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Reducing the prime cardiopulmonary bypass volume during paediatric cardiac surgery. 在儿科心脏手术中减少心肺旁路的初始容量。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-11-01 DOI: 10.1177/02676591241296319
Laurent Mathieu, César Brunetti, Jean Detchepare, Maude Flambard, Christine Germain, Elise Langouet, Nadir Tafer, François Roubertie, Alexandre Ouattara
{"title":"Reducing the prime cardiopulmonary bypass volume during paediatric cardiac surgery.","authors":"Laurent Mathieu, César Brunetti, Jean Detchepare, Maude Flambard, Christine Germain, Elise Langouet, Nadir Tafer, François Roubertie, Alexandre Ouattara","doi":"10.1177/02676591241296319","DOIUrl":"10.1177/02676591241296319","url":null,"abstract":"<p><p>IntroductionDespite technological advances, the use of homologous blood to prime the cardiopulmonary bypass (CPB) circuits of infants under 10 kg remains common. However, such rapid massive transfusion may increase post-CPB morbidity.MethodWe retrospectively included consecutive patients weighing 2.3-10 kg who underwent cardiac surgery under CPB. Patients were divided into two groups based on their priming volumes: low priming volume (LPV) (below the median volume) or high priming volume (HPV) (the median volume or above).ResultsThe study included 208 patients, of whom 104 had priming volumes below the median [37.9 (28.4-51.7) mL/kg] and 104 had at least the median volume. We recorded positive correlations between the priming volume, on the one hand, and the peak creatinine and CRP levels within 5 days postoperatively, the duration of intensive care unit (ICU) stay, and the mechanical ventilation time, on the other. A relationship was also observed between a higher median priming volume and the need for renal replacement therapy in the ICU and mediastinitis.ConclusionAlthough the differences in priming volume between the twogroups were small, they significantly influenced the postoperative complications. Perfusionists should seek to limit the priming volume to reduce the post-CPB inflammatory response, the duration of ICU stay, and possibly the risk of mediastinitis.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1346-1353"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The discussion of the relationship between cardiopulmonary bypass and postoperative thyroid function changes in pediatric congenital heart disease, and the analysis of oral thyroid hormone therapy and cardiac prognosis. 讨论小儿先天性心脏病心肺旁路术与术后甲状腺功能变化之间的关系,分析口服甲状腺激素治疗与心脏预后的关系。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-11-01 DOI: 10.1177/02676591241298200
Liang Zhao, Fengjie Song, Minghua Mu, Chunjie Mu, Xiaoyu Zhang, Haobo Ren, Jiahui Xie, Runwei Ma
{"title":"The discussion of the relationship between cardiopulmonary bypass and postoperative thyroid function changes in pediatric congenital heart disease, and the analysis of oral thyroid hormone therapy and cardiac prognosis.","authors":"Liang Zhao, Fengjie Song, Minghua Mu, Chunjie Mu, Xiaoyu Zhang, Haobo Ren, Jiahui Xie, Runwei Ma","doi":"10.1177/02676591241298200","DOIUrl":"10.1177/02676591241298200","url":null,"abstract":"<p><p>ObjectiveThis study aims to investigate the relationship between CPB factors and changes in TH levels in postoperative patients and the effect of oral levothyroxine sodium tablets on outcomes in patients with postoperative TF abnormalities.MethodsSelect patients who underwent CHD surgery between September 2017 and September 2023 and were aged 13 years or younger. The relationship between CPB and postoperative TF changes and the influencing factors were analyzed. In addition, patients with different diseases and ages were divided into the medication group and the non-medication group. The primary outcome was postoperative ejection fraction (EF), and the secondary outcomes were PICU hospitalization days and total hospital cost.ResultsSeven hundred 53 patients were included. The longer the CPB time and ACC time, the lower the postoperative triiodothyronine (T3) and thyroxin (T4) levels (<i>p</i> < 0.001 and <i>p</i> < 0.001). The longer the CPB time, the more pronounced the postoperative T3 level abnormality (<i>p</i> < 0.001). The