Reviews in the Neurosciences最新文献_第4页

The role of long noncoding RNAs in amyotrophic lateral sclerosis. 长非编码 RNA 在肌萎缩性脊髓侧索硬化症中的作用。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-03-08 Print Date: 2024-07-26 DOI: 10.1515/revneuro-2023-0155

Darya Rajabi, Shaghayegh Khanmohammadi, Nima Rezaei

{"title":"The role of long noncoding RNAs in amyotrophic lateral sclerosis.","authors":"Darya Rajabi, Shaghayegh Khanmohammadi, Nima Rezaei","doi":"10.1515/revneuro-2023-0155","DOIUrl":"10.1515/revneuro-2023-0155","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a poor prognosis leading to death. The diagnosis and treatment of ALS are inherently challenging due to its complex pathomechanism. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides involved in different cellular processes, incisively gene expression. In recent years, more studies have been conducted on lncRNA classes and interference in different disease pathologies, showing their promising contribution to diagnosing and treating neurodegenerative diseases. In this review, we discussed the role of lncRNAs like NEAT1 and C9orf72-as in ALS pathogenesis mechanisms caused by mutations in different genes, including TAR DNA-binding protein-43 (TDP-43), fused in sarcoma (FUS), superoxide dismutase type 1 (SOD1). NEAT1 is a well-established lncRNA in ALS pathogenesis; hence, we elaborate on its involvement in forming paraspeckles, stress response, inflammatory response, and apoptosis. Furthermore, antisense lncRNAs (as-lncRNAs), a key group of transcripts from the opposite strand of genes, including ZEB1-AS1 and ATXN2-AS, are discussed as newly identified components in the pathology of ALS. Ultimately, we review the current standing of using lncRNAs as biomarkers and therapeutic agents and the future vision of further studies on lncRNA applications.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"533-547"},"PeriodicalIF":3.4,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dendritic spines and their role in the pathogenesis of neurodevelopmental and neurological disorders. 树突棘及其在神经发育和神经系统疾病发病机制中的作用。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-03-05 Print Date: 2024-07-26 DOI: 10.1515/revneuro-2023-0151

Aisan Akhgari, Tanja Maria Michel, Manouchehr Seyedi Vafaee

引用次数: 0

Analysis of radiological features in patients with post-stroke depression and cognitive impairment. 脑卒中后抑郁和认知障碍患者的放射学特征分析。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-02-29 Print Date: 2024-07-26 DOI: 10.1515/revneuro-2023-0120

Jun Mu, Jiayi Li

引用次数: 0

Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis. 铜锌超氧化物歧化酶 1 (SOD1) 在肌萎缩性脊髓侧索硬化症中的潜在致病机制。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-02-22 Print Date: 2024-07-26 DOI: 10.1515/revneuro-2024-0010

Xin-Xin Wang, Wen-Zhi Chen, Cheng Li, Ren-Shi Xu

{"title":"Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis.","authors":"Xin-Xin Wang, Wen-Zhi Chen, Cheng Li, Ren-Shi Xu","doi":"10.1515/revneuro-2024-0010","DOIUrl":"10.1515/revneuro-2024-0010","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease which damages upper and lower motor neurons (UMN and LMN) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related UMN and LMN, accompanying with the pathological signs leaded by the cortical spinal lateral tract lesion. The pathogenesis about ALS is not fully understood, and no specific drugs are available to cure and prevent the progression of this disease at present. In this review, we reviewed the structure and associated functions of copper-zinc superoxide dismutase 1 (SOD1), discuss why SOD1 is crucial to the pathogenesis of ALS, and outline the pathogenic mechanisms of SOD1 in ALS that have been identified at recent years, including glutamate-related excitotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, axonal transport disruption, prion-like propagation, and the non-cytologic toxicity of glial cells. This review will help us to deeply understand the current progression in this field of SOD1 pathogenic mechanisms in ALS.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"549-563"},"PeriodicalIF":3.4,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria and MICOS - function and modeling. 线粒体和 MICOS - 功能和模型。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-02-19 Print Date: 2024-07-26 DOI: 10.1515/revneuro-2024-0004

Haym Benaroya

引用次数: 0

Inflammation and oxidative stress in epileptic children: from molecular mechanisms to clinical application of ketogenic diet. 癫痫儿童的炎症和氧化应激：从分子机制到生酮饮食的临床应用。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-02-14 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0128

Azam Ildarabadi, Seyedeh Nooshan Mir Mohammad Ali, Fatemeh Rahmani, Narjes Mosavari, Elham Pourbakhtyaran, Nima Rezaei

