Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"Low-dose rivaroxaban added to aspirin decreases thrombin generation but does not affect fibrin clot properties: a preliminary study.","authors":"Tomasz Nowakowski, Kamila W Undas, Anetta Undas","doi":"10.20452/pamw.16978","DOIUrl":"10.20452/pamw.16978","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr virus and immune chaos: the link between reactivation and toll-like receptor dysregulation in immunodeficiency.","authors":"Paulina Mertowska, Sebastian Mertowski, Aleksandra Kozińska, Małgorzata Sobstyl, Jacek Roliński, Ewelina Grywalska","doi":"10.20452/pamw.16973","DOIUrl":"https://doi.org/10.20452/pamw.16973","url":null,"abstract":"<p><strong>Introduction: </strong>The immune system protects against pathogens, and its dysfunction leads to primary and secondary immunodeficiencies, increasing infection susceptibility. Epstein-Barr virus (EBV) reactivation is linked to immune homeostasis disorders, particularly in common variable immunodeficiency (CVID) and chronic lymphocytic leukemia (CLL). Toll-like receptor (TLR) pathways play a crucial role in innate immunity, and their deregulation may contribute to immune dysfunction.</p><p><strong>Objectives: </strong>This study aimed to assess the impact of EBV reactivation on immune homeostasis, focusing on TLR2, TLR4, TLR7, and TLR9 expression in T and B lymphocyte subpopulations and their soluble forms in CVID and CLL patients.</p><p><strong>Patients and methods: </strong>The study included 60 CVID patients, 60 CLL patients, and 30 healthy controls. EBV antigens, viral DNA levels, T and B lymphocyte immunophenotypes, and serum soluble TLR (sTLR) concentrations were analyzed using flow cytometry and ELISA.</p><p><strong>Results: </strong>EBV reactivation was detected in 55% of CVID and 60% of CLL patients. These patients showed significant TLR expression disturbances and increased sTLR levels. Notably, TLR7 and TLR9 expression was elevated on CD4+ and CD8+ T cells and CD19+ B cells, correlating with EBV load and immune dysfunction severity.</p><p><strong>Conclusions: </strong>EBV reactivation plays a key role in TLR pathway deregulation in CVID and CLL, potentially worsening disease progression and infection risk. TLR expression and sTLR levels could serve as biomarkers for EBV reactivation, aiding therapeutic strategies to stabilize immune responses.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma in a young adult patient with hypoplastic left heart syndrome with Fontan circulation.","authors":"Agnieszka Sarnecka, Paweł Skorek, Natalia Bajorek, Maciej Skubera, Lidia Tomkiewicz-Pająk","doi":"10.20452/pamw.16971","DOIUrl":"https://doi.org/10.20452/pamw.16971","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid ablation with simultaneous right atrial appendage occlusion in a patient with supraventricular tachycardia and post-traumatic scar of the right atrium: an unusual histopathological finding.","authors":"Mariusz Kowalewski, Sebastian Stec, Natalia Ogorzelec, Wiesława Grajkowska, Małgorzata Kołos, Piotr Suwalski","doi":"10.20452/pamw.16972","DOIUrl":"https://doi.org/10.20452/pamw.16972","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive recurrent cysts of ovaries with oligomenorrhea as a clinical manifestation of pituitary gonadotropinoma.","authors":"Adam D Durma, Marek Saracyn, Patrycjusz Zieniuk, Krzysztof Szturo, Grzegorz Zieliński, Grzegorz Kamiński","doi":"10.20452/pamw.16969","DOIUrl":"https://doi.org/10.20452/pamw.16969","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single pathology: two clinical and therapeutic perspectives. Popliteal aneurysm thrombosis as a rare cause of the acute lower limb ischemia.","authors":"Maryla Kuczyńska, Monika Zbroja-Putowska, Katarzyna Drelich, Agata Zarajczyk, Michał Sojka, Anna Drelich-Zbroja","doi":"10.20452/pamw.16961","DOIUrl":"https://doi.org/10.20452/pamw.16961","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Has high compliance with enhanced recovery after surgery protocol improved 5-year survival? A cohort study of 468 non-metastatic colorectal cancer patients.","authors":"Magdalena Pisarska-Adamczyk, Karolina Zawadzka, Grzegorz Torbicz, Urszula Popiela, Piotr Małczak, Michał Wysocki, Piotr Major, Mateusz Rubinkiewicz","doi":"10.20452/pamw.16960","DOIUrl":"https://doi.org/10.20452/pamw.16960","url":null,"abstract":"<p><strong>Introduction: </strong>The well-documented immediate benefits of Enhanced Recovery After Surgery (ERAS) highlight the need to explore its long-term impact, particularly on survival outcomes in colorectal cancer.