longer the CPB time, ACC time, and DHCA time, the more pronounced the postoperative T4 level abnormalities (<i>p</i> < 0.001 and <i>p</i> < 0.001 and <i>p</i> = 0.046). The postoperative EF of patients in the medication group was slightly higher than that of the non-medication group, and the EF before discharge was significantly higher than that of the non-medication group (<i>p</i> = 0.021, <i>p</i> = 0.015, and <i>p</i> = 0.024). Postoperative PICU days in the medication group [3.0 (2.0,7.0) versus4.0 (2.0,10.0), <i>p</i> = 0.020] were shorter than the non-medication group, and the proportion of ≤ 5 days was more [154 (66.1%) versus304 (58.5%), <i>p</i> = 0.047]. The total hospitalization cost was slightly lower in the medication group (<i>p</i> < 0.05).ConclusionThe duration of CPB, ACC, and DHCA in the open surgery process for CHD affects patients' thyroid function in the postoperative period. In our study, we found that oral levothyroxine sodium tablets are beneficial to the children's postoperative recovery.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1354-1363"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ensuring quality information for patients tool to assess patient information on CABG websites: Systemic search and evaluation. 确保患者信息质量:评估CABG网站患者信息的工具:系统搜索和评估。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-12-03 DOI: 10.1177/02676591241303842
Chun Wai Tai, Lam Wing Kwan, Jeremy Chan, Gianni D Angelini
{"title":"Ensuring quality information for patients tool to assess patient information on CABG websites: Systemic search and evaluation.","authors":"Chun Wai Tai, Lam Wing Kwan, Jeremy Chan, Gianni D Angelini","doi":"10.1177/02676591241303842","DOIUrl":"10.1177/02676591241303842","url":null,"abstract":"<p><p>BackgroundCoronary artery bypass surgery (CABG) is the most common cardiac surgical procedure worldwide. The Internet is often the first place for patients to obtain medical information and may influence their health-seeking behaviour. This study aimed to assess the quality of online CABG information for patients.MethodsA review was conducted on the available CABG information online using four search terms in Google: \"coronary artery bypass grafting\", \"CABG\", \"bypass surgery\", and \"coronary surgery\". Websites on the first three pages of each search term were assessed by two independent assessors using the Ensuring Quality Information for Patients (EQIP) tool (score 0-36).Results71 websites in total were eligible for the evaluation. Most websites originated from the USA and the UK (35% for both). The median EQIP score was 16.5. Most websites used everyday language (94%) in short sentences (83%). More than half (60%) of the websites addressed qualitative complications and risks of surgery. Only 1/3 of the websites described treatment alternatives, precautions before surgery, and warning signs after surgery. Only about 1/10 of websites could address quality-of-life issues and resolution of complications.ConclusionMost online sites concerning CABG scores were low in EQIP tool assessment in terms of quality and readability with insufficient sources. Minimal information is provided regarding the quantitative risks and complications. Enhancement of the credibility and informativeness of websites is needed to reduce patients' anxiety about surgical procedures and help with treatment options for coronary artery disease. Education and investigation on the consistency of high-quality websites may help patient identify high quality medical information.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1468-1476"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Female patients with acute aortic dissection type A (AADA): A gender-selective evaluation of the intensity of the surgical treatment. 急性主动脉夹层 A 型(AADA)女性患者:手术治疗强度的性别选择性评估。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-11-25 DOI: 10.1177/02676591241303325
Morsi Arar, Andreas Martens, Linda Rudolph, Heike Krueger, Victoria Arar, Erik Beckmann, Malakh Shrestha, Tim Kaufeld
