Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献

{"title":"A cascade of complications: management of spiral dissection and simultaneous life-threatening remote coronary vasospasm.","authors":"Tomasz Lemek, Jakub Garbacz, Stanisław Bartuś, Michał Chyrchel","doi":"10.20452/pamw.17328","DOIUrl":"10.20452/pamw.17328","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of encephalitis in systemic lupus erythematosus.","authors":"Alicja Szklarska, Joanna Bielewicz, Konrad Rejdak","doi":"10.20452/pamw.17330","DOIUrl":"10.20452/pamw.17330","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin G4-related disease presenting with a giant coronary artery aneurysm.","authors":"Natalia Wiligórska, Anna M Rysiak, Piotr Trochimiuk, Ilona Michałowska, Izabela Wojtkowska","doi":"10.20452/pamw.17350","DOIUrl":"10.20452/pamw.17350","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare clinical presentation of enterococcal aortic valve endocarditis mimicking polymyalgia rheumatica.","authors":"Katarzyna Kurnicka, Martyna Dziewit, Paweł Czub, Krzysztof Wróbel, Marzena Olesińska","doi":"10.20452/pamw.17341","DOIUrl":"10.20452/pamw.17341","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between plasma proteomic profiles and subclinical variations in left atrial strain in adults without overt cardiovascular disease: the role of cardiometabolic factors.","authors":"Marta K Markowska, Małgorzata Chlabicz, Wojciech Łaguna, Natalia Zieleniewska, Marlena Dubatówka, Jacek Jamiołkowski, Natalia Sieńkowska, Marcin Kondraciuk, Karol A Kamiński","doi":"10.20452/pamw.17358","DOIUrl":"10.20452/pamw.17358","url":null,"abstract":"<p><strong>Introduction: </strong>Associations between plasma proteomic profiles and left atrial strain (LAS) may provide insights into biological processes that underly variations in atrial function in adults without overt cardiovascular disease (CVD).</p><p><strong>Objectives: </strong>We aimed to assess the associations between circulating proteins and phasic LAS, and explore the potential influence of cardiometabolic factors on these relationships.</p><p><strong>Patients and methods: </strong>Study participants included individuals from the population of the Bialystok PLUS (Bialystok Polish Longitudinal University Study), examined between 2018 and 2024, including adults aged 35-70 years who had complete echocardiographic data and plasma samples available for proteomic profiling. Individuals with overt cardiovascular, inflammatory, neoplastic, or neurodegenerative disease were excluded. LA reservoir (LASr), conduit (LAScd), and contraction (LASct) strains were assessed on speckle‑tracking echocardiography. Plasma proteomic profiling was performed using the Olink Reveal platform. The associations between 1034 proteins and LAS parameters were analyzed using age‑adjusted linear models with false discovery rate (FDR) correction (<i>q</i> ≤0.1). Additional analyses evaluated the influence of cardiometabolic risk factors and overlap with conventional echocardiographic parameters.</p><p><strong>Results: </strong>The study included 414 adults at a median (interquartile range) age of 51 (43-61) years; 47.3% were men. After age adjustment, significant associations were observed exclusively for LAScd, with 30 proteins meeting the FDR threshold, whereas no proteins showed associations with LASr or LASct. The proteins linked to LAScd were mainly involved in metabolic regulation, inflammation, cellular stress responses, and tissue remodeling. The proteomic signature of LAScd showed only partial overlap with conventional echocardiographic phenotypes. After further adjustment for cardiometabolic risk factors, no associations remained significant after FDR correction.</p><p><strong>Conclusions: </strong>In adults without overt CVD, LAScd was the only component of LAS associated with a distinct age‑adjusted plasma proteomic profile. The observed associations were substantially influenced by cardiometabolic risk factors, suggesting that the identified proteomic patterns primarily reflect underlying cardiometabolic processes. Further longitudinal studies are needed to determine the clinical significance of these findings.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"136 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in biopsy-confirmed kidney disease in the adult population of central Poland: a single-region cohort study of 13-year duration (2011-2023).","authors":"Maja Nowicka, Małgorzata Wągrowska-Danilewicz, Michał Olkowski, Barbara Piekarska, Paweł Edyko, Dariusz Popiela, Ilona Kurnatowska","doi":"10.20452/pamw.17344","DOIUrl":"10.20452/pamw.17344","url":null,"abstract":"<p><strong>Introduction: </strong>Demographic, socioeconomic, and environmental factors, including infections, vaccination, and health care availability, may influence an array of renal diseases.</p><p><strong>Objectives: </strong>This study aimed to examine trends in biopsy‑confirmed kidney disease in the adult Polish population (2011-2023), with emphasis on shifts during and after the COVID‑19 pandemic.