Neuroscientist最新文献_第2页

Targeting the TRPM4 Channel for Neurologic Diseases: Opportunity and Challenge. 靶向TRPM4通道治疗神经疾病：机遇与挑战

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-10-01 Epub Date: 2025-02-26 DOI: 10.1177/10738584251318979

Gayathri Rajamanickam, Zhenyu Hu, Ping Liao

{"title":"Targeting the TRPM4 Channel for Neurologic Diseases: Opportunity and Challenge.","authors":"Gayathri Rajamanickam, Zhenyu Hu, Ping Liao","doi":"10.1177/10738584251318979","DOIUrl":"10.1177/10738584251318979","url":null,"abstract":"As a monovalent cation channel, the transient receptor potential melastatin 4 (TRPM4) channel is a unique member of the transient receptor potential family. Abnormal TRPM4 activity has been identified in various neurologic disorders, such as stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, amyotrophic lateral sclerosis, pathologic pain, and epilepsy. Following brain hypoxia/ischemia and inflammation, TRPM4 up-regulation and enhanced activity contribute to the cell death of neurons, vascular endothelial cells, and astrocytes. Enhanced ionic influx via TRPM4 leads to cell volume increase and oncosis. Depolarization of membrane potential following TRPM4 activation and interaction between TRPM4 and N-methyl-d-aspartate receptors exacerbate excitotoxicity during hypoxia. Importantly, TRPM4 expression and activity remain low in healthy neurons, making it an ideal drug target. Current approaches to inhibit or modulate the TRPM4 channel have various limitations that hamper the interpretation of TRPM4 physiology in the nervous system and potentially hinder their translation into therapy. In this review, we discuss the pathophysiologic roles of TRPM4 and the different inhibitors that modulate TRPM4 activity for potential treatment of neurologic diseases.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"464-482"},"PeriodicalIF":3.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracerebral Hemorrhage: An Acute Manifestation of Small Vessel Disease? 脑出血：小血管疾病的急性表现？

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-09-06 DOI: 10.1177/10738584251364772

Li-Li Tang, Yu-Jia Jin, Xue Qun Chen, Peiran Jiang, Feng Gao, Lu-Sha Tong

{"title":"Intracerebral Hemorrhage: An Acute Manifestation of Small Vessel Disease?","authors":"Li-Li Tang, Yu-Jia Jin, Xue Qun Chen, Peiran Jiang, Feng Gao, Lu-Sha Tong","doi":"10.1177/10738584251364772","DOIUrl":"https://doi.org/10.1177/10738584251364772","url":null,"abstract":"Although intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) have long been considered distinct clinical entities, emerging evidence reveals significant overlap in their etiologies and imaging markers. This review aims to explore the relationship between ICH and cSVD, suggesting that ICH may represent an acute manifestation of small vessel disease. ICH is primarily caused by cerebral amyloid angiopathy and hypertension, while cSVD is mainly attributed to cerebral amyloid angiopathy and arteriolosclerosis. Hypertension-induced arteriolosclerosis is one of the most common pathologic changes in cSVD. This overlap in etiology suggests a close relationship between ICH and cSVD. In patients with ICH, multiple imaging markers of cSVD are often observed. Recent studies suggest that enlarged perivascular spaces, one of the imaging markers of cSVD, may serve as a pathway for hematoma expansion. Additionally, diffusion-weighted imaging lesions are frequently observed in patients with ICH. These lesions are likely to be based on underlying cSVD and may evolve into other cSVD markers, such as white matter hyperintensity, lacunar infarctions, or microbleeds. These findings highlight the complex interplay between ICH and cSVD, suggesting that ICH could be considered an acute expression of cSVD rather than an entirely separate entity.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"10738584251364772"},"PeriodicalIF":3.9,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons from the use of in vivo cellular calcium imaging in primary sensory neurons and spinal cord. 初级感觉神经元和脊髓体内细胞钙成像的应用经验。

