Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"Epicardial fat: a non-invasive, non-contrast imaging biomarker for high-risk plaque monitoring in computed tomography.","authors":"Jan Henzel, Mariusz Kruk, Cezary Kępka, Magdalena Makarewicz-Wujec, Piotr Trochimiuk, Łukasz Wardziak, Hubert Krysztofiak, Piotr N Rudziński, Rafał Dąbrowski, Zofia Dzielińska, Marcin Demkow","doi":"10.20452/pamw.17129","DOIUrl":"https://doi.org/10.20452/pamw.17129","url":null,"abstract":"<p><strong>Introduction: </strong>Coronary computed tomography angiography (CCTA) is a viable method for monitoring vulnerable plaque, however, non-contrast calcium scoring (CAS) has a limited utility in this context. The search for novel non-contrast imaging biomarkers able to track high-risk plaque is necessary.</p><p><strong>Objectives: </strong>To investigate associations between low attenuation plaque (LAP) identified through CCTA and non-contrast CAS, pericardial adipose tissue (PAT), and epicardial adipose tissue (EAT) in patients with non-obstructive coronary atherosclerosis undergoing serial CCTA.</p><p><strong>Patients and methods: </strong>We analyzed data from 89 participants (40% women, 60 [7.7] years) of the dietary intervention to stop coronary atherosclerosis in the computed tomography study. CCTA was performed at baseline and repeated at mean follow-up of 66.8 (13.7) weeks. CAS and cardiac fat were measured in non-contrast reconstructions and analyzed in relation to contrast-derived LAP.</p><p><strong>Results: </strong>Mean decrease in LAP burden was 0.23 (1.0) % (P = 0.04), median decrease in PAT volume was 4.2 (-36.9; 8.3) cm³ (P <0.001), median decrease in EAT volume was 2.8 (-12.2; 6.7) cm³ (P = 0.01), and median increase in CAS was 21.2 (1.7; 71.7) Agatston units (P <0.001). Positive correlations were found between changes in LAP burden and both PAT and EAT volumes (r = 0.349, P = 0.001, and r = 0.490, P <0.001, respectively), but not with change in CAS. Multivariable linear regression analysis identified EAT as independent predictor of LAP regression (95% CI, 0.007; 0.032; P = 0.003).</p><p><strong>Conclusions: </strong>Pericardial and epicardial fat volumes and their dynamics are positively associated with LAP burden, while CAS is not. Monitoring EAT volume using non-contrast computed tomography may facilitate the assessment of high-risk plaque progression or regression, overcoming the limitations of CAS.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating short-chain fatty acids and subclinical cardiovascular disease in type 2 diabetes mellitus.","authors":"Hui-Ju Tsai, Wei-Chung Tsai, Ping-Shaou Yu, Wei-Chun Hung, Wei-Wen Hung, Yi-Chun Tsai","doi":"10.20452/pamw.17128","DOIUrl":"https://doi.org/10.20452/pamw.17128","url":null,"abstract":"<p><strong>Introduction: </strong> Type 2 diabetes (T2D) is linked to a higher risk of cardiovascular disease (CVD). However, evidence on the impact of different short-chain fatty acids (SCFAs) on subclinical CVD is limited in patients with T2D.</p><p><strong>Objectives: </strong> This study was aimed to investigate the associations between circulating SCFA levels and subclinical CVD in patients with T2D.</p><p><strong>Patients and methods: </strong> This cross-sectional study enrolled 326 patients with T2D from November 2016 to June 2020. The levels of nine SCFAs including formate, acetate, propionate, butyrate, isobutyrate, methylbutyrate, valerate, isovalerate and methylvalerate in fasting serum were measured using liquid chromatography mass spectrometry. Cardiac structure and function were evaluated by echocardiography. Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV), as a parameter of arterial stiffness, were measured. Multivariable linear and logistic model were adjusted for traditional risk factors including cholesterol and glycated hemoglobin (HbA1C).</p><p><strong>Results: </strong> The mean age of the patients was 63.5 (10.4) years and 56.4% were male. The median HbA1C level was 7.0%. The adjusted odd ratios of left ventricular hypertrophy were 2.39 and 2.60 for tertiles 3 of formate and isobutyrate compared with tertiles 1 of formate and isobutyrate, respectively. Higher circulating butyrate / isobutyrate ratio was significantly associated with decreased risk of diastolic dysfunction. An inverse relationship between circulating valerate level and arterial stiffness was found. Patients with the highest tertile of circulating butyrate level had lower risk of abnormal ABI.</p><p><strong>Conclusions: </strong> Our study demonstrates that serum SCFAs are potential biomarkers of the early stage of cardiovascular remodeling in patients with T2D.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the epidemiology of pituitary adenomas in Poland.","authors":"Adrian F Daly","doi":"10.20452/pamw.17124","DOIUrl":"https://doi.org/10.20452/pamw.17124","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical impact of vitamin C deficiency in patients hospitalized with community-acquired pneumonia.","authors":"Yogesh Sharma, Arduino A Mangoni, Richard Woodman, Rashmi Shahi, Chris Horwood, Campbell Thompson","doi":"10.20452/pamw.17067","DOIUrl":"10.20452/pamw.17067","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of autoimmune disease development and exacerbation in patients receiving subcutaneous allergen immunotherapy: a cross-sectional study.","authors":"Dominika Ochab-Krupnik, Piotr Lacwik, Anna Mościcka, Beata Kręcisz, Maciej Kupczyk, Cezary