Neuroscientist最新文献_第8页

Highlander. 高地人

IF 5.6 3区医学

Neuroscientist Pub Date : 2024-02-01 DOI: 10.1177/10738584231225116

引用次数: 0

Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption. 癫痫的神经行为和临床并发症：白质网络破坏的作用。

IF 5.6 3区医学

Neuroscientist Pub Date : 2024-02-01 Epub Date: 2022-02-22 DOI: 10.1177/10738584221076133

Alena Stasenko, Christine Lin, Leonardo Bonilha, Boris C Bernhardt, Carrie R McDonald

{"title":"Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.","authors":"Alena Stasenko, Christine Lin, Leonardo Bonilha, Boris C Bernhardt, Carrie R McDonald","doi":"10.1177/10738584221076133","DOIUrl":"10.1177/10738584221076133","url":null,"abstract":"Epilepsy is a common neurological disorder associated with alterations in cortical and subcortical brain networks. Despite a historical focus on gray matter regions involved in seizure generation and propagation, the role of white matter (WM) network disruption in epilepsy and its comorbidities has sparked recent attention. In this review, we describe patterns of WM alterations observed in focal and generalized epilepsy syndromes and highlight studies linking WM disruption to cognitive and psychiatric comorbidities, drug resistance, and poor surgical outcomes. Both tract-based and connectome-based approaches implicate the importance of extratemporal and temporo-limbic WM disconnection across a range of comorbidities, and an evolving literature reveals the utility of WM patterns for predicting outcomes following epilepsy surgery. We encourage new research employing advanced analytic techniques (e.g., machine learning) that will further shape our understanding of epilepsy as a network disorder and guide individualized treatment decisions. We also address the need for research that examines how neuromodulation and other treatments (e.g., laser ablation) affect WM networks, as well as research that leverages larger and more diverse samples, longitudinal designs, and improved magnetic resonance imaging acquisitions. These steps will be critical to ensuring generalizability of current research and determining the extent to which neuroplasticity within WM networks can influence patient outcomes.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"105-131"},"PeriodicalIF":5.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393207/pdf/nihms-1790070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neuroscientist Comments. 神经科学家评论。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2023-10-23 DOI: 10.1177/10738584231207803

引用次数: 0

Hidden Brain Anatomy in Peter Paul Rubens's Copy of "The Battle of Anghiari" by Leonardo da Vinci: "The Battle of Anghiari" and Brain Anatomy. 彼得·保罗·鲁本斯（Peter Paul Rubens）复制的达·芬奇（Leonardo da Vinci）的《安希亚里之战》（The Battle of Anghiari）中隐藏的脑解剖学：《安希埃里之战”与脑解剖学。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2022-04-22 DOI: 10.1177/10738584221094748

Grigol Keshelava

引用次数: 3

Perspectives on Neuroscience and Behavior. 神经科学与行为展望。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2023-10-24 DOI: 10.1177/10738584231207812

引用次数: 0

Targeted Molecular Strategies for Genetic Neurodevelopmental Disorders: Emerging Lessons from Dravet Syndrome. 遗传性神经发育障碍的靶向分子策略：Dravet综合征的新经验教训。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2022-04-13 DOI: 10.1177/10738584221088244

Robert Lersch, Rawan Jannadi, Leonie Grosse, Matias Wagner, Marius Frederik Schneider, Celina von Stülpnagel, Florian Heinen, Heidrun Potschka, Ingo Borggraefe

{"title":"Targeted Molecular Strategies for Genetic Neurodevelopmental Disorders: Emerging Lessons from Dravet Syndrome.","authors":"Robert Lersch, Rawan Jannadi, Leonie Grosse, Matias Wagner, Marius Frederik Schneider, Celina von Stülpnagel, Florian Heinen, Heidrun Potschka, Ingo Borggraefe","doi":"10.1177/10738584221088244","DOIUrl":"10.1177/10738584221088244","url":null,"abstract":"Dravet syndrome is a severe developmental and epileptic encephalopathy mostly caused by heterozygous mutation of the SCN1A gene encoding the voltage-gated sodium channel α subunit Nav1.1. Multiple seizure types, cognitive deterioration, behavioral disturbances, ataxia, and sudden unexpected death associated with epilepsy are a hallmark of the disease. Recently approved antiseizure medications such as fenfluramine and cannabidiol have been shown to reduce seizure burden. However, patients with Dravet syndrome are still medically refractory in the majority of cases, and there is a high demand for new therapies aiming to improve behavioral and cognitive outcome. Drug-repurposing approaches for SCN1A-related Dravet syndrome are currently under investigation (i.e., lorcaserin, clemizole, and ataluren). New therapeutic concepts also arise from the field of precision medicine by upregulating functional SCN1A or by activating Nav1.1. These include antisense nucleotides directed against the nonproductive transcript of SCN1A with the poison exon 20N and against an inhibitory noncoding antisense RNA of SCN1A. Gene therapy approaches such as adeno-associated virus-based upregulation of SCN1A using a transcriptional activator (ETX101) or CRISPR/dCas technologies show promising results in preclinical studies. Although these new treatment concepts still need further clinical research, they offer great potential for precise and disease modifying treatment of Dravet syndrome.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 6","pages":"732-750"},"PeriodicalIF":5.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Neuroscientist Comments. 神经科学家评论。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2023-10-24 DOI: 10.1177/10738584231207804