IF 3.9 3区医学

Neuroscientist Pub Date : 2025-08-14 DOI: 10.1177/10738584251360724

John Shannonhouse, Yan Zhang, Hyeonwi Son, Eungyung Kim, Deoksoo Han, Joon Tae Park, Yu Shin Kim

{"title":"Lessons from the use of in vivo cellular calcium imaging in primary sensory neurons and spinal cord.","authors":"John Shannonhouse, Yan Zhang, Hyeonwi Son, Eungyung Kim, Deoksoo Han, Joon Tae Park, Yu Shin Kim","doi":"10.1177/10738584251360724","DOIUrl":"https://doi.org/10.1177/10738584251360724","url":null,"abstract":"Primary somatosensory neurons, glial cells in the peripheral ganglia, and neural circuits in the spinal cord function as dynamic network circuits that transmit information to the brain. Although a variety of methods and techniques have been used to study individual neurons or tissue explants, the number of neurons that can be monitored is limited. Imaging intact primary sensory neurons, such as those in the dorsal root ganglion and trigeminal ganglia, and the spinal cord in vivo using fluorescent calcium markers helps overcome the limitations of previous methods and techniques by allowing researchers to monitor tens to thousands of cells simultaneously. This allows researchers to conduct experiments to elucidate somatosensory mechanisms and responses to axonal injury that were previously difficult or impossible to observe. Using this approach, researchers have studied dynamic neural network circuits, connectivity, responses to soft and deep touch, heat, cold, chemicals, inflammation, and injury, and they have repeatedly imaged individual neurons over long periods of time. Approaches include using calcium-sensitive fluorescent dyes and genetically encoded markers, performing terminal exposure surgeries, using chambers designed to monitor large numbers of cells or repeatedly imaging small numbers of cells, and imaging animals with or without anesthesia. This review discusses the advantages and disadvantages of in vivo calcium imaging for studying somatosensory and axonal injury in peripheral sensory ganglia and the dorsal spinal cord, as well as anticipated future directions.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"10738584251360724"},"PeriodicalIF":3.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin in Human Social Network Cooperation. 人类社会网络合作中的催产素。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2024-11-29 DOI: 10.1177/10738584241293366

Xiaochun Han, Yina Ma

引用次数: 0

Hidden in the white matter: Current views on interstitial white matter neurons. 隐藏在白质中：目前对白质间质神经元的看法。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2024-10-04 DOI: 10.1177/10738584241282969

Maximilian Fischer, Maria Kukley

{"title":"Hidden in the white matter: Current views on interstitial white matter neurons.","authors":"Maximilian Fischer, Maria Kukley","doi":"10.1177/10738584241282969","DOIUrl":"10.1177/10738584241282969","url":null,"abstract":"The mammalian brain comprises two structurally and functionally distinct compartments: the gray matter (GM) and the white matter (WM). In humans, the WM constitutes approximately half of the brain volume, yet it remains significantly less investigated than the GM. The major cellular elements of the WM are neuronal axons and glial cells. However, the WM also contains cell bodies of the interstitial neurons, estimated to number 10 to 28 million in the adult bat brain, 67 million in Lar gibbon brain, and 450 to 670 million in the adult human brain, representing as much as 1.3%, 2.25%, and 3.5% of all neurons in the cerebral cortex, respectively. Many studies investigated the interstitial WM neurons (IWMNs) using immunohistochemistry, and some information is available regarding their electrophysiological properties. However, the functional role of IWMNs in physiologic and pathologic conditions largely remains unknown. This review aims to provide a concise update regarding the distribution and properties of interstitial WM neurons, highlight possible functions of these cells as debated in the literature, and speculate about other possible functions of the IWMNs and their interactions with glial cells. We hope that our review will inspire new research on IWMNs, which represent an intriguing cell population in the brain.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"381-408"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints. 类风湿关节炎和骨关节炎的神经生物学相关性：滑膜关节损伤感觉神经和自主神经的重塑和可塑性。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2024-12-12 DOI: 10.1177/10738584241293049

Sharon Mathew, Sadaf Ashraf, Susan Shorter, Gianluca Tozzi, Stella Koutsikou, Saak V Ovsepian

