Nutrition Metabolism and Cardiovascular Diseases最新文献_第6页

Cardiovascular health and coffee: Insights from a recent cohort study. 心血管健康和咖啡：来自最近一项队列研究的见解。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-05-05 DOI: 10.1016/j.numecd.2025.104115

Anna Vittoria Mattioli

{"title":"Cardiovascular health and coffee: Insights from a recent cohort study.","authors":"Anna Vittoria Mattioli","doi":"10.1016/j.numecd.2025.104115","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104115","url":null,"abstract":"Coffee consumption has long been a subject of debate in cardiovascular health, with concerns over its potential pro-arrhythmic effects and transient increases in blood pressure. The recent study by Zhou et al. provides compelling evidence that moderate coffee intake (1-3 cups per day) is associated with reduced all-cause and cardiovascular mortality, particularly among individuals with pre-existing cardiovascular and cerebrovascular diseases. This commentary expands on the study's findings, highlighting potential mechanisms of protection, including anti-inflammatory and antioxidant effects, as well as its impact on endothelial function and metabolism. Additionally, it underscores key knowledge gaps, such as the influence of brewing methods, genetic variability in caffeine metabolism, and sex differences in cardiovascular responses to coffee consumption. While habitual coffee intake appears safe and potentially beneficial for most individuals, further research is needed to refine personalized recommendations based on genetic, hormonal, and metabolic differences. Given coffee's widespread consumption, incorporating these insights into clinical guidelines and public health recommendations could have significant implications for disease prevention and management.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104115"},"PeriodicalIF":3.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dyslipidemia and statin use in people with HIV-1 infection: beyond the lipid-lowering effect. HIV-1感染者的血脂异常和他汀类药物的使用：超出降脂效果。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-05-03 DOI: 10.1016/j.numecd.2025.104110

Gianluca Gazzaniga, Marco Ridolfi, Alessandro Lazzaro, Tommaso Brogi, Pasquale Pignatelli, Daniele Pastori, Ivano Mezzaroma

{"title":"Dyslipidemia and statin use in people with HIV-1 infection: beyond the lipid-lowering effect.","authors":"Gianluca Gazzaniga, Marco Ridolfi, Alessandro Lazzaro, Tommaso Brogi, Pasquale Pignatelli, Daniele Pastori, Ivano Mezzaroma","doi":"10.1016/j.numecd.2025.104110","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104110","url":null,"abstract":"Aims: Advances in antiretroviral therapy have transformed HIV-1 infection into a chronic condition, enabling people living with HIV-1 (PWH) to achieve life expectancies comparable to those of the uninfected population. Consequently, a range of co-morbidities, particularly an increased incidence of cardiovascular events, has becoming more evident. Among these, dyslipidemia stands out as a significant risk factor with a multifactorial pathogenesis. The aim of this narrative review is to highlight the multifactorial origins of dyslipidemia in PWH, to provide an overview of drug interactions between statins and antiretroviral therapy, and examine the unique anti-inflammatory and immunomodulatory properties of statins in this context.Data synthesis: Some studies indicate a reduction of mortality and cardiovascular risk in PWH treated with statins. However, the benefit of statin therapy is variable and seems to be dependent on HIV-1 length exposure and type of antiretroviral drugs and seems to be lower in individuals without comorbidities or additional risk factors. Statins are often underdosed for the perceived risk of drug interactions. Beyond their lipid-lowering effects, statins exert additional benefits, including anti-inflammatory and immunomodulatory actions on vascular tissues, monocyte-macrophages, and lymphocytes. These effects have sparked interest in their potential applications beyond dyslipidemia treatment.Conclusions: Statins may provide a clinical benefit in PWH by lowering LDL cholesterol and modulating immunity and inflammation. However, there is a clinical need for HIV-1-specific LDL cholesterol targets given the excess cardiovascular risk in this population, as well as for the identification of high-risk subgroups that may benefit most from statin treatment.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104110"},"PeriodicalIF":3.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fasting-mimicking diet programme reduces abdominal adipose tissue while preserving abdominal muscle mass in persons with type 2 diabetes. 在2型糖尿病患者中，模拟禁食的饮食方案可以减少腹部脂肪组织，同时保持腹部肌肉质量。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-30 DOI: 10.1016/j.numecd.2025.104111

