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New Insights into IGF-1 Signaling in the Heart. IGF-1 信号在心脏中的新发现。
IF 5.3 2区 医学
Physiology Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI: 10.1152/physiol.00003.2024
Wang-Soo Lee, E Dale Abel, Jaetaek Kim
{"title":"New Insights into IGF-1 Signaling in the Heart.","authors":"Wang-Soo Lee, E Dale Abel, Jaetaek Kim","doi":"10.1152/physiol.00003.2024","DOIUrl":"10.1152/physiol.00003.2024","url":null,"abstract":"<p><p>Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart diseases and contribute to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging, and remodeling.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis. 血管稳态中的 ECM 微环境：动脉粥样硬化的新目标。
IF 5.3 2区 医学
Physiology Pub Date : 2024-09-01 DOI: 10.1152/physiol.00028.2023
Lu Zhang, Qianqian Feng, Wei Kong
{"title":"ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis.","authors":"Lu Zhang, Qianqian Feng, Wei Kong","doi":"10.1152/physiol.00028.2023","DOIUrl":"10.1152/physiol.00028.2023","url":null,"abstract":"<p><p>Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"39 5","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology in Perspective. 透视生理学
IF 5.3 2区 医学
Physiology Pub Date : 2024-09-01 DOI: 10.1152/physiol.00033.2024
Nikki Forrester
{"title":"Physiology in Perspective.","authors":"Nikki Forrester","doi":"10.1152/physiol.00033.2024","DOIUrl":"10.1152/physiol.00033.2024","url":null,"abstract":"","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"39 5","pages":"246"},"PeriodicalIF":5.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charting the Molecular Terrain of Exercise: The Power of Multi-Omic Mapping. 绘制运动分子地形图：多分子图谱的力量
IF 5.3 2区 医学
Physiology Pub Date : 2024-08-13 DOI: 10.1152/physiol.00024.2024
Daniel H Katz, Malene E Lindholm, Euan A Ashley
{"title":"Charting the Molecular Terrain of Exercise: The Power of Multi-Omic Mapping.","authors":"Daniel H Katz, Malene E Lindholm, Euan A Ashley","doi":"10.1152/physiol.00024.2024","DOIUrl":"10.1152/physiol.00024.2024","url":null,"abstract":"<p><p>Physical activity plays a fundamental role in human health and disease. Exercise has been shown to improve a wide variety of disease states, and the scientific community is committed to understanding the precise molecular mechanisms that underlie the exquisite benefits. This review provides an overview of molecular responses to acute exercise and chronic training, particularly energy mobilization and generation, structural adaptation, inflammation, and immune regulation. Further it offers a detailed discussion on known molecular signals and systemic regulators activated during various forms of exercise and their role in orchestrating health benefits. Critically, the increasing use of multi-omic technologies is explored with an emphasis on how multi-omic and multi-tissue studies contribute to a more profound understanding of exercise biology. These data inform anticipated future advancement in the field and highlight the prospect of integrating exercise with pharmacology for personalized disease prevention and treatment.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Membrane Tension Gradients, Membrane Flows, and Cellular Processes. 细胞膜张力梯度、膜流和细胞过程。
IF 5.3 2区 医学
Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-19 DOI: 10.1152/physiol.00007.2024
Qi Yan, Carolina Gomis Perez, Erdem Karatekin
{"title":"Cell Membrane Tension Gradients, Membrane Flows, and Cellular Processes.","authors":"Qi Yan, Carolina Gomis Perez, Erdem Karatekin","doi":"10.1152/physiol.00007.2024","DOIUrl":"10.1152/physiol.00007.2024","url":null,"abstract":"<p><p>Cell membrane tension affects and is affected by many fundamental cellular processes, yet it is poorly understood. Recent experiments show that membrane tension can propagate at vastly different speeds in different cell types, reflecting physiological adaptations. Here we briefly review the current knowledge about membrane tension gradients, membrane flows, and their physiological context.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology in Perspective. 透视生理学
IF 5.3 2区 医学
Physiology Pub Date : 2024-07-01 DOI: 10.1152/physiol.00025.2024
Nikki Forrester
{"title":"Physiology in Perspective.","authors":"Nikki Forrester","doi":"10.1152/physiol.00025.2024","DOIUrl":"10.1152/physiol.00025.2024","url":null,"abstract":"","PeriodicalId":49694,"journal":{"name":"Physiology","volume":"39 4","pages":"178"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Pathogen and Pesticide Resistance in Honey Bees. 蜜蜂对病原体和杀虫剂的抗药性机制。
IF 5.3 2区 医学
Physiology Pub Date : 2024-07-01 Epub Date: 2024-02-27 DOI: 10.1152/physiol.00033.2023
Leonard J Foster, Nadejda Tsvetkov, Alison McAfee
