Nutrition Metabolism and Cardiovascular Diseases最新文献

{"title":"Safety and efficacy of inclisiran in treating hypercholesterolemia: A systemic review and meta-analysis.","authors":"Zhiling Cheng, Meiling Gao, Yang Liu, Wei Yan, Zhihan Zhang, Ning Jiao, Congxin Li","doi":"10.1016/j.numecd.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.10.017","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the efficacy and safety of inclisiran in the treatment of hypercholesterolemia.</p><p><strong>Date synthesis: </strong>Randomized controlled trials comparing inclisiran with a placebo were searched until April 2024. Overall, 8 studies involving 4947 patients were included. Inclisiran reduced low-density lipoprotein cholesterol (mean difference [MD]: -46.95 %; 95 % confidence interval [CI]: -53.26 to -40.46; P < 0.05), proprotein convertase subtilisin/kexin type 9 (MD: -70.80 %; 95 % CI: -76.52 to -65.08; P < 0.05), serum total cholesterol (MD: -29.47 %; 95 % CI: -32.56 to -26.39; P < 0.05), non-high-density lipoprotein cholesterol (MD: -40.46 %; 95 % CI: -45.24 to -35.68; P < 0.05), apolipoprotein B (MD: -36.77 %; 95 % CI: -40.94 to -32.61; P < 0.05), and lipoprotein(a) (MD: -20.04 %; 95 % CI: -24.2 to -15.87; P < 0.05) levels but increased high-density lipoprotein cholesterol level (MD: 6.09 %; 95 % CI: 3.63 to 8.55; P < 0.05). The incidences of adverse events, serious adverse events, headache, nasopharyngitis, and muscular adverse reactions were not significantly different between the inclisiran and placebo groups. Inclisiran reduced the incidence of cardiovascular adverse reactions (odds ratio [OR] = 0.79; 95 % CI: 0.65 to 0.96; P = 0.02) and increased the incidence of injection-site reactions (OR = 4.79; 95 % CI: 2.18 to 10.52; P < 0.05).</p><p><strong>Conclusion: </strong>Inclisiran is effective in treating hypercholesterolemia and has a good safety profile.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103779"},"PeriodicalIF":3.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of adherence to 24-hour movement guidelines in adolescents: Objective versus subjective measures.","authors":"Rafaela Cavalheiro do Espírito Santo, Geiziane Melo, Viney Prakash Dubey, Cesar Agostinis-Sobrinho","doi":"10.1016/j.numecd.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.10.016","url":null,"abstract":"<p><strong>Background and aims: </strong>Previous studies have investigated the concordance between objective and subjective measures for assessing physical activity, sedentary behaviour, and sleep duration separately. However, no studies have compared adherence to the 24-h movement guidelines using both objective and subjective measures in adolescents. The aim of this study was to compare adherence to the 24-h movement guidelines using both objective and subjective measures.</p><p><strong>Methods and results: </strong>A comprehensive search was conducted in PubMed, Scopus, Web of Science, EMBASE, CINAHL, and SPORTDiscus up to May 2024. A meta-analysis using a random-effects model was conducted, and a p-value of <0.05 was considered statistically significant of the 5968 studies identified, only 42 met the inclusion criteria, with the included studies reporting a mean age of participants ranging from 11.99 to 17.99 years, comprising a total sample of 856,235 participants. There was no statistically significant difference between objective and self-reported measures of adherence to the 24-h movement guidelines (p > 0.05). When analysing each behaviour separately, there was a statistically significant difference between objective and self-reported measures of physical activity and sleep time (p < 0.05). Regarding sedentary behaviour, all studies used subjective measures; therefore, no meta-analysis was performed for screen time as all studies relied on subjective measures.</p><p><strong>Conclusion: </strong>Based on these findings, both objective and subjective measures can be used to assess adherence to the 24-h movement guidelines in adolescents. Thus, researchers and policymakers can choose either objective or subjective methods to assess adherence to the 24-h movement guidelines, with decisions tailored to the clinical context.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103778"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitual coffee consumption and risk of cardiovascular and all-cause mortality in the PAMELA hypertensive population.","authors":"Fosca Quarti-Trevano, Rita Facchetti, Cesare Cuspidi, Giuseppe Mancia, Guido Grassi","doi":"10.1016/j.numecd.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.10.014","url":null,"abstract":"<p><strong>Background and aims: </strong>Evidence has been provided that in the normotensive population chronic coffee consumption does not adversely affect cardiovascular and total mortality. Whether and to what extent this is the case also in high risk cardiovascular patients such as those with elevated blood pressure (BP) is largely debated.