Physiology最新文献_第2页

The nose knows: Olfaction as a metabolic gatekeeper in health and disease. 鼻子知道：嗅觉是健康和疾病的代谢看门人。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-23 DOI: 10.1152/physiol.00007.2025

Diogo Manoel, Eman Abou Moussa, Asma Al-Naama, Luis R Saraiva

{"title":"The nose knows: Olfaction as a metabolic gatekeeper in health and disease.","authors":"Diogo Manoel, Eman Abou Moussa, Asma Al-Naama, Luis R Saraiva","doi":"10.1152/physiol.00007.2025","DOIUrl":"https://doi.org/10.1152/physiol.00007.2025","url":null,"abstract":"Long regarded as an accessory sense, olfaction is now emerging as a metabolic architect-an active agent in energy homeostasis, appetite regulation, and systemic physiology. This review explores the converging lines of evidence positioning the olfactory system not as a passive enhancer of flavor but as a dynamic mediator between environment, behavior, and internal metabolic state. Food odors engage specific olfactory receptors (ORs), which are embedded in neural circuits that project to hypothalamic, limbic, and reward regions. These circuits modulate insulin release, lipid metabolism, thermogenesis, and feeding behavior-often before a single bite is taken. This sensory-metabolic dialogue is continuously tuned by hormonal signals (e.g., leptin, ghrelin, insulin) and deeply shaped by genetic variation across the ~400 human OR genes, where individual differences in perception carry metabolic consequences. Yet this ancient sensory system now operates in a radically altered chemical landscape. Synthetic volatiles, industrial food aromas, and urban pollutants desensitize olfactory pathways, potentially contributing to overeating and metabolic disease. In parallel, a new therapeutic frontier is emerging: targeted modulation of olfactory pathways-via intranasal hormones, neuromodulation, sensory retraining, and personalized interventions informed by OR genotypes-offers a compelling strategy for precision metabolic care. Revisiting Sydney Whiting's 1853 satire, in which \"Smell\" was cast as a meddling underling at the digestive gates, we now find this once-overlooked sentinel wielding remarkable authority. The nose, it turns out, knows-and may yet hold the key to rebalancing metabolism in a world that smells very different from the one we evolved to navigate.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the Hippo pathway for cardiac regeneration. 靶向Hippo通路的心脏再生。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-13 DOI: 10.1152/physiol.00003.2025

Rich Gang Li, Fansen Meng, James F Martin

引用次数: 0

Transforming Physiology and Healthcare through Foundation Models. 通过基础模型转变生理学和医疗保健。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2025-01-20 DOI: 10.1152/physiol.00048.2024

Ryan C Godwin, Avery Tung, Dan E Berkowitz, Ryan L Melvin

{"title":"Transforming Physiology and Healthcare through Foundation Models.","authors":"Ryan C Godwin, Avery Tung, Dan E Berkowitz, Ryan L Melvin","doi":"10.1152/physiol.00048.2024","DOIUrl":"10.1152/physiol.00048.2024","url":null,"abstract":"Recent developments in artificial intelligence (AI) may significantly alter physiological research and healthcare delivery. Whereas AI applications in medicine have historically been trained for specific tasks, recent technological advances have produced models trained on more diverse datasets with much higher parameter counts. These new, \"foundation\" models raise the possibility that more flexible AI tools can be applied to a wider set of healthcare tasks than in the past. This review describes how these newer models differ from conventional task-specific AI, which relies heavily on focused datasets and narrow, specific applications. By examining the integration of AI into diagnostic tools, personalized treatment strategies, biomedical research, and healthcare administration, we highlight how these newer models are revolutionizing predictive healthcare analytics and operational workflows. In addition, we address ethical and practical considerations associated with the use of foundation models by highlighting emerging trends, calling for changes to existing guidelines, and emphasizing the importance of aligning AI with clinical goals to ensure its responsible and effective use.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Circuits of Fear and Anxiety: Insights from a Neuroethological Perspective. 恐惧和焦虑的神经回路：从神经行为学角度的见解。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-12-11 DOI: 10.1152/physiol.00042.2024

Fernando Falkenburger Melleu, Newton Sabino Canteras

{"title":"Neural Circuits of Fear and Anxiety: Insights from a Neuroethological Perspective.","authors":"Fernando Falkenburger Melleu, Newton Sabino Canteras","doi":"10.1152/physiol.00042.2024","DOIUrl":"10.1152/physiol.00042.2024","url":null,"abstract":"The predatory imminence continuum (PIC) of antipredator defensive behavior has been a helpful strategy for modeling anxiety and fear-related disorders in nonclinical research. The PIC is divided into three different sequential stages that reflect defensive behavioral strategy in response to predatory imminence. However, the PIC was experimentally addressed with a series of shock-based fear conditioning experiments rather than predatory threats. In this article, we consider the PIC in a more naturalistic behavioral setting, focusing on analyzing the neural systems of animals responding to terrestrial and aerial predators. Of relevance, there is a sequential engagement of the distinct neural circuits along each phase of the PIC. In the preencounter phase, prefrontal cortical networks are particularly involved in planning and organizing behavioral responses to ambiguous threats. As the predatory cues or the real predator is detected, there is an engagement of amygdalar and hippocampal > hypothalamic pathways in conjunction with the periaqueductal gray, which organize fear responses. This dynamic particularly reveals how specific neural circuits are set into action to subserve distinct defensive responses. Moreover, we further explore the neural circuits governing other fearful situations outside the context of the PIC, including agonistic social encounters and interoceptive challenges. This analysis reveals an interesting overlap between the neural systems responding to these threats and those involved in response to predatory threats. The present review clarifies how defensive circuits respond to natural threats and provides a more realistic view of the neural systems underlying anxiety and fear responses.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Cardiac Function by the Autonomic Nervous System. 自律神经系统对心脏功能的调节。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1152/physiol.00018.2024