{"title":"Female patients with acute aortic dissection type A (AADA): A gender-selective evaluation of the intensity of the surgical treatment.","authors":"Morsi Arar, Andreas Martens, Linda Rudolph, Heike Krueger, Victoria Arar, Erik Beckmann, Malakh Shrestha, Tim Kaufeld","doi":"10.1177/02676591241303325","DOIUrl":"10.1177/02676591241303325","url":null,"abstract":"<p><p>ObjectiveAcute aortic dissection type A (AADA) is a condition that affects both genders and requires urgent surgical intervention as non-operative treatment is often associated with a poor prognosis. Studies have proven that less aggressive surgical treatments influence the outcome for female patients in the fields of several diseases. The purpose of this study was to report and analyze our results in the selective cohort of female patients with AADA to detect differences in the treatment of this group of patients.MethodsBetween January 2000 and July 2018, 141 adult female patients with acute aortic dissection (AAD) underwent repair of the aorta in our department. A total of 75 patients received a proximal arch. replacement (group A), and 66 patients received a subtotal (replacement of the brachiocephalic trunk) and/or total arch. replacement with elephant trunk or frozen elephant trunk (group B).ResultsThe median age in group A was 70.7 years (range 60.7-74.7 years) and in group B 66.3 years (range 55.6-71.3 years). Operation times were significantly longer in group B (total operation time: A = 286.9 min (range 225.0-341.0 min), B = 341 min (range 266.0-392 min), <i>p</i> = .003; cardiopulmonary bypass time: A = 189.0 min (range 139.0-138 min), B = 238 min (range 176.8-300.5 min), <i>p</i> < .001; circulatory arrest time: A = 27.0 min (range 21.0-37.0 min), B = 42.0 min (range 32.0-56.3 min), <i>p</i> < .001). There were no significant differences between the groups regarding 30-day mortality (A = 24% (<i>n</i> = 18), B = 19.7% (<i>n</i> = 13), <i>p</i> = .538) and rate of reoperation (A = 13.3% (<i>n</i> = 10), B = 15.2% (<i>n</i> = 10), <i>p</i> = .757) or the preoperative characteristics.ConclusionOur study showed no significant difference in mortality rate depending on the type of operation. Based on these results, a proximal arch. replacement should be considered as the first line of operation technique if the individual situation allows. For inexperienced clinics and surgeons in particular, we recommend limited aortic repair in patients with AADA. Finally, location of the intimal tear remains the essential factor for the evaluation of the surgical treat.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1439-1447"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early results of female patients who underwent mitral valve surgery through periareolar incision approach. 通过乳晕周围切口方法接受二尖瓣手术的女性患者的早期疗效。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-11-25 DOI: 10.1177/02676591241303850
Alper Selim Kocaoglu, Cengiz Ovali
{"title":"Early results of female patients who underwent mitral valve surgery through periareolar incision approach.","authors":"Alper Selim Kocaoglu, Cengiz Ovali","doi":"10.1177/02676591241303850","DOIUrl":"10.1177/02676591241303850","url":null,"abstract":"<p><p>BackgroundApproaches that require less invasive procedures, offer heal in a shorter time and provide better cosmetic results have gained importance with the technological and modern developments in cardiac surgery. Esthetically preferred results can be achieved after heart valve surgery using a periareolar incision, especially in female patients. In the present study, we aimed to present our results after surgery using periareolar incision in female patients.MethodsWe retrospectively evaluated the 1-year follow-up results in the postoperative period of isolated mitral valve replacement and tricuspid valve repair with mitral valve replacement using a periareolar incision with direct observation in 32 patients between 2020 and 2023. At the end of 1-year follow-up, we evaluated the patients' visual satisfaction with the incision site using a visual analog scale.ResultsAccording to the postoperative follow-up results, no prosthetic mitral valve dysfunction was detected in any of the patients at the 1st year echocardiography controls. Mild tricuspid valve insufficiency was detected in 3 patients who underwent tricuspid valve repair. Besides, a high level of satisfaction was observed in the patients' incision site evaluations with a visual analog scale at the end of the first year, and no numbness was reported in the periareolar region in any of the patients.ConclusionOur study shows that surgical results similar to conventional methods can be achieved with the periareolar approach, and patient satisfaction and recovery times are shorter and more satisfying. We also think that the periareolar incision can be made without videoassisted equipment and this may reduce the surgical cost.