Pałczyński","doi":"10.20452/pamw.17068","DOIUrl":"10.20452/pamw.17068","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon cause and treatment of acute pulmonary embolism.","authors":"Marta Kwiatkowska, Agnieszka Sawicka, Jerzy Leszczyński, Michał Sajdek, Piotr Sobieraj","doi":"10.20452/pamw.17039","DOIUrl":"10.20452/pamw.17039","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare immune adverse event in the treatment of non-small-cell lung carcinoma: durvalumab-associated optic neuritis.","authors":"Grzegorz Chmielewski, Rafał Stando, Katarzyna Amanowicz","doi":"10.20452/pamw.17056","DOIUrl":"10.20452/pamw.17056","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edmund Biernacki: a forgotten father of clinical hematology.","authors":"Anna Maria Jurczyszyn, Michał Bator, Artur Jurczyszyn, Ryszard W Gryglewski","doi":"10.20452/pamw.17107","DOIUrl":"https://doi.org/10.20452/pamw.17107","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patients with primary biliary cholangitis treated with ursodeoxycholic acid.","authors":"Magdalena Rogalska, Aleksandra Berkan-Kawińska, Jakub Klapaczyński, Witold Musierowicz, Krystyna Dobrowolska, Marta Wawrzynowicz-Syczewska, Jerzy Jaroszewicz, Włodzimierz Mazur, Krzysztof Tomasiewicz, Piotr Zieliński, Dorota Zarębska-Michaluk, Robert Flisiak","doi":"10.20452/pamw.17071","DOIUrl":"10.20452/pamw.17071","url":null,"abstract":"<p><strong>Introduction: </strong> Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease. Despite established first‑line therapy with ursodeoxycholic acid (UDCA), many patients do not achieve biochemical remission. Data on the characteristics of PBC in Poland remain limited.</p><p><strong>Objectives: </strong> The aim of this study was to characterize demographic, clinical, and serological features of Polish patients with PBC and the effects of treatment in a multicenter retrospective cohort.</p><p><strong>Patients and methods: </strong>A total of 364 patients from 10 hepatology centers were included. Data on demographics, laboratory tests, autoantibodies, and markers of the disease severity were collected between January 6 and March 8, 2025 and analyzed according to the duration of UDCA treatment (<2 vs ≥2 years).</p><p><strong>Results: </strong> Women constituted 92.3% of the cohort. Most patients were aged 60-80 years, but the proportion of men was relatively higher in the groups below 50 and over 80 years old. Cirrhosis was diagnosed in 35.2% of the patients. Antimitochondrial antibodies were present in 94.4%, and anti‑Ro52 antibodies in 34.1% of the study participants. Anti‑gp210 and anti‑sp100 antibodies were more frequent in the patients with longer disease duration. No substantial differences in liver biochemistry were found between short- and long‑term UDCA use groups, except for lower γ‑glutamyl transferase activity with longer treatment. Despite pruritus found in 46% of the patients, antipruritic therapy was rarely used.</p><p><strong>Conclusions: </strong> This is the first national study to characterize PBC in Poland. Its findings suggest limited long‑term efficacy of UDCA and unmet needs in symptom management. Anti‑gp210, anti‑sp100, and anti‑Ro52 antibodies may serve as important serologic markers. Prospective studies are needed to confirm these observations.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits from statins in anticoagulated venous thromboembolism patients: recent advances.","authors":"Carmine Siniscalchi, Manuela Basaglia, Pierpaolo Di Micco, Alberto Parise, Nicoletta Cerundolo, Tiziana Meschi","doi":"10.20452/pamw.17058","DOIUrl":"10.20452/pamw.17058","url":null,"abstract":"<p><p>Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, remains a major cause of morbidity and mortality worldwide. Although oral anticoagulation is the cornerstone of VTE treatment, recurrent events and long‑term complications, such as post‑thrombotic syndrome, persist in a significant proportion of patients. Recent evidence suggests that statins, traditionally used for lipid‑lowering therapy, may exert pleiotropic beneficial effects in patients with VTE, particularly those already receiving anticoagulants. These benefits include anti‑inflammatory, antithrombotic (eg, anticoagulant, antiplatelet, and profibrinolytic actions), endothelial‑stabilizing, and immunomodulatory properties. Clinical and observational studies have highlighted that statin use is associated with reduced risk of recurrent VTE and improved survival, even in the absence of hyperlipidemia. This review synthesizes the current evidence on the role of statins in anticoagulated patients with VTE, exploring mechanistic insights, clinical trial data, and real‑world findings. We also discuss the potential synergistic effects between statins and anticoagulants, as well as safety considerations, particularly in elderly and polymedicated populations. Furthermore, we address the limitations of existing studies and outline future research directions to establish whether statins should be systematically considered in secondary prevention strategies for VTE. In conclusion, statins appear to confer significant adjunctive benefits in anticoagulated VTE patients, with an acceptable safety profile. Integration of statins into VTE management may represent a cost‑effective and widely accessible intervention to enhance patient outcomes, though prospective randomized controlled trials are still needed to confirm causality and determine the optimal use.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}