Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献_第2页

Opioid crisis and opiophobia in Poland: doctors' perceptions of opioids and the role of cannabinoids in the opioid-sparing approach. 阿片类药物危机和阿片类药物恐惧症在波兰：医生对阿片类药物的看法和大麻素在阿片类药物节约方法中的作用。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-10 DOI: 10.20452/pamw.17248

Michał Graczyk, Łukasz Pawlak, Katarzyna Mądra-Gackowska

引用次数: 0

Mechanical thrombectomy as a bailout therapy for highly resistant coronary thrombus in a young patient with ST-segment elevation myocardial infarction. 机械取栓术作为年轻st段抬高型心肌梗死患者高抵抗性冠状动脉血栓的救助治疗。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-25 DOI: 10.20452/pamw.17264

Szymon Glanowski, Alicja Czech, Anna Manikowska, Łukasz Niewiara, Jacek Legutko, Paweł Kleczyński

引用次数: 0

TERT promoter variants in risk stratification of Polish patients with papillary thyroid carcinoma. 波兰甲状腺乳头状癌患者风险分层中的TERT启动子变异。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-17 DOI: 10.20452/pamw.17252

Dagmara Rusinek, Aleksandra Pfeifer, Jolanta Krajewska, Jadwiga Zebracka-Gala, Malgorzata Kowalska, Sebastian Student, Ewa Zembala-Nozynska, Ewa Chmielik, Barbara Jarzab, Marta Cieslicka, Agnieszka Czarniecka, Malgorzata Oczko-Wojciechowska

{"title":"TERT promoter variants in risk stratification of Polish patients with papillary thyroid carcinoma.","authors":"Dagmara Rusinek, Aleksandra Pfeifer, Jolanta Krajewska, Jadwiga Zebracka-Gala, Malgorzata Kowalska, Sebastian Student, Ewa Zembala-Nozynska, Ewa Chmielik, Barbara Jarzab, Marta Cieslicka, Agnieszka Czarniecka, Malgorzata Oczko-Wojciechowska","doi":"10.20452/pamw.17252","DOIUrl":"10.20452/pamw.17252","url":null,"abstract":"Introduction: Despite extensive research, no independent molecular markers have been identified that could optimize the treatment of patients with papillary thyroid carcinoma (PTC). Proper recurrence risk stratification is crucial for further clinical management and determining the extent of treatment aggressiveness.Objectives: We focused on the TERT promoter (TERTp) variants, identified in previous research as a poor prognostic factor in patients with PTC, with the aim to analyze the clinical utility of TERTp variants in risk‑stratification of PTC patients.Patients and methods: We analyzed a set of 188 PTCs for BRAF V600E and TERTp variants to investigate the associations of TERTp variants with clinical factors and their impact on time‑to‑progression.Results: Key observations included an association between the co‑occurrence of BRAF V600E and TERTp variants and persistent disease, poorer response to treatment, and recurrences, as compared with PTCs without these alterations. The results also suggest that the presence of TERTp variants is associated with a shorter time‑to‑relapse.Conclusions: Detection of TERTp variants should be considered in routine diagnostic procedures, as this would significantly improve patient classification into risk groups.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Nabothian cyst mimicking metastatic disease on post-therapy iodine-131 single-photon emission computed tomography / computed tomography. 治疗后碘-131单光子发射计算机断层扫描/计算机断层扫描显示宫颈纳伯提囊肿模拟转移性疾病。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-04-08 DOI: 10.20452/pamw.17270

Remigiusz Domin, Paulina Ziółkowska, Piotr Stajgis, Paweł Gut, Marek Ruchała, Rafał Czepczyński

引用次数: 0

Potassium-competitive acid blockers for erosive reflux disease and stress ulcer prophylaxis: a narrative review. 钾竞争性酸阻滞剂用于糜烂性反流疾病和应激性溃疡预防：叙述性回顾。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 DOI: 10.20452/pamw.17285

