Neuroscientist最新文献

Art, Intuition, and Identity in Ramón y Cajal. 拉蒙-卡哈尔的艺术、直觉与身份。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-03-10 DOI: 10.1177/10738584241234049

Dawn Hunter, Javier DeFelipe, Arpan R Mehta, Bevil R Conway

{"title":"Art, Intuition, and Identity in Ramón y Cajal.","authors":"Dawn Hunter, Javier DeFelipe, Arpan R Mehta, Bevil R Conway","doi":"10.1177/10738584241234049","DOIUrl":"10.1177/10738584241234049","url":null,"abstract":"In the history of neuroscience, Cajal stands tall. Many figures in the late 19th and early 20th centuries made major contributions to neuroscience-Sherrington, Ferrier, Jackson, Holmes, Adrian, and Békésy, to name a few. But in the public mind, Cajal is unique. His application of the Golgi method, with an array of histologic stains, unlocked a wealth of new knowledge on the structure and function of the brain. Here we argue that Cajal's success should not only be attributed to the importance of his scientific contributions but also to the artistic visual language that he created and to his pioneering self-branding, which exploited methods of the artist, including classical drawing and the new invention of photography. We argue that Cajal created his distinctive visual language and self-branding strategy by interweaving an ostensibly objective research product with an intimately subjective narrative about the brain and himself. His approach is evident in the use of photography, notably self-portraits, which furthered broad engagement initially inspired by his scientific drawings. Through his visual language, Cajal made an impact in art and culture far beyond the bounds of science, which has sustained his scientific legacy.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"125-140"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Trip To The Moon.

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327385

引用次数: 0

Microglia, Trem2, and Neurodegeneration. 小胶质细胞、Trem2 和神经退行性变

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-05-20 DOI: 10.1177/10738584241254118

Qian Shi, Raul A Gutierrez, Manzoor A Bhat

{"title":"Microglia, Trem2, and Neurodegeneration.","authors":"Qian Shi, Raul A Gutierrez, Manzoor A Bhat","doi":"10.1177/10738584241254118","DOIUrl":"10.1177/10738584241254118","url":null,"abstract":"Microglia are a specialized type of neuroimmune cells that undergo morphological and molecular changes through multiple signaling pathways in response to pathological protein aggregates, neuronal death, tissue injury, or infections. Microglia express Trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. Trem2 has emerged as a critical modulator of microglial activity, especially in many neurodegenerative disorders. Human TREM2 mutations are associated with an increased risk of developing Alzheimer disease (AD) and other neurodegenerative diseases. Trem2 plays dual roles in neuroinflammation and more specifically in disease-associated microglia. Most recent developments on the molecular mechanisms of Trem2, emphasizing its role in uptake and clearance of amyloid β (Aβ) aggregates and other tissue debris to help protect and preserve the brain, are encouraging. Although Trem2 normally stimulates defense mechanisms, its dysregulation can intensify inflammation, which poses major therapeutic challenges. Recent therapeutic approaches targeting Trem2 via agonistic antibodies and gene therapy methodologies present possible avenues for reducing the burden of neurodegenerative diseases. This review highlights the promise of Trem2 as a therapeutic target, especially for Aβ-associated AD, and calls for more mechanistic investigations to understand the context-specific role of microglial Trem2 in developing effective therapies against neurodegenerative diseases.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"159-176"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modern molecular mechanism for an ancient psychoactive substance: TMEM132B as a novel protein controlling alcohol actions in the brain.

