Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"Tailored approaches to transcatheter aortic valve implantation in patients with protruding coronary stents.","authors":"Krzysztof Greberski, Maciej Dąbrowski, Radosław Jarząbek, Rafał Wolny, Adam Witkowski, Paweł Bugajski","doi":"10.20452/pamw.16980","DOIUrl":"https://doi.org/10.20452/pamw.16980","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misleading diagnosis of ST-segment elevation myocardial infarction in a patient receiving 5-fluorouracil.","authors":"Artur Dziewierz, Dariusz Łukasik, Andrzej Witkowski, Łukasz Wiśniowski, Francesco Pelliccia, Tomasz Rakowski","doi":"10.20452/pamw.16979","DOIUrl":"https://doi.org/10.20452/pamw.16979","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirolimus treatment of generalized lymphatic anomaly with a set of congenital defects.","authors":"Piotr Piekarczyk, Katarzyna Błasińska, Mateusz Polaczek, Magdalena Bilny-Paluch, Elżbieta Radzikowska","doi":"10.20452/pamw.16977","DOIUrl":"https://doi.org/10.20452/pamw.16977","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic features and therapeutic dilemmas in a patient with clinically significant multivalvular disease and the left atrial appendage thrombus.","authors":"Weronika Basak, Ewa Wlazłowska-Struzik, Paweł Szymkiewicz, Krzysztof Wróbel, Piotr Pruszczyk, Katarzyna Kurnicka","doi":"10.20452/pamw.16976","DOIUrl":"https://doi.org/10.20452/pamw.16976","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative stress perfusion cardiovascular magnetic resonance: clinical implications for patients with suspected myocardial ischemia.","authors":"Sonia Borodzicz-Jazdzyk, Roel Hoek, Caitlin E M Vink, Geoffrey W de Mooij, Adriaan Wilgenhof, Luuk H G A Hopman, Mitchel Benovoy, Marco J W Götte","doi":"10.20452/pamw.16975","DOIUrl":"https://doi.org/10.20452/pamw.16975","url":null,"abstract":"<p><strong>Introduction: </strong>Recent technical advances in stress perfusion cardiovascular magnetic resonance (CMR) allow for myocardial blood flow (MBF) quantification (quantitative perfusion CMR; QP CMR). However, clinical utility of QP CMR compared to conventional grey scale qualitative assessment (QA) is unknown.</p><p><strong>Objectives: </strong>The study aimed to compare the clinical conclusions on ischemia detection derived from conventional grey-scale QA of stress perfusion CMR imaging and QP CMR in a real-world population of patients with suspected myocardial ischemia.</p><p><strong>Patients and methods: </strong>This study retrospectively analyzed 101 patients with suspected myocardial ischemia referred for adenosine stress perfusion CMR imaging. QA of grey-scale first-pass perfusion CMR was performed by level 3 CMR experts. In QP, stress and rest MBF (ml/g/min) were calculated for automatically determined myocardial segments. Each patient and coronary territory was classified by both QA and QP, in a blinded manner, as either ischemic or non-ischemic.  Results: QP classified more coronary territories as ischemic compared to QA (46% vs. 17%, P <0.001). In the per-patient analysis, QP diagnosed myocardial ischemia in 64 patients (63%), and QA in 40 (40%) (P <0.001). Ischemia was diagnosed by QA but not QP in 7% of patients  (QA+/QP-). In 31% of patients, QP established a new diagnosis of myocardial ischemia (QA-/QP+).</p><p><strong>Conclusion: </strong>QP CMR detects more ischemic coronary territories compared to QA and holds promise for identifying cases of myocardial ischemia that may be overlooked by QA alone in a real-world patient population.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic profile associated with coronary artery disease: a higher level of indoleamine 2,3-dioxygenase activity and lower tryptophan concentrations predict a worse prognosis.","authors":"Marcin Kondraciuk, Małgorzata Chlabicz, Jacek Jamiołkowski, Emilia Sawicka-Śmiarowska, Magda Łapińska, Natalia Sieńkowska, Natalia Zieleniewska, Adrian Godlewski, Michał Ciborowski, Adam Krętowski, Karol A Kamiński","doi":"10.20452/pamw.16974","DOIUrl":"https://doi.org/10.20452/pamw.16974","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolites can lead to novel discoveries in cardiovascular disease (CVD).</p><p><strong>Objectives: </strong>The aim of the study was to investigate whether a metabolomic profile is associated with mortality in patients with coronary artery disease (CAD).