Perfusion-Uk最新文献

{"title":"Does cannulation site affect outcomes of antegrade cerebral perfusion in aortic arch surgery? A meta-analysis of axillary versus innominate access.","authors":"Kristine Santos, Eren Cetinel, Joo Young Belen Kim Kim, José Manuel Comprido, Mario Saul Lira Castañeda, Tomasz Płonek","doi":"10.1177/02676591251389386","DOIUrl":"https://doi.org/10.1177/02676591251389386","url":null,"abstract":"<p><p>BackgroundThe optimal arterial cannulation strategy for establishing antegrade cerebral perfusion during aortic arch surgery remains a subject of ongoing debate. Our meta-analysis compares outcomes between axillary artery (AxA) and innominate artery (InA) cannulation.MethodsA literature search was conducted for studies that compared AxA and InA cannulation in aortic surgery. RevMan 8.13.0 was used to calculate effect estimates reported as odds ratios (OR) and mean differences (MD), with their 95% confidence intervals (CI). Subgroup analyses were performed for (a) randomised controlled trials (RCT) and propensity-matched cohorts, (b) elective cases, and (c) emergent cases.ResultsWe included seven studies comprising 1763 patients, of whom 1063 (60%) underwent AxA cannulation. AxA cannulation was associated with significantly longer cardiopulmonary bypass (CPB) time than InA cannulation [MD 23.7 min; 95% CI 9.7 to 37.8; <i>p</i> < 0.001]. ICU stay [MD 0.4 days; 95% CI -0.2 to 1.1; <i>p</i> = 0.21] and hospital stay [MD 0.5 days; 95% CI -0.3 to 1.4; <i>p</i> = 0.23] were comparable. No significant differences were observed in 30-days mortality [OR 1.1; <i>p</i> = 0.55], stroke [OR 1.3; <i>p</i> = 0.43], seizure [OR 0.8; <i>p</i> = 0.81], acute kidney injury [OR 1.4; <i>p</i> = 0.18], delirium [OR 0.8; <i>p</i> = 0.64], or reoperation for bleeding [OR 1.3; <i>p</i> = 0.51]. Subgrou<i>p</i> analyses of elective and emergent cases confirmed the CPB time difference, with no significant differences in other clinical outcomes.ConclusionsWhile AxA was associated with longer CPB time, other clinical outcomes were comparable between the two cannulation strategies, suggesting that InA cannulation may represent a safe and efficient alternative in selected cases. However, due to surgical heterogeneity, predominance of observational data, and low-certainty evidence for most outcomes, we cannot establish true equivalence and thus our findings should be interpreted cautiously and validated by future randomised controlled trials.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251389386"},"PeriodicalIF":1.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of changes in cardiopulmonary bypass circuit design on pressure loss, wall shear stress, and venous drainage flow.","authors":"Noriaki Sakai, Takuya Ishigami, Naoto Hagino, Taisei Yamaguchi, Miho Takimoto, Tomoyuki Goto, Masafumi Matsumura","doi":"10.1177/02676591251388335","DOIUrl":"https://doi.org/10.1177/02676591251388335","url":null,"abstract":"<p><p>IntroductionBlood damage during cardiopulmonary bypass can trigger postoperative inflammatory responses and organ injury. Therefore, optimizing the blood circuit design to minimize damage remains essential. However, variations in venous drainage circuit configurations persist across facilities, and standardization remains limited.MethodsHerein, we conducted computational fluid dynamics (CFD) analysis using the finite volume method to investigate the influence of venous drainage circuit shape on pressure loss, wall shear stress (WSS), and venous drainage flow. The circuit inner diameter (8-14 mm) and branching angle (20°-160°) varied, while the head pressure was set at -70 cmH₂O.ResultsThe venous drainage flow decreased as the branching angle increased, although not significantly. The pressure loss increased at higher flow rates, with a more pronounced effect when the inner diameter was reduced. Similarly, the WSS increased with both higher flow rates and smaller inner diameters, suggesting an elevated risk of blood damage. Multiple regression analysis identified venous drainage flow and circuit inner diameter as the primary determinants of WSS. Moreover, an inner diameter of 12 mm was determined to be optimal, as it effectively maintained venous drainage, while minimizing pressure loss and reducing the WSS.ConclusionsAppropriate selection of circuit inner diameter is critical for mitigating the risk of blood damage, while ensuring the necessary venous drainage flow (∼7.0 L/min) for cardiopulmonary bypass in adults. These findings may facilitate the standardization and optimization of cardiopulmonary bypass circuit designs, thereby advancing safer cardiopulmonary support technologies.