Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

Unilateral multicystic kidney associated with 17q12 duplication, presenting with mass effect symptoms in a young patient. 单侧多囊肾合并17q12重复，一例年轻患者出现肿块效应症状。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-08 DOI: 10.20452/pamw.17296

Krystian Wolny, Krzysztof Hoppe, Vimbisoyashe I Matshaba, Anna Materna-Kiryluk, Krzysztof Pawlaczyk

引用次数: 0

Rasmussen aneurysm: minimally invasive management of a rare complication of recurrent pulmonary tuberculosis. 拉斯穆森动脉瘤：复发性肺结核罕见并发症的微创治疗。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-07 DOI: 10.20452/pamw.17295

Jan Sobstyl, Kamila Mozga, Wojciech Czyżewski, Jakub Litak, Michał Sojka

引用次数: 0

Erectile dysfunction and quality of life after myocardial infarction: a cross-sectional study with routine point-of-care penile Doppler ultrasonography. 心肌梗死后勃起功能障碍和生活质量：一项常规点护理阴茎多普勒超声的横断面研究。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-04 DOI: 10.20452/pamw.17288

Filip Tkaczyk, Artur Dziewierz, Aleksandra Piotrowska, Zbigniew Siudak

{"title":"Erectile dysfunction and quality of life after myocardial infarction: a cross-sectional study with routine point-of-care penile Doppler ultrasonography.","authors":"Filip Tkaczyk, Artur Dziewierz, Aleksandra Piotrowska, Zbigniew Siudak","doi":"10.20452/pamw.17288","DOIUrl":"https://doi.org/10.20452/pamw.17288","url":null,"abstract":"Introduction: Erectile dysfunction (ED) is common in men after myocardial infarction (MI) and is associated with poorer quality of life and systemic vascular disease. Previous studies have primarily relied on questionnaires, rarely including objective assessment of penile hemodynamics.Objectives: To assess the quality of life in men with ED after MI treated with percutaneous coronary intervention (PCI) including routine assessment of penile hemodynamics using point-of-care resting Doppler ultrasonography.Patients and methods: This observational, cross-sectional, single-center study included 600 men: 400 after MI treated with PCI and 200 without MI/PCI (controls). ED was assessed using the IIEF-5 questionnaire, and quality of life was assessed using the SF-36. Echocardiography, carotid Doppler ultrasound, and resting penile Doppler ultrasound were performed. Associations were analyzed using Spearman correlation and multivariate linear regression.Results: All patients after MI had ED. Quality of life was significantly lower than in controls globally (SF-36: 121.3 (8.9) vs. 134.6 (7.5); P <0.001) and in the physical and mental components. Penile Doppler parameters differed between groups and correlated with IIEF-5. In multivariate analysis, the strongest predictor of quality of life was erectile function (IIEF-5), followed by LVEF, BMI, heart rate, and vascular parameters (IMT, carotid and penile flow).Conclusions: ED severity is a major independent determinant of quality of life in men after MI/PCI. Penile hemodynamic parameters reflect systemic vascular burden and functional status. Integrated ED assessment, including IIEF-5 and routine resting penile Doppler ultrasound, can support risk stratification and post-MI care.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inherited thrombophilia and polygenic risk scores in venous thromboembolism: from classical testing to genomic risk prediction. 静脉血栓栓塞的遗传性血栓和多基因风险评分：从经典检测到基因组风险预测。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-04 DOI: 10.20452/pamw.17287

Benilde Cosmi, Grigoris Gerotziafas, Peter Marschang, Matija Kozak, Mariella Catalano, Agata Stanek

{"title":"Inherited thrombophilia and polygenic risk scores in venous thromboembolism: from classical testing to genomic risk prediction.","authors":"Benilde Cosmi, Grigoris Gerotziafas, Peter Marschang, Matija Kozak, Mariella Catalano, Agata Stanek","doi":"10.20452/pamw.17287","DOIUrl":"https://doi.org/10.20452/pamw.17287","url":null,"abstract":"Venous thromboembolism (VTE) is a disorder due to the interaction between genetic, individually acquired and environmental factors. The aim of this narrative review is to summarize advances in genetic susceptibility to first and recurrent VTE, focusing on GWAS-derived polygenic risk scores and sequencing-based approaches, and to discuss current barriers to clinical implementation. Testing for the classical inherited thrombophilias, such as the deficiencies of natural anticoagulants antithrombin, protein C and S and the Factor V Leiden variant and the G20210A of Factor II could improve risk stratification and therapeutic decisions in VTE, although their role in VTE management remains controversial. The knowledge regarding genetic susceptibility for VTE progressed in the last two decades, beyond the classical thrombophilias, thanks to the evolution from single-gene Sanger sequencing to genome wide sequencing (GWAS) and next generation sequencing. GWAS has allowed to construct polygenic risk scores (PRS) combining the effects of multiple single-nucleotide polymorphisms. PRS could significantly improve VTE risk prediction beyond clinical factors. The integration of genetic and clinical data could improve predictive accuracy. In addition, combining GWAS with transcriptome-wide association studies and Mendelian randomization has shown that genetic risk may change across different clinical presentations of VTE and that recurrent VTE differs genetically and biologically from the initial VTE event, being associated with variants such as those of kininogen 1 and fibrinogen. PRS can stratify VTE risk beyond traditional factors in European-ancestry cohorts; recurrence may have a partially distinct genetic / proteomic architecture, but prospective clinical utility remains to be established and integrating this advanced knowledge into clinical practice remains a future challenge in VTE management.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac implantable electronic devices in patients referred for transcatheter tricuspid edge-to-edge repair: clinical characteristics and impact on procedure eligibility. 经导管三尖瓣边缘到边缘修复患者心脏植入式电子装置：临床特征和对手术资格的影响。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-04 DOI: 10.20452/pamw.17290