Marjolein P Schoonakker, Elske L van den Burg, Petra G van Peet, Saskia le Cessie, Eleanor Penny, Mattijs E Numans, Hanno Pijl, Hildo J Lamb

{"title":"A fasting-mimicking diet programme reduces abdominal adipose tissue while preserving abdominal muscle mass in persons with type 2 diabetes.","authors":"Marjolein P Schoonakker, Elske L van den Burg, Petra G van Peet, Saskia le Cessie, Eleanor Penny, Mattijs E Numans, Hanno Pijl, Hildo J Lamb","doi":"10.1016/j.numecd.2025.104111","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104111","url":null,"abstract":"Background and aim: This study evaluated the effects of a fasting-mimicking diet (FMD) programme alongside usual care on abdominal visceral- (aVAT) and subcutaneous (aSAT) adipose tissue, and abdominal muscle area (aMA) in persons with type 2 diabetes in primary care.Methods and results: 100 persons with type 2 diabetes using metformin and/or diet alone for glycemic control were randomly assigned to receive an FMD for 5 consecutive days each month plus usual care or usual care only for 12 months. The treatment effect of the FMD on aVAT, aSAT and aMA as well as associations between changes in aVAT, aSAT or aMA, and changes in metabolic parameters were assessed. 89 participants completed baseline visits including MRI. The adjusted estimated treatment effect after 12 months in the FMD group was a loss of 37.9 cm2 (95 % CI -54.7, to -21.0) in aVAT, 20.9 cm2 (95 %CI -34.5 to -7.3) in aSAT and -1.6 cm2 (95 % CI -4.6 to 1.4) in aMA compared to the control group. Changes in aVAT and aSAT were strongly associated with change in HbA1c and moderately with other metabolic parameters.Conclusions: A 12-month FMD programme reduced both aVAT and aSAT, while aMA remained unaffected compared to controls in persons with type 2 diabetes. The decline in aVAT and aSAT was associated with a reduction of several metabolic parameters, including HbA1c. A monthly FMD programme yields various health benefits in type 2 diabetes and appears to be a valuable treatment option as adjunct to usual care.Trial registration: ClinicalTrials.gov: NCT03811587, 05-11-2018.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104111"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial. 乳制品摄入对循环脂肪酸的影响及其与血压的关系：一项随机交叉试验。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-30 DOI: 10.1016/j.numecd.2025.104112

Hana Arghavani, Jean-François Bilodeau, Iwona Rudkowska

{"title":"Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial.","authors":"Hana Arghavani, Jean-François Bilodeau, Iwona Rudkowska","doi":"10.1016/j.numecd.2025.104112","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104112","url":null,"abstract":"Background and aims: This study aimed to investigate the effects of high and adequate dairy intake (>4, 2-3 serving/day, respectively) on circulating fatty acids (FAs) and their associations with blood pressure (BP).Methods and results: A randomized crossover clinical trial was conducted with 27 participants (8 women, 19 men) at the CHU de Québec-Université Laval Research Center. Participants were assigned to either a high-dairy (HD) or adequate-dairy (AD) diet for six weeks, followed by a six-week washout period before crossing over. Plasma phospholipid-bound FAs were analyzed using gas chromatography, and BP and arterial stiffness were measured at each visit. Partial correlation analyses, generalized linear mixed models and machine learning techniques were employed to analyze the data. Pentadecanoic acid (15:0) and heptadecanoic acid (17:0) were positively correlated with dairy intake and showed increases after the HD. Palmitic acid (16:0) and total saturated FAs were positively associated with systolic (SBP) and diastolic (DBP), while 17:0 was inversely associated with diastolic BP.Conclusions: HD was associated with increased 15:0 and 17:0. Notably, 17:0 had an inverse association with diastolic BP, while 16:0 was positively linked. These findings highlight the importance of dietary strategies that incorporate specific FAs to enhance cardiovascular health.Registration number: NCT02961179.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104112"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between coffee and adiponectin according to the obesity status: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan. 根据肥胖状况，咖啡和脂联素之间的关系：日本德岛多机构合作队列研究的横断面分析。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-28 DOI: 10.1016/j.numecd.2025.104103

Masashi Ishizu, Takeshi Watanabe, Yuka Torii, Kahori Kita, Akari Matsuura, Taichi Unohara, Sakurako Katsuura-Kamano, Hirokazu Uemura

