Circulating short-chain fatty acids and subclinical cardiovascular disease in type 2 diabetes mellitus.

IF 4.7 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Hui-Ju Tsai, Wei-Chung Tsai, Ping-Shaou Yu, Wei-Chun Hung, Wei-Wen Hung, Yi-Chun Tsai
{"title":"Circulating short-chain fatty acids and subclinical cardiovascular disease in type 2 diabetes mellitus.","authors":"Hui-Ju Tsai, Wei-Chung Tsai, Ping-Shaou Yu, Wei-Chun Hung, Wei-Wen Hung, Yi-Chun Tsai","doi":"10.20452/pamw.17128","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong> Type 2 diabetes (T2D) is linked to a higher risk of cardiovascular disease (CVD). However, evidence on the impact of different short-chain fatty acids (SCFAs) on subclinical CVD is limited in patients with T2D.</p><p><strong>Objectives: </strong> This study was aimed to investigate the associations between circulating SCFA levels and subclinical CVD in patients with T2D.</p><p><strong>Patients and methods: </strong> This cross-sectional study enrolled 326 patients with T2D from November 2016 to June 2020. The levels of nine SCFAs including formate, acetate, propionate, butyrate, isobutyrate, methylbutyrate, valerate, isovalerate and methylvalerate in fasting serum were measured using liquid chromatography mass spectrometry. Cardiac structure and function were evaluated by echocardiography. Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV), as a parameter of arterial stiffness, were measured. Multivariable linear and logistic model were adjusted for traditional risk factors including cholesterol and glycated hemoglobin (HbA1C).</p><p><strong>Results: </strong> The mean age of the patients was 63.5 (10.4) years and 56.4% were male. The median HbA1C level was 7.0%. The adjusted odd ratios of left ventricular hypertrophy were 2.39 and 2.60 for tertiles 3 of formate and isobutyrate compared with tertiles 1 of formate and isobutyrate, respectively. Higher circulating butyrate / isobutyrate ratio was significantly associated with decreased risk of diastolic dysfunction. An inverse relationship between circulating valerate level and arterial stiffness was found. Patients with the highest tertile of circulating butyrate level had lower risk of abnormal ABI.</p><p><strong>Conclusions: </strong> Our study demonstrates that serum SCFAs are potential biomarkers of the early stage of cardiovascular remodeling in patients with T2D.</p>","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20452/pamw.17128","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction:  Type 2 diabetes (T2D) is linked to a higher risk of cardiovascular disease (CVD). However, evidence on the impact of different short-chain fatty acids (SCFAs) on subclinical CVD is limited in patients with T2D.

Objectives:  This study was aimed to investigate the associations between circulating SCFA levels and subclinical CVD in patients with T2D.

Patients and methods:  This cross-sectional study enrolled 326 patients with T2D from November 2016 to June 2020. The levels of nine SCFAs including formate, acetate, propionate, butyrate, isobutyrate, methylbutyrate, valerate, isovalerate and methylvalerate in fasting serum were measured using liquid chromatography mass spectrometry. Cardiac structure and function were evaluated by echocardiography. Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV), as a parameter of arterial stiffness, were measured. Multivariable linear and logistic model were adjusted for traditional risk factors including cholesterol and glycated hemoglobin (HbA1C).

Results:  The mean age of the patients was 63.5 (10.4) years and 56.4% were male. The median HbA1C level was 7.0%. The adjusted odd ratios of left ventricular hypertrophy were 2.39 and 2.60 for tertiles 3 of formate and isobutyrate compared with tertiles 1 of formate and isobutyrate, respectively. Higher circulating butyrate / isobutyrate ratio was significantly associated with decreased risk of diastolic dysfunction. An inverse relationship between circulating valerate level and arterial stiffness was found. Patients with the highest tertile of circulating butyrate level had lower risk of abnormal ABI.

Conclusions:  Our study demonstrates that serum SCFAs are potential biomarkers of the early stage of cardiovascular remodeling in patients with T2D.

循环短链脂肪酸与2型糖尿病亚临床心血管疾病
2型糖尿病(T2D)与较高的心血管疾病(CVD)风险相关。然而,关于不同短链脂肪酸(SCFAs)对T2D患者亚临床CVD影响的证据有限。目的:本研究旨在探讨T2D患者循环SCFA水平与亚临床CVD之间的关系。患者和方法:本横断面研究于2016年11月至2020年6月招募了326例T2D患者。采用液相色谱质谱法测定空腹血清中甲酸酯、乙酸酯、丙酸酯、丁酸酯、异丁酸酯、甲基丁酸酯、戊酸酯、异戊酸酯和甲基戊酸酯等9种SCFAs的含量。超声心动图评价心脏结构和功能。测量踝-肱指数(ABI)和肱-踝脉搏波速度(baPWV)作为动脉刚度参数。对胆固醇和糖化血红蛋白(HbA1C)等传统危险因素进行多变量线性和logistic模型调整。结果:患者平均年龄63.5(10.4)岁,男性占56.4%。中位HbA1C水平为7.0%。甲酸三分酯和异丁酸三分酯与甲酸三分酯和异丁酸三分酯相比,左室肥厚的调整奇比分别为2.39和2.60。较高的循环丁酸/异丁酸比值与舒张功能障碍风险降低显著相关。循环戊酸水平与动脉硬度呈反比关系。循环丁酸水平最高的患者发生ABI异常的风险较低。结论:我们的研究表明,血清SCFAs是T2D患者早期心血管重构的潜在生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.50
自引率
0.00%
发文量
176
审稿时长
6-12 weeks
期刊介绍: Polish Archives of Internal Medicine is an international, peer-reviewed periodical issued monthly in English as an official journal of the Polish Society of Internal Medicine. The journal is designed to publish articles related to all aspects of internal medicine, both clinical and basic science, provided they have practical implications. Polish Archives of Internal Medicine appears monthly in both print and online versions.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信