Perfusion-Uk最新文献

{"title":"Complex cardiac and orthopedic surgery in a 14-year-old with DiGeorge syndrome from a Jehovah's Witness household: A blood conservation approach.","authors":"Maria E Hoyos, Mario A O'Connor, Brian Kaufman, Cynthia Keene, Madeline Loftin, Hugo R Martinez, Charles D Fraser, Erin Gottlieb","doi":"10.1177/02676591251340940","DOIUrl":"10.1177/02676591251340940","url":null,"abstract":"<p><p>This case report discusses the management of a 15-year-old Jehovah's Witness (JW) with DiGeorge syndrome, complex congenital heart disease (CHD), and severe neuromuscular scoliosis requiring major orthopedic surgery. Refusal of blood transfusions required preoperative optimization and advanced blood conservation strategies. The patient underwent multiple cardiac surgeries and spinal fusion. This case emphasizes multidisciplinary coordination and blood management strategies for surgical cases with religious restrictions.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"221-224"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of HTK solution in protecting cardiomyocytes against oxidative stress by upregulating Nrf2 during cardiac arrest and resuscitation: a rat model with a right thoracotomy.","authors":"BingMei Qiu, Lei Wang, PeiCheng Ding, AnLi Wang, Xing Zhang, Qian Li, ChangTian Wang, ShanWu Feng","doi":"10.1177/02676591241307365","DOIUrl":"10.1177/02676591241307365","url":null,"abstract":"<p><p>IntroductionThe objective of this study was to establish a rat model for cardiopulmonary bypass (CPB) with cardiac arrest and resuscitation and to investigate the regulatory role of HTK solution in protecting cardiomyocytes against oxidative stress by upregulating Nrf2.Methods40 rats were randomly assigned to four groups: the control (Ctrl), the histidine-tryptophan-ketoglutarate (HTK), 4:1 blood cardioplegia (BC) and del Nido cardioplegia (DN) groups. The cardiopulmonary bypass (CPB) procedure was implemented and sustained for a duration of 1 hour. Subsequent to the cessation of CPB, the rats were subjected to monitoring and observation for an additional 2 hours. Following this observation period, the heart and blood samples were procured for subsequent analysis.ResultsThe MDA was significantly higher in the HTK group, BC group, and DN group compared to the Ctrl group. The HTK group had lower MDA levels than the BC group. Regarding MPO activity, it increased in the HTK group, BC group, and DN group relative to the Ctrl group. Both the BC and DN groups exhibited elevated MPO levels compared to the HTK group. SOD levels were significantly lower in the HTK, BC, and DN groups compared to the Ctrl group. The HTK group had higher SOD levels than the BC group. With respect to miRNA-210-3P and Nrf2, the expression were more efficient in the HTK, BC, and DN groups compared to the Ctrl group. The BC and DN groups showed reduced expression efficiency over the HTK group. Western blot analysis indicated that the ratio of Nrf2 target was higher in the HTK group, BC group, and DN group in comparison to the Ctrl group. Both the BC and DN groups had lower protein content compared to the HTK group. Immunohistochemistry scoring of HIF1-α and nuclear Nrf2 revealed higher scores in the HTK, BC, and DN groups compared to the Ctrl group. The HTK group achieved higher scores than both the BC and DN groups.ConclusionVaried degrees of oxidative stress damage were exhibited by three distinct cardioplegia solutions. The HTK group demonstrated a superior antioxidant effect. The protective response of the HTK solution against oxidative stress may be linked to the up-regulation of Nrf2.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"197-211"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal hepatic failure for early-onset group B streptococcal sepsis successfully treated using hemoperfusion with Jafron cartridge during V-A ECMO support.","authors":"Elisa Barberi, Giacomo Bianchi, Vitali Pak, Cornel Marusceac, Dorela Haxhiademi, Nadia Assanta, Michele Guarino, Paolo Antonio Del Sarto","doi":"10.1177/02676591251366418","DOIUrl":"10.1177/02676591251366418","url":null,"abstract":"<p><p>IntroductionManagement of neonatal Group B Streptococcal (GBS) sepsis with multi-organ failure requires innovative approaches when conventional therapies prove insufficient.Case ReportA term neonate developed severe respiratory failure and septic shock from GBS infection, necessitating veno-arterial extracorporeal membrane oxygenation (V-A ECMO) initiation at 24 hours of life. During ECMO support, the patient developed hepatic dysfunction with severe hyperbilirubinemia (peak total/direct bilirubin: 36.9/31.6 mg/dL). A Jafron HA60 hemoadsorption cartridge was integrated into the ECMO circuit, resulting in a 38% bilirubin reduction within 24 hours. Despite complications including lung atelectasis, renal dysfunction, and nosocomial COVID-19, the patient was successfully decannulated after 15 days, extubated after 24 days, and discharged home after 48 days with normal neurological outcomes.DiscussionThis case highlights the application of hemoadsorption technology for managing hepatic failure in neonatal ECMO.ConclusionHemoadsorption therapy represents a promising adjunctive treatment for neonates with severe hyperbilirubinemia during ECMO support.