</p><p><strong>Methods and results: </strong>We analyzed data collected in 943 hypertensive patients belonging to the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study, which were classified as coffee consumers and non-consumers (self report). Cardiovascular and total mortality were evaluated at the 25 year follow-up taking into account a number of variables including office and 24-h ambulatory BP. When data were analyzed as unadjusted values no significant difference in hazard ratios for cardiovascular and total mortality was detected in coffee consumers and non-consumers considering office (0.85 and 0.83 respectively, PNS) or 24-h (1.08 vs 0.80 respectively, PNS) BP. This was the case also when the data were adjusted for confounders (age, sex, BP, lipid profile, plasma glucose and cholesterol levels, renal function, previous cardiovascular events) or when analyzed according to presence or absence of antihypertensive treatment.</p><p><strong>Conclusions: </strong>Thus in mild-to-moderate hypertensive patients chronic coffee consumption does not exert deleterious long-term effects on cardiovascular and total mortality. This is the case in both genders and in treated and untreated hypertensive patients.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103776"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry.","authors":"Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura I Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto D'Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, José Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor M Becerra-Munoz, Michael Kang-Yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Marinucci Lucia, Guiducci Vincenzo, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Vincent Flavien, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Francisco Bosa Ojeda, Robert Rodríguez-Sanchez, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, João António Brum Silveira, Rodrigo Zoni, Ivan Bessonov, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopulos, Carlos E Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Anne Bellemain-Appaix, Gustavo Pessah, Giuliana Cortese, Guido Parodi, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia","doi":"10.1016/j.numecd.2024.09.031","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.031","url":null,"abstract":"<p><strong>Background and aim: </strong>Diabetes has been shown in last decades to be associated with a significantly higher mortality among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary PCI (PPCI). Therefore, the aim of current study was to evaluate the impact of diabetes on times delays, reperfusion and mortality in a contemporary STEMI population undergoing PPCI, including treatment during the COVID pandemic.</p><p><strong>Methods and results: </strong>The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry involving PPCI centers from Europe, Latin America, South-East Asia and North-Africa, including patients treated from 1st of March until June 30, 2019 and 2020. Primary study endpoint of this analysis was in-hospital mortality. Secondary endpoints were postprocedural TIMI 0-2 flow and 30-day mortality. Our population is represented by 16083 STEMI patients. A total of 3812 (23,7 %) patients suffered from diabetes. They were older, more often males as compared to non-diabetes. Diabetic patients were less often active smokers and had less often a positive family history of CAD, but they were more often affected by hypertension and hypercholesterolemia, with higher prevalence of previous STEMI and previous CABG. Diabetic patients had longer ischemia time, had more often anterior MI, cardiogenic shock, rescue PCI and multivessel disease. They had less often out-of-hospital cardiac arrest and in-stent thrombosis, received more often a mechanical support, received less often a coronary stent and DES. Diabetes was associated with a significantly impaired postprocedural TIMI flow (TIMI 0-2: 9.8 % vs 7.2 %, adjusted OR [95 % CI] = 1.17 [1.02-1.38], p = 0.024) and higher mortality (in-hospital: 9.1 % vs 4.8 %, Adjusted OR [95 % CI] = 1.70 [1.43-2.02], p < 0.001; 30-day mortality: 10.8 % vs 6 %, Adjusted HR [95 % CI] = 1.46 [1.26-1.68], p < 0.001) as compared to non-diabetes, particularly during the pandemic.</p><p><strong>Conclusions: </strong>Our study showed that in a contemporary STEMI population undergoing PPCI, diabetes is significantly associated with impaired epicardial reperfusion that translates into higher in-hospital and 30-day mortality, particularly during the pandemic.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103763"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Kawada: The meta-analysis of nut intake and prostate cancer risk.","authors":"Arghavan Balali, Gholamreza Askari, Javad Anjom-Shoae, Omid Sadeghi","doi":"10.1016/j.numecd.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.10.004","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103765"},"PeriodicalIF":3.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of obesity in primary care patients: The IBERICAN study.","authors":"Sergio Cinza-Sanjurjo, Miguel A Prieto-Díaz, Vicente Pallares-Carratala, Rafael Manuel Mico-Pérez, Alfonso Barquilla-García, Sonsoles M Velilla-Zancada, José Polo-García, Verónica Ortiz-Ainaga, Antonio Segura-Fragoso, Leovigildo Ginel-Mendoza, Vicente Martín-Sánchez","doi":"10.1016/j.numecd.2024.09.021","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.021","url":null,"abstract":"<p><strong>Background and aims: </strong>Obesity has an important role in the prognosis of the patients, and important regional differences were described in Spain. The aim is to determine the prevalence of obesity in Spanish primary care patients and its geographical distribution.