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1455-1460"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors and outcomes associated with right ventricular function in patients with acute respiratory distress syndrome treated with Veno-venous extracorporeal membrane oxygenation. 接受静脉体外膜氧合治疗的成人呼吸窘迫综合征患者右心室功能的相关预测因素和预后。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-08-23 DOI: 10.1177/02676591241277947
Roman Melamed, Jason Block, Summer L Martins, Daniel Bullard, Leeore Levinstein, Angela Phillips, Ramiro Saavedra
{"title":"Predictors and outcomes associated with right ventricular function in patients with acute respiratory distress syndrome treated with Veno-venous extracorporeal membrane oxygenation.","authors":"Roman Melamed, Jason Block, Summer L Martins, Daniel Bullard, Leeore Levinstein, Angela Phillips, Ramiro Saavedra","doi":"10.1177/02676591241277947","DOIUrl":"10.1177/02676591241277947","url":null,"abstract":"<p><p>IntroductionRight ventricular dysfunction is associated with mortality in patients with acute respiratory distress syndrome (ARDS) but information in veno-venous extracorporeal membrane oxygenation (ECMO) settings is limited. Study objectives were to examine factors associated with right ventricular (RV) systolic dysfunction (RVSD) and RV dilation in ECMO patients with ARDS, to compare outcomes in those with and without RVSD and RV dilation defined by qualitative and quantitative parameters, and to describe RVSD evolution during ECMO.MethodsRetrospective observational study of adult ARDS patients supported with ECMO at a tertiary care hospital.ResultsOf a total of 62 patients, 56% had RVSD and 61% had RV dilation by qualitative assessment. Male gender, COVID-19, hypercarbia, and pneumothorax were associated with RVSD and RV dilation. In-hospital mortality was significantly higher in patients with RV dilation vs. no dilation (42% vs. 17%, <i>p</i> = .05) but comparisons for patients with and without RVSD (37% vs. 26%, respectively) did not reach statistical significance. Findings were similar when RV size and function were quantified by right to left ventricle end-diastolic area ratio and fractional area change (39% vs. 21% and 36% vs. 20% respectively; p = NS). Of 39 patients with multiple echocardiograms, 9 of 18 with initially normal RV function developed RVSD while RV function normalized in 10 of 21 patients who began ECMO with RVSD.ConclusionsStudy results suggest an association of RV dilation and RVSD with worse outcomes and a dynamic nature of RV function necessitating close monitoring during the ECMO course.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1461-1467"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A stented elephant trunk procedure with retrograde cerebral perfusion for a rare type of pseudoaneurysm with an aberrant right subclavian artery. 对右侧锁骨下动脉异常的罕见假性动脉瘤进行逆行脑灌注的大象干支架手术。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-10-18 DOI: 10.1177/02676591241293677
Tao Yang, Zhifa Zheng, Lingbo Yang, Nan Wu, Zhenhao Liu, Xuening Wang
