Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"Rare immune adverse event in the treatment of non-small-cell lung carcinoma: durvalumab-associated optic neuritis.","authors":"Grzegorz Chmielewski, Rafał Stando, Katarzyna Amanowicz","doi":"10.20452/pamw.17056","DOIUrl":"10.20452/pamw.17056","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patients with primary biliary cholangitis treated with ursodeoxycholic acid.","authors":"Magdalena Rogalska, Aleksandra Berkan-Kawińska, Jakub Klapaczyński, Witold Musierowicz, Krystyna Dobrowolska, Marta Wawrzynowicz-Syczewska, Jerzy Jaroszewicz, Włodzimierz Mazur, Krzysztof Tomasiewicz, Piotr Zieliński, Dorota Zarębska-Michaluk, Robert Flisiak","doi":"10.20452/pamw.17071","DOIUrl":"10.20452/pamw.17071","url":null,"abstract":"<p><strong>Introduction: </strong>Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease. Despite established first‑line therapy with ursodeoxycholic acid (UDCA), many patients do not achieve biochemical remission. Data on the characteristics of PBC in Poland remain limited.</p><p><strong>Objectives: </strong>The aim of this study was to characterize demographic, clinical, and serological features of Polish patients with PBC and the effects of treatment in a multicenter retrospective cohort.</p><p><strong>Patients and methods: </strong>A total of 364 patients from 10 hepatology centers were included. Data on demographics, laboratory tests, autoantibodies, and markers of the disease severity were collected between January 6 and March 8, 2025 and analyzed according to the duration of UDCA treatment (<2 vs ≥2 years).</p><p><strong>Results: </strong>Women constituted 92.3% of the cohort. Most patients were aged 60-80 years, but the proportion of men was relatively higher in the groups below 50 and over 80 years old. Cirrhosis was diagnosed in 35.2% of the patients. Antimitochondrial antibodies were present in 94.4%, and anti‑Ro52 antibodies in 34.1% of the study participants. Anti‑gp210 and anti‑sp100 antibodies were more frequent in the patients with longer disease duration. No substantial differences in liver biochemistry were found between short- and long‑term UDCA use groups, except for lower γ‑glutamyl transferase activity with longer treatment. Despite pruritus found in 46% of the patients, antipruritic therapy was rarely used.</p><p><strong>Conclusions: </strong>This is the first national study to characterize PBC in Poland. Its findings suggest limited long‑term efficacy of UDCA and unmet needs in symptom management. Anti‑gp210, anti‑sp100, and anti‑Ro52 antibodies may serve as important serologic markers. Prospective studies are needed to confirm these observations.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edmund Biernacki: a forgotten father of clinical hematology.","authors":"Anna Maria Jurczyszyn, Michał Bator, Artur Jurczyszyn, Ryszard W Gryglewski","doi":"10.20452/pamw.17107","DOIUrl":"10.20452/pamw.17107","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of thoracoabdominal tumor with intracardiac extension in a young woman.","authors":"Michał Majewski, Andrzej Kułach, Edward Pietrzyk, Nina Zbylut, Marcin Misiek, Grzegorz Smolka","doi":"10.20452/pamw.17072","DOIUrl":"10.20452/pamw.17072","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic foot syndrome in a woman without obesity with newly diagnosed diabetes.","authors":"Izabela Koch-Koźlak, Magdalena Michalak, Maciej Chudziński, Dorota Zozulińska-Ziółkiewicz, Aleksandra Araszkiewicz","doi":"10.20452/pamw.17059","DOIUrl":"10.20452/pamw.17059","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Watermelon stomach and recurrent anemia in a patient with heart failure and permanent atrial fibrillation.","authors":"Mikołaj Derewońko, Magdalena Dudek, Małgorzata Tomaszewska, Filip Waśniewski, Ewa Straburzyńska-Migaj, Marta Kałużna-Oleksy","doi":"10.20452/pamw.17089","DOIUrl":"10.20452/pamw.17089","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits from statins in anticoagulated venous thromboembolism patients: recent advances.","authors":"Carmine Siniscalchi, Manuela Basaglia, Pierpaolo Di Micco, Alberto Parise, Nicoletta Cerundolo, Tiziana Meschi","doi":"10.20452/pamw.17058","DOIUrl":"10.20452/pamw.17058","url":null,"abstract":"<p><p>Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, remains a major cause of morbidity and mortality worldwide. Although oral anticoagulation is the cornerstone of VTE treatment, recurrent events and long‑term complications, such as post‑thrombotic syndrome, persist in a significant proportion of patients. Recent evidence suggests that statins, traditionally used for lipid‑lowering therapy, may exert pleiotropic beneficial effects in patients with VTE, particularly those already receiving anticoagulants. These benefits include anti‑inflammatory, antithrombotic (eg, anticoagulant, antiplatelet, and profibrinolytic actions), endothelial‑stabilizing, and immunomodulatory properties. Clinical and observational studies have highlighted that statin use is associated with reduced risk of recurrent VTE and improved survival, even in the absence of hyperlipidemia. This review synthesizes the current evidence on the role of statins in anticoagulated patients with VTE, exploring mechanistic insights, clinical trial data, and real‑world findings. We also discuss the potential synergistic effects between statins and anticoagulants, as well as safety considerations, particularly in elderly and polymedicated populations. Furthermore, we address the limitations of existing studies and outline future research directions to establish whether statins should be systematically considered in secondary prevention strategies for VTE. In conclusion, statins appear to confer significant adjunctive benefits in anticoagulated VTE patients, with an acceptable safety profile. Integration of statins into VTE management may represent a cost‑effective and widely accessible intervention to enhance patient outcomes, though prospective randomized controlled trials are still needed to confirm causality and determine the optimal use.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting the genetic landscape of dilated cardiomyopathy in Poland: first insights from a national perspective.","authors":"Paweł Rubiś","doi":"10.20452/pamw.17125","DOIUrl":"10.20452/pamw.17125","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrections: Association between atrial fibrillation and cognitive performance in older individuals.","authors":"","doi":"10.20452/pamw.17126","DOIUrl":"https://doi.org/10.20452/pamw.17126","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 9","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peutz-Jeghers syndrome as a sign of prostate cancer progression.","authors":"Justyna Putek, Jacek C Szepietowski","doi":"10.20452/pamw.17053","DOIUrl":"10.20452/pamw.17053","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}