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed 1662 first native kidney biopsies performed in the residents of the Lodz voivodeship (central Poland; population, 2 million). Clinical and histopathological data were stratified by age, sex, and time period (pre-COVID‑19, COVID‑19, post-COVID‑19), and compared with those reported by the same center in the years 1990-2010.</p><p><strong>Results: </strong>Between 2011 and 2023, biopsy frequency increased from 43.9 to 102.2 per million population, with a temporary decline during the COVID‑19 pandemic and a significant rise afterwards. The proportion of older patients increased, while nephrotic‑range proteinuria became a less common biopsy indication. During the COVID‑19 pandemic, the patients presented with poorer renal function, and had higher rates of acute kidney disease. Immunoglobulin A nephropathy (IgAN) was the most frequent diagnosis (17.4%), with its proportion increasing during and after the pandemic, followed by focal segmental glomerulosclerosis (FSGS; 16.3%), membranous nephropathy (9.4%), and diabetic kidney disease (DKD; 8%). Frequency of minimal‑change disease declined, other nephropathies remained stable, and a relative rise in tubulointerstitial disorders was observed. In comparison with the years 1990-2010, the annual number of biopsies more than tripled, with a markedly older patient population and increased frequencies of FSGS, DKD, and crescentic glomerulonephritis or necrotizing vasculitis.</p><p><strong>Conclusions: </strong>Over 3 decades, biopsy frequency in the Lodz voivodeship has increased, particularly among older adults, with IgAN becoming the most common diagnosis.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic virtual biopsy for phenotyping of abnormal cardiac masses based on computed tomography: proof-of-concept study.","authors":"Piotr Trochimiuk, Agnieszka Segiet-Święcicka, Mariusz Kruk, Edyta Kaczmarska-Dyrda, Zofia Dzielińska, Marcin Demkow, Cezary Kępka","doi":"10.20452/pamw.17346","DOIUrl":"10.20452/pamw.17346","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiac masses can present a diagnostic challenge on cardiac imaging. Differentiating between tumors, such as myxomas, and non‑neoplastic lesions, such as thrombi, is essential for appropriate management and treatment planning.</p><p><strong>Objectives: </strong>The aim of this study was to explore the feasibility of radiomics‑based \"virtual biopsy\" in distinguishing between different types of cardiac masses on computed tomography (CT).</p><p><strong>Patients and methods: </strong>A total of 89 patients were included in the analysis, of which 42 (47.2%) were diagnosed with myxoma, 37 (41.6%) with thrombus, and 10 (11.2%) had other diagnoses (fibroelastoma in 6 cases [6.7%], sarcoma in 2 cases [2.2%], and angioma and metastasis in 1 case [1.1%] each). Region of interest (ROI) selection and calculation of radiomic features were performed within the syngo.via Frontier Radiomics platform. Three‑dimensional ROI of the cardiac masses for CT examination was manually delineated. A multivariate least absolute shrinkage and selection operator-based model was developed for both binary (thrombus vs tumor) and multiclass (thrombus vs myxoma vs other) classifications.</p><p><strong>Results: </strong>The exploratory multiclass radiomics model demonstrated good preliminary discriminatory performance, with validation areas under the curve ranging from 0.771 to 0.933; however, class‑specific estimates, particularly for the heterogeneous \"other\" category, should be interpreted with caution due to the small validation cohort. These findings suggest that radiomic features can capture subtle differences between distinct cardiac mass types, enabling noninvasive tissue characterization.</p><p><strong>Conclusions: </strong>This proof‑of‑concept study provides the first evidence that a multiclass CT‑based radiomics model can differentiate between myxomas, thrombi, and other cardiac masses. Radiomics‑based virtual biopsy may potentially complement conventional imaging; however, these exploratory findings require validation in larger, multicenter cohorts before clinical application.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney biopsy still rules the diagnosis of glomerular disease: new insights into trends in biopsy-proven kidney disease in Poland.","authors":"Tomasz Stompór, Justyna Zbrzeźniak-Suszczewicz","doi":"10.20452/pamw.17405","DOIUrl":"https://doi.org/10.20452/pamw.17405","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"136 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus anticoagulant testing before and after direct oral anticoagulant removal in patients suspected of antiphospholipid syndrome: a real-life experience.","authors":"Joanna Ochotnicka, Magdalena Spryńca, Aleksandra Mosurek, Anetta Undas, Ewa Wypasek","doi":"10.20452/pamw.17390","DOIUrl":"https://doi.org/10.20452/pamw.17390","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"136 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond thrombus vs tumor: what computed tomography radiomics of cardiac masses must show next.","authors":"Artur Dziewierz, Francesco Pelliccia","doi":"10.20452/pamw.17404","DOIUrl":"https://doi.org/10.20452/pamw.17404","url":null,"abstract":"","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":"136 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}