引用次数: 0

Brain Circuits Underlying Narcolepsy. 嗜睡症背后的脑回路。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2021-10-27 DOI: 10.1177/10738584211052263

Sara Katherine Pintwala, John Peever

引用次数: 1

How Can Digital Mental Health Enhance Psychiatry? 数字心理健康如何增强精神病学？

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-12-01 Epub Date: 2022-06-04 DOI: 10.1177/10738584221098603

Emilie Stern, Jean-Arthur Micoulaud Franchi, Guillaume Dumas, Jeverson Moreira, Stephane Mouchabac, Julia Maruani, Pierre Philip, Michel Lejoyeux, Pierre A Geoffroy

{"title":"How Can Digital Mental Health Enhance Psychiatry?","authors":"Emilie Stern, Jean-Arthur Micoulaud Franchi, Guillaume Dumas, Jeverson Moreira, Stephane Mouchabac, Julia Maruani, Pierre Philip, Michel Lejoyeux, Pierre A Geoffroy","doi":"10.1177/10738584221098603","DOIUrl":"https://doi.org/10.1177/10738584221098603","url":null,"abstract":"The use of digital technologies is constantly growing around the world. The wider-spread adoption of digital technologies and solutions in the daily clinical practice in psychiatry seems to be a question of when, not if. We propose a synthesis of the scientific literature on digital technologies in psychiatry and discuss the main aspects of its possible uses and interests in psychiatry according to three domains of influence that appeared to us: 1) assist and improve current care: digital psychiatry allows for more people to have access to care by simply being more accessible but also by being less stigmatized and more convenient; 2) develop new treatments: digital psychiatry allows for new treatments to be distributed via apps, and practical guidelines can reduce ethical challenges and increase the efficacy of digital tools; and 3) produce scientific and medical knowledge: digital technologies offer larger and more objective data collection, allowing for more detection and prevention of symptoms. Finally, ethical and efficacy issues remain, and some guidelines have been put forth on how to safely use these solutions and prepare for the future.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 6","pages":"681-693"},"PeriodicalIF":5.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Noninvasive Brain Stimulation: Multiple Effects on Cognition. 非侵入性脑刺激：对认知的多重影响。

IF 5.6 3区医学

Neuroscientist Pub Date : 2023-10-01 Epub Date: 2022-07-29 DOI: 10.1177/10738584221113806

Gesa Hartwigsen, Juha Silvanto

{"title":"Noninvasive Brain Stimulation: Multiple Effects on Cognition.","authors":"Gesa Hartwigsen, Juha Silvanto","doi":"10.1177/10738584221113806","DOIUrl":"10.1177/10738584221113806","url":null,"abstract":"Noninvasive brain stimulation (NIBS) techniques are widely used tools for the study and rehabilitation of cognitive functions. Different NIBS approaches aim to enhance or impair different cognitive processes. The methodological focus for achieving this has been on stimulation protocols that are considered either inhibitory or facilitatory. However, despite more than three decades of use, their application is based on incomplete and overly simplistic conceptualizations of mechanisms of action. Such misconception limits the usefulness of these approaches in the basic science and clinical domains. In this review, we challenge this view by arguing that stimulation protocols themselves are neither inhibitory nor facilitatory. Instead, we suggest that all induced effects reflect complex interactions of internal and external factors. Given these considerations, we present a novel model in which we conceptualize NIBS effects as an interaction between brain activity and the characteristics of the external stimulus. This interactive model can explain various phenomena in the brain stimulation literature that have been considered unexpected or paradoxical. We argue that these effects no longer seem paradoxical when considered from the viewpoint of state dependency.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":"29 5","pages":"639-653"},"PeriodicalIF":5.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10118487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10