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251388335"},"PeriodicalIF":1.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TEG6s-Derived R ratio accurately reflects the anti-Xa level after cardiac surgery: A proof-of-concept study.","authors":"Takahiro Tamura, Tatsuro Yokoyama","doi":"10.1177/02676591251388353","DOIUrl":"https://doi.org/10.1177/02676591251388353","url":null,"abstract":"<p><p>IntroductionIn the postoperative intensive care setting after cardiac surgery with cardiopulmonary bypass (CPB), particularly in patients requiring continued anticoagulation for prosthetic devices such as mechanical valves or extracorporeal support, unfractionated heparin (UFH) is commonly monitored using the activated partial thromboplastin time (aPTT). However, it may inadequately reflect anticoagulant activity in critically ill patients. The TEG6s system is a viscoelastic testing platform that enables bedside coagulation monitoring. This proof-of-concept study aimed to evaluate the utility of TEG6s-derived indices for estimating the anti-Xa level following CPB.MethodsWe prospectively enrolled 131 adult patients undergoing elective cardiac or aortic surgery with CPB. Paired blood samples were collected at intensive care unit admission and 4 h later. Heparin concentrations were measured using a chromogenic anti-Xa assay. Thromboelastography (TEG) parameters including the reaction times for the citrated kaolin without and with heparinase assays and their ratio (R ratio) and difference were obtained. Their correlations with the anti-Xa level were assessed using Pearson's and Spearman's analyses. Linear and polynomial regression models were used to evaluate predictive performance.ResultsThe R ratio and reaction time difference showed strong correlations with the plasma anti-Xa level (r = 0.738 and r = 0.733, respectively; <i>p</i> < 0.001). These correlations were comparable to that of the aPTT ratio (r = 0.813). The second-order polynomial regression model using the R ratio had the highest predictive accuracy (R² = 0.584, root mean square error = 0.134).ConclusionsThe R ratio may be a supplementary indicator of a residual heparin effect, particularly in cases with discordant aPTT findings.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251388353"},"PeriodicalIF":1.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of post-operative inflammatory biomarkers between minimal invasive extracorporeal circulation and conventional extracorporeal circulation in cardiac surgery. A meta-analysis of 15 randomized control trials.","authors":"Karam R Motawea, Momen Ibrahim, Amro Essam Amer, Omneya Kandil, Youmna Abourady, Marc Pelletier, Yasir Abu-Omar, Mohammad El-Diasty","doi":"10.1177/02676591251385872","DOIUrl":"https://doi.org/10.1177/02676591251385872","url":null,"abstract":"<p><p>Background/AimRecent literature suggested that the use of Minimal Invasive Extracorporeal Circulation (MIECC) may mitigate the inflammatory response in patients undergoing cardiac surgery. We aimed to perform a meta-analysis to compare post-operative inflammatory biomarkers between MIECC and conventional cardiopulmonary bypass in cardiac surgery.MethodsWe searched PubMed, Web of Science, Scopus, and Cochrane Library for randomized control trials (RCTs) that quantified systemic inflammatory mediators after the use of MIECC compared to conventional extracorporeal circulation (CECC).ResultsFifteen RCTs with a total of 1189 patients were identified. The inflammatory markers that were investigated included Tumor Necrosis Factor α (TNF-α), Interleukin 6 (IL-6), Interleukin 8 (IL-8), Interleukin 10 (IL-10), Elastase, C-Reactive protein (CRP) in addition to leucocyte count. No significant difference between both groups was detected for TNF-α and IL-6 at (30 minutes, 1 to 2 hours, 6 hours, 24 hours, and 48 hours), IL-8 at (30 minutes and 48 hours), Interleukin 10 at 6 hours, Elastase at (30 minutes to 1 hour, and 24 hours), CRP at 48 hours, and leucocytic count at (2 hours, 6 hours, 24 hours, and 48 hours). Pooled analysis showed a significant association between MIECC group and lower levels of TNF-α at 6 hours (<i>p</i>-value <.0001), IL-8 at 6 hours (<i>p</i>-value = .0005) and 24 hours (<i>p</i>-value = .005), IL-10 at 24 hours (<i>p</i>-value <.00,001), and Elastase at 6 hours (<i>p</i>-value = .04). However, CRP was lower, at 24 hours, in the CECC group (MD = 1.42, 95% CI = 0.13 to 2.71, <i>p</i>-value = .03).ConclusionOur findings suggest that MIECC may be associated with lower levels of systemic inflammatory mediators early after cardiac surgery. However, the impact of this reduction on clinical outcomes needs to be defined to justify the use of MIECC in the routine clinical practice.