{"title":"A stented elephant trunk procedure with retrograde cerebral perfusion for a rare type of pseudoaneurysm with an aberrant right subclavian artery.","authors":"Tao Yang, Zhifa Zheng, Lingbo Yang, Nan Wu, Zhenhao Liu, Xuening Wang","doi":"10.1177/02676591241293677","DOIUrl":"10.1177/02676591241293677","url":null,"abstract":"<p><p>BackgroundAberrant right subclavian artery (ARSA) is a rare congenital vascular anomaly that increases the risk of aortic dissection (AD). Although several treatment options for cases of AD with ARSA have been proposed, such as traditional surgery, thoracic endovascular aortic repair, and a hybrid procedure, a consensus regarding the optimal treatment strategy has not yet been established. And there are no reported cases of pseudoaneurysm combined with ARSA.Case presentationA 44-year-old male was admitted with a 7-days history of chest pain. A physical examination was almost normal. Computed tomography angiography (CTA) showed an ARSA arose from the distal aortic arch and pseudoaneurysm located distal to the origin of the ARSA. The stented elephant trunk (SET) procedure with retrograde cerebral perfusion (RCP) was performed under moderate hypothermic circulatory arrest. The postoperative CTA demonstrated a well-perfused ARSA, left subclavian artery (LSA), left common carotid artery (LCCA), and right common carotid artery (RCCA), and occluded pseudoaneurysm with no endoleaks. He was discharged on postoperative day 9 and was doing well during his 6-months follow-up.ConclusionsWith a smaller incision, a simple cannulation method, shorter surgical and circulatory arrest times, fewer blood transfusion requirements, and effective brain protection, the SET procedure with RCP can be a safe and feasible treatment option for complicated aortic arch anomalies with ARSA.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1499-1503"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of veno-arterial extracorporeal membrane oxygenation return cannula side hole structure on aortic hemodynamic features under different perfusion levels. 不同灌注水平下静脉-动脉体外膜氧合回流套管侧孔结构对主动脉血流动力学特征的影响。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-10-26 DOI: 10.1177/02676591241297308
Yifeng Xi, Yuan Li, Hongyu Wang, Anqiang Sun, Xiaoyan Deng, Zengsheng Chen, Yubo Fan
{"title":"Effects of veno-arterial extracorporeal membrane oxygenation return cannula side hole structure on aortic hemodynamic features under different perfusion levels.","authors":"Yifeng Xi, Yuan Li, Hongyu Wang, Anqiang Sun, Xiaoyan Deng, Zengsheng Chen, Yubo Fan","doi":"10.1177/02676591241297308","DOIUrl":"10.1177/02676591241297308","url":null,"abstract":"<p><p>IntroductionThe interaction between primary left ventricular output and Veno-arterial extracorporeal membrane pulmonary oxygenation (VA ECMO) flow may impede the perfusion of aortic vessels with hyperoxic blood, leading to differential oxygenation. ECMO return cannula design significantly influences the perfusion level of blood supplied via ECMO. This study aimed to investigate the impact of various cannula designs (side hole number) on intravascular flow patterns under different blood perfusion conditions.MethodsSix return cannula models with different side hole number and three cardiac output waveforms were designed based on clinical data for comparative analysis.ResultsThe position of the blood mixing zone (MZ) was influenced by the flow-volume ratio of the heart output (CO/(CO+Qec)) and cannula design. As the CO/(CO+Qec) and the number of side holes in the cannula increased, the MZ shifted from the ascending aorta to the descending aorta. Concurrently, aortic wall and scalar shear stress on the impact side of ECMO cannulation reduced progressively. Return cannula with side holes effectively mitigated discrepancies in the perfusion of the renal artery and inadequate perfusion of the lower limb vessels on the cannula side while simultaneously reducing damage to the vessel walls and blood. However, increasing the number of side holes in the return cannulas resulted in diminished perfusion of the aortic arch bifurcation vessels by hyperoxic blood supplied via ECMO.ConclusionIncreasing the number of return cannula side holes for VA ECMO femoral artery cannulation improves hypoxic perfusion in the lower limb and reduces vascular endothelial injury, but may also lead to inadequate hypoxic perfusion in the upper body.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1338-1345"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus anticoagulant and valvular cardiac surgery. 狼疮抗凝剂和心脏瓣膜手术。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-10-26 DOI: 10.1177/02676591241293010
Pooja Bola Rajendra Devendra Kamath, Deborah L Braham, Deepa J Arachchillage, Dennis Loja
