk Factor for Hip Fracture in Older Adults During Low-Temperature Periods: A Cross-Sectional Study.","authors":"Ming-Hsiu Chiang, Yi-Jie Kuo, Shu-Wei Huang, Duy Nguyen Anh Tran, Tai-Yuan Chuang, Yu-Pin Chen, Chung-Ying Lin","doi":"10.3390/medicina60121962","DOIUrl":"https://doi.org/10.3390/medicina60121962","url":null,"abstract":"<p><p><i>Background and Objectives</i>: The incidence of hip fractures is increasing, and there have been reports linking cold weather to a higher risk of fractures. This study aimed to evaluate clinical variables in hip fracture patients who may predispose them to such fractures under different temperatures. <i>Materials and Methods</i>: This is a cross-sectional study conducted at a single medical center, enrolling older adults (≥60 years) who had experienced a hip fracture. Comprehensive clinical histories and detailed information regarding each patient's hip fracture were obtained. All meteorological data were extracted from the Taiwan Central Weather Bureau database. Multiple clinical parameters that may have a close connection with the temperature at which the hip fracture occurred were screened. Statistical analysis involved using the Pearson correlation test or the independent Student's <i>t</i> test, followed by generalized estimating equation analysis. <i>Results</i>: The cohort comprised 506 older adults with hip fractures. Initial univariate analysis revealed that a history of past cerebrovascular diseases, Charlson Comorbidity Index, patient age, and preinjury Barthel Index were significantly related to the temperature at which the hip fractures occurred. The generalized estimating equation analysis indicated that only the Charlson Comorbidity Index had a considerably inverse association with temperature. This finding suggests that for older adults with a higher Charlson Comorbidity Index, hip fractures tend to occur at lower temperatures and vice versa. <i>Conclusions</i>: Comorbidities are the only clinical concern that predisposes older adults to hip fractures under colder temperatures. This epidemiological finding could guide future patient education and hip fracture prevention programs.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Prevention of Biofilm on Cochlear Implants: A Systematic Review.","authors":"Alexios Tsikopoulos, Konstantinos Tsikopoulos, Konstantinos Sidiropoulos, Gabriele Meroni, Stefanos Triaridis, Lorenzo Drago, Paraskevi Papaioannidou","doi":"10.3390/medicina60121959","DOIUrl":"https://doi.org/10.3390/medicina60121959","url":null,"abstract":"<p><p><i>Background and Objectives:</i> Biofilm formation on cochlear implants (CIs) poses a major problem for surgeons, leading to a high incidence of explantation and revision surgery. Therefore, developing appropriate and cost-effective biofilm detection and prevention techniques is of the essence. In this systematic review, we sought to investigate the development of biofilm formation on CIs. We also elaborated on experimental preventative biofilm measures. <i>Materials and Methods:</i> We conducted a systematic search of both in vitro and in vivo literature published in PubMed, Scopus, and ScienceDirect, until 15 June 2024, for published studies evaluating the biofilm formation and strategies for inhibiting biofilm formation on CIs. Depending on the type of the included study, we assessed quality with the modified Consolidated Standards of Reporting Trials tool, the Joanna Briggs Institute Case Reports Critical Appraisal Tool, a modified Delphi technique, and the ROBINS-I tool. We synthesized the available information on biofilm formation on CIs and the infection prevention capacity of the included antibiofilm agents. <i>Results:</i> A total of 26 studies were included in this systematic review. Biofilms in CIs are usually localized in their recesses such as their removable magnet pocket as opposed to their smooth surfaces. <i>S. aureus</i> and <i>P. aeruginosa</i> are the most commonly isolated microorganisms, and they tend to be strong biofilm producers. The optimal treatment strategy for a biofilm-infected CI is explantation. Most of the examined biofilm prevention methods in CIs present sufficient antibiofilm activity. <i>Conclusions:</i> Biofilm formation in CIs is considered one of the most dreadful complications. There have been no specific guidelines for the treatment of those cases, with removal and/or replacement of the CI being the treatment of choice. Various experimental prevention methods provide promising antibiofilm activity both in vivo and in vitro.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in Strength After Multimodal Pain Management Concept in Patients with Cervical Radiculopathy-A Non-Randomized, Uncontrolled Clinical Trial.","authors":"Gerd Zirkl, Jens Schaumburger, Matthias Gehentges, Moritz Kaiser","doi":"10.3390/medicina60121961","DOIUrl":"https://doi.org/10.3390/medicina60121961","url":null,"abstract":"<p><p><i>Background and Objective</i>: Although multimodal pain therapy (MPT) is widely used in pain management for chronic cervical radiculopathy, its effect on increasing muscle strength in patients with cervical radiculopathy is not well documented. This study aimed to evaluate the impact of a structured multimodal pain management program on muscle strength in these patients, using objective strength measurements as indicators of therapeutic success. <i>Materials and Methods</i>: This non-randomized, uncontrolled, prospective clinical study initially included 35 patients, but 10 were excluded due to incomplete data, resulting in a final sample of 25 patients (14 women and 11 men, aged 42 to 84 years) with cervical radiculopathy who underwent a multimodal pain management program at a specialized orthopedic clinic. Muscle strength was measured at admission and discharge using a hand-held dynamometer. Pain levels were assessed with the Numeric Rating Scale. An uncontrolled study design was chosen for ethical reasons, as it was deemed inappropriate to form a control group that would be deprived of necessary anti-inflammatory or analgesic medications. <i>Result</i>: Significant improvements were observed in overall muscle strength, with an 11% increase from 114.78 kg to 127.41 kg (<i>p</i> = 0.003). The strongest increase in strength was observed in the proximal cervical muscle groups, with a notable 22.9% (<i>p</i> < 0.001)improvement in the muscles involved in cervical inclination. However, no significant strength gains were detected in the peripheral muscle groups of the upper arm. Pain scores on the NRS decreased by 54.2% (<i>p</i> < 0.001). <i>Conclusions</i>: This study demonstrates that a multimodal pain management approach leads to significant improvements in muscle strength and pain reduction in patients with cervical radiculopathy. The increase in cervical muscle strength is closely associated with pain relief and improved functional outcomes, highlighting the value of conservative pain management strategies for these patients.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"60 12","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}