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251385872"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entropy-guided sevoflurane administration during cardiopulmonary bypass surgery in the paediatric population.","authors":"Abhinay Ankur, Alok Kumar, Markose L Paret, Saajan Joshi, Badal Parikh","doi":"10.1177/02676591251386601","DOIUrl":"https://doi.org/10.1177/02676591251386601","url":null,"abstract":"<p><p>BackgroundMaintaining optimal anesthetic depth during cardiopulmonary bypass (CPB) in pediatric patients is challenging due to altered physiology and unreliable conventional monitoring. Entropy, a processed electroencephalogram metric, offers a potential solution. This study aimed to evaluate the relationship between end oxygenator sevoflurane concentration and entropy values during pediatric CPB using fixed-dose versus entropy-guided sevoflurane administration.MethodologyA prospective, randomized study was conducted on 62 pediatric patients undergoing congenital heart surgery with CPB. Patients were allocated into two groups: Group A received fixed-dose sevoflurane (1% v/v), and Group B received sevoflurane titrated to maintain entropy values between 40 and 60. Parameters such as end oxygenator sevoflurane concentration, entropy (Response and State entropy, RE and SE), and sevoflurane consumption were recorded intraoperatively. Postoperative hemodynamic data, length of stay, and complication rates were assessed.ResultsEntropy-guided patients showed significantly higher end oxygenator sevoflurane concentrations [1.64 (1.51-1.85)% versus 1.0%, <i>p</i> = .001] and sevoflurane consumption (1.26 ± 0.12 vs 0.645 ± 0.03 mL/min, <i>p</i> = .001). RE and SE values were significantly lower in the entropy group (<i>p</i> = .001), indicating better anesthetic depth control. A negative correlation was found between entropy and sevoflurane concentration (r = -0.6987, <i>p</i> = .02). Despite higher postoperative inotropic scores in the entropy group (<i>p</i> = .001), no significant differences were found in length of stay, mechanical ventilation duration, or morbidity and mortality rates between groups.ConclusionEntropy-guided sevoflurane administration during pediatric CPB provides improved anesthetic depth control at the cost of higher anesthetic and inotropic requirements. However, it does not adversely affect clinical outcomes, supporting its safety and potential utility in refining pediatric anesthesia practices.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"2676591251386601"},"PeriodicalIF":1.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of acute type A aortic dissection repair in patients under the age of 75 versus 75 and older.","authors":"Reyna Jones, Sarah Yousef, James A Brown, Derek Serna-Gallegos, Danial Ahmad, Jianhui Zhu, Kathirvel Subramaniam, Rama Joshi, Theresa Gelzinis, Julie Phillippi, Pyongsoo Yoon, Johannes Bonatti, David Kaczorowski, Danny Chu, Ibrahim Sultan","doi":"10.1177/02676591241313170","DOIUrl":"10.1177/02676591241313170","url":null,"abstract":"<p><p>ObjectiveElderly patients are less likely to undergo surgery for an acute type A aortic dissection (ATAAD). This study aims to understand the risks of surgical treatment in patients 75 and older.MethodsThis was a retrospective study using an institutional database of patients who underwent ATAAD repair from 2007 to 2021. Outcomes were compared between patients <75 and patients <math><mrow><mo>≥</mo></mrow></math> 75. Logistic regression was performed for operative mortality, and Cox regression was performed for long-term mortality.ResultsA total of 601 patients underwent surgery for ATAAD, 112 (18.6%) of whom were ≥75. Patients ≥75 were significantly more likely to undergo hemiarch replacement (vs total arch replacement) and concomitant CABG. Operative mortality was 16.1% in patients ≥75 versus 10.2% in those <75 (<i>p</i> = 0.078). On multivariable logistic regression, age ≥75 was not significantly associated with operative mortality (<i>p</i> = 0.068). Effect of age on long-term mortality was time-dependent: on Cox regression, being 75 or older and within one-year post-discharge was significantly associated with an increased hazard of death (time-dependent HR 4.56; 95% CI, 2.31-9.06; <i>p</i> < 0.001), while age was not associated with an increased hazard of death after the first postoperative year (<i>p</i> = 0.779).ConclusionDespite reduced survival during the first postoperative year among patients 75 years and older, operative mortality and late survival were similar across each group. By implication, age alone should not be a deterrent to operative intervention in ATAAD patients, even though further investigation is needed to determine opportunities for improving survival during the first postoperative year after ATAAD repair.