Epicardial fat: a non-invasive, non-contrast imaging biomarker for high-risk plaque monitoring in computed tomography.

IF 4.7 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Jan Henzel, Mariusz Kruk, Cezary Kępka, Magdalena Makarewicz-Wujec, Piotr Trochimiuk, Łukasz Wardziak, Hubert Krysztofiak, Piotr N Rudziński, Rafał Dąbrowski, Zofia Dzielińska, Marcin Demkow
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引用次数: 0

Abstract

Introduction: Coronary computed tomography angiography (CCTA) is a viable method for monitoring vulnerable plaque, however, non-contrast calcium scoring (CAS) has a limited utility in this context. The search for novel non-contrast imaging biomarkers able to track high-risk plaque is necessary.

Objectives: To investigate associations between low attenuation plaque (LAP) identified through CCTA and non-contrast CAS, pericardial adipose tissue (PAT), and epicardial adipose tissue (EAT) in patients with non-obstructive coronary atherosclerosis undergoing serial CCTA.

Patients and methods: We analyzed data from 89 participants (40% women, 60 [7.7] years) of the dietary intervention to stop coronary atherosclerosis in the computed tomography study. CCTA was performed at baseline and repeated at mean follow-up of 66.8 (13.7) weeks. CAS and cardiac fat were measured in non-contrast reconstructions and analyzed in relation to contrast-derived LAP.

Results: Mean decrease in LAP burden was 0.23 (1.0) % (P = 0.04), median decrease in PAT volume was 4.2 (-36.9; 8.3) cm³ (P <0.001), median decrease in EAT volume was 2.8 (-12.2; 6.7) cm³ (P = 0.01), and median increase in CAS was 21.2 (1.7; 71.7) Agatston units (P <0.001). Positive correlations were found between changes in LAP burden and both PAT and EAT volumes (r = 0.349, P = 0.001, and r = 0.490, P <0.001, respectively), but not with change in CAS. Multivariable linear regression analysis identified EAT as independent predictor of LAP regression (95% CI, 0.007; 0.032; P = 0.003).

Conclusions: Pericardial and epicardial fat volumes and their dynamics are positively associated with LAP burden, while CAS is not. Monitoring EAT volume using non-contrast computed tomography may facilitate the assessment of high-risk plaque progression or regression, overcoming the limitations of CAS.

心外膜脂肪:计算机断层扫描中用于高危斑块监测的非侵入性、非对比成像生物标志物。
简介:冠状动脉计算机断层血管造影(CCTA)是一种监测易损斑块的可行方法,然而,非对比钙评分(CAS)在这方面的应用有限。寻找能够追踪高风险斑块的新型非对比成像生物标志物是必要的。目的:研究CCTA检测出的低衰减斑块(LAP)与非造影剂CAS、心包脂肪组织(PAT)和心外膜脂肪组织(EAT)在接受系列CCTA治疗的非阻塞性冠状动脉粥样硬化患者中的相关性。患者和方法:在计算机断层扫描研究中,我们分析了89名参与者(40%为女性,60[7.7]岁)通过饮食干预阻止冠状动脉粥样硬化的数据。在基线时进行CCTA,并在平均随访66.8(13.7)周时重复。在非造影剂重建中测量CAS和心脏脂肪,并分析与造影剂衍生LAP的关系。结果:LAP负担平均减少0.23 (1.0)% (P = 0.04), PAT体积中位数减少4.2 (-36.9;8.3)cm³(P)结论:心包和心外膜脂肪体积及其动态与LAP负担呈正相关,而CAS与LAP负担无关。利用非造影剂计算机断层扫描监测EAT容量有助于评估高风险斑块的进展或消退,克服了CAS的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
176
审稿时长
6-12 weeks
期刊介绍: Polish Archives of Internal Medicine is an international, peer-reviewed periodical issued monthly in English as an official journal of the Polish Society of Internal Medicine. The journal is designed to publish articles related to all aspects of internal medicine, both clinical and basic science, provided they have practical implications. Polish Archives of Internal Medicine appears monthly in both print and online versions.
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