Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"The efficacy of pasireotide treatment in a patient with Crooke cell adenoma.","authors":"Katarzyna Maliszewska, Anna Popławska-Kita, Aleksandra Gilis-Januszewska, Przemysław Witek, Tomasz Łyson, Adam Kretowski","doi":"10.20452/pamw.16928","DOIUrl":"10.20452/pamw.16928","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic liver disease in patients treated for chronic hepatitis B.","authors":"Jakub Janczura, Michał Brzdęk, Krystyna Dobrowolska, Robert Flisiak, Diana Martonik, Kinga Brzdęk, Robert Pleśniak, Dominika Kukla-Woźnica, Małgorzata Wajdowicz, Dorota Zarębska-Michaluk","doi":"10.20452/pamw.16942","DOIUrl":"10.20452/pamw.16942","url":null,"abstract":"<p><strong>Introduction: </strong>Steatotic liver disease (SLD) can worsen the prognosis of other chronic liver diseases, including viral hepatitis.</p><p><strong>Objectives: </strong>The aim of the study was to assess patients with chronic hepatitis B virus (HBV) infection according to the presence or absence of SLD.</p><p><strong>Patients and methods: </strong>The study included consecutive white patients with chronic hepatitis B treated with nucleos(t)ide analogs (NAs), entecavir or tenofovir, for a median (interquartile range) of 6 (2-11) years, and evaluated between January 2023 and June 2024.</p><p><strong>Results: </strong>Of the 273 patients included in the analysis, 86 were diagnosed with SLD. Men constituted the majority of the overall population, with a higher percentage in the SLD group (77.9% vs 63.6%; P = 0.02). The burden of comorbidities was higher in the SLD group than in the non‑SLD group (P <0.001), including obesity (P <0.001), diabetes (P = 0.004), and gout (P = 0.03). Cirrhosis was diagnosed in 16.3% of the patients with SLD and 11.8% of those without SLD (P = 0.31). Aminotransferase activity was higher in the SLD group (P <0.001), while HBe antigen positivity was significantly less frequent in this population, and HBV DNA viral load was comparable between the groups. More than 97% of all patients achieved HBV DNA clearance during therapy, with a negative rate of 69.5% and 66.7% in the SLD and non‑SLD groups, respectively, after 1 year of treatment.</p><p><strong>Conclusion: </strong>Liver steatosis was diagnosed in nearly one‑third of HBV‑infected patients treated with NAs. These patients were more likely to have obesity, diabetes, and gout, as compared with the non‑SLD population. Despite higher baseline aminotransferase activity in the SLD group, virological HBV activity and response to therapy were comparable between the patients with and without SLD.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in medical writing: the inconvenient truth behind our automated future.","authors":"Anastasios Koulaouzidis, George Koulaouzidis, Maria Marlicz, Dafni Charisopoulou, Wojciech Marlicz","doi":"10.20452/pamw.16985","DOIUrl":"https://doi.org/10.20452/pamw.16985","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"135 3","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maturity-onset diabetes of the young type 5 as one of the least common forms of monogenic diabetes.","authors":"Edyta Cichocka, Beata Kwiatek, Marta Stachowska, Janusz Gumprecht","doi":"10.20452/pamw.16929","DOIUrl":"10.20452/pamw.16929","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenge of oncocytic adrenal neoplasm of uncertain malignant potential.","authors":"Karolina Węgrzyn, Grzegorz Sokołowski, Marcin Motyka, Anna Grochowska, Alicja Hubalewska-Dydejczyk, Marta Opalińska","doi":"10.20452/pamw.16932","DOIUrl":"10.20452/pamw.16932","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misleading diagnosis of ST-segment elevation myocardial infarction in a patient receiving 5-fluorouracil.","authors":"Artur Dziewierz, Dariusz Łukasik, Andrzej Witkowski, Łukasz Wiśniowski, Francesco Pelliccia, Tomasz Rakowski","doi":"10.20452/pamw.16979","DOIUrl":"https://doi.org/10.20452/pamw.16979","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirolimus treatment of generalized lymphatic anomaly with a set of congenital defects.","authors":"Piotr Piekarczyk, Katarzyna Błasińska, Mateusz Polaczek, Magdalena Bilny-Paluch, Elżbieta Radzikowska","doi":"10.20452/pamw.16977","DOIUrl":"https://doi.org/10.20452/pamw.16977","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic features and therapeutic dilemmas in a patient with clinically significant multivalvular disease and the left atrial appendage thrombus.","authors":"Weronika Basak, Ewa Wlazłowska-Struzik, Paweł Szymkiewicz, Krzysztof Wróbel, Piotr Pruszczyk, Katarzyna