Adam Rdzanek, Adam Piasecki, Jacopo Lin, Mariusz Tomaniak, Maria Królikowska, Pavlo Matsko, Agata Markiewicz, Michał Janiel, Ewa Pędzich, Agnieszka Kapłon Cieślicka, Ewa Ostrowska, Paweł Pawłowicz, Jarosław Trębacz, Rafał Gałąska, Patrycjusz Stokłosa, Sebastian Stefaniak, Michał Chmielecki, Paolo Denti, Andrzej Gackowski, Marek Grygier, Jerzy Pręgowski, Marcin Grabowski, Piotr Scisło, Francesco Maisano

引用次数: 0

A rare case of craniopharyngioma in the pituitary stalk region mimicking lymphocytic hypophysitis. 罕见的垂体柄区颅咽管瘤表现为淋巴细胞性垂体炎。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-04 DOI: 10.20452/pamw.17289

Adrian Czechowski, Ewelina Rzepka, Edyta Tkacz, Grzegorz Zieliński, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk

引用次数: 0

Cladribine treatment of a young patient with isolated progressive pulmonary Langerhans histiocytosis complicated by invasive aspergillosis. 克拉德宾治疗一例孤立进行性肺朗格汉斯组织细胞增多症合并侵袭性曲霉病的年轻患者。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-04 DOI: 10.20452/pamw.17292

Piotr Piekarczyk, Mateusz Pajer, Włodzimierz Kupis, Emil Wojda, Urszula Nowicka, Elżbieta Radzikowska

引用次数: 0

Interstitial lung abnormalities progression upon treatment with cabazitaxel for metastatic prostate cancer. 卡巴他赛治疗转移性前列腺癌后肺间质异常进展。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-05-04 DOI: 10.20452/pamw.17291

Martyna Pniaczek, Stanisław Boznański, Natalia Kowalska, Emil Szmalec, Aleksandra Wojnarska, Krzysztof Sładek

引用次数: 0

Three-dimensional catheter ablation of atypical atrial flutter in a lung transplant recipient. 三维导管消融治疗肺移植受者不典型心房扑动。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-17 DOI: 10.20452/pamw.17256

Przemysław Rusztyn, Michał M Farkowski, Bartosz Mruk, Mariusz Kowalewski, Piotr Korczyński, Robert J Gil

引用次数: 0

Biological and targeted synthetic treatment of SAPHO syndrome: systematic literature review. SAPHO综合征的生物学和靶向性综合治疗：系统文献综述。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 DOI: 10.20452/pamw.17286

Jakub Wroński, Agnieszka Adamska, Jagoda Urba, Agnieszka Foryś, Emilia Kudraszewska

{"title":"Biological and targeted synthetic treatment of SAPHO syndrome: systematic literature review.","authors":"Jakub Wroński, Agnieszka Adamska, Jagoda Urba, Agnieszka Foryś, Emilia Kudraszewska","doi":"10.20452/pamw.17286","DOIUrl":"https://doi.org/10.20452/pamw.17286","url":null,"abstract":"Introduction: SAPHO syndrome is a rare autoimmune/autoinflammatory disorder with no approved therapies or standardized management guidelines. Biologic and targeted synthetic DMARDs (b/tsDMARDs) are increasingly used off-label.Objectives: This review systematically evaluates the evidence for their efficacy in SAPHO.Patients and methods: A PRISMA-guided search of PubMed was conducted through March 31, 2025. Studies of any design reporting outcomes of b/tsDMARDs in patients with SAPHO fulfilling the modified Kahn criteria were included. Exclusion criteria were non-English language, inaccessible full text, and insufficient treatment details. Data on patient characteristics, drug class, follow-up duration, and treatment response were extracted. Because all included studies were case reports or case series, the risk of bias was not assessed. Treatment responses were summarized using descriptive statistics.Results: Of 1,610 screened records, 106 studies comprising 385 instances of b/tsDMARD use met the inclusion criteria; no randomized controlled trials were identified. TNF inhibitors were used in 203 patients, with complete skeletal and skin responses in 81% and 72%, respectively. JAK inhibitors (77 patients) were associated with reported complete response rates of 89% (skeletal) and 94% (skin). Other b/tsDMARD classes-including IL-17, IL-23, IL-1, and IL-6 inhibitors, as well as PDE4 inhibitors-demonstrated variable and generally lower efficacy.Conclusions: Evidence for b/tsDMARDs in SAPHO remains limited to low-quality, uncontrolled studies with substantial heterogeneity and probable publication bias. TNF and JAK inhibitors are among the most consistently effective therapies reported in the available literature, but high-quality research, including randomized trials or prospective registries, is urgently needed to inform evidence-based management.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0