{"title":"Mechanisms of Pathogen and Pesticide Resistance in Honey Bees.","authors":"Leonard J Foster, Nadejda Tsvetkov, Alison McAfee","doi":"10.1152/physiol.00033.2023","DOIUrl":"10.1152/physiol.00033.2023","url":null,"abstract":"<p><p>Bees are the most important insect pollinators of the crops humans grow, and <i>Apis mellifera</i>, the Western honey bee, is the most commonly managed species for this purpose. In addition to providing agricultural services, the complex biology of honey bees has been the subject of scientific study since the 18th century, and the intricate behaviors of honey bees and ants, fellow hymenopterans, inspired much sociobiological inquest. Unfortunately, honey bees are constantly exposed to parasites, pathogens, and xenobiotics, all of which pose threats to their health. Despite our curiosity about and dependence on honey bees, defining the molecular mechanisms underlying their interactions with biotic and abiotic stressors has been challenging. The very aspects of their physiology and behavior that make them so important to agriculture also make them challenging to study, relative to canonical model organisms. However, because we rely on <i>A. mellifera</i> so much for pollination, we must continue our efforts to understand what ails them. Here, we review major advancements in our knowledge of honey bee physiology, focusing on immunity and detoxification, and highlight some challenges that remain.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Vascular Dysfunctions in Cystic Fibrosis. 囊性纤维化的肺血管功能障碍。
IF 5.3 2区 医学
Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-19 DOI: 10.1152/physiol.00024.2023
Jean-Pierre Amoakon, Goutham Mylavarapu, Raouf S Amin, Anjaparavanda P Naren
{"title":"Pulmonary Vascular Dysfunctions in Cystic Fibrosis.","authors":"Jean-Pierre Amoakon, Goutham Mylavarapu, Raouf S Amin, Anjaparavanda P Naren","doi":"10.1152/physiol.00024.2023","DOIUrl":"10.1152/physiol.00024.2023","url":null,"abstract":"<p><p>Cystic fibrosis (CF) is an inherited disorder caused by a deleterious mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Given that the CFTR protein is a chloride channel expressed on a variety of cells throughout the human body, mutations in this gene impact several organs, particularly the lungs. For this very reason, research regarding CF disease and CFTR function has historically focused on the lung airway epithelium. Nevertheless, it was discovered more than two decades ago that CFTR is also expressed and functional on endothelial cells. Despite the great strides that have been made in understanding the role of CFTR in the airway epithelium, the role of CFTR in the endothelium remains unclear. Considering that the airway epithelium and endothelium work in tandem to allow gas exchange, it becomes very crucial to understand how a defective CFTR protein can impact the pulmonary vasculature and overall lung function. Fortunately, more recent research has been dedicated to elucidating the role of CFTR in the endothelium. As a result, several vascular dysfunctions associated with CF disease have come to light. Here, we summarize the current knowledge on pulmonary vascular dysfunctions in CF and discuss applicable therapies.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? 我们的大脑如何处理积极和消极的热感线索？
IF 5.3 2区 医学
Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-27 DOI: 10.1152/physiol.00034.2023
Jose G Grajales-Reyes, Bandy Chen, David Meseguer, Marc Schneeberger
{"title":"Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?","authors":"Jose G Grajales-Reyes, Bandy Chen, David Meseguer, Marc Schneeberger","doi":"10.1152/physiol.00034.2023","DOIUrl":"10.1152/physiol.00034.2023","url":null,"abstract":"<p><p>Whether it is the dramatic suffocating sensation from a heat wave in the summer or the positive reinforcement arising from a hot drink on a cold day; we can certainly agree that our thermal environment underlies our daily rhythms of sensation. Extensive research has focused on deciphering the central circuits responsible for conveying the impact of thermogenesis on mammalian behavior. Here, we revise the recent literature responsible for defining the behavioral correlates that arise from thermogenic fluctuations in mammals. We transition from the physiological significance of thermosensation to the circuitry responsible for the autonomic or behavioral responses associated with it. Subsequently, we delve into the positive and negative valence encoded by thermoregulatory processes. Importantly, we emphasize the crucial junctures where reward, pain, and thermoregulation intersect, unveiling a complex interplay within these neural circuits. Finally, we briefly outline fundamental questions that are pending to be addressed in the field. Fully deciphering the thermoregulatory circuitry in mammals will have far-reaching medical implications. For instance, it may lead to the identification of novel targets to overcome thermal pain or allow the maintenance of our core temperature in prolonged surgeries.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergism Between Hypothalamic Astrocytes and Neurons in Metabolic Control. 下丘脑星形胶质细胞和神经元在新陈代谢控制中的协同作用
IF 5.3 2区 医学
Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI: 10.1152/physiol.00009.2024
Laura M Frago, Alfonso Gómez-Romero, Roberto Collado-Pérez, Jesús Argente, Julie A Chowen
{"title":"Synergism Between Hypothalamic Astrocytes and Neurons in Metabolic Control.","authors":"Laura M Frago, Alfonso Gómez-Romero, Roberto Collado-Pérez, Jesús Argente, Julie A Chowen","doi":"10.1152/physiol.00009.2024","DOIUrl":"10.1152/physiol.00009.2024","url":null,"abstract":"<p><p>Astrocytes are no longer considered as passive support cells. In the hypothalamus, these glial cells actively participate in the control of appetite, energy expenditure, and the processes leading to obesity and its secondary complications. Here we briefly review studies supporting this conclusion and the advances made in understanding the underlying mechanisms.</p>","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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