</p><p><strong>Objectives: </strong>The aim of this study was to analyze the impact of ERAS protocol compliance on the long-term outcomes after laparoscopic colorectal resection.</p><p><strong>Patients methods: </strong>Data from 468 patients who underwent laparoscopic colorectal resection between 2013 and 2017 were prospectively collected. Patients were divided into two groups based on their adherence to the ERAS protocol: group 1 with a compliance rate <80% and group 2 with a compliance rate of ≥80%. The association between ERAS protocol compliance and a 5-year survival was assessed with use of Kaplan-Meier method with log-rank tests. Additionally, survival analysis was done separately for groups depending on cancer stages.</p><p><strong>Results: </strong>Group 1 consisted of 128 patients, while Group 2 included 340 patients. There were no statistically significant differences between the groups in terms of sex, age, BMI, ASA scale or comorbidities.  The Kaplan-Meier curve and log-rank test analyses indicated that the two groups of ERAS protocol adherence did not significantly differ in terms of a 5-year overall survival. In patients with AJCC stage 1-2 cancer, those with ERAS compliance of ≥80% had a significantly higher 5-year survival rate than those with compliance <80%, indicating that greater adherence to the ERAS protocol is associated with improved survival outcomes. In case of AJCC cancer stage 3 patients, the ERAS compliance did not significantly alter survival rates.</p><p><strong>Conclusion: </strong>High adherence to the ERAS protocol appeared to improve a 5-year survival rate in patients with AJCC stage I-II of colorectal cancer.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in lipoprotein(a) concentrations in patients with acute coronary syndrome.","authors":"Joanna Satała, Anna Witkowska, Agnieszka Pawlos, Agnieszka Woźniak, Marlena Broncel, Ewelina Woźniak, Paulina Gorzelak-Pabiś","doi":"10.20452/pamw.16959","DOIUrl":"https://doi.org/10.20452/pamw.16959","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, interest has been growing in lipoprotein(a) (Lp(a)) as an independent risk factor for cardiovascular diseases. European Society of Cardiology (ESC) recommends a single measurement of Lp(a) concentration as a guide to determining cardiovascular risk group and appropriate treatment. Although initially assumed to be genetically determined, a growing number of reports indicate that Lp(a) concentration may change over time.</p><p><strong>Objectives: </strong>The aim of the study was to compare changes in the concentration of Lp(a) in ACS patients at the moment of ACS and three months later.</p><p><strong>Patients and methods: </strong>Forty patients with acute coronary syndrome (ACS) were enrolled and divided into ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI)+ unstable angina (UA) groups. The lipid, CRP, hs-TnT, NT-proBNP and Lp(a) levels were determined in these patients using routine laboratory methods, with IL-33 levels measured using ELISA.</p><p><strong>Results: </strong>Among all ACS patients, 9 out of 40 (22.5%) had elevated Lp(a) levels (>75 nmol/L); this proportion was higher in STEMI (n = 8; 35%) compared to NSTEMI+UA (n = 2; 13%). All patients with ACS demonstrated significantly higher Lp(a) serum levels three months after ACS. The Lp(a) level at the moment of ACS and three months later differed significantly with those among STEMI patients (P = 0.03), all patients with ACS (P = 0.003) and NSTEMI+UA (P = 0.003).</p><p><strong>Conclusion: </strong>Measuring Lp(a) level during ACS may be insufficient for accurate diagnosis and effective treatment, as its concentration increases after three months. Therefore, ACS may be regarded as another non-genetic factor influencing Lp(a) concentration.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk and psoriatic arthritis.","authors":"Fabiola Atzeni, Alessandra Alciati","doi":"10.20452/pamw.16964","DOIUrl":"10.20452/pamw.16964","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 2","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden cardiac arrest in the course of mitral valve prolapse: can we prevent it?","authors":"Cezary Maciejewski, Ewa Lewandowska, Michał Peller, Robert Kowalik, Marcin Grabowski, Paweł Balsam","doi":"10.20452/pamw.16899","DOIUrl":"10.20452/pamw.16899","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}