{"title":"Association between coffee and adiponectin according to the obesity status: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan.","authors":"Masashi Ishizu, Takeshi Watanabe, Yuka Torii, Kahori Kita, Akari Matsuura, Taichi Unohara, Sakurako Katsuura-Kamano, Hirokazu Uemura","doi":"10.1016/j.numecd.2025.104103","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104103","url":null,"abstract":"Background and aims: Coffee may contribute to the prevention of metabolic abnormalities in both obese and normal weight Japanese adults. Although evidence suggests a relationship between coffee and serum adiponectin, stratified analyses according to the obesity status have not yet been reported. This cross-sectional study examined the relationship between coffee intake and serum high molecular weight (HMW)-adiponectin, which is the most active form of adiponectin, according to the obesity status.Methods and results: The baseline data of 606 participants (aged 35-69 years) living in Tokushima prefecture in the Japan Multi-Institutional Collaborative Cohort Study were analyzed. Coffee intake was assessed using a questionnaire. Participants were stratified by the presence or absence of obesity (normal weight: BMI<25 kg/m2; obesity: BMI≥25 kg/m2). Multiple linear regression analyses adjusted for potential confounders were performed to examine the association between coffee intake and HMW-adiponectin or other diabetic factors. Coffee intake was associated with serum HMW-adiponectin in normal weight subjects (Coffee intake ≥3 cups/day, β for model 2 1.02, 95 % CI 0.30, 1.74), but not in obese subjects. Moreover, filtered/instant coffee intake was associated with serum HMW-adiponectin in normal weight subjects (Coffee intake ≥3 cups/day, β for model 2 0.93, 95 % CI 0.21, 1.65), but not in obese subjects.Conclusion: The present study suggests that coffee intake, particularly filtered/instant coffee, is associated with serum HMW-adiponectin in normal weight Japanese adults.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104103"},"PeriodicalIF":3.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trajectory of body shape in early and middle life and hyperuricemia: an observational study integrating mendelian randomization analysis. 早期和中期体型轨迹与高尿酸血症：一项整合孟德尔随机化分析的观察性研究。

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-27 DOI: 10.1016/j.numecd.2025.104107

Huanxiang Zhang, Wei Liao, Fengling Wang, Feng Jiang, Fayaz Ahmad, Xiaotian Liu, Jian Hou, Yuqian Li, Zhengxing Mao, Zhaohui Zheng, Chongjian Wang

{"title":"Trajectory of body shape in early and middle life and hyperuricemia: an observational study integrating mendelian randomization analysis.","authors":"Huanxiang Zhang, Wei Liao, Fengling Wang, Feng Jiang, Fayaz Ahmad, Xiaotian Liu, Jian Hou, Yuqian Li, Zhengxing Mao, Zhaohui Zheng, Chongjian Wang","doi":"10.1016/j.numecd.2025.104107","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104107","url":null,"abstract":"Background and aim: Although it is recognized that obesity is linked to hyperuricemia, the research on how obesity at different stages of life affects hyperuricemia is still unclear.Methods and results: Body shape trajectory of over the first 50 years of life in Henan Rural Cohort Study was accessed by using a group-based trajectory modeling approach. Multivariate logistic regression was utilized to estimate odd ratio (OR) for hyperuricemia. Causation was further assessed using mendelian randomization (MR). Five distinct trajectories were identified and a total of 22,655 participants were enrolled for final analysis. Compared to lean-stable participants, medium-moderate increase, heavy-stable, and lean-marked increase showed significantly higher OR and 95 % confidence interval (CI) for hyperuricemia, with 1.27 (1.07, 1.50), 1.81 (1.48, 2.21) and 1.84 (1.51, 2.25) for women, 1.25 (1.01, 1.54), 1.35 (1.02, 1.77) and 1.91 (1.50, 2.43) for men. This positive association was weakened in women with high healthy lifestyle score, but the weakening effect was not significant in men. Genetically predicted birth weight, childhood body mass index (BMI), and adult BMI were significantly associated with serum uric acid (SUA), with regression coefficient (β) and 95 % CI was -0.09 (-0.14, -0.04), 0.10 (0.04, 0.16), 0.20 (0.16, 0.24), respectively.Conclusion: Body shape trajectory is closely associated with hyperuricemia, with MR analysis suggesting potential causal links. lifelong weight management and maintaining healthy lifestyles can reduce the adverse effects of weight gain on hyperuricemia.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104107"},"PeriodicalIF":3.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral fat and its dynamic changes are associated with incident stroke: evidence from the China Health and Retirement Longitudinal Study. 内脏脂肪及其动态变化与卒中事件相关：来自中国健康与退休纵向研究的证据

