比较接受体外膜氧合疗法的儿科患者输注红细胞和输注止血药及其与血栓形成的关系。

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Perfusion-Uk Pub Date : 2025-04-01 Epub Date: 2024-06-08 DOI:10.1177/02676591241260185
Michael J Martinez, Tahmineh Romero, Myke D Federman
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引用次数: 0

摘要

目的评估体外膜肺氧合(ECMO)儿科患者输注红细胞与血栓形成的关系,并将其与输注其他血液制品及其与血栓形成的关系进行比较:该研究是一项多中心前瞻性观察研究,涉及接受 ECMO 治疗的 19 岁以下患者:分析了 514 名患者,其中 282 名(55%)为新生儿(≤31 天),302 名(58.7%)为男性。在不考虑其他血液制品的情况下对整个群体进行分析时,每 10 毫升/千克包装红细胞(PRBC)导致血栓形成的平均数量增加 1.0%(1.010; 1.008,1.013; p < .001)。在新生儿中,每使用 10 毫升/千克 PRBC,血栓形成的平均次数就会增加 0.9% (1.009; 1.003,1.013; p < .001)。在儿童患者中,PRBC 每增加 10 毫升/千克,血栓形成的平均数量就会增加 1.2% (1.012; 1.008,1.012; p < .001)。PRBC、血小板和FFP的血栓平均数量增加百分比相似,但低温沉淀物的血栓平均数量增加百分比显著增加:结论:输注红细胞和止血剂可能与 ECMO 儿童患者的血栓形成有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of red blood cell transfusions and hemostatic transfusions and their relation to thromboses in pediatric patients receiving extracorporeal membrane oxygenation therapy.

ObjectiveTo evaluate the association of RBC transfusions with thrombosis in pediatric patients on extracorporeal membrane oxygenation (ECMO) and compare this with the transfusion of other blood products and their association with thrombosis.MethodsThis was a secondary analysis of the Bleeding and Thrombosis during ECMO (BATE) study, which was a multicenter prospective observational study involving patients less than 19 years of age treated with ECMO.Results514 patients were analyzed, of which 282 (55%) were neonates (≤31 days) and 302 (58.7%) were male. When analyzing the entire cohort independently of other blood products, each 10 mL/kg of packed red blood cells (PRBCs) was associated with a 1.0% increase in the average number of thromboses (1.010; 1.008,1.013; p < .001). In neonates, each 10 mL/kg of PRBC was associated with a 0.9% increase in the average number of thromboses (1.009; 1.003,1.013; p < .001). In pediatric patients, each 10 mL/kg of PRBC was associated with a 1.2% increase in the average number of thromboses (1.012; 1.008,1.012; p < .001). The percent increase in the average number of thromboses was similar between PRBCs, platelets, and FFP, but increased significantly with cryoprecipitate.ConclusionsRBC transfusions and hemostatic transfusions are likely associated with thromboses in pediatric patients on ECMO.

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来源期刊
Perfusion-Uk
Perfusion-Uk 医学-外周血管病
CiteScore
3.00
自引率
8.30%
发文量
203
审稿时长
6-12 weeks
期刊介绍: Perfusion is an ISI-ranked, peer-reviewed scholarly journal, which provides current information on all aspects of perfusion, oxygenation and biocompatibility and their use in modern cardiac surgery. The journal is at the forefront of international research and development and presents an appropriately multidisciplinary approach to perfusion science.
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