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":"41 2","pages":"120-123"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative hemoglobin changes following ultrafiltration in cardiac patients.","authors":"Ethan Forsberg, Douglas Smego, Kirk Bingham, Christopher Blaylock","doi":"10.1177/02676591251344852","DOIUrl":"10.1177/02676591251344852","url":null,"abstract":"<p><p>IntroductionThis retrospective study investigated the relationship between differing thresholds of Conventional Ultrafiltration (CUF) and postoperative hemoglobin (HGB) in cardiac surgery cases involving cardiopulmonary bypass.MethodsThe study utilized EPIC and STS data for patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). It included three groups: those without CUF (<i>n</i> = 106), low CUF (volume <20 mL/kg; <i>n</i> = 33), and high CUF (volume ≥20 mL/kg); <i>n</i> = 18). HGB levels were assessed at the following points: Pre-operative, end-bypass, first hour in the ICU, discharge, and 30 days post-procedure. Total intravenous fluid administration at 72 hours postoperatively was also evaluated.ResultsThere was no significant difference between the three groups in HGB pre-operatively, end-bypass, or during the first hour in the ICU. At discharge, the non-CUF group had significantly higher HGB levels than the high CUF group (<i>p</i> = 0.028), and HGB in the low CUF group was not significantly different from the high CUF (<i>p</i> = 0.102) group. At 30 days, HGB in the low CUF group was significantly higher than those with high CUF (<i>p</i> = 0.022). Additionally, HGB levels in the non-CUF group were not significantly different than those with high CUF (0.078). Surprisingly, there was no difference in total IV fluid volume administered at 72 hours post-op (<i>p</i> = 0.181) between any of the groups.ConclusionsLow CUF is superior to no CUF, and high CUF in the preservation of hemoglobin levels - even at 30 days. Additionally, CUF of any volume was not associated with increased IV fluid resuscitation postoperatively.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"182-186"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal membrane oxygenation for systemic lupus erythematosus: An ELSO registry analysis.","authors":"Maria Pereira, Danielle Guffey, Katherine Doane, Eyal Muscal, Carla Levin, Peter Rycus, Marc Anders, Andrea Ontaneda","doi":"10.1177/02676591251346069","DOIUrl":"10.1177/02676591251346069","url":null,"abstract":"<p><p>The success of extracorporeal membrane oxygenation (ECMO) in treating Systemic Lupus Erythematosus (SLE) and the risk factors associated with mortality remain uncertain. <i>Methods:</i> We describe the survival outcomes at discharge of the largest SLE cohort on ECMO support. We performed a retrospective cohort study of the Extracorporeal Life Support Organization registry database from 2012 to 2022. Pediatric and adult survivor groups were analyzed using descriptive statistics for the primary study outcome of survival to hospital discharge. Risk predictors for survival were determined by logistic regression.<i>Results:</i> We included 48 children and 368 adults with SLE. Overall, 198 patients (54%) survived to hospital discharge, with a survival of 52% and 47% of pediatric and adult patients, respectively.<i>Conclusion:</i> We conclude that ECMO can be considered a life supporting strategy in pediatric and adult SLE patients.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"173-181"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is thiol/disulfide homeostasis an early predictor of postoperative neurocognitive dysfunction in near infrared spectroscopy-guided coronary artery bypass surgery patients: A prospective study.","authors":"Elvin Kesimci, Çağla Yazar, Deniz Topçu, Nüket Akovalı, Zeynep Kayhan","doi":"10.1177/02676591251350517","DOIUrl":"10.1177/02676591251350517","url":null,"abstract":"<p><p>IntroductionIn cardiac surgery, cerebral dysfunction due to intraoperative cerebral microembolism, hypoperfusion, low perfusion pressure, hypothermia and rewarming is one of the most frequent morbidities in the postoperative period and results in tissue hypoxia and reperfusion damage. Given the possible link among oxidative stress and neurocognitive dysfunctions, we hypothesized that dynamic thiol-disulfide homeostasis could be an early predictor of cognitive impairment in cardiac surgery in parallel to the changes in cerebral oxygenation.MethodsSeventy-one patients undergoing elective coronary artery bypass graft (CABG) surgery were prospectively studied. The patients were assesed by Mini-Mental State Examination (MMSE) test, pre and postoperatively. In the operating room, following standard monitorization, a near-infrared spectroscopy (NIRS) sensor was placed for continuous measurement of regional cerebral oxygenation (rSO₂). The blood samples were obtained for thiol/disulphide homeostatic (TDH) parameters