Andrea Denegri, Michal Pruc, Pawel Kozyra, Ayman El-Menyar, Lukasz Szarpak, Zbigniew Siudak

{"title":"Potassium-competitive acid blockers for erosive reflux disease and stress ulcer prophylaxis: a narrative review.","authors":"Andrea Denegri, Michal Pruc, Pawel Kozyra, Ayman El-Menyar, Lukasz Szarpak, Zbigniew Siudak","doi":"10.20452/pamw.17285","DOIUrl":"https://doi.org/10.20452/pamw.17285","url":null,"abstract":"Potassium-competitive acid blockers (P-CABs) are the first mechanistically distinct oral acid suppressants to challenge proton pump inhibitors (PPIs) in routine practice. By reversibly inhibiting gastric H+/K+-ATPase without requiring acid activation, they provide rapid onset of action, durable 24-hour acid control, and less dependence on meal timing and CYP2C19 variability. These pharmacologic features are clinically relevant in acid-related disorders, but the clinical evidence is not uniform across individual compounds. Within the class, the most mature efficacy and safety data are derived from vonoprazan, whereas newer agents, including zastaprazan, remain supported by a more limited evidence base. In erosive esophagitis, randomized trials indicate that P-CABs are effective acid suppressants, but compound-specific conclusions are more appropriate than broad assumptions of interchangeable class effects. For zastaprazan specifically, phase III data show that 20 mg is noninferior to esomeprazole 40 mg at week 8, with higher week-4 healing rates in a predominantly low-grade population. By contrast, no clinical trials have directly evaluated any P-CAB for stress ulcer prophylaxis in critically ill adults. Current intensive care unit guidelines continue to support PPIs or histamine-2 receptor antagonists for patients at high risk of stress-related gastrointestinal bleeding, and pantoprazole remains the best-established benchmark. This review integrates mechanistic, pharmacokinetic, efficacy, safety, regulatory, and guideline data relevant to P-CABs, with particular attention to zastaprazan, while distinguishing compound-specific findings from broader class-level considerations.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrections: Large mass in the left atrium: the importance of proper anticoagulation. 纠正：左心房大肿块：适当抗凝的重要性。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 DOI: 10.20452/pamw.17282

引用次数: 0

Systematic review and meta-analysis of the safety and efficacy of transvenous lead extraction in octogenarian patients. 八十多岁患者经静脉拔铅的安全性和有效性的系统回顾和荟萃分析。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-05 DOI: 10.20452/pamw.17246

Gerald Drożdż, Adrian Doroszko, Waldemar Banasiak, Malgorzata Sobieszczanska, Kuba Ptaszkowski, Dariusz Jagielski

{"title":"Systematic review and meta-analysis of the safety and efficacy of transvenous lead extraction in octogenarian patients.","authors":"Gerald Drożdż, Adrian Doroszko, Waldemar Banasiak, Malgorzata Sobieszczanska, Kuba Ptaszkowski, Dariusz Jagielski","doi":"10.20452/pamw.17246","DOIUrl":"10.20452/pamw.17246","url":null,"abstract":"Introduction: As the global population ages and the use of cardiac implantable electronic devices (CIEDs) increases, transvenous lead extraction (TLE) is being performed more frequently in elderly patients. Concerns remain regarding its safety and efficacy in octogenarians, and age‑specific recommendations are limited.Objectives: We aimed to assess procedural success, complication rates, and mortality associated with TLE in patients aged 80 years or older in comparison with younger individuals.Patients and methods: A systematic search of PubMed, Cochrane CENTRAL, SciELO, and ScienceDirect was conducted up to December 2024. Studies reporting TLE outcomes in octogenarians and younger patients were included according to predefined criteria. A meta‑analysis was performed to compare procedural success, complications, and mortality between the age groups.Results: Seventeen studies including 15 984 patients were analyzed. Complete lead extraction success was 96.7% in octogenarians and 96.2% in the patients aged below 80 years. No significant differences were observed in major or minor procedural complications. In‑hospital mortality was low and comparable between the groups. Although long‑term mortality was higher in the octogenarians, this reflected greater baseline comorbidity and frailty rather than increased procedural risk. None of the included studies demonstrated higher periprocedural danger of TLE in elderly patients.Conclusions: TLE is safe and effective in patients aged 80 years and older, with outcomes comparable to younger individuals. Advanced age alone should not preclude referral for lead extraction.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabry cardiomyopathy: a mixed pattern of ischemic and nonischemic myocardial injury. 法布里心肌病：缺血性和非缺血性心肌损伤的混合模式。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-20 DOI: 10.20452/pamw.17262