Omar A Hafez, Rui B Chang

引用次数: 0

Targeting Sleep Physiology to Modulate Glymphatic Brain Clearance. 以睡眠生理为目标，调节大脑甘油清除。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-11-27 DOI: 10.1152/physiol.00019.2024

Timo van Hattem, Lieuwe Verkaar, Elena Krugliakova, Nico Adelhöfer, Marcel Zeising, Wilhelmus H I M Drinkenburg, Jurgen A H R Claassen, Róbert Bódizs, Martin Dresler, Yevgenia Rosenblum

{"title":"Targeting Sleep Physiology to Modulate Glymphatic Brain Clearance.","authors":"Timo van Hattem, Lieuwe Verkaar, Elena Krugliakova, Nico Adelhöfer, Marcel Zeising, Wilhelmus H I M Drinkenburg, Jurgen A H R Claassen, Róbert Bódizs, Martin Dresler, Yevgenia Rosenblum","doi":"10.1152/physiol.00019.2024","DOIUrl":"10.1152/physiol.00019.2024","url":null,"abstract":"Sleep has been postulated to play an important role in the removal of potentially neurotoxic molecules, such as amyloid-β, from the brain via the glymphatic system. Disturbed sleep, on the other hand, may contribute to the accumulation of neurotoxins in brain tissue, eventually leading to neuronal death. A bidirectional relationship has been proposed between impaired sleep and neurodegenerative processes, which start years before the onset of clinical symptoms associated with conditions like Alzheimer's and Parkinson's diseases. Given the heavy burden these conditions place on society, it is imperative to develop interventions that promote efficient brain clearance, thereby potentially aiding in the prevention or slowing of neurodegeneration. In this review, we explore whether the metabolic clearance function of sleep can be enhanced through sensory (e.g., auditory, vestibular) or transcranial (e.g., magnetic, ultrasound, infrared light) stimulation, as well as pharmacological (e.g., antiepileptics) and behavioral (e.g., sleeping position, physical exercise, cognitive intervention) modulation of sleep physiology. A particular focus is placed on strategies to enhance slow-wave activity during nonrapid eye movement sleep as a driver of glymphatic brain clearance. Overall, this review provides a comprehensive overview on the potential preventative and therapeutic applications of sleep interventions in combating neurodegeneration, cognitive decline, and dementia.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sweat the Small Stuff. 为小事操心。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-12-24 DOI: 10.1152/physiol.00057.2024

Kyle J Mahoney

引用次数: 0

Off to the Races: How the Thoroughbred Is Helping Us Understand Skeletal Muscle. 比赛开始：纯种马如何帮助我们理解骨骼肌。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-12-26 DOI: 10.1152/physiol.00062.2024

Madison R Barshick

引用次数: 0

Histone Deacetylases in Metabolism: the Known and the Unexplored. 代谢中的组蛋白去乙酰化酶：已知与未知。

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-10-29 DOI: 10.1152/physiol.00044.2024

Somaya Y Ibrahim, Jayden Carter, Rushita A Bagchi

引用次数: 0

A Multiscale Perspective on Chromatin Architecture through Polymer Physics. 通过聚合物物理学透视染色质结构的多尺度视角

IF 5.3 2区医学

Physiology Pub Date : 2025-05-01 Epub Date: 2024-11-27 DOI: 10.1152/physiol.00050.2024

Francesca Vercellone, Andrea M Chiariello, Andrea Esposito, Mattia Conte, Alex Abraham, Andrea Fontana, Florinda Di Pierno, Fabrizio Tafuri, Sougata Guha, Sumanta Kundu, Ciro Di Carluccio, Mario Nicodemi, Simona Bianco

{"title":"A Multiscale Perspective on Chromatin Architecture through Polymer Physics.","authors":"Francesca Vercellone, Andrea M Chiariello, Andrea Esposito, Mattia Conte, Alex Abraham, Andrea Fontana, Florinda Di Pierno, Fabrizio Tafuri, Sougata Guha, Sumanta Kundu, Ciro Di Carluccio, Mario Nicodemi, Simona Bianco","doi":"10.1152/physiol.00050.2024","DOIUrl":"10.1152/physiol.00050.2024","url":null,"abstract":"The spatial organization of chromatin within the eukaryotic nucleus is critical in regulating key cellular functions, such as gene expression, and its disruption can lead to disease. Advances in experimental techniques, such as Hi-C and microscopy, have significantly enhanced our understanding of chromatin's intricate and dynamic architecture, revealing complex patterns of interaction at multiple scales. Along with experimental methods, physics-based computational models, including polymer phase separation and loop-extrusion mechanisms, have been developed to explain chromatin structure in a principled manner. Here, we illustrate genomewide applications of these models, highlighting their ability to predict chromatin contacts across different scales and to spread light on the underlying molecular determinants. Additionally, we discuss how these models provide a framework for understanding alterations in chromosome folding associated with disease states, such as SARS-CoV-2 infection and pathogenic structural variants, providing valuable insights into the role of chromatin architecture in health and disease.","PeriodicalId":49694,"journal":{"name":"Physiology","volume":" ","pages":"0"},"PeriodicalIF":5.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0