{"title":"Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints.","authors":"Sharon Mathew, Sadaf Ashraf, Susan Shorter, Gianluca Tozzi, Stella Koutsikou, Saak V Ovsepian","doi":"10.1177/10738584241293049","DOIUrl":"10.1177/10738584241293049","url":null,"abstract":"Swelling, stiffness, and pain in synovial joints are primary hallmarks of osteoarthritis and rheumatoid arthritis. Hyperactivity of nociceptors and excessive release of inflammatory factors and pain mediators play a crucial role, with emerging data suggesting extensive remodelling and plasticity of joint innervations. Herein, we review structural, functional, and molecular alterations in sensory and autonomic axons wiring arthritic joints and revisit mechanisms implicated in the sensitization of nociceptors, leading to chronic pain. Sprouting and reorganization of sensory and autonomic fibers with the invasion of ectopic branches into surrounding inflamed tissues are associated with the upregulation of pain markers. These changes are frequently complemented by a phenotypic switch of sensory and autonomic profiles and activation of silent axons, inferring homeostatic adjustments and reprogramming of innervations. Identifying critical molecular players and neurobiological mechanisms underpinning the rewiring and sensitization of joints is likely to elucidate causatives of neuroinflammation and chronic pain, assisting in finding new therapeutic targets and opportunities for interventions.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"425-444"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How does autophagy impact neurological function? 自噬如何影响神经功能？

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1177/10738584251324459

Angeleen Fleming, Ana Lopez, Matea Rob, Sarayu Ramakrishna, So Jung Park, Xinyi Li, David C Rubinsztein

引用次数: 0

Islands and Neurology: An Exploration into a Unique Association. 岛屿与神经学：探索独特的联系。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2024-06-06 DOI: 10.1177/10738584241257927

Debjyoti Dhar, Samim Mm, Naznin Parvin, Treshita Dey, Anantini Pal, Pramod Kumar Pal

{"title":"Islands and Neurology: An Exploration into a Unique Association.","authors":"Debjyoti Dhar, Samim Mm, Naznin Parvin, Treshita Dey, Anantini Pal, Pramod Kumar Pal","doi":"10.1177/10738584241257927","DOIUrl":"10.1177/10738584241257927","url":null,"abstract":"The current study investigates the intricate connection between neurology and islands shedding light on the historical, epidemiological, and genetic aspects. Based on an elaborate literature review, we identified neurological conditions having a significant clustering in an island(s), confined to a particular island(s), named after an island, and described first in an island. The genetic factors played a crucial role, uncovering disorders like Cayman ataxia, Machado Joseph disease, SGCE-mediated dystonia-myoclonus syndrome, X-linked dystonia parkinsonism, hereditary transthyretinrelated amyloidosis, Charcot Marie Tooth 4F, and progressive myoclonic epilepsy syndromes, that exhibited remarkable clustering in diverse islands. Local customs also left enduring imprints. Practices such as cannibalism in Papua New Guinea led to Kuru, while cycad seed consumption in Guam triggered Lytico-Bodig disease. Toxin-mediated neurologic disorders exhibited intricate island connections, exemplified by Minamata disease in Kyushu islands and atypical parkinsonism in French Caribbean islands. Additionally, the Cuban epidemic of amblyopia and neuropathy was associated with severe nutritional deficiencies. This study pioneers a comprehensive review narrating the genetic, environmental, and cultural factors highlighting the spectrum of neurological disorders in island settings. It enriches the medical literature with a unique understanding of the diverse influences shaping neurological health in island environments.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"336-348"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mRNA in axonal terminals: a role in memory. 轴突终末mRNA：在记忆中的作用。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2025-07-16 DOI: 10.1177/10738584251358733

引用次数: 0

Neuronal Death: Now You See It, Now You Don't. 神经元死亡现在你看到了，现在你看不到了。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-08-01 Epub Date: 2024-09-24 DOI: 10.1177/10738584241282632

Trevor Balena, Kevin Staley

引用次数: 0