at 5 stages of the surgical procedure as; T₁: before anesthesia induction; T₂: 20 min after anesthesia induction, T₃: 20 min after aortic cross-clamping; T₄: 20 min after removal of aortic cross-clamp; and T₅: 24 h after surgery.ResultsPostoperative 24 hours' MMSE scores were significantly lower than the preoperative scores (<i>p</i> < .001). Total and native thiol measurements were significantly higher at T₅ in comparison to T₂, T₃ and T₄ (<i>p</i> < .001).ConclusionAlthough abnormal TDH values are involved in the pathogenesis of various diseases, we couldn't show that TDH was an early predictor of neurocognitive dysfunction after CABG surgery, the changes in total, native thiol and disulphide levels were in parallel with changes in NIRS values, indicating the changes observed as a result of anesthesia induction, IR injury and postoperative course. As this is the first study evaluating TDH changes as a predictor of ischemia-reperfusion injury in CABG by evaluating NIRS and MMSE scores, we believe that our study will enlighten the current literature.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"212-220"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of concomitant mitral valve intervention on clinical outcomes during atrial myxoma surgery.","authors":"Demir Cetintas, Mustafa Selcuk Atasoy, Ahmet Yuksel, Hakan Guven, Ufuk Turan Kursat Korkmaz, Iris Irem Kan, Yusuf Velioglu, Ayhan Muduroglu, Serdar Badem, Ali Onder Kilic, Gencehan Kumtepe, Mustafa Aldemir, Erhan Renan Ucaroglu, Murat Bicer","doi":"10.1177/02676591251345727","DOIUrl":"10.1177/02676591251345727","url":null,"abstract":"<p><p>IntroductionThe aim of this study was to examine whether concomitant mitral valve intervention affected the clinical outcomes in patients undergoing atrial myxoma surgery.Materials and MethodsWe included a total of 97 patients who underwent surgery for atrial myxoma between February 1990 and July 2024 in this study. Among them, 19 patients underwent concomitant mitral valve intervention and these patients comprised the mitral valve group while remaining 78 patients comprised the myxoma-alone group. Preoperative clinical characteristics, operative data, postoperative outcomes and complications of the patients were retrospectively reviewed, and compared between the groups.ResultsThere were no significant differences between the groups in terms of preoperative basic demographic and clinical characteristics, except for the mean diameter of mass and frequency of atrial fibrillation. In the postoperative period, only new-onset atrial fibrillation rate was significantly greater in the mitral valve group than in the myxoma-alone group. In terms of other postoperative outcomes and complications, no significant differences were found between the groups and both groups were statistically similar. During the postoperative period, no valve-related adverse event occurred in patients undergoing mitral valve replacement. In eight of nine patients undergoing mitral valve repair for moderate or severe mitral regurgitation, absent or mild mitral regurgitation was observed. In one patient undergoing mitral valve repair for severe mitral regurgitation, the regurgitation regressed to moderate and this patient was followed asymptomatically with medical treatment.ConclusionOur study demonstrated that concomitant mitral valve intervention did not significantly affect the clinical outcomes in patients undergoing atrial myxoma surgery.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"147-154"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in cardiopulmonary exercise testing variables after surgery for primary mitral regurgitation.","authors":"Jonathan Afoke, Simon Gibbs, Sunthar Kanaganayagam, Domenico Bruno, Luke Howard, Prakash Punjabi","doi":"10.1177/02676591251346035","DOIUrl":"10.1177/02676591251346035","url":null,"abstract":"<p><p>AimsDescribe differences in changes in cardiopulmonary exercise testing after surgery for severe primary mitral regurgitation between class I and class II indications for surgery. Methods Prospective observational study of patients who underwent transthoracic echocardiogram and cardiopulmonary exercise testing pre-operatively and six months after surgery. Results Forty three of the fifty patients recruited between February 2017 and October 2018 were included in per protocol analysis. Seven patients were excluded-two patients did not meet inclusion criteria after further investigation, two patients were unable to perform pre-operative cardiopulmonary exercise testing, two patients had post-operative mortality, one patient declined post-operative cardiopulmonary exercise testing. Median age was 64 years and 15 patients (34.9%) were female. Thirty five patients had impaired post-operative functional capacity defined as post-operative left ventricular ejection fraction on echocardiogram <50% and/or post-operative percentage predicted peak VO2 ≤ 84%). In patients with class I indication for surgery (n = 30), there was no significant change post-operatively in ppVO2 (81 (69-88) % vs. 79 (60-87) %, p = 0.09). In patients with class II indication for surgery (n = 13), there was a significant fall post-operatively in ppVO2 (82 (79-92) % vs. (74 (68-86) %, p < 0.01). In the univariate analysis, pre-operative ppVO2 ≤ 84% (p < 0.01) was a predictor for impaired post-operative functional capacity. Conclusions Patients with class I indication have persistently abnormal exercise performance six months after surgery. Patients with class II indication for surgery have worse exercise performance parameters six months after surgery. Pre-operative ppVO2 ≤84% is an independent predictor of impaired post-operative functional capacity at six months.