</p><p><strong>Methods and results: </strong>Prevalence study that included patients from the baseline interview of the IBERICAN study. Obesity was defined as a body mass index (BMI) greater than or equal to 30 kg/m² and abdominal obesity as a WC greater than or equal to 102 cm in men and 88 cm in women. Prevalence risks were calculated using unconditional logistic regression models, adjusting for socio-demographic variables and lifestyles. 58.8 % of the patients were obese according to any of the criteria used and 30.5 % met both criteria simultaneously. 33.7 % had a BMI greater than or equal to 30 kg/m² and 55.6 % had abdominal obesity. Women, older patients, rural residents, and retirees presented a higher risk of obesity. On the other hand, a higher economic status or education, regular exercise and high adherence to a Mediterranean diet were protective factors. The prevalence of obesity was heterogeneously distributed, and Canary Islands, Cantabria and Castilla la Mancha had significantly high risks of combined obesity (aOR = 1.80; 1.50 and 1.46 respectively).</p><p><strong>Conclusions: </strong>Obesity is a highly prevalent disease in primary care patients, with significant geographical differences in Spain.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103751"},"PeriodicalIF":3.3,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the aggregate index of systemic inflammation and cardiovascular risk in peritoneal dialysis patients.","authors":"Qiqi Yan, Guiling Liu, Ruifeng Wang, Dandan Li, Xiaoli Chen, Jingjing Cong, Deguang Wang","doi":"10.1016/j.numecd.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.10.012","url":null,"abstract":"<p><strong>Background and aim: </strong>The aggregate index of systemic inflammation (AISI), a novel inflammatory biomarker, is associated with various diseases. However, its association with cardiovascular risk in patients treated with peritoneal dialysis (PD) remains unclear. This study aims to explore the relationship between AISI and cardiovascular risk in this high-risk population, providing new insights for risk stratification and guiding clinical decision-making.</p><p><strong>Methods and results: </strong>This retrospective study enrolled 316 patients who underwent PD catheter insertion at the Second Affiliated Hospital of Anhui Medical University between January 1, 2010, and July 31, 2022. The optimal cut-off value of AISI for predicting cardiovascular events (CVE) was 213.58 using ROC curve analysis. Based on this cut-off value, patients were classified into high and low AISI groups. During a median follow-up of 39 (22, 66) months, 110 patients (34.8 %) developed CVE, and 37 patients (11.7 %) experienced cardiovascular mortality. Kaplan-Meier curves showed that the cumulative incidence of CVE (P < 0.001) and cardiovascular mortality (P = 0.002) were significantly higher in the high AISI group. After adjusting for potential confounding factors, a higher AISI remained an independent risk factor for both CVE (hazard ratio: 2.052; 95 % CI: 1.330-3.164; P = 0.001) and cardiovascular mortality (hazard ratio: 2.651; 95 % CI: 1.088-6.455; P = 0.032) in patients treated with PD. Subgroup analyses showed no significant interactions between AISI and the subgroup variables (P for interaction >0.05).</p><p><strong>Conclusions: </strong>Elevated AISI levels are independently associated with an increased risk of CVE and cardiovascular mortality in patients treated with PD. AISI may have significant implications for clinical practice.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103774"},"PeriodicalIF":3.3,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a CVD mortality risk score using nutritional predictors: A risk prediction model in the Golestan Cohort Study","authors":"Masoumeh Jabbari ,&nbsp;Meisam Barati ,&nbsp;Ali Kalhori ,&nbsp;Hassan Eini-Zinab ,&nbsp;Farid Zayeri ,&nbsp;Hossein Poustchi ,&nbsp;Akram Pourshams ,&nbsp;Azita Hekmatdoost ,&nbsp;Reza Malekzadeh","doi":"10.1016/j.numecd.2024.10.008","DOIUrl":"10.1016/j.numecd.2024.10.008","url":null,"abstract":"<div><h3>Background and aim</h3><div>We aimed to develop a dietary score using prediction model method for evaluating the risk of cardiovascular disease (CVD) mortality and suggesting a simple and practical scoring system within the healthcare context.</div></div><div><h3>Method and results</h3><div>A total of 43878 adult participants (aged 37–80 years) from the Golestan Cohort Study (GCS) were included in analysis. A random split of the subjects into the derivation (n = 28930) and the validation sets (n = 14948) was done. The Cox proportional hazard model was used to develop prediction model for the 8-year risk of CVD mortality. The model's discrimination and calibration were assessed by C-statistic and calibration plot, respectively. To enhance clinical utility, we devised a point-based scoring system derived from our model. This prediction model was developed by nine predictors including age, physical activity level (MET minutes/week), waist-to-hip ratio, tea intake (cup/day), vegetable intake (gr/1000 kcal/day), white meat intake (gr/1000 kcal/day), salt intake (gr/1000 kcal/day), dairy intake (Cup/1000 kcal/day), and percentage of protein intake. The model had an acceptable discrimination in both derivation (C-statistic: 0.76, p &lt; 0.001) and validation (C- statistic: 0.77, p &lt; 0.001) samples. Also, the calibration of model in both derivation and validation datasets was 0.81.