{"title":"Lupus anticoagulant and valvular cardiac surgery.","authors":"Pooja Bola Rajendra Devendra Kamath, Deborah L Braham, Deepa J Arachchillage, Dennis Loja","doi":"10.1177/02676591241293010","DOIUrl":"10.1177/02676591241293010","url":null,"abstract":"<p><p>Despite its name, lupus anticoagulant (LAC) neither exclusively occurs in lupus nor induces anticoagulation. It is an antiphospholipid antibody found in 2%-4% of the population that promotes clot formation by targeting phospholipid-protein complexes in cell membranes. However, in vitro, LAC exhibits paradoxical effects, prolonging clotting times in phospholipid-dependent assays such as Activated Partial Thromboplastin Time (APTT). This unpredictability extends to point-of-care tests like Activated Clotting Time (ACT), which are frequently used to monitor anticoagulation during cardiac surgeries involving cardiopulmonary bypass (CPB). High doses of unfractionated heparin (UFH) are administered in these procedures, but the presence of LAC complicates ACT measurements, creating challenges for both anesthesiologists and surgeons. This case report highlights the clinical implications of LAC in perioperative management, underscoring the difficulties in ensuring adequate anticoagulation during CPB.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1495-1498"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive cerebral autoregulation monitoring during paediatric cardiac surgery without cardiopulmonary bypass requiring intraoperative cross-clamping of one of the carotid arteries. 在无需心肺旁路的儿科心脏手术中进行无创脑自动调节监测,要求术中横断其中一条颈动脉。
IF 1.1 4区 医学
Perfusion-Uk Pub Date : 2025-09-01 Epub Date: 2024-11-26 DOI: 10.1177/02676591241304100
Rafal Berger, Sebastian Ewert, Rodrigo Sandoval Boburg, Felix Neunhoeffer, Harry Magunia, Mario Lescan, Christian Schlensak, Migdat Mustafi
{"title":"Non-invasive cerebral autoregulation monitoring during paediatric cardiac surgery without cardiopulmonary bypass requiring intraoperative cross-clamping of one of the carotid arteries.","authors":"Rafal Berger, Sebastian Ewert, Rodrigo Sandoval Boburg, Felix Neunhoeffer, Harry Magunia, Mario Lescan, Christian Schlensak, Migdat Mustafi","doi":"10.1177/02676591241304100","DOIUrl":"10.1177/02676591241304100","url":null,"abstract":"<p><p>IntroductionNeurologic complications remain one of the major risks after pediatric cardiac surgery. Cerebral autoregulation (CA) is a physiologic mechanism regulating cerebral perfusion. A dynamic intraoperative evaluation can possibly detect the impairment of the cerebral regulatory function during surgery. The aim of the present study was to evaluate the utility of dynamic cerebral blood perfusion monitoring using cerebral oxygenation index (COx) as CA parameter during pediatric cardiac surgery without cardiopulmonary bypass (CPB) requiring intraoperative cross-clamping of one carotid artery to perform the procedure.Materials and methodsProspective intraoperative autoregulation monitoring was performed in 14 children under the age of 1 year requiring elective cardiac surgery with intraoperative cross-clamping of one of carotid artery. Procedures requiring the use of CPB and redo surgeries were excluded.ResultsImpaired CA could be measured during 33.8% of cross-clamping time on the ipsilateral side and 30.1% on the contralateral side. The difference in COx was not significant before (<i>p</i> = 0.7), during (<i>p</i> = 0.29) and after cross clamping (<i>p</i> = 0.63), but a significant difference in COx levels throughout the entire cohort was noted individually. The mean ABP during normal (COx <0.4) CA was 61.8 mmHg (95% CI 60.7 - 62.9) and 62.9 mmHg (95% CI 61.9 - 63.9) for cross clamped and opposite side. During impaired (COx >0.4) CA the ABP values were 58.9 mmHg (95% CI 57.7 - 60.1, <i>p</i> < 0.05) and 56 mmHg (95% CI 54.8 - 57.3, <i>p</i> < 0.05) respectively.ConclusionsA dynamic intraoperative monitoring of CA during pediatric cardiac surgery is possible and allows to confirm the impairment of autoregulation during cross-clamping of one of the carotid arteries.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1448-1454"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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