Neuroscientist最新文献_第4页

Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation. 认知中的神经元振荡：唐氏综合征作为小鼠到人类的转化模型。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-06-01 Epub Date: 2024-09-24 DOI: 10.1177/10738584241271414

Pishan Chang, Marta Pérez-González, Jessica Constable, Daniel Bush, Karen Cleverley, Victor L J Tybulewicz, Elizabeth M C Fisher, Matthew C Walker

{"title":"Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.","authors":"Pishan Chang, Marta Pérez-González, Jessica Constable, Daniel Bush, Karen Cleverley, Victor L J Tybulewicz, Elizabeth M C Fisher, Matthew C Walker","doi":"10.1177/10738584241271414","DOIUrl":"10.1177/10738584241271414","url":null,"abstract":"Down syndrome (DS), a prevalent cognitive disorder resulting from trisomy of human chromosome 21 (Hsa21), poses a significant global health concern. Affecting approximately 1 in 800 live births worldwide, DS is the leading genetic cause of intellectual disability and a major predisposing factor for early-onset Alzheimer's dementia. The estimated global population of individuals with DS is 6 million, with increasing prevalence due to advances in DS health care. Global efforts are dedicated to unraveling the mechanisms behind the varied clinical outcomes in DS. Recent studies on DS mouse models reveal disrupted neuronal circuits, providing insights into DS pathologies. Yet, translating these findings to humans faces challenges due to limited systematic electrophysiological analyses directly comparing human and mouse. Additionally, disparities in experimental procedures between the two species pose hurdles to successful translation. This review provides a concise overview of neuronal oscillations in human and rodent cognition. Focusing on recent DS mouse model studies, we highlight disruptions in associated brain function. We discuss various electrophysiological paradigms and suggest avenues for exploring molecular dysfunctions contributing to DS-related cognitive impairments. Deciphering neuronal oscillation intricacies holds promise for targeted therapies to alleviate cognitive disabilities in DS individuals.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"308-325"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

About time. 关于时间。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1177/10738584251344120

引用次数: 0

Phosphoinositides: Nanoscale Effects on Neuronal Membranes. 磷酸肌苷：对神经元膜的纳米效应。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-05-29 DOI: 10.1177/10738584251337664

Kohgaku Eguchi

{"title":"Phosphoinositides: Nanoscale Effects on Neuronal Membranes.","authors":"Kohgaku Eguchi","doi":"10.1177/10738584251337664","DOIUrl":"https://doi.org/10.1177/10738584251337664","url":null,"abstract":"Phosphoinositides (PIs) are essential regulators of neuronal function, playing pivotal roles in processes such as synaptic transmission, membrane excitability, and long-term synaptic plasticity. The seven PI isoforms, including PI(4)P, PI(4,5)P2, and PI(3,4,5)P2, exhibit distinct subcellular distributions that are tightly regulated by specific kinases and phosphatases. These isoforms contribute to key neuronal processes by modulating protein interactions and signaling pathways. Recent advances in visualization techniques, such as biosensor-based live imaging and SDS-digested freeze-fracture replica labeling, have provided new insights into the spatial distributions and dynamic behaviors of PI isoforms in neurons, particularly at synapses.However, significant questions remain, such as how specific PI isoforms coordinate signaling events in distinct subcellular compartments and how these lipids influence critical neuronal processes like vesicular trafficking and synaptic plasticity. Addressing these challenges will require the continued development of advanced imaging technologies, which are essential for mapping nanoscale distributions of PIs and their dynamic roles in neuronal processes. Here, I will review current findings, advancements in visualization methodologies, and key research directions. This review will be helpful for understanding the roles of PIs in neuronal physiology, their broad impacts on neuronal signaling, and the technological breakthroughs needed to uncover these complex processes.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"10738584251337664"},"PeriodicalIF":3.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Art, Intuition, and Identity in Ramón y Cajal. 拉蒙-卡哈尔的艺术、直觉与身份。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-03-10 DOI: 10.1177/10738584241234049

Dawn Hunter, Javier DeFelipe, Arpan R Mehta, Bevil R Conway

{"title":"Art, Intuition, and Identity in Ramón y Cajal.","authors":"Dawn Hunter, Javier DeFelipe, Arpan R Mehta, Bevil R Conway","doi":"10.1177/10738584241234049","DOIUrl":"10.1177/10738584241234049","url":null,"abstract":"In the history of neuroscience, Cajal stands tall. Many figures in the late 19th and early 20th centuries made major contributions to neuroscience-Sherrington, Ferrier, Jackson, Holmes, Adrian, and Békésy, to name a few. But in the public mind, Cajal is unique. His application of the Golgi method, with an array of histologic stains, unlocked a wealth of new knowledge on the structure and function of the brain. Here we argue that Cajal's success should not only be attributed to the importance of his scientific contributions but also to the artistic visual language that he created and to his pioneering self-branding, which exploited methods of the artist, including classical drawing and the new invention of photography. We argue that Cajal created his distinctive visual language and self-branding strategy by interweaving an ostensibly objective research product with an intimately subjective narrative about the brain and himself. His approach is evident in the use of photography, notably self-portraits, which furthered broad engagement initially inspired by his scientific drawings. Through his visual language, Cajal made an impact in art and culture far beyond the bounds of science, which has sustained his scientific legacy.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"125-140"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Trip To The Moon. 月球之旅。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327385

