HIF2α:生理和病理中氧传感系统之间的接口。

IF 10.3 2区 医学 Q1 PHYSIOLOGY
Physiology Pub Date : 2025-09-01 Epub Date: 2025-02-13 DOI:10.1152/physiol.00043.2024
Tammie Bishop, Peter J Ratcliffe
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引用次数: 0

摘要

在海拔适应最初描述的100多年后,现在很清楚,许多这些反应是由转录因子缺氧诱导因子(HIF-2α)的特定亚型介导的。在这里,我们回顾了这项工作,包括与氧化学敏感反应本身的联系,以及与副神经节瘤(一种经常影响化学敏感组织的肿瘤)的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypoxia-Inducible Factor 2α: at the Interface between Oxygen Sensing Systems in Physiology and Pathology.

More than 100 years after the original descriptions of altitude adaptation, it is now clear that many of these responses are mediated by a specific isoform of the transcription factor hypoxia-inducible factor (HIF)-2α. Here, we review this work, including connectivity with the oxygen chemosensitive response itself and with paraganglioma, a tumor often affecting chemosensitive tissues.

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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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