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327384

引用次数: 0

The effect of traumatic brain injury on learning and memory: A synaptic focus. 创伤性脑损伤对学习和记忆的影响：突触聚焦

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-09-24 DOI: 10.1177/10738584241275583

Eric Eyolfson, Kirsten R B Suesser, Holly Henry, Itziar Bonilla-Del Río, Pedro Grandes, Richelle Mychasiuk, Brian R Christie

{"title":"The effect of traumatic brain injury on learning and memory: A synaptic focus.","authors":"Eric Eyolfson, Kirsten R B Suesser, Holly Henry, Itziar Bonilla-Del Río, Pedro Grandes, Richelle Mychasiuk, Brian R Christie","doi":"10.1177/10738584241275583","DOIUrl":"10.1177/10738584241275583","url":null,"abstract":"Deficits in learning and memory are some of the most commonly reported symptoms following a traumatic brain injury (TBI). We will examine whether the neural basis of these deficits stems from alterations to bidirectional synaptic plasticity within the hippocampus. Although the CA1 subregion of the hippocampus has been a focus of TBI research, the dentate gyrus should also be given attention as it exhibits a unique ability for adult neurogenesis, a process highly susceptible to TBI-induced damage. This review examines our current understanding of how TBI results in deficits in synaptic plasticity, as well as how TBI-induced changes in endocannabinoid (eCB) systems may drive these changes. Through the synthesis and amalgamation of existing data, we propose a possible mechanism for eCB-mediated recovery in synaptic plasticity deficits. This hypothesis is based on the plausible roles of CB1 receptors in regulating inhibitory tone, influencing astrocytes and microglia, and modulating glutamate release. Dysregulation of the eCBs may be responsible for deficits in synaptic plasticity and learning following TBI. Taken together, the existing evidence indicates eCBs may contribute to TBI manifestation, pathogenesis, and recovery, but it also suggests there may be a therapeutic role for the eCB system in TBI.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"195-214"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking Down Glioma-Microenvironment Crosstalk. 打破胶质瘤与微环境的相互影响

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-07-26 DOI: 10.1177/10738584241259773

Raghavskandhan Ramachandran, Alexander F Jeans

引用次数: 0

The once and future therapeutic potential of psychedelics.

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327386

引用次数: 0

Forthcoming Articles.

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327443

引用次数: 0

How does autophagy impact neurological function?

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-03-13 DOI: 10.1177/10738584251324459

Angeleen Fleming, Ana Lopez, Matea Rob, Sarayu Ramakrishna, So Jung Park, Xinyi Li, David C Rubinsztein

引用次数: 0

Harnessing Intelligence from Brain Cells In Vitro.

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-03-13 DOI: 10.1177/10738584251321438

Brett J Kagan, Forough Habibollahi, Brad Watmuff, Azin Azadi, Finn Doensen, Alon Loeffler, Seung Hoon Byun, Bram Servais, Candice Desouza, Kwaku Dad Abu-Bonsrah, Nicole Kerlero de Rosbo

{"title":"Harnessing Intelligence from Brain Cells In Vitro.","authors":"Brett J Kagan, Forough Habibollahi, Brad Watmuff, Azin Azadi, Finn Doensen, Alon Loeffler, Seung Hoon Byun, Bram Servais, Candice Desouza, Kwaku Dad Abu-Bonsrah, Nicole Kerlero de Rosbo","doi":"10.1177/10738584251321438","DOIUrl":"https://doi.org/10.1177/10738584251321438","url":null,"abstract":"Harnessing intelligence from brain cells in vitro requires a multidisciplinary approach integrating wetware, hardware, and software. Wetware comprises the in vitro brain cells themselves, where differentiation from induced pluripotent stem cells offers ethical scalability; hardware typically involves a life support system and a setup to record the activity from and deliver stimulation to the brain cells; and software is required to control the hardware and process the signals coming from and going to the brain cells. This review provides a broad summary of the foundational technologies underpinning these components, along with outlining the importance of technology integration. Of particular importance is that this new technology offers the ability to extend beyond traditional methods that assess primarily the survival and spontaneous activity of neural cultures. Instead, the focus returns to the core function of neural tissue: the neurocomputational ability to process information and respond accordingly. Therefore, this review also covers work that, despite the relatively early state of current technology, has provided novel and meaningful understandings in the field of neuroscience along with opening exciting avenues for future research.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"10738584251321438"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0