Neuroscientist最新文献

Forever Young. 永远年轻。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-09-13 DOI: 10.1177/10738584251376248

引用次数: 0

Harnessing Intelligence from Brain Cells In Vitro. 利用体外脑细胞的智力。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-03-13 DOI: 10.1177/10738584251321438

Brett J Kagan, Forough Habibollahi, Brad Watmuff, Azin Azadi, Finn Doensen, Alon Loeffler, Seung Hoon Byun, Bram Servais, Candice Desouza, Kwaku Dad Abu-Bonsrah, Nicole Kerlero de Rosbo

{"title":"Harnessing Intelligence from Brain Cells In Vitro.","authors":"Brett J Kagan, Forough Habibollahi, Brad Watmuff, Azin Azadi, Finn Doensen, Alon Loeffler, Seung Hoon Byun, Bram Servais, Candice Desouza, Kwaku Dad Abu-Bonsrah, Nicole Kerlero de Rosbo","doi":"10.1177/10738584251321438","DOIUrl":"10.1177/10738584251321438","url":null,"abstract":"Harnessing intelligence from brain cells in vitro requires a multidisciplinary approach integrating wetware, hardware, and software. Wetware comprises the in vitro brain cells themselves, where differentiation from induced pluripotent stem cells offers ethical scalability; hardware typically involves a life support system and a setup to record the activity from and deliver stimulation to the brain cells; and software is required to control the hardware and process the signals coming from and going to the brain cells. This review provides a broad summary of the foundational technologies underpinning these components, along with outlining the importance of technology integration. Of particular importance is that this new technology offers the ability to extend beyond traditional methods that assess primarily the survival and spontaneous activity of neural cultures. Instead, the focus returns to the core function of neural tissue: the neurocomputational ability to process information and respond accordingly. Therefore, this review also covers work that, despite the relatively early state of current technology, has provided novel and meaningful understandings in the field of neuroscience along with opening exciting avenues for future research.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"536-555"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Cortical Interneurons in Substance Use Disorder: From Mechanisms to Therapeutic Perspectives. 物质使用障碍的皮质中间神经元研究：从机制到治疗角度。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-01-08 DOI: 10.1177/10738584241310156

Sai Shi, Tianzhen Chen, Hang Su, Min Zhao

引用次数: 0

Connectivity in the Human Cerebral Cortex: A Fundamental Problem and a Possible Explanation for the Cognitive Power of Vertebrates. 人类大脑皮层的连通性：脊椎动物认知能力的一个基本问题和可能的解释。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-05-31 DOI: 10.1177/10738584251337656

R Douglas Fields

引用次数: 0

Sleep Patterns and Human Brain Health. 睡眠模式与人类大脑健康

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-01-30 DOI: 10.1177/10738584241309850

Anders M Fjell, Kristine B Walhovd

{"title":"Sleep Patterns and Human Brain Health.","authors":"Anders M Fjell, Kristine B Walhovd","doi":"10.1177/10738584241309850","DOIUrl":"10.1177/10738584241309850","url":null,"abstract":"It is a widely held opinion that sleep is important for human brain health. Here we examine the evidence for this view, focusing on normal variations in sleep patterns. We discuss the functions of sleep and highlight the paradoxical implications of theories seeing sleep as an adaptive capacity versus the theory that sleep benefits clearance of metabolic waste from the brain. We also evaluate the proposition that sleep plays an active role in consolidation of memories. Finally, we review research on possible effects of chronic sleep deprivation on brain health. We find that the evidence for a causal role of sleep in human brain health is surprisingly weak relative to the amount of attention to sleep in science and society. While there are well-established associations between sleep parameters and aspects of brain health, results are generally not consistent across studies and measures, and it is not clear to what extent alterations in sleep patterns represent symptoms or causes. Especially, the proposition that long sleep (>8 hours) in general is beneficial for long-term brain health in humans seems to lack empirical support. We suggest directions for future research to establish a solid foundation of knowledge about a role of sleep in brain health based on longitudinal studies with frequent sampling, attention to individual differences, and more ecologically valid intervention studies.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"483-498"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1 agonists: Good for what ails you? GLP-1激动剂：对你有什么好处？

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-09-13 DOI: 10.1177/10738584251379859

引用次数: 0

Forthcoming Articles. 即将出版的文章。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-09-13 DOI: 10.1177/10738584251376250

引用次数: 0

Microglial Regulation of Neural Networks in Neuropsychiatric Disorders. 神经精神疾病中神经网络的小胶质调节。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-02-11 DOI: 10.1177/10738584251316558

Zi-Lin Cao, Li-Xia Zhu, Hong-Mei Wang, Li-Juan Zhu

引用次数: 0

Astrocyte synchronization and behavior. 星形胶质细胞同步和行为。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-09-13 DOI: 10.1177/10738584251376249

引用次数: 0

The brain in Spain: The legacy of Santiago Ramón y Cajal. 西班牙的大脑：圣地亚哥的遗产Ramón y Cajal。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-01-19 DOI: 10.1177/10738584241297663

Emmanuel Drouin, Ricardo Martínez Murillo, Patrick Hautecoeur

{"title":"The brain in Spain: The legacy of Santiago Ramón y Cajal.","authors":"Emmanuel Drouin, Ricardo Martínez Murillo, Patrick Hautecoeur","doi":"10.1177/10738584241297663","DOIUrl":"10.1177/10738584241297663","url":null,"abstract":"The legacy of Santiago Ramón y Cajal, Spain's first Nobel laureate neuroscientist recognized as the founding father of modern neuroscience, is to be preserved in a new museum in Madrid: the National Museum of Natural Sciences (MNCN), one of the most important scientific research institutes in the country sciences in the scope of natural sciences of the Spanish National Research Council. For a boy who dreamed of being an artist but started his career apprenticed to first a barber and then a cobbler, Santiago Ramón y Cajal made a distinguished mark in science. One of Cajal's most important contributions to our understanding of the brain was his discovery of the direction of the information flow within neurons and in neural circuits, which he called the \"dynamic polarization law,\" without a doubt the founding principle of neurosciences. The exposition planned by the MNCN is a perfect occasion to show the academy and, it is hoped, the general public at large the beautiful organization of the nervous system as first acknowledged by modern science. With the highly motivated organizers of this well-planned initiative, neuroscientists at the Cajal Institute are confident that this sample of the Cajal legacy will also be taken as an esthetic experience for those who approach it for the first time. It might be that science and art often go together.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"453-457"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0