Mateusz Lucki, Michał Lesiak, Tomasz Smukowski, Maciej Lesiak

引用次数: 0

When rare matters: aortic valve destruction in myeloperoxidase antineutrophil cytoplasmic antibody-associated microscopic polyangiitis. 罕见情况：主动脉瓣破坏伴髓过氧化物酶引起的抗中性粒细胞细胞质抗体相关性显微多血管炎。

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-17 DOI: 10.20452/pamw.17257

Katarzyna Romejko, Ksymena Leśniak, Julia Hanke, Magdalena Potapowicz-Krysztofiak, Karol Gawalski, Stanisław Niemczyk

引用次数: 0

Lipoprotein(a) and clinical outcomes after transcatheter aortic valve implantation: a prospective, multicenter cohort study. 经导管主动脉瓣植入术后脂蛋白(a)和临床结果：一项前瞻性、多中心队列研究

IF 4.7 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2026-04-29 Epub Date: 2026-03-17 DOI: 10.20452/pamw.17253

Grzegorz Procyk, Paweł Tyrna, Izabela Młynarczuk-Biały, Jan Budzianowski, Anna Olasińska-Wiśniewska, Janusz Kochman, Aleksandra Gąsecka

{"title":"Lipoprotein(a) and clinical outcomes after transcatheter aortic valve implantation: a prospective, multicenter cohort study.","authors":"Grzegorz Procyk, Paweł Tyrna, Izabela Młynarczuk-Biały, Jan Budzianowski, Anna Olasińska-Wiśniewska, Janusz Kochman, Aleksandra Gąsecka","doi":"10.20452/pamw.17253","DOIUrl":"10.20452/pamw.17253","url":null,"abstract":"Introduction: Severe aortic stenosis (AS) can be treated with transcatheter aortic valve implantation (TAVI). There is emerging evidence suggesting that high lipoprotein(a) (Lp[a]) levels may be associated with worse outcomes after TAVI.Objectives: We aimed to compare major adverse cardiac and cerebrovascular events (MACCEs) within 12 months after TAVI and long‑term survival in patients with high and low Lp(a) levels.Patients and methods: In this prospective, multicenter cohort study we included patients with severe AS qualified for TAVI with stored plasma available for Lp(a) measurement. The patients were stratified into high- and low‑Lp(a) groups (cutoff, 30 mg/dl). Two primary end points were 12‑month MACCE and long‑term overall survival. Secondary end points were individual components of MACCE.Results: Between November 2018 and September 2021, TAVI was performed across 3 clinical sites; stored plasma was available for Lp(a) level measurement in 82 patients. We observed no difference in MACCE occurrence in the high- and low‑Lp(a) groups. In unadjusted analyses, the patients with elevated Lp(a) levels had worse long‑term survival during median follow‑up of 2.8 years (log‑rank P = 0.045) but this difference lost significance after adjustments for age and sex in a Cox regression model (hazard ratio, 2.85; 95% CI, 0.85-9.55; P = 0.054). None of the secondary end points differed significantly between the groups.Conclusions: The patients with elevated Lp(a) level had a comparable risk of 12‑month MACCE after TAVI to those with low Lp(a) level but might have worse long‑term survival. Long‑term findings should be considered exploratory and require further confirmation.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0