</p><p><strong>Methods: </strong>The study group consisted of 170 participants with CAD who were hospitalized due to acute coronary syndrome or elective percutaneous coronary intervention 12-26 months before evaluation (mean[SD] months, 16.3 [2.2]). A total of 132 metabolites were profiled by liquid chromatography-tandem mass spectrometry, and sums/ratios of 102 metabolite concentrations were calculated. Dates of death from all causes were obtained from the Polish Ministry of Digital Affairs.</p><p><strong>Results: </strong>The median age of the group was 62 years (IQR 58-66), 68.8% (n=117) were male. The median follow-up time was 6.4 years (IQR 5.5-6.5). After adjustment for CVD risk factors affecting survival in the population analyzed (i.e. age, statin dose, current smoking, estimated glomerular filtration rate, and high-sensitivity C-reactive protein) with Bonferroni's correction, tryptophan (Trp) was negatively associated with death (HR = 0.558, 95%CI = 0.38-0.82, P = 0.003), whereas indoleamine 2,3-dioxygenase (IDO) activity level was positively associated with death (HR = 2.925, 95%CI = 1.71-5.01, P <0.001). Survival analysis showed that patients with IDO activity levels above he median had statistically worse survival than patients with lower activity levels (log-rank test, P = 0.009). In contrast, patients with Trp concentration below the median had worse survival than those with higher levels (log-rank test,  P = 0.03).</p><p><strong>Conclusions: </strong>In patients with CAD, the increased IDO activity level predicts a worse long-term prognosis independently of known CVD risk factors.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose rivaroxaban added to aspirin decreases thrombin generation but does not affect fibrin clot properties: a preliminary study.","authors":"Tomasz Nowakowski, Kamila W Undas, Anetta Undas","doi":"10.20452/pamw.16978","DOIUrl":"https://doi.org/10.20452/pamw.16978","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr virus and immune chaos: the link between reactivation and toll-like receptor dysregulation in immunodeficiency.","authors":"Paulina Mertowska, Sebastian Mertowski, Aleksandra Kozińska, Małgorzata Sobstyl, Jacek Roliński, Ewelina Grywalska","doi":"10.20452/pamw.16973","DOIUrl":"https://doi.org/10.20452/pamw.16973","url":null,"abstract":"<p><strong>Introduction: </strong>The immune system protects against pathogens, and its dysfunction leads to primary and secondary immunodeficiencies, increasing infection susceptibility. Epstein-Barr virus (EBV) reactivation is linked to immune homeostasis disorders, particularly in common variable immunodeficiency (CVID) and chronic lymphocytic leukemia (CLL). Toll-like receptor (TLR) pathways play a crucial role in innate immunity, and their deregulation may contribute to immune dysfunction.</p><p><strong>Objectives: </strong>This study aimed to assess the impact of EBV reactivation on immune homeostasis, focusing on TLR2, TLR4, TLR7, and TLR9 expression in T and B lymphocyte subpopulations and their soluble forms in CVID and CLL patients.</p><p><strong>Patients and methods: </strong>The study included 60 CVID patients, 60 CLL patients, and 30 healthy controls. EBV antigens, viral DNA levels, T and B lymphocyte immunophenotypes, and serum soluble TLR (sTLR) concentrations were analyzed using flow cytometry and ELISA.</p><p><strong>Results: </strong>EBV reactivation was detected in 55% of CVID and 60% of CLL patients. These patients showed significant TLR expression disturbances and increased sTLR levels. Notably, TLR7 and TLR9 expression was elevated on CD4+ and CD8+ T cells and CD19+ B cells, correlating with EBV load and immune dysfunction severity.</p><p><strong>Conclusions: </strong>EBV reactivation plays a key role in TLR pathway deregulation in CVID and CLL, potentially worsening disease progression and infection risk. TLR expression and sTLR levels could serve as biomarkers for EBV reactivation, aiding therapeutic strategies to stabilize immune responses.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma in a young adult patient with hypoplastic left heart syndrome with Fontan circulation.","authors":"Agnieszka Sarnecka, Paweł Skorek, Natalia Bajorek, Maciej Skubera, Lidia Tomkiewicz-Pająk","doi":"10.20452/pamw.16971","DOIUrl":"https://doi.org/10.20452/pamw.16971","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid ablation with simultaneous right atrial appendage occlusion in a patient with supraventricular tachycardia and post-traumatic scar of the right atrium: an unusual histopathological finding.","authors":"Mariusz Kowalewski, Sebastian Stec, Natalia Ogorzelec, Wiesława Grajkowska, Małgorzata Kołos, Piotr Suwalski","doi":"10.20452/pamw.16972","DOIUrl":"https://doi.org/10.20452/pamw.16972","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}