Seminars in Fetal & Neonatal Medicine最新文献

A practical review of iron deficiency in pregnancy.

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-03-01 DOI: 10.1016/j.siny.2025.101611

Kimberly A Moyle

引用次数: 0

Severe anemia predisposes very premature infants to transfusion-associated necrotizing enterocolitis. 严重贫血易使早产儿患输血相关性坏死性小肠结肠炎。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-26 DOI: 10.1016/j.siny.2025.101615

Akhil Maheshwari

引用次数: 0

The value of thromboelastography to neonatology. 血栓弹性成像对新生儿科的价值。

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101610

Francesca Manzoni, Ludovica Raymo, Vittoria Carolina Bronzoni, Andrea Tomaselli, Stefano Ghirardello, Monica Fumagalli, Giacomo Cavallaro, Genny Raffaeli

{"title":"The value of thromboelastography to neonatology.","authors":"Francesca Manzoni, Ludovica Raymo, Vittoria Carolina Bronzoni, Andrea Tomaselli, Stefano Ghirardello, Monica Fumagalli, Giacomo Cavallaro, Genny Raffaeli","doi":"10.1016/j.siny.2025.101610","DOIUrl":"https://doi.org/10.1016/j.siny.2025.101610","url":null,"abstract":"Hemostatic derangements are common in critically ill and premature neonates. Nevertheless, hemostasis assessment in neonates is still challenging. The hemostatic system undergoes age-related physiological changes during its maturation and exhibits quantitative and qualitative differences between infants and adults. Conventional coagulation tests are mainly responsive to procoagulant factors, regardless of the contribution of cellular elements, anticoagulants and fibrinolytic contributors and, therefore, their role in predicting bleeding in neonatal acquired coagulopathy is somewhat limited. Viscoelastic coagulation tests offer a promising alternative, enabling a bedside and real-time assessment of the entire hemostatic process in short turn-around times with a limited amount of blood. These tests allow a targeted hemostatic monitoring and a tailored management of blood products and anticoagulation. The routine use of VCTs in the NICU remains limited, especially for premature infants, due to the lack of established normative ranges. In this review we will provide an overview of the main evidence related to the clinical application of viscoelastic monitoring in the neonatal setting.","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":" ","pages":"101610"},"PeriodicalIF":2.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should granulocyte transfusion therapy for septic neutropenic neonates be resurrected?

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101616

Shelley M Lawrence

{"title":"Should granulocyte transfusion therapy for septic neutropenic neonates be resurrected?","authors":"Shelley M Lawrence","doi":"10.1016/j.siny.2025.101616","DOIUrl":"https://doi.org/10.1016/j.siny.2025.101616","url":null,"abstract":"Nearly half a century ago, granulocyte transfusions were trialed in critically ill, septic, neutropenic neonates and showed improved survival when used concurrently with antimicrobials. Benefits were particularly noteworthy for Gram-negative and fungal infections. The introduction of granulocyte colony-stimulating factor into clinical medicine in 1991 and inherent problems associated with granulocyte procurement for transfusion caused granulocyte transfusions to become nearly extinct for this patient population. Simultaneous technological and clinical management advancements have enabled the survival of younger neonates, who are at the highest risk for neutropenia and neonatal sepsis. These infants have well-documented developmental deficiencies in the number and functional capabilities of their neutrophils compared to older patients. A continued surge in antimicrobial resistance and an increasing number of Gram-negative infections have created an urgent need for clinicians to rethink old therapies and consider new ones. This review details the evolution of granulocyte transfusions and whether they should be resurrected in neonatal patients.","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":" ","pages":"101616"},"PeriodicalIF":2.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health and societal infant mortality burden of neonatal hemolytic disorders.

