Clinical characteristics of patients with primary biliary cholangitis treated with ursodeoxycholic acid.

IF 4.7 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Magdalena Rogalska, Aleksandra Berkan-Kawińska, Jakub Klapaczyński, Witold Musierowicz, Krystyna Dobrowolska, Marta Wawrzynowicz-Syczewska, Jerzy Jaroszewicz, Włodzimierz Mazur, Krzysztof Tomasiewicz, Piotr Zieliński, Dorota Zarębska-Michaluk, Robert Flisiak
{"title":"Clinical characteristics of patients with primary biliary cholangitis treated with ursodeoxycholic acid.","authors":"Magdalena Rogalska, Aleksandra Berkan-Kawińska, Jakub Klapaczyński, Witold Musierowicz, Krystyna Dobrowolska, Marta Wawrzynowicz-Syczewska, Jerzy Jaroszewicz, Włodzimierz Mazur, Krzysztof Tomasiewicz, Piotr Zieliński, Dorota Zarębska-Michaluk, Robert Flisiak","doi":"10.20452/pamw.17071","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong> Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease. Despite established first‑line therapy with ursodeoxycholic acid (UDCA), many patients do not achieve biochemical remission. Data on the characteristics of PBC in Poland remain limited.</p><p><strong>Objectives: </strong> The aim of this study was to characterize demographic, clinical, and serological features of Polish patients with PBC and the effects of treatment in a multicenter retrospective cohort.</p><p><strong>Patients and methods: </strong>A total of 364 patients from 10 hepatology centers were included. Data on demographics, laboratory tests, autoantibodies, and markers of the disease severity were collected between January 6 and March 8, 2025 and analyzed according to the duration of UDCA treatment (<2 vs ≥2 years).</p><p><strong>Results: </strong> Women constituted 92.3% of the cohort. Most patients were aged 60-80 years, but the proportion of men was relatively higher in the groups below 50 and over 80 years old. Cirrhosis was diagnosed in 35.2% of the patients. Antimitochondrial antibodies were present in 94.4%, and anti‑Ro52 antibodies in 34.1% of the study participants. Anti‑gp210 and anti‑sp100 antibodies were more frequent in the patients with longer disease duration. No substantial differences in liver biochemistry were found between short- and long‑term UDCA use groups, except for lower γ‑glutamyl transferase activity with longer treatment. Despite pruritus found in 46% of the patients, antipruritic therapy was rarely used.</p><p><strong>Conclusions: </strong> This is the first national study to characterize PBC in Poland. Its findings suggest limited long‑term efficacy of UDCA and unmet needs in symptom management. Anti‑gp210, anti‑sp100, and anti‑Ro52 antibodies may serve as important serologic markers. Prospective studies are needed to confirm these observations.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20452/pamw.17071","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction:  Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease. Despite established first‑line therapy with ursodeoxycholic acid (UDCA), many patients do not achieve biochemical remission. Data on the characteristics of PBC in Poland remain limited.

Objectives:  The aim of this study was to characterize demographic, clinical, and serological features of Polish patients with PBC and the effects of treatment in a multicenter retrospective cohort.

Patients and methods: A total of 364 patients from 10 hepatology centers were included. Data on demographics, laboratory tests, autoantibodies, and markers of the disease severity were collected between January 6 and March 8, 2025 and analyzed according to the duration of UDCA treatment (<2 vs ≥2 years).

Results:  Women constituted 92.3% of the cohort. Most patients were aged 60-80 years, but the proportion of men was relatively higher in the groups below 50 and over 80 years old. Cirrhosis was diagnosed in 35.2% of the patients. Antimitochondrial antibodies were present in 94.4%, and anti‑Ro52 antibodies in 34.1% of the study participants. Anti‑gp210 and anti‑sp100 antibodies were more frequent in the patients with longer disease duration. No substantial differences in liver biochemistry were found between short- and long‑term UDCA use groups, except for lower γ‑glutamyl transferase activity with longer treatment. Despite pruritus found in 46% of the patients, antipruritic therapy was rarely used.

Conclusions:  This is the first national study to characterize PBC in Poland. Its findings suggest limited long‑term efficacy of UDCA and unmet needs in symptom management. Anti‑gp210, anti‑sp100, and anti‑Ro52 antibodies may serve as important serologic markers. Prospective studies are needed to confirm these observations.

熊去氧胆酸治疗原发性胆管炎的临床特点。
原发性胆管炎(PBC)是一种慢性自身免疫性胆汁淤积性肝病。尽管建立了熊去氧胆酸(UDCA)的一线治疗,但许多患者并没有达到生化缓解。关于波兰PBC特征的数据仍然有限。目的:在一项多中心回顾性研究中,研究波兰PBC患者的人口学、临床和血清学特征及其治疗效果。患者和方法:共纳入来自10个肝病中心的364例患者。在2025年1月6日至3月8日期间收集人口统计学、实验室检测、自身抗体和疾病严重程度标志物的数据,并根据UDCA治疗的持续时间进行分析(结果:女性占队列的92.3%)。大多数患者年龄在60-80岁之间,但在80岁年龄组中男性患者相对较多。35.2%的患者被诊断为肝硬化。抗线粒体抗体占94.4%,抗ro52抗体占34.1%。抗gp210和抗sp100抗体在病程较长的患者中出现较多。短期和长期UDCA组之间肝脏生化无显著差异,但治疗时间越长,GGT活性越低。尽管46%的患者有瘙痒,但很少使用止痒治疗。结论:这是波兰首次对PBC进行全国性研究。研究结果表明,UDCA的长期疗效有限,男性的潜在诊断延迟,症状管理方面的需求未得到满足。抗gp210、抗sp100和抗ro52抗体可作为重要的血清学标志物。需要前瞻性研究来证实这些观察结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.50
自引率
0.00%
发文量
176
审稿时长
6-12 weeks
期刊介绍: Polish Archives of Internal Medicine is an international, peer-reviewed periodical issued monthly in English as an official journal of the Polish Society of Internal Medicine. The journal is designed to publish articles related to all aspects of internal medicine, both clinical and basic science, provided they have practical implications. Polish Archives of Internal Medicine appears monthly in both print and online versions.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信