Neuroscientist最新文献_第9页

The Neuroscientist Comments. 神经科学家评论。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-06-01 DOI: 10.1177/10738584231166317

引用次数: 0

Forthcoming Articles. 即将出版的文章。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-06-01 DOI: 10.1177/10738584231166315

引用次数: 0

Perspectives on Neuroscience and Behavior. 神经科学与行为透视。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-06-01 DOI: 10.1177/10738584231166318

{"title":"Perspectives on Neuroscience and Behavior.","authors":"","doi":"10.1177/10738584231166318","DOIUrl":"https://doi.org/10.1177/10738584231166318","url":null,"abstract":"A recent review discussed the evidence that I N i -methyl-d-aspartate receptor (NMDA) hypofunction, neuroimmune dysregulation, and mitochondrial energy metabolism acted through a \"central hub\" of oxidative stress that resulted in impaired oligodendrocytes and parvalbumin-GABAergic neuron microcircuits that produce the impaired neural synchronization and cognitive, emotional, and social deficits seen in schizophrenia (Cuenod and others 2022) Now, genome-wide polygenic risk scores (GW-PRSs) and pathway-specific polygenic risk scores (PRSs) have been studied in two samples of first episode of psychosis patients. Oxidative stress was the only one of the five pathways that showed significant enrichment in both sample 1 ( I P i <.03) and sample 2 ( I P i <.002) in Oxidative stress and psychosis, (Pistis and others 2022). Now, it has been found that increased neuropsychiatric symptoms correlate with the increased blood oxidative stress toxicity (OSTOX)/antioxidant (ANTIOX) ratio ( I r i SP 2 sp = 0.186) in 120 patients with long COVID and 36 controls. [Extracted from the article] Copyright of Neuroscientist is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 3","pages":"272"},"PeriodicalIF":5.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9409341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal Circuits Associated with Fear Memory: Potential Therapeutic Targets for Posttraumatic Stress Disorder. 与恐惧记忆相关的神经回路:创伤后应激障碍的潜在治疗靶点。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-06-01 DOI: 10.1177/10738584211069977

Yan Yan, Ailikemu Aierken, Chunjian Wang, Wei Jin, Zhenzhen Quan, Zhe Wang, Hong Qing, Junjun Ni, Juan Zhao

{"title":"Neuronal Circuits Associated with Fear Memory: Potential Therapeutic Targets for Posttraumatic Stress Disorder.","authors":"Yan Yan, Ailikemu Aierken, Chunjian Wang, Wei Jin, Zhenzhen Quan, Zhe Wang, Hong Qing, Junjun Ni, Juan Zhao","doi":"10.1177/10738584211069977","DOIUrl":"https://doi.org/10.1177/10738584211069977","url":null,"abstract":"Posttraumatic stress disorder (PTSD) is a psychiatric disorder that is associated with long-lasting memories of traumatic experiences. Extinction and discrimination of fear memory have become therapeutic targets for PTSD. Newly developed optogenetics and advanced in vivo imaging techniques have provided unprecedented spatiotemporal tools to characterize the activity, connectivity, and functionality of specific cell types in complicated neuronal circuits. The use of such tools has offered mechanistic insights into the exquisite organization of the circuitry underlying the extinction and discrimination of fear memory. This review focuses on the acquisition of more detailed, comprehensive, and integrated neural circuits to understand how the brain regulates the extinction and discrimination of fear memory. A future challenge is to translate these researches into effective therapeutic treatment for PTSD from the perspective of precise regulation of the neural circuits associated with the extinction and discrimination of fear memories.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 3","pages":"332-351"},"PeriodicalIF":5.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9775357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Influencing Human Behavior with Noninvasive Brain Stimulation: Direct Human Brain Manipulation Revisited. 用无创脑刺激影响人类行为:重新审视直接的人脑操作。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-06-01 DOI: 10.1177/10738584211067744

Shirley Fecteau

引用次数: 2

DNA Damage and Repair in Migraine: Oxidative Stress and Beyond. 偏头痛的DNA损伤和修复:氧化应激及其他。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-06-01 DOI: 10.1177/10738584221090836