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101620

Ramesh Vidavalur, Vinod K Bhutani

{"title":"Health and societal infant mortality burden of neonatal hemolytic disorders.","authors":"Ramesh Vidavalur, Vinod K Bhutani","doi":"10.1016/j.siny.2025.101620","DOIUrl":"https://doi.org/10.1016/j.siny.2025.101620","url":null,"abstract":"Hemolytic disorders in neonates, once exceedingly common causes of infant mortality, have become increasingly rare and now largely non-fatal. Global advancements in neonatal care and deeper understanding of the mechanisms of neonatal hemolysis have significantly improved survival outcomes, particularly among those in high-income countries. However, regional disparities persist due to non-equitable healthcare access. Their long-lasting health consequences have been attributed to social, demographic factors that are most likely amenable to healthcare governance. In this review, we focus our attention to neonatal hemolytic disorders to i) analyze data resourced from the Global Burden of Disease (GBD) 2021 report; ii) study the trends in infant mortality rates (IMR) as related to hemolytic disorders including its severe complication, extreme hyperbilirubinemia (EHB-IMR); iii) evaluate geospatial disparities among GBD super regions; and iv) examine these trends in relation to the socio-demographic index (SDI) of the countries that comprise the \"super-regions\". From 1991 to 2021, global EHB-related IMR has declined significantly, from 73 to 25 per 100,000 live births. By 2021, EHB and kernicterus accounted for only 0.7 % of all under-five deaths. High-income countries have dramatically minimized hemolytic disease fatalities, but matched progress eludes regions like South Asia and sub-Saharan Africa. The inverse relationship between SDI and EHB-IMR highlight these national disparities to manifest as slower decline in IMR. In order to achieve equitable healthcare access for all regions, an improved understanding of the societal risk factors would guide re-engineering solutions that are also empowered by audited resource utilization to evaluate remedial governance policies.","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":" ","pages":"101620"},"PeriodicalIF":2.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal diagnosis and treatment of congenital anemias.

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101613

Yair J Blumenfeld

引用次数: 0

Revised World Health Organization (WHO) classification of G6PD gene variants: Relevance to neonatal hyperbilirubinemia.

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101619

Jon F Watchko, Vinod K Bhutani

引用次数: 0

Recent advances in NICU platelet transfusions.

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101609

Patricia Davenport, Martha Sola-Visner

引用次数: 0

Iron supplementation for infants in the NICU: What preparation, how much, and how long is optimal?

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101612

Sandra Juul, Kendell German

引用次数: 0

Platelet transfusion and bleeding risk.

IF 2.9 3区医学

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-02-25 DOI: 10.1016/j.siny.2025.101608

Valeria Cortesi, Enrico Lopriore, Susanna Fustolo-Gunnink

{"title":"Platelet transfusion and bleeding risk.","authors":"Valeria Cortesi, Enrico Lopriore, Susanna Fustolo-Gunnink","doi":"10.1016/j.siny.2025.101608","DOIUrl":"https://doi.org/10.1016/j.siny.2025.101608","url":null,"abstract":"In neonatal patients, bleeding is a multifactorial event in which several factors may play a pathogenic role. Among these, thrombocytopenia is often considered a risk factor for bleeding, although a causal relationship has never been demonstrated. In fact, major bleeding mainly occurs in non-thrombocytopenic newborns and thrombocytopenic newborns rarely experience major bleeding. Therefore, parameters other than platelet count might better assess the hemostatic function and define bleeding risk. Historically, neonatologists aimed to reduce the risk of bleeding by administering platelet transfusions. However, recent studies demonstrated that transfusing newborns at higher threshold is associated with an increased risk of death, bleeding, bronchopulmonary dysplasia and neurodevelopmental impairment. The mechanism behind this association is not known and various hypotheses have been proposed, including the non-hemostatic effects of adult-derived platelets transfused into neonates. Alternatively, the rapid volume expansion caused by a platelet transfusion might cause hemodynamic instability and cardiocirculatory overload. Guidelines about platelet transfusions should now include this recent evidence and adopt more stringent thresholds. Future research should focus on finding alternative or improved transfusion products more suitable for newborns.","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":" ","pages":"101608"},"PeriodicalIF":2.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0