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-27 DOI: 10.1016/j.numecd.2025.104101

Mengyue Lin, Yilian Zhou, Sirui Han, Muli Wu, Jiaxin Xiao, Ying Li, Haoxian Tang, Xuerui Tan, Yequn Chen

{"title":"Visceral fat and its dynamic changes are associated with incident stroke: evidence from the China Health and Retirement Longitudinal Study.","authors":"Mengyue Lin, Yilian Zhou, Sirui Han, Muli Wu, Jiaxin Xiao, Ying Li, Haoxian Tang, Xuerui Tan, Yequn Chen","doi":"10.1016/j.numecd.2025.104101","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104101","url":null,"abstract":"Background and aims: Central obesity demonstrated an association with stroke, while the association between visceral fat accumulation and stroke required further investigation. We aimed to evaluate the association of Chinese visceral adiposity index (CVAI) and its dynamic change patterns with stroke risk.Methods and results: A total of 9052 individuals from a nationally representative cohort were included. The main outcome was a self-reported physician's diagnosis of stroke. Multivariable Cox and logistic regression models were employed to evaluate the association of the exposure with stroke. The shape of the association was explored using restricted cubic splines. The mean age of the study population was 60.0 ± 9.5 years, and the median follow-up period was 7 years. A linear dose-response association between baseline CVAI and stroke risk was observed. Compared with the lowest CVAI quartile, those in the second, third, and fourth quartiles had 1.62, 1.72, and 2.08 times higher risk, respectively. Additionally, each standard deviation increase in CVAI induced 23 % increased risk of stroke. Among the five CVAI change patterns, the low-stable pattern carried a greatest protective effect against stroke (OR = 0.35, 95 % CI: 0.21-0.58); the decreasing pattern exhibited greater risk reduction compared to the moderate and the increasing patterns (with reference to the persistent-high pattern). In terms of identifying high-risk individuals of stroke, CVAI outperformed other obesity indices.Conclusion: Higher baseline CVAI and a persistent-high pattern were associated with increased risk of incident stroke. Maintaining a low level of CVAI or reducing it may have potential benefits for stroke prevention.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104101"},"PeriodicalIF":3.3,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between visceral fat area to skeletal muscle mass ratio and hyperuricemia among non-elderly US adults. 非老年美国成年人内脏脂肪面积与骨骼肌质量比与高尿酸血症之间的关系

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-25 DOI: 10.1016/j.numecd.2025.104106

Zhaoxiang Wang, Menghuan Wu, Qichao Yang

{"title":"Association between visceral fat area to skeletal muscle mass ratio and hyperuricemia among non-elderly US adults.","authors":"Zhaoxiang Wang, Menghuan Wu, Qichao Yang","doi":"10.1016/j.numecd.2025.104106","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104106","url":null,"abstract":"Background and aim: Sarcopenic visceral obesity is linked to an elevated metabolic risk. Our aim was to explore the possible link between visceral fat area to skeletal muscle mass ratio (VSR) and hyperuricemia risk in non-elderly U.S. adults.Methods and results: This cross-sectional study evaluated 5519 non-elderly adults from the National Health and Nutrition Examination Survey (NHANES) database. Visceral fat area (VFA) and appendicular skeletal muscle mass (ASM) were measured using dual-energy X-ray absorptiometry (DXA). Hyperuricemia was identified by serum uric acid (SUA) levels of 7 mg/dL or more in males and 6 mg/dL or more in females. Logistic regression, restricted cubic spline (RCS), and subgroup analyses were applied to investigate the association between VSR and hyperuricemia risk. As VSR levels increase, the prevalence of hyperuricemia becomes more pronounced (6.35 % vs. 14.45 % vs. 14.68 % vs. 17.03 %, P < 0.001). After adjusting for confounding factors, elevated VSR levels are associated with an increased risk of hyperuricemia (OR = 1.136, 95 %CI:1.051-1.229, P = 0.001). Individuals in the fourth quartile of VSR exhibit a higher risk of developing hyperuricemia compared to those in the first quartile (OR = 2.299, 95 %CI:1.328-3.979, P = 0.003). No specific populations were identified in the subgroup analysis. RCS analysis further supports a dose-response relationship.Conclusions: VSR could serve as an epidemiological instrument to assess the impact of sarcopenic visceral obesity on the risk of hyperuricemia.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104106"},"PeriodicalIF":3.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic syndrome severity score and long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries. 非阻塞性冠状动脉心肌梗死患者代谢综合征严重程度评分和长期心血管预后