Michal Fila, Aleksandra Jablkowska, Elzbieta Pawlowska, Janusz Blasiak

{"title":"DNA Damage and Repair in Migraine: Oxidative Stress and Beyond.","authors":"Michal Fila, Aleksandra Jablkowska, Elzbieta Pawlowska, Janusz Blasiak","doi":"10.1177/10738584221090836","DOIUrl":"https://doi.org/10.1177/10738584221090836","url":null,"abstract":"Energy generation in the brain to ameliorate energy deficit in migraine leads to oxidative stress as it is associated with reactive oxygen species (ROS) that may damage DNA and show a pronociceptive action in meninges mediated by transient receptor potential cation channel subfamily A member 1 (TRPA1). Recent studies show high levels of single-strand breaks (SSBs) at specific sites in the genome of postmitotic neurons and point at SSB repair (SSBR) as an important element of homeostasis of the central nervous system. DNA topoisomerase 1 (TOP1) is stabilized in the DNA damage-inducing state by neuronal stimulation, including cortical spreading depression. Impairment in poly (ADP-ribose) polymerase 1 (PARP-1) and X-ray repair cross complementing 1 (XRCC1), key SSBR proteins, may be linked with migraine by transient receptor potential melastatin 2 (TRPM2). TRPM2 may also mediate the involvement of migraine-related neuroinflammation with PARP-1 activated by oxidative stress–related SSBs. In conclusion, aberrant activity of SSBR evoked by compromised PARP-1 and XRCC1 may contribute to pathological phenomena in the migraine brain. Such aberrant SSBR results in the lack of repair or misrepair of SSBs induced by ROS or resulting from impaired TOP1. Therefore, components of SSBR may be considered a prospective druggable target in migraine.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 3","pages":"277-286"},"PeriodicalIF":5.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9407900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease. 大脑老化与阿尔茨海默病交汇处的微胶质细胞 TREM2

IF 3.5 3区医学

Neuroscientist Pub Date : 2023-06-01 Epub Date: 2021-09-02 DOI: 10.1177/10738584211040786

Wenhui Qu, Ling Li

{"title":"Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease.","authors":"Wenhui Qu, Ling Li","doi":"10.1177/10738584211040786","DOIUrl":"10.1177/10738584211040786","url":null,"abstract":"As resident immune cells of the brain, microglia serve pivotal roles in regulating neuronal function under both physiological and pathological conditions, including aging and the most prevalent neurodegenerative disease, Alzheimer's disease (AD). Instructed by neurons, microglia regulate synaptic function and guard brain homeostasis throughout life. Dysregulation of microglial function, however, can lead to dire consequences, including aggravated cognitive decline during aging and exacerbated neuropathology in diseases. The triggering receptor expressed on myeloid cells 2 (TREM2) is a key regulator of microglial function. Loss-of-function variants of TREM2 are associated with an increased risk of AD. TREM2 orchestrates the switch of microglial transcriptome programming that modulates microglial chemotaxis, phagocytosis, and inflammatory responses, as well as microglial regulation of synaptic function in health and disease. Intriguingly, the outcome of microglial/TREM2 function is influenced by age and the context of neuropathology. This review summarizes the rapidly growing research on TREM2 under physiological conditions and in AD, particularly highlighting the impact of TREM2 on neuronal function.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 3","pages":"302-316"},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9413960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biobanking for Neurodegenerative Diseases: Challenge for Translational Research and Data Privacy. 神经退行性疾病的生物银行:转化研究和数据隐私的挑战。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-04-01 DOI: 10.1177/10738584211036693

Emilia Giannella, Valentino Notarangelo, Caterina Motta, Giulia Sancesario

{"title":"Biobanking for Neurodegenerative Diseases: Challenge for Translational Research and Data Privacy.","authors":"Emilia Giannella, Valentino Notarangelo, Caterina Motta, Giulia Sancesario","doi":"10.1177/10738584211036693","DOIUrl":"https://doi.org/10.1177/10738584211036693","url":null,"abstract":"Biobanking has emerged as a strategic challenge to promote knowledge on neurological diseases, by the application of translational research. Due to the inaccessibility of the central nervous system, the advent of biobanks, as structure collecting biospecimens and associated data, are essential to turn experimental results into clinical practice. Findings from basic research, omics sciences, and in silico studies, definitely require validation in clinically well-defined cohorts of patients, even more valuable when longitudinal, or including preclinical and asymptomatic individuals. Finally, collecting biological samples requires a great effort to guarantee respect for transparency and protection of sensitive data of patients and donors. Since the European General Data Protection Regulation 2016/679 has been approved, concerns about the use of data in biomedical research have emerged. In this narrative review, we focus on the essential role of biobanking for translational research on neurodegenerative diseases. Moreover, we address considerations for biological samples and data collection, the importance of standardization in the preanalytical phase, data protection (ethical and legal) and the role of donors in improving research in this field.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 2","pages":"190-201"},"PeriodicalIF":5.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10738584211036693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9285247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Alzheimer's Disease Genetics: A Dampened Microglial Response? 阿尔茨海默病遗传学：小胶质细胞反应减弱？

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-04-01 Epub Date: 2021-06-18 DOI: 10.1177/10738584211024531

Zena K Chatila, Elizabeth M Bradshaw

引用次数: 10

Insights into Enhancer RNAs: Biogenesis and Emerging Role in Brain Diseases. 对增强子rna的洞察:生物发生和在脑部疾病中的新作用。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-04-01 DOI: 10.1177/10738584211046889

Yuxin Shen, Zhengyi Huang, Ruiqing Yang, Yunlong Chen, Qiang Wang, Linbo Gao

引用次数: 3