Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

Increased turnover of non-malignant T lymphocytes in patients with chronic lymphocytic leukemia may affect clinical progression.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-14 DOI: 10.20452/pamw.16955

Agata Kosmaczewska, Lidia Ciszak, Irena Frydecka, Edyta Pawlak, Aleksandra Szteblich, Tomasz Wróbel, Dariusz Wołowiec

{"title":"Increased turnover of non-malignant T lymphocytes in patients with chronic lymphocytic leukemia may affect clinical progression.","authors":"Agata Kosmaczewska, Lidia Ciszak, Irena Frydecka, Edyta Pawlak, Aleksandra Szteblich, Tomasz Wróbel, Dariusz Wołowiec","doi":"10.20452/pamw.16955","DOIUrl":"https://doi.org/10.20452/pamw.16955","url":null,"abstract":"Introduction: A unique feature of chronic lymphocytic leukemia (CLL) is the increased number of circulating T cells preventing malignant B cells from undergoing apoptosis. Dysregulated expression of p27Kip1 and cyclin D2 (G1 phase regulators controlling lymphocyte survival) was examined in leukemic B cells but not non-malignant T cells.Objectives: Assessment of anti-apoptotic p27Kip1 and cyclin D2 in peripheral blood (PB) leukemic B and T cells in relation to ex vivo apoptosis in CLL patients with different clinical courses.Patients and methods: Using flow cytometry, we determined G1 regulators' expression and apoptosis of B and T cells in 47 previously untreated CLL patients (median age 60.0; 26 men) with stable disease (SD), progressive disease (PD), and 39 controls, matched for age and sex.Results: We noted increased apoptosis within T cells in CLL patients compared to controls (P <0.001), whereas B cells exhibited failed apoptosis. All patients exerted higher p27Kip1 and cyclin D2 expression in leukemic B and T cells compared to controls (P <0.001). Comparative analysis between B and T cells showed pronounced T cell apoptosis in only PD patients (P <0.001). In SD patients, G1 regulators' expression was higher in T cells than in B cells (P ≤0.02). Increased p27Kip1 expression and low apoptosis within B cells, and lower cyclin D2 expression and high apoptosis within T cells were predictive of earlier disease progression.Conclusions: CLL progression is associated with increased T-cell turnover triggered by dysregulated expression of G1 regulators, suggesting the involvement of the non-malignant T-cell compartment in disease pathogenesis and clinical outcomes.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune thrombocytopenic purpura in a patient with the presence of a left atrial thrombus who underwent mitral valve replacement.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16950

Natalia Maruszak, Joanna Zdziarska, Barbara Zawiślak, Renata Rajtar-Salwa, Stanisław Bartuś, Danuta Sorysz

引用次数: 0

Oral manifestations of systemic sclerosis: a grave challenge or a great opportunity for early and adequate diagnosis?

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16952

Jakub Bukowski, Agnieszka Cabała, Małgorzata Płatek-Kopeć, Joanna Śręba

引用次数: 0

Predictive analysis of lipidome patterns in gestational diabetes mellitus risk assessment.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16953

Marija S Matutinovic, Aleksandra Zeljkovic, Jelena Vekic, Daniela Ardalic, Željko Mikovic, Aleksandra Stefanovic

引用次数: 0

A supervised telemedical monitoring in the heart failure population in regions of social exclusion is associated with an improvement in functional capacity and quality of life.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16954

Piotr Wańczura, David Aebisher, Wojciech Stecko, Hubert Bukowski, Marek Kos, Andrzej Przybylski, Jarosław Zalewski

{"title":"A supervised telemedical monitoring in the heart failure population in regions of social exclusion is associated with an improvement in functional capacity and quality of life.","authors":"Piotr Wańczura, David Aebisher, Wojciech Stecko, Hubert Bukowski, Marek Kos, Andrzej Przybylski, Jarosław Zalewski","doi":"10.20452/pamw.16954","DOIUrl":"https://doi.org/10.20452/pamw.16954","url":null,"abstract":"Introduction: Telemedicine is intended to provide medical care to patients in remote areas.Objectives: This study sought to investigate whether the application of e-health solutions for patients with heart failure (HF) who live in regions of social exclusion would improve their functional performance and quality of life (QoL).Patients and methods: In this prospective, non-controlled study carried out between June and December 2023, HF patients were enrolled in 14 primary care units located in 5 rural voivodeships in eastern Poland. All patients were evaluated at baseline and after 3 months using the New York Heart Association (NYHA) scale, Chronic Heart Failure Questionnaire (CHFQ), and EuroQol Visual Analogue Scale (EQVAS), and monitored by a general practitioner under the supervision of a cardiologist.Results: In 429 patients with HF, more than 100 000 telemedical examinations/consultations were performed resulting in 575 treatment modifications. During the 3-month program, one patient died. Simultaneously, an improvement in NYHA scale by median of 1 class (interquartile range 0-1, P <0.001) was identified. A 6% improvement in QoL was found in emotional function measured by CHFQ (P <0.001) while a 7.7% improvement in subjective health status measured by EQVAS (P <0.001). A history of atrial fibrillation (odds ratio [OR] 1.539, 95% confidence interval [CI] 1.021-2.353) and no history of cancer (OR 2.793, 95% CI 1.224-6.369) were associated with the NYHA class improvement.Conclusions: The applied telemedical model of care under the specialist's supervision was associated with an improvement in NYHA class and QoL in the HF population from regions of social exclusion.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medium-bore lightning flash catheter aspiration thrombectomy in acute pulmonary embolism: first experience in Poland.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16951

