Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"Long-term follow-up after successful multistage intravascular repair of acute aortic dissection associated with cocaine exposure.","authors":"Rafał Maciąg, Ignacy Sterliński, Zbigniew Gałązka, Andrzej Januszewicz, Reinhold Kreutz, Magdalena Januszewicz","doi":"10.20452/pamw.17321","DOIUrl":"10.20452/pamw.17321","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating metabolomic and lipidomic profiles distinguish patients with de novo acute heart failure and worsening of heart failure.","authors":"Michał Tkaczyszyn, Mateusz Guzik, Gracjan Iwanek, Robert Zymliński, Piotr Gajewski, Paulina Fortuna, Gabriela Maciejewska, Łukasz Lewandowski, Mariusz Fleszar, Piotr Ponikowski, Jan Biegus","doi":"10.20452/pamw.17337","DOIUrl":"10.20452/pamw.17337","url":null,"abstract":"<p><strong>Introduction: </strong>We hypothesized that de novo acute heart failure (AHF) and worsening of pre-existing HF (WHF) reflect distinct underlying metabolic states.</p><p><strong>Objectives: </strong>Our aim was to compare the circulating metabolomic and lipidomic profiles in de novo AHF and WHF.</p><p><strong>Patients and methods: </strong>We performed metabolomic and lipidomic analyses of venous blood collected from 274 patients admitted for AHF to a single tertiary referral cardiology center between 2021 and 2023.</p><p><strong>Results: </strong>WHF patients (67%) were older, more often had coronary artery disease, and presented with slightly higher left ventricular ejection fraction. De novo AHF was characterized by higher levels of sphingolipids, angiotensin (1-7), and purine-related metabolites, indicating a proinflammatory and proapoptotic state and oxidative stress, with metabolomic signals of neurohormonal activation despite no differences in conventional neurohormonal biomarkers. WHF was associated with elevated levels of amino acid derivatives, glucuronidated compounds, and organic acids, which reflect altered energy metabolism and detoxification adaptations. Lipidomic analysis showed higher levels of glycerophospholipids (glycerophosphoethanolamines [GPEtn], glycerophosphoglycerols, glycerophosphates, and sulfoquinovosyldiacylglycerols) and lower levels of sphingomyelins and selected GPEtn species in WHF, which may be related to impaired cellular membrane integrity or cellular injury. Biomarkers of catabolism and inflammation were also associated with pre-existing disease. In exploratory Cox modeling, several metabolites demonstrated reproducible associations with 12-month all-cause mortality independent of clinical covariates.</p><p><strong>Conclusions: </strong>De novo AHF was characterized by a metabolomic profile indicative of a pro-inflammatory state and neurohormonal activation, while patients hospitalized for exacerbated pre-existing disease presented with metabo-lipidomic signatures of abnormal energy metabolism, catabolic state, and cellular injury.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of pericarditis: recent advances.","authors":"Massimo Imazio","doi":"10.20452/pamw.17327","DOIUrl":"10.20452/pamw.17327","url":null,"abstract":"<p><p>Pericarditis is the most frequent pericardial syndrome and a common cause of chest pain in emergency and cardiology practice. Over the past 2 decades, its management has moved from largely empirical anti‑inflammatory treatment toward a mechanism‑based, risk‑stratified, and imaging‑supported approach. Diagnosis remains clinical, based on the presence of typical chest pain, pericardial rub, electrocardiographic changes, and pericardial effusion; yet, inflammatory biomarkers and multimodality imaging, especially cardiac magnetic resonance, increasingly support diagnostic confidence, differential diagnosis, and therapeutic decision‑making. For most patients with acute idiopathic or presumed viral pericarditis, aspirin or a nonsteroidal anti‑inflammatory drug combined with colchicine is the first‑line therapy, with exercise restriction recommendations and follow‑up guided by symptoms and C‑reactive protein level. Corticosteroids should be avoided when possible, or used at low‑to‑moderate doses only for selected indications, because they promote chronicity and recurrence in unselected cases. A major recent advance is the recognition of recurrent pericarditis as an autoinflammatory, interleukin (IL)-1-mediated disease in a substantial proportion of patients with an inflammatory phenotype. Data from randomized trials and registries now support IL‑1 inhibition (eg, anakinra or rilonacept) in corticosteroid‑dependent and colchicine‑resistant recurrent pericarditis, as such treatment is associated with rapid symptom control, possibility to withdraw corticosteroids, and marked reduction in recurrences. Remaining challenges include optimal treatment duration, cost of and access to biologics, management of patients without overt systemic inflammation, and personalized strategies for tapering and return to activity.