Kurnicka","doi":"10.20452/pamw.16976","DOIUrl":"https://doi.org/10.20452/pamw.16976","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative stress perfusion cardiovascular magnetic resonance: clinical implications for patients with suspected myocardial ischemia.","authors":"Sonia Borodzicz-Jazdzyk, Roel Hoek, Caitlin E M Vink, Geoffrey W de Mooij, Adriaan Wilgenhof, Luuk H G A Hopman, Mitchel Benovoy, Marco J W Götte","doi":"10.20452/pamw.16975","DOIUrl":"https://doi.org/10.20452/pamw.16975","url":null,"abstract":"<p><strong>Introduction: </strong>Recent technical advances in stress perfusion cardiovascular magnetic resonance (CMR) allow for myocardial blood flow (MBF) quantification (quantitative perfusion CMR; QP CMR). However, clinical utility of QP CMR compared to conventional grey scale qualitative assessment (QA) is unknown.</p><p><strong>Objectives: </strong>The study aimed to compare the clinical conclusions on ischemia detection derived from conventional grey-scale QA of stress perfusion CMR imaging and QP CMR in a real-world population of patients with suspected myocardial ischemia.</p><p><strong>Patients and methods: </strong>This study retrospectively analyzed 101 patients with suspected myocardial ischemia referred for adenosine stress perfusion CMR imaging. QA of grey-scale first-pass perfusion CMR was performed by level 3 CMR experts. In QP, stress and rest MBF (ml/g/min) were calculated for automatically determined myocardial segments. Each patient and coronary territory was classified by both QA and QP, in a blinded manner, as either ischemic or non-ischemic.  Results: QP classified more coronary territories as ischemic compared to QA (46% vs. 17%, P <0.001). In the per-patient analysis, QP diagnosed myocardial ischemia in 64 patients (63%), and QA in 40 (40%) (P <0.001). Ischemia was diagnosed by QA but not QP in 7% of patients  (QA+/QP-). In 31% of patients, QP established a new diagnosis of myocardial ischemia (QA-/QP+).</p><p><strong>Conclusion: </strong>QP CMR detects more ischemic coronary territories compared to QA and holds promise for identifying cases of myocardial ischemia that may be overlooked by QA alone in a real-world patient population.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic profile associated with coronary artery disease: a higher level of indoleamine 2,3-dioxygenase activity and lower tryptophan concentrations predict a worse prognosis.","authors":"Marcin Kondraciuk, Małgorzata Chlabicz, Jacek Jamiołkowski, Emilia Sawicka-Śmiarowska, Magda Łapińska, Natalia Sieńkowska, Natalia Zieleniewska, Adrian Godlewski, Michał Ciborowski, Adam Krętowski, Karol A Kamiński","doi":"10.20452/pamw.16974","DOIUrl":"https://doi.org/10.20452/pamw.16974","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolites can lead to novel discoveries in cardiovascular disease (CVD).</p><p><strong>Objectives: </strong>The aim of the study was to investigate whether a metabolomic profile is associated with mortality in patients with coronary artery disease (CAD).</p><p><strong>Methods: </strong>The study group consisted of 170 participants with CAD who were hospitalized due to acute coronary syndrome or elective percutaneous coronary intervention 12-26 months before evaluation (mean[SD] months, 16.3 [2.2]). A total of 132 metabolites were profiled by liquid chromatography-tandem mass spectrometry, and sums/ratios of 102 metabolite concentrations were calculated. Dates of death from all causes were obtained from the Polish Ministry of Digital Affairs.</p><p><strong>Results: </strong>The median age of the group was 62 years (IQR 58-66), 68.8% (n=117) were male. The median follow-up time was 6.4 years (IQR 5.5-6.5). After adjustment for CVD risk factors affecting survival in the population analyzed (i.e. age, statin dose, current smoking, estimated glomerular filtration rate, and high-sensitivity C-reactive protein) with Bonferroni's correction, tryptophan (Trp) was negatively associated with death (HR = 0.558, 95%CI = 0.38-0.82, P = 0.003), whereas indoleamine 2,3-dioxygenase (IDO) activity level was positively associated with death (HR = 2.925, 95%CI = 1.71-5.01, P <0.001). Survival analysis showed that patients with IDO activity levels above he median had statistically worse survival than patients with lower activity levels (log-rank test, P = 0.009). In contrast, patients with Trp concentration below the median had worse survival than those with higher levels (log-rank test,  P = 0.03).</p><p><strong>Conclusions: </strong>In patients with CAD, the increased IDO activity level predicts a worse long-term prognosis independently of known CVD risk factors.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}