The bone-heart axis in the pathogenesis of cardiovascular diseases: A narrative review

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-03-01 DOI:10.1016/j.numecd.2025.103872

Anita Vergatti , Veronica Abate , Gabriella Iannuzzo , Antonio Barbato , Gianpaolo De Filippo , Domenico Rendina

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Abstract

Cardiovascular diseases (CVDs) cause about 30% of deaths worldwide, increasing social and economic burden in our societies. Although the treatment of the canonical cardiovascular risk factors has reduced the impact of CVDs on morbidity and mortality in the past few years, they continue to represent a major health problem. The definition of the biological properties of the bone-heart axis has led to new insights in the pathogenesis of CVDs; hence, the aim of this review is to try to elucidate the role of this axis on the susceptibility to CVDs. There is evidence that the bone interacts with extra-skeletal organs, including the cardiovascular system, through its endocrine functions. Clinical and experimental data strongly indicate that the interplay between the bone and the cardiovascular system represents a future tool for the prevention, diagnosis and treatment of CVDs. The identification of these non-canonical cardiovascular risk factors could prompt pharmacological research towards new target therapy aimed at precision medicine.

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骨-心轴在心血管疾病发病机制中的研究进展

心血管疾病（cvd）造成全世界约30%的死亡，增加了我们社会的社会和经济负担。虽然在过去几年中，对典型心血管危险因素的治疗已经降低了心血管疾病对发病率和死亡率的影响，但它们仍然是一个主要的健康问题。骨-心轴生物学特性的定义为心血管疾病的发病机制提供了新的见解；因此，本综述的目的是试图阐明该轴在心血管疾病易感性中的作用。有证据表明，骨骼通过其内分泌功能与包括心血管系统在内的骨骼外器官相互作用。临床和实验数据有力地表明，骨骼和心血管系统之间的相互作用代表了心血管疾病预防、诊断和治疗的未来工具。这些非典型心血管危险因素的识别可以促进针对精准医学的新靶点治疗的药理学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.