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"165-172"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No benefit of adding mannitol to cardiopulmonary bypass priming solution assessing cystatin C. A randomized clinical trial.","authors":"Andreas Sköld, Alain Dardashti, Sandra Lindstedt, Snejana Hyllén","doi":"10.1177/02676591251344857","DOIUrl":"10.1177/02676591251344857","url":null,"abstract":"<p><p>IntroductionThere is no recommendation regarding the optimal prime solution for the cardiopulmonary bypass circuit in adult cardiac surgery. Despite the lack of scientific evidence, mannitol has frequently been added to the prime solution with intention to prevent acute kidney injury. The aim of this study was to investigate the impact of mannitol in cardiopulmonary bypass circuit prime in patients with preoperative renal dysfunction.MethodsThis prospective, randomized, double-blind study included 70 patients, who underwent coronary artery bypass grafting. One group received 1200 mL of a prime based on Ringer's acetate (<i>n</i> = 35), and the other a prime consisting of 1000 mL Ringer's acetate and 200 mL mannitol (<i>n</i> = 35). Primary endpoint were levels of Cystatin C, a renal function biomarker. Changes in renal-related parameters, electrolytes, osmolality and acid-base status were monitored.ResultsThe median cystatin C on day four in the mannitol group were 1.6 mg/L (IQR 1.4-2.0 mg/L) and 1,8 mg/L (IQR 1.5-2.1 mg/L) in the Ringer's acetate group at the same time. Using mixed model analysis, no differences in cystatin C (<i>p</i> = 0.442), creatinine (<i>p</i> = 0.203), estimated glomerular filtration rate (<i>p</i> = 0.264) and urea (<i>p</i> = 0.141) could be detected between the groups. The mannitol group showed a more pronounced reduction in sodium levels after cardiopulmonary bypass circuit commencement compared to the Ringer's acetate group <i>p</i> < 0.001.ConclusionsIn patients with preoperative renal dysfunction, the addition of mannitol in the prime solution did not show any renoprotective effect measured by cystatin C compared to a cardiopulmonary bypass circuit prime based on Ringer's acetate. This study was reported to ClinicalTrials.org, id: NCT03302286. Effects of Extra Corporeal Circuit Prime on Electrolytes Balance and Clinical Outcome Following Cardiac Surgery https://clinicaltrials.gov/study/NCT03302286?id=NCT03302286&rank=1.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"155-164"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of changes in plasma osmolarity and pump time during cardiopulmonary bypass use.","authors":"María Teresa Politi, Marcelo Izurieta, Virginia Barba, Sarah Di Benedetto, Raúl Ferreyra, Guillermo Bortman, Antonio Piazza, Claudia Capurro","doi":"10.1177/02676591251348804","DOIUrl":"10.1177/02676591251348804","url":null,"abstract":"<p><p>AimsTo evaluate the roles of intraoperative changes in plasma osmolarity and pump time as predictor factors on postoperative hemodynamic instability and mid-term clinical outcomes, in adults undergoing cardiovascular surgeries with cardiopulmonary bypass.MethodsThis observational study included 172 adults undergoing cardiovascular surgery with cardiopulmonary bypass. Intraoperative changes in calculated plasma osmolarity were calculated from biochemical analyses of venous blood samples. Outcomes included the requirement for vasoactive drugs 24 hours postoperatively and mortality at 2 years. Multivariate logistic regression models adjusted for EuroSCORE II were used to analyze the data.ResultsBoth changes in calculated plasma osmolarity (OR = 1.78; 95% CI 1.18-2.27; <i>p</i> = .0074) and pump time (OR = 1.18; 95% CI 1.05-1.35; <i>p</i> = .0090) were independently associated with higher odds of requiring vasoactive drugs 24 hours postoperatively. At 2 years, changes in calculated plasma osmolarity (OR = 1.99, 95% CI 1.15-3.42; <i>p</i> = .0114) were associated with the combined outcome of death, hospitalization, and/or repeat cardiovascular surgery, independently of pump time (OR = 1.01; 95% CI 0.98-1.03; <i>p</i> = .2340), but not to mortality alone.ConclusionsChanges in plasma osmolarity and pump time during cardiopulmonary bypass were associated with postoperative hemodynamic instability. Additionally, changes in plasma osmolarity were associated with adverse outcomes at 2 years.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"187-196"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}