</div></div><div><h3>Conclusion</h3><div>This is the first attempt to develop a risk prediction model of CVD mortality and the risk scoring system by the majority of nutritional predictors in a large cohort study. This nutritional risk assessment tool is suitable for motivating at-risk individuals to make lifestyle and dietary pattern changes to reduce future risk to prevent health problems.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103770"},"PeriodicalIF":3.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nut consumption on blood lipids: An updated systematic review and meta-analysis of randomized controlled trials.","authors":"Stephanie K Nishi, Indira Paz-Graniel, Jiaqi Ni, Cristina Valle-Hita, Nadine Khoury, Jesús F Garcia-Gavilán, Nancy Babio, Jordi Salas-Salvadó","doi":"10.1016/j.numecd.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.10.009","url":null,"abstract":"<p><strong>Aims: </strong>Nuts are nutrient-dense foods touted for their health-promoting effects, especially regarding cardiovascular health, yet inconsistencies in the literature remain in relation to their effect on blood lipids. Hence, a systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of nut intake on blood lipids.</p><p><strong>Data synthesis: </strong>MEDLINE-PubMed and Cochrane databases were searched. 113 unique trials met eligibility criteria (n = 8060 adults with various health status) assessing the effect of a median daily dose of 45.5 g/d of nuts compared to a non-nut control on blood lipid outcomes met inclusion criteria. Overall, nut consumption resulted in moderate reductions in total cholesterol (mean difference, -0.14 mmol/L [95 % confidence interval, -0.18 to -0.10 mmol/L]) and LDL-C (-0.12 mmol/L [-0.14 to -0.09 mmol/L]), with small reductions in triglycerides (-0.05 mmol/L [-0.07 to -0.03 mmol/L]), TC:HDL-C (-0.11 [-0.16 to -0.06]), LDL-C:HDL-C (-0.19 [-0.24 to -0.12]), and apolipoprotein B (-0.04 g/L [-0.06 to -0.02 g/L]). There was no significant impact on HDL-cholesterol or other assessed measures. Certainty of evidence was high for apolipoprotein A, and generally moderate/low for all other outcomes. Sensitivity analysis did not change the evidence on the main outcomes. Significant effect modifications in subgroup analysis were shown for most of the lipid parameters assessed. None of these subgroup effects altered the evidence of heterogeneity for any primary outcome.</p><p><strong>Conclusions: </strong>Current evidence provides a good indication that consuming nuts may advantageously affect blood lipids in adults with a mix of health status.</p><p><strong>Prospero registration: </strong>PROSPERO identifier, CRD42022358688.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"103771"},"PeriodicalIF":3.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk and yogurt consumption and its association with cardiometabolic risk factors in patients with type 2 diabetes: The Fukuoka Diabetes Registry","authors":"Masahito Yoshinari ,&nbsp;Toshiaki Ohkuma ,&nbsp;Masanori Iwase ,&nbsp;Takanari Kitazono","doi":"10.1016/j.numecd.2024.10.010","DOIUrl":"10.1016/j.numecd.2024.10.010","url":null,"abstract":"<div><h3>Background and aim</h3><div>The effects of dairy products on cardiometabolic risk factors in patients with diabetes, especially in Asians, have yet to be fully investigated. Therefore, we aimed to characterise the relationship between milk and yogurt consumption and cardiometabolic risk factors in Japanese patients with diabetes.</div></div><div><h3>Methods and results</h3><div>A total of 4,438 patients with type 2 diabetes were studied. Milk and yogurt consumption was assessed using a validated self-administered diet history questionnaire, and the relationships with cardiometabolic risk factors were evaluated cross-sectionally. High consumption of milk and yogurt was significantly associated with lower body mass index, blood pressure, serum triglyceride concentration and urinary albumin-to-creatinine ratio; and higher low-density lipoprotein-cholesterol concentration (<em>P</em> for trend &lt;0.01). Greater milk and yogurt consumption was also associated with lower likelihood of having metabolic syndrome and chronic kidney disease (CKD) (<em>P</em> for trend &lt;0.001). Multivariable-adjusted odds ratios for metabolic syndrome and CKD in the highest quartile of milk and yogurt consumption, <em>vs</em>. the lowest quartile, were 0.75 (95% confidence interval 0.62–0.91) and 0.72 (0.59–0.89), respectively. However, the likelihood of having a high low-density lipoprotein-cholesterol concentration became higher with greater milk and yogurt consumption (<em>P</em> for trend &lt;0.001).</div></div><div><h3>Conclusions</h3><div>Higher milk and yogurt consumption is associated with superior control of cardiovascular risk factors, including CKD, in Japanese patients with type 2 diabetes.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103772"},"PeriodicalIF":3.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}