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversation aids with absolute estimates and certainty of evidence to elicit people's perspectives on reducing saturated fat intake: a cross‑sectional regional survey in 7 countries.","authors":"Małgorzata Maraj, Anna Prokop-Dorner, Claudia Valli, Marija F Žuljević, Danielle M de S S Dos Santos Danielle M de S S Dos Santos, Qi Wang, Nirjhar R Ghosh, Jessica Gillespie-Friesen, Boris C Reyes, Clara Pons Boyero, Sylwia Warzecha, Joanna Zając, Heloísa Theodoro, Luis P N Lopes, Lehana Thabane, Karolina Majdak, Katarzyna Zawisza, Anton Svendrovski, Long Ge, Tina Poklepović-Peričić, Luciane Cruz Lopes, Pablo Alonso-Coello, Gordon H Guyatt, Bradley C Johnston, Małgorzata M Bała","doi":"10.20452/pamw.17303","DOIUrl":"10.20452/pamw.17303","url":null,"abstract":"<p><strong>Introduction: </strong>Patients are increasingly recognized as key interest holders in health care decision‑making. Integrating patient perspective is crucial to patient‑centered, evidence‑based nutrition guideline recommendations.</p><p><strong>Objectives: </strong>Our aim was to examine individual willingness to decrease consumption of foods high in saturated fatty acids (SFAs) after being informed about the estimated absolute risk reduction (ARR) of myocardial infarction (MI), together with the certainty of the supporting evidence based on a Cochrane systematic review.</p><p><strong>Patients and methods: </strong>Respondents from 7 countries were presented with a conversation aid with the ARR of MI, together with the certainty of evidence, and asked about their willingness to reduce their intake of SFA‑rich foods. Using a multivariable logistic regression model, we explored 12 variables to identify factors underlying respondent willingness to introduce dietary fat changes.</p><p><strong>Results: </strong>We analyzed 3663 respondents from Brazil, Canada, China, Croatia, Poland, Spain, and the United States. Overall, 50.2% were willing to reduce their SFA intake. Women (odds ratio [OR], 1.51; 95% CI, 1.29-1.77), nonomnivores (OR, 1.73; 95% CI, 1.37-2.19), and respondents from Spain, China, and Brazil (OR, 2.45; 95% CI, 1.83-3.27; OR, 4.36; 95% CI, 3.49-5.45; and OR, 1.31; 95% CI, 1.08-1.58, respectively) showed greater willingness, whereas those from Croatia or holding a university degree showed lower willingness (OR, 0.7; 95% CI, 0.51-0.95; OR, 0.73; 95% CI, 0.61-0.87, respectively).</p><p><strong>Conclusions: </strong>The significant variation in people willingness (depending, eg, on sex, education levels, or dietary pattern) to reduce their intake of SFA‑rich foods underscores potential importance of incorporating patient preference when developing dietary guideline recommendations, and of promoting individualized evidence‑based care using absolute effects and certainty of evidence.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Links of BMP4, BMPR1A and GREM1 expression in subcutaneous and visceral adipose tissue with metabolic syndrome and their regulation by insulin and weight loss.","authors":"Marta Dobrzycka, Magdalena Stefanowicz, Natalia Matulewicz, Agnieszka Nikołajuk, Piotr Myśliwiec, Jacek Dadan, Irina Kowalska, Monika Karczewska-Kupczewska","doi":"10.20452/pamw.17391","DOIUrl":"https://doi.org/10.20452/pamw.17391","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas diffusion during endoscopic argon plasma coagulation may mimic gastrointestinal perforation.","authors":"Michal Aporowicz, Michal Sowa, Anna Sliwa, Krzysztof Kaliszewski","doi":"10.20452/pamw.17389","DOIUrl":"https://doi.org/10.20452/pamw.17389","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus anticoagulant testing pre- and post-direct oral anticoagulants removal procedure in patients suspected of antiphospholipid syndrome: a real-life experience.","authors":"Joanna Ochotnicka, Magdalena Spryńca, Aleksandra Mosurek, Anetta Undas, Ewa Wypasek","doi":"10.20452/pamw.17390","DOIUrl":"https://doi.org/10.20452/pamw.17390","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the gap: isotretinoin-induced axial spondyloarthritis mimicking nonradiographic axial spondyloarthritis.","authors":"Konrad Kaleta, Kamil Możdżeń, Anna Smardz, Jarosław Nowakowski, Mariusz Korkosz, Katarzyna Wawrzycka-Adamczyk","doi":"10.20452/pamw.17387","DOIUrl":"https://doi.org/10.20452/pamw.17387","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary vein thrombosis presenting with a stroke as a complication of metastatic adrenocortical carcinoma.","authors":"Jan Domański, Mateusz Mucha, Zuzanna Roszkowska, Adrianna Gładka, Małgorzata Bobrowicz, Urszula Ambroziak","doi":"10.20452/pamw.17383","DOIUrl":"https://doi.org/10.20452/pamw.17383","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Perugini grade 3 99mTc-DPD uptake does not indicate transthyretin amyloid cardiomyopathy: a mass spectrometry-confirmed case of AL cardiac amyloidosis.","authors":"Daria Keller, Paulina Ziółkowska, Sylwia Sławek-Szmyt, Justyna Rajewska-Tabor, Dominik Dytfeld, Ewa Straburzyńska-Migaj","doi":"10.20452/pamw.17382","DOIUrl":"10.20452/pamw.17382","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}