临床相关垂体腺瘤:单中心视角的流行病学研究。

IF 4.7 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Aleksandra Derwich-Rudowicz, Katarzyna B Kubiak, Kacper Wojciechowski, Katarzyna Kobusińska, Norbert Wąsik, Włodzimierz Liebert, Marek Ruchała, Nadia Sawicka-Gutaj
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引用次数: 0

摘要

垂体腺瘤(PA)是一种异质性的中枢神经系统病变,多数为良性。它们占所有原发性脑肿瘤的13.5-20%,并且发病率呈上升趋势。目的:我们回顾性分析PA患者,以确定特定的流行病学特征,特别关注一系列手术切除的PA。患者和方法:我们分析了2018-2023年间在波兰波兹南内分泌科诊断为PA的所有患者(n = 1111),并特别关注临床相关的PA (n = 194)。本文回顾了临床病史、人口学特征、肿瘤特征和诊断结果。PA的发生被定义为PA的新诊断。结果:新诊断的PA患者1111例,其中男性403例(36.3%),女性708例(63.7%),年发病率为4.11/10万人。结论:尽管大多数PA被诊断为女性,但临床相关肿瘤在男性中更为常见。男性患者被诊断为NFPA的频率明显高于女性,并且肿瘤大小在就诊时更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinically relevant pituitary adenomas: a single-center epidemiological study.

Introduction: Pituitary adenomas (PAs) are a heterogeneous group of central nervous system lesions that are mostly benign. They account for 13.5%-20% of all primary brain tumors, and their incidence is rising.

Objectives: We retrospectively analyzed patients with PA to determine their specific epidemiological characteristics, focusing specifically on a series of surgically resected PAs.

Patients and methods: We analyzed all patients diagnosed with PA (n = 1111) and hospitalized in the Department of Endocrinology, Poznań, Poland, between 2018 and 2023, with a special focus on clinically relevant PAs qualified for transsphenoidal surgery (n = 194). Medical history, demographic characteristics, tumor features, and diagnostic results were reviewed. The incidence of PAs was defined as a new diagnosis of PA.

Results: We identified 1111 patients with newly diagnosed PA, including 403 men (36.3%), with an annual incidence rate of 4.11/100 000 population. Women were diagnosed at a younger age than men (P <0.001). In the group qualified for surgery (n = 194), the most common diagnosis was nonfunctioning PA (NFPA; 76%). Men were diagnosed with NFPA more often (P = 0.02) and presented with larger tumors (P = 0.005). The patients with NFPA were older at diagnosis (P <0.001). Larger tumors were associated with an increased risk of complications, such as visual field defects, headaches, and hypopituitarism. Although 90% of the patients were diagnosed with multimorbidity and over half with polypharmacy, we did not find any association between comorbidities and the tumor type.

Conclusions: Although most PAs were diagnosed in women, clinically relevant tumors were more frequent in men. Male patients were diagnosed with NFPA significantly more often than women, and their tumors were larger at presentation.

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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
176
审稿时长
6-12 weeks
期刊介绍: Polish Archives of Internal Medicine is an international, peer-reviewed periodical issued monthly in English as an official journal of the Polish Society of Internal Medicine. The journal is designed to publish articles related to all aspects of internal medicine, both clinical and basic science, provided they have practical implications. Polish Archives of Internal Medicine appears monthly in both print and online versions.
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