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-25 DOI: 10.1016/j.numecd.2025.104104

Side Gao, Sizhuang Huang, Xinming Liu, Mengyue Yu, Lin Zhao

{"title":"Metabolic syndrome severity score and long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries.","authors":"Side Gao, Sizhuang Huang, Xinming Liu, Mengyue Yu, Lin Zhao","doi":"10.1016/j.numecd.2025.104104","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104104","url":null,"abstract":"Background and aim: Metabolic syndrome (MetS) is a cluster of metabolic disorders that promotes the risk of cardiovascular diseases. Beyond the dichotomous criteria of MetS, a continuous MetS scoring model enables the quantification of MetS severity and performs well in risk prediction. However, the impact of MetS score in myocardial infarction with nonobstructive coronary arteries (MINOCA) remains unclear. We aim to clarify the implications of MetS and its severity in a Chinese cohort of MINOCA.Methods and results: A total of 1179 MINOCA patients were enrolled with a median follow-up of 41.7 months. An age-sex-ethnicity-specific MetS scoring model tailored to the Chinese adults was used to assess the MetS severity. The primary endpoint was a composite of major adverse cardiovascular events (MACE) including all-cause death, nonfatal MI, stroke, revascularization, and hospitalization for unstable angina or heart failure. Nearly a quarter of patients had MetS and they had worse outcomes after MINOCA. At multivariate Cox model, a higher MetS score was significantly associated with an increased risk of MACE (adjusted HR 2.00, 95 % CI: 1.47-2.74, p < 0.001). Restricted cubic splines analysis showed a non-linear relationship between the MetS score and event risk. At receiver-operating characteristic curves, the MetS score outperformed the binary defined MetS in predicting MACE and yielded a more accurate prognostic value in MINOCA.Conclusions: The MetS severity score was an independent predictor of adverse events after MINOCA and thus may serve as a valuable tool for risk stratification, providing a rationale for the MetS score-guided interventions in MINOCA population.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104104"},"PeriodicalIF":3.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary folate and hyperuricemia based on inflammation and cardiovascular disease status. 膳食叶酸与基于炎症和心血管疾病状态的高尿酸血症之间的关系

IF 3.3 3区医学

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-25 DOI: 10.1016/j.numecd.2025.104108

Eugene Chang, Yoonjin Shin

{"title":"Association between dietary folate and hyperuricemia based on inflammation and cardiovascular disease status.","authors":"Eugene Chang, Yoonjin Shin","doi":"10.1016/j.numecd.2025.104108","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104108","url":null,"abstract":"Background and aims: The impact of dietary folate intake on serum uric acid is not yet conclusive. This study aims to investigate the association between dietary folate intake and the risk of hyperuricemia according to inflammatory status and comorbidities in Korean adults.Methods and results: The cross-sectional analysis was conducted on 14,445 subjects aged ≥19 years enrolled in the Korea National Health and Nutrition Examination Survey (KNHNES) from 2016 to 2021. Dietary folate intake was assessed using the 24-h recall method. Dietary folate consumption was positively associated with the intake of beans, vegetables, and fruits, and negatively associated with cereals and meat intake. After adjusting for potential confounders, increased folate intake was found to be associated with a decreased risk of hyperuricemia (odds ratio for the highest tertile compared to the lowest tertile = 0.71 (95 % CI: 0.62-0.82)). The protective effect of folate intake against hyperuricemia was higher in individuals with normal inflammatory status compared to those with low-grade inflammation. Furthermore, the protective effect was greater in individuals without hypertension, dyslipidemia, and cardiovascular disease compared to those with these conditions.Conclusion: These results suggest that dietary intake may help mitigate hyperuricemia, and individuals with inflammatory condition or cardiovascular diseases may require higher intake levels to achieve similar protective effects compared to healthy individuals.","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104108"},"PeriodicalIF":3.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0