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1600-1606"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative iatrogenic type B aortic dissection. Temporary perfusion pause, immediate restoration and final solution.","authors":"Dionysios Pavlopoulos, Vasilis Kollias, Ioannis Toumpoulis, Kostas Antonopoulos, Christos Verikokos, Dimitrios Angouras","doi":"10.1177/02676591251314762","DOIUrl":"10.1177/02676591251314762","url":null,"abstract":"<p><p>We present the case of a 74-year-old female patient with a 50 mm ascending aortic aneurysm who underwent ascending aorta replacement. During routine open heart surgery, suboptimal flow in the cardiopulmonary bypass circuit, led to the discovery of a type B aortic dissection with substantial flow in the false lumen. Conservative management was chosen, focusing on blood pressure control in the ICU. Despite an initial uneventful recovery the patient developed malperfusion syndrome prompting consideration of endovascular repair. Following a temporary improvement, malperfusion symptoms recurred, leading to a successful endovascular repair, with complete thrombosis of the false lumen.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1714-1716"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the impact of extracorporeal membrane oxygenation (ECMO) oxygenator shunt flow on neonatal hemolysis: An in vitro study.","authors":"Christopher Nemeh, Caleb Varner, Nicholas Schmoke, Elon Trager, Yeu Sanz Wu, Michael Brewer, Caitlin Cain-Trivette, Nikki Aw, Richard O Francis, Diana Vargas Chaves, Eva W Cheung, William Middlesworth","doi":"10.1177/02676591251322000","DOIUrl":"10.1177/02676591251322000","url":null,"abstract":"<p><p>IntroductionExtracorporeal membrane oxygenation (ECMO) is utilized in critically ill neonates with severe cardiopulmonary failure. Hemolysis is a potential complication and is associated with significantly increased morbidity and mortality. The etiology of hemolysis in neonates is multifactorial, including shear forces generated by the ECMO pump, higher flow resistance from smaller tubing and smaller cannulas, the oxygenator, and other patient factors. Centrifugal pumps and oxygenators commonly have shunts with partially occluding clamps to regulate blood flow. We hypothesized that these clamps are significant contributors to hemolysis.MethodAn in vitro study was conducted with three identical ECMO circuits containing an integrated polymethylpentene (PMP) oxygenator and centrifugal pump (Cardiohelp HLS 5.0) and 1/4″ arteriovenous (AV) loop tubing. The circuits were primed with equal components, including expired ABO-compatible packed red blood cells (pRBCs), 25% albumin, 5% albumin, sodium bicarbonate, heparin, and calcium chloride. Circuit A had a completely occluded shunt. Circuit B had a partially occluded shunt, allowing 500 mL/min of shunt flow back to the oxygenator. Circuit C had a fully open shunt, generating 1000 mL/min of shunt flow back to the oxygenator. Plasma-free hemoglobin values were measured serially over 5 days.ResultsBaseline plasma-free hemoglobin levels were equal in all three circuits. Circuit C had the greatest increase in plasma-free hemoglobin daily (26.3 mg/dL/day) compared to Circuit A and Circuit B, which were 14.1 mg/dL/day and 12.9 mg/dL/day, respectively.ConclusionsOur data suggests that partially occluding clamps are not a significant contributor to hemolysis; rather, increased flow through the oxygenator significantly increased the rate of hemolysis in neonatal ECMO circuits.