{"title":"Inflammation and oxidative stress in epileptic children: from molecular mechanisms to clinical application of ketogenic diet.","authors":"Azam Ildarabadi, Seyedeh Nooshan Mir Mohammad Ali, Fatemeh Rahmani, Narjes Mosavari, Elham Pourbakhtyaran, Nima Rezaei","doi":"10.1515/revneuro-2023-0128","DOIUrl":"10.1515/revneuro-2023-0128","url":null,"abstract":"Childhood epilepsy affects up to 1 % of children. It has been shown that 30 % of patients are resistant to drug treatments, making further investigation of other potential treatment strategies necessary. One such approach is the ketogenic diet (KD) showing promising results and potential benefits beyond the use of current antiepileptic drugs. This study aims to investigate the effects of KD on inflammation and oxidative stress, as one of the main suggested mechanisms of neuroprotection, in children with epilepsy. This narrative review was conducted using the Medline and Google Scholar databases, and by searching epilepsy, drug-resistant epilepsy, child, children, ketogenic, ketogenic diet, diet, ketogenic, keto, ketone bodies (BHB), PUFA, gut microbiota, inflammation, inflammation mediators, neurogenic inflammation, neuroinflammation, inflammatory marker, adenosine modulation, mitochondrial function, MTOR pathway, Nrf2 pathway, mitochondrial dysfunction, PPARɣ, oxidative stress, ROS/RNS, and stress oxidative as keywords. Compelling evidence underscores inflammation and oxidative stress as pivotal factors in epilepsy, even in cases with genetic origins. The ketogenic diet effectively addresses these factors by reducing ROS and RNS, enhancing antioxidant defenses, improving mitochondrial function, and regulating inflammatory genes. Additionally, KD curbs pro-inflammatory cytokine and chemokine production by dampening NF-κB activation, inhibiting the NLRP3 inflammasome, increasing brain adenosine levels, mTOR pathway inhibition, upregulating PPARɣ expression, and promoting a healthy gut microbiota while emphasizing the consumption of healthy fats. KD could be considered a promising therapeutic intervention in patients with epilepsy particularly in drug-resistant epilepsy cases, due to its targeted approach addressing oxidative stress and inflammatory mechanisms.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"473-488"},"PeriodicalIF":3.4,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic machine learning applications on clinical populations using functional near infrared spectroscopy: a review. 使用功能性近红外光谱对临床人群进行诊断性机器学习应用：综述。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-02-05 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0117

Aykut Eken, Farhad Nassehi, Osman Eroğul

{"title":"Diagnostic machine learning applications on clinical populations using functional near infrared spectroscopy: a review.","authors":"Aykut Eken, Farhad Nassehi, Osman Eroğul","doi":"10.1515/revneuro-2023-0117","DOIUrl":"10.1515/revneuro-2023-0117","url":null,"abstract":"Functional near-infrared spectroscopy (fNIRS) and its interaction with machine learning (ML) is a popular research topic for the diagnostic classification of clinical disorders due to the lack of robust and objective biomarkers. This review provides an overview of research on psychiatric diseases by using fNIRS and ML. Article search was carried out and 45 studies were evaluated by considering their sample sizes, used features, ML methodology, and reported accuracy. To our best knowledge, this is the first review that reports diagnostic ML applications using fNIRS. We found that there has been an increasing trend to perform ML applications on fNIRS-based biomarker research since 2010. The most studied populations are schizophrenia (n = 12), attention deficit and hyperactivity disorder (n = 7), and autism spectrum disorder (n = 6) are the most studied populations. There is a significant negative correlation between sample size (>21) and accuracy values. Support vector machine (SVM) and deep learning (DL) approaches were the most popular classifier approaches (SVM = 20) (DL = 10). Eight of these studies recruited a number of participants more than 100 for classification. Concentration changes in oxy-hemoglobin (ΔHbO) based features were used more than concentration changes in deoxy-hemoglobin (ΔHb) based ones and the most popular ΔHbO-based features were mean ΔHbO (n = 11) and ΔHbO-based functional connections (n = 11). Using ML on fNIRS data might be a promising approach to reveal specific biomarkers for diagnostic classification.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"421-449"},"PeriodicalIF":3.4,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empowering brain cancer diagnosis: harnessing artificial intelligence for advanced imaging insights. 增强脑癌诊断能力：利用人工智能获得先进的成像见解。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-30 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0115

Omar S Al-Kadi, Roa'a Al-Emaryeen, Sara Al-Nahhas, Isra'a Almallahi, Ruba Braik, Waleed Mahafza

引用次数: 0

Diversity of amyloid beta peptide actions. 淀粉样β肽作用的多样性。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-29 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0100

Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan

{"title":"Diversity of amyloid beta peptide actions.","authors":"Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan","doi":"10.1515/revneuro-2023-0100","DOIUrl":"10.1515/revneuro-2023-0100","url":null,"abstract":"Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer's disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight. The main efforts in pharmacology are aimed at reducing Aβs concentration to prevent their accumulation, aggregation, formation of senile plaques, neuronal death, and neurodegeneration. However, a number of publications have demonstrated certain beneficial physiological effects of Aβs. Simultaneously, it is indicated that the effects of Aβs turn into pathological due to the development of certain diseases in the body. The accumulation of C- and N-terminal truncated Aβs under diverse conditions is supposed to play a role in AD development. The significance of transformation of glutamate residue at positions 3 or 11 of Aβs catalyzed by glutaminyl cyclase making them more degradation resistant, hydrophobic, and prone to aggregation, as well as the participation of dipeptidyl peptidase IV in these transformations are discussed. The experimental data presented confirm the maintenance of physiological, nonaggregated state of Aβs by plant preparations. In conclusion, this review suggests that in the fight against AD, instead of removing Aβs, preference should be given to the treatment of common diseases. Glutaminyl cyclase and dipeptidyl peptidase IV can be considered as targets in AD treatment. Flavonoids and plant preparations that possess antiamyloidogenic propensity are proposed as beneficial neuroprotective, anticancer, and antidiabetic food additives.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"387-398"},"PeriodicalIF":3.4,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving frontiers: endovascular strategies for the treatment of delayed cerebral ischemia. 不断发展的前沿：治疗迟发性脑缺血的血管内治疗策略。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2024-01-25 Print Date: 2024-06-25 DOI: 10.1515/revneuro-2023-0148

David-Dimitris Chlorogiannis, Athina-Maria Aloizou, Theodoros Mavridis, Jonathan Andreas Sänger, Anargyros Chlorogiannis, Nikolaos Madouros, Panagiotis Papanagiotou

引用次数: 0