Sylwia Sławek-Szmyt, Aneta Klotzka, Sonia Nartowicz, Stanisław Jankiewicz, Maciej Lesiak, Aleksander Araszkiewicz

引用次数: 0

Long-term microvascular alterations in kidney transplant recipients after SARS-CoV-2 infection.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-11 DOI: 10.20452/pamw.16948

Edyta Dąbrowska, Jacek Wolf, Maksym Jopek, Marcin Hellmann, Paulina Sulecka, Mateusz Ślizień, Katarzyna Michalska-Małecka, Joanna Konopa, Bogdan Biedunkiewicz, Leszek Tylicki, Krzysztof Narkiewicz, Alicja Dębska-Ślizień

{"title":"Long-term microvascular alterations in kidney transplant recipients after SARS-CoV-2 infection.","authors":"Edyta Dąbrowska, Jacek Wolf, Maksym Jopek, Marcin Hellmann, Paulina Sulecka, Mateusz Ślizień, Katarzyna Michalska-Małecka, Joanna Konopa, Bogdan Biedunkiewicz, Leszek Tylicki, Krzysztof Narkiewicz, Alicja Dębska-Ślizień","doi":"10.20452/pamw.16948","DOIUrl":"https://doi.org/10.20452/pamw.16948","url":null,"abstract":"Introduction: The long-term cardiovascular consequences of COVID-19 in organ recipients have been insufficiently studied.Objective: The aim of our study was to evaluate the association between COVID-19 and microvascular abnormalities in kidney transplant recipients 8 weeks after SARS-CoV-2 infection. Patients and methods: The study population consisted of 54 kidney transplant recipients, and was divided into two subgroups: patients with a history of COVID-19 (n = 35) and patients without a history of COVID-19 (n = 21). We assessed both the structure and function of microcirculation.Results: The study group was aged 47.6 (12.7) years and included 54% of women. Patients with and without a history of COVID-19 did not differ in baseline characteristics. Compared to patients without a history of COVID-19, subjects after SARS-CoV-2 infection had substantially lower values of ischemic response: IRmax; 7.0 (5.0-8.7) vs. 9.6 (8.8-11.5), P = 0.04; IR index 3.1 (2.3-4.2) vs 7.2 (5.2-8.2), P = 0.01), with the IR index further confirmed in a multivariable analysis. Logistic regression analysis showed that estimated glomerular filtration rate was linked to microvascular functional decline, expressed by a poorer normoxia oscillatory index (odds ratio 0.95, CI 0.90-0.99, P = 0.047). C-reactive protein was associated with arterioles' wall thickness (R = 0.42, P = 0.02) and wall-to-lumen ratio (R = 0.48, P = 0.01).Conclusion: We documented that microvascular dysfunction was associated with SARS-CoV-2 infection and is detectable 8 weeks after the acute phase in kidney transplant recipients.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrial septostomy with veno-arterial extracorporeal membrane oxygenation in cardiogenic shock: a bridge to heart transplantation.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-10 DOI: 10.20452/pamw.16947

Mikołaj Błaziak, Roman Przybylski, Weronika Wietrzyk, Bartosz Balcer, Natalia Dolata, Wiktor Kuliczkowski

引用次数: 0

Expanding the phenotype of myosin heavy chain 11 (MYH11)-related thoracic aortic disease: a case of mitral annular disjunction in a family.

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-10 DOI: 10.20452/pamw.16946

Agnieszka M Żebrowska, Krzysztof Jaworski, Joanna K Ponińska, Mateusz Śpiewak, Rafał Płoski, Zofia T Bilińska

引用次数: 0

How to manage an adrenal incidentaloma in a hypertensive patient?

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-07 DOI: 10.20452/pamw.16949

Agnieszka Łebek-Szatańska, Andrzej Januszewicz, Sylwia Kołodziejczyk-Kruk, Marek Kabat, Mateusz Śpiewak, Magdalena Januszewicz

{"title":"How to manage an adrenal incidentaloma in a hypertensive patient?","authors":"Agnieszka Łebek-Szatańska, Andrzej Januszewicz, Sylwia Kołodziejczyk-Kruk, Marek Kabat, Mateusz Śpiewak, Magdalena Januszewicz","doi":"10.20452/pamw.16949","DOIUrl":"https://doi.org/10.20452/pamw.16949","url":null,"abstract":"An adrenal incidentaloma (AI) is a mass discovered on imaging that was not performed for suspected adrenal diseases. Technological advancements in imaging modalities that are widely available, a growing awareness of preventive care and an aging population, have led to an increase in the detection of adrenal incidentalomas, generating diagnostic and therapeutic dilemmas for clinicians. Every patient with an adrenal incidentaloma should undergo careful evaluation: 1) to establish the etiology of the tumor, 2) to detect all hormonally active lesions, including secondary forms of hypertension. Hormonal hypertension carries a higher risk of cardiovascular complications and target organ damage than essential hypertension, independently of blood pressure control. In this review, we discuss the current 2023 European Society of Endocrinology guidelines on the management of adrenal incidentalomas, in the context of other experts' documents (including Polish Society of Endocrinology recommendations), with the main focus on the two secondary forms of hypertension - primary aldosteronism and pheochromocytoma - that should not be missed in clinical practice.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0