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1646-1652"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of clinico-metabolic profiles between St Thomas and del Nido cardioplegia solutions: A pilot study.","authors":"Amit Rastogi, Prabhat Tewari, Shantanu Pande, Rimjhim Trivedi, Surendra Kumar Agarwal, Durgesh Dubey, Dinesh Kumar","doi":"10.1177/02676591241311726","DOIUrl":"10.1177/02676591241311726","url":null,"abstract":"<p><p>IntroductionCardioplegia (CP) is integral to myocardial protection during cardiac surgery. Two standard cardioplegic solutions viz. Del Nido solution (DNS) and St Thomas solution (STS) are widely used in cardiac surgeries. The DNS is a single-dose CP that offers superior myocardial protection in adults, and studies have claimed myocardial injury in STS patients. The elevated circulatory level of citric acid cycle intermediate, succinate is a metabolic hallmark of ischemia. Its rapid oxidation after reperfusion causes ischemia-reperfusion (IR) injury through mitochondrial reactive oxygen species production. Succinate has been identified as an early marker of IR injury through blood plasma/serum-based clinical metabolomics studies. The primary objective of the study was metabolomic profiling of succinate from the coronary sinus and venous blood.MethodsTwo blood samples each were obtained from coronary sinus (CS) & venous reservoir from patients before the application of aortic cross-clamp and after the release of aortic cross-clamp from 22 patients divided into two groups. The blood-serum metabolic profiles were measured by 800 MHz NMR spectrometer and compared using univariate statistical analysis methods. The study also compared the two groups' cardiopulmonary bypass variables and left ventricle functions.ResultDNS leads to increased serum levels of succinate in the coronary sinus blood after the reperfusion compared to STS. The results of our study are consistent with a previous study that found DNS administration (90 minutes) increases the inflammatory response in the myocardium.ConclusionNMR-based serum metabolomics revealed significantly increased circulatory succinate in coronary sinus blood of patients administered with DNS cardioplegia in comparison to STS cardioplegia. URL- https://ctri.nic.in/Clinicaltrials/login.php.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1585-1591"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing active learning activities for didactic perfusion courses.","authors":"Catherine Kim, Ronald Gerrits","doi":"10.1177/02676591251314930","DOIUrl":"10.1177/02676591251314930","url":null,"abstract":"<p><p>BackgroundIn the world of academia, traditional lecturing has been the most common pedagogical approach for centuries. However, it can create an environment for students to be passive learners in the classroom. Alternatively, active learning is a pedagogical approach intended to encourage students to engage with content in manners which have been associated with improved exam performance, final course grades, clinical reasoning skills, and critical thinking skills. Given that perfusion is inherently a profession where didactic information must be applied in practice, the implementation of active learning in didactic courses is worth considering. Although active learning is practiced in perfusion education through participation in simulations and clinical rotations, there are no easily identifiable active learning resources available to supplement didactic perfusion courses. In response, written active learning activities were specifically designed for didactic perfusion courses.MethodsThe activities were designed based on the format for guided inquiry worksheets, the incorporation of the learning cycle, and the implementation of process oriented guided inquiry learning (POGIL) strategies. Key concepts were identified, learning objectives were specified, and models (figures or tables of data) were created as targets of engagement and analysis. Following each model, questions and prompts are given to guide students through identifying, understanding, and exploring the concepts incorporated in the activity as well as opportunities to apply the newly gained knowledge and understanding.ResultsTen active learning activities have been developed based on the methods summarized above.ConclusionWhile the purposes of this paper are to inform the perfusion community of active learning and to share guidelines on how to create active learning activities for didactic perfusion courses, the goals of the activities are to provide examples to perfusion educators and to guide students in understanding basic perfusion concepts in a clinically relevant manner. It is recommended that perfusion students complete these activities alongside their didactic perfusion courses.</p>","PeriodicalId":49707,"journal":{"name":"Perfusion-Uk","volume":" ","pages":"1559-1566"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}