引用次数: 0

Microglia, Trem2, and Neurodegeneration. 小胶质细胞、Trem2 和神经退行性变

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-05-20 DOI: 10.1177/10738584241254118

Qian Shi, Raul A Gutierrez, Manzoor A Bhat

{"title":"Microglia, Trem2, and Neurodegeneration.","authors":"Qian Shi, Raul A Gutierrez, Manzoor A Bhat","doi":"10.1177/10738584241254118","DOIUrl":"10.1177/10738584241254118","url":null,"abstract":"Microglia are a specialized type of neuroimmune cells that undergo morphological and molecular changes through multiple signaling pathways in response to pathological protein aggregates, neuronal death, tissue injury, or infections. Microglia express Trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. Trem2 has emerged as a critical modulator of microglial activity, especially in many neurodegenerative disorders. Human TREM2 mutations are associated with an increased risk of developing Alzheimer disease (AD) and other neurodegenerative diseases. Trem2 plays dual roles in neuroinflammation and more specifically in disease-associated microglia. Most recent developments on the molecular mechanisms of Trem2, emphasizing its role in uptake and clearance of amyloid β (Aβ) aggregates and other tissue debris to help protect and preserve the brain, are encouraging. Although Trem2 normally stimulates defense mechanisms, its dysregulation can intensify inflammation, which poses major therapeutic challenges. Recent therapeutic approaches targeting Trem2 via agonistic antibodies and gene therapy methodologies present possible avenues for reducing the burden of neurodegenerative diseases. This review highlights the promise of Trem2 as a therapeutic target, especially for Aβ-associated AD, and calls for more mechanistic investigations to understand the context-specific role of microglial Trem2 in developing effective therapies against neurodegenerative diseases.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"159-176"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modern molecular mechanism for an ancient psychoactive substance: TMEM132B as a novel protein controlling alcohol actions in the brain. 一种古老精神活性物质的现代分子机制：TMEM132B作为一种控制酒精在大脑中的作用的新蛋白质。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327384

引用次数: 0

The effect of traumatic brain injury on learning and memory: A synaptic focus. 创伤性脑损伤对学习和记忆的影响：突触聚焦

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-09-24 DOI: 10.1177/10738584241275583

Eric Eyolfson, Kirsten R B Suesser, Holly Henry, Itziar Bonilla-Del Río, Pedro Grandes, Richelle Mychasiuk, Brian R Christie

{"title":"The effect of traumatic brain injury on learning and memory: A synaptic focus.","authors":"Eric Eyolfson, Kirsten R B Suesser, Holly Henry, Itziar Bonilla-Del Río, Pedro Grandes, Richelle Mychasiuk, Brian R Christie","doi":"10.1177/10738584241275583","DOIUrl":"10.1177/10738584241275583","url":null,"abstract":"Deficits in learning and memory are some of the most commonly reported symptoms following a traumatic brain injury (TBI). We will examine whether the neural basis of these deficits stems from alterations to bidirectional synaptic plasticity within the hippocampus. Although the CA1 subregion of the hippocampus has been a focus of TBI research, the dentate gyrus should also be given attention as it exhibits a unique ability for adult neurogenesis, a process highly susceptible to TBI-induced damage. This review examines our current understanding of how TBI results in deficits in synaptic plasticity, as well as how TBI-induced changes in endocannabinoid (eCB) systems may drive these changes. Through the synthesis and amalgamation of existing data, we propose a possible mechanism for eCB-mediated recovery in synaptic plasticity deficits. This hypothesis is based on the plausible roles of CB1 receptors in regulating inhibitory tone, influencing astrocytes and microglia, and modulating glutamate release. Dysregulation of the eCBs may be responsible for deficits in synaptic plasticity and learning following TBI. Taken together, the existing evidence indicates eCBs may contribute to TBI manifestation, pathogenesis, and recovery, but it also suggests there may be a therapeutic role for the eCB system in TBI.","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":" ","pages":"195-214"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking Down Glioma-Microenvironment Crosstalk. 打破胶质瘤与微环境的相互影响

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2024-07-26 DOI: 10.1177/10738584241259773

Raghavskandhan Ramachandran, Alexander F Jeans

引用次数: 0

The once and future therapeutic potential of psychedelics. 迷幻药现在和未来的治疗潜力。

IF 3.5 3区医学

Neuroscientist Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1177/10738584251327386

引用次数: 0