Seminars in Fetal & Neonatal Medicine最新文献

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Non-invasive cardiac output monitoring in neonates: From technologic promise to clinical practice. 新生儿无创心输出量监测:从技术前景到临床实践。
IF 2.9 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-08-26 DOI: 10.1016/j.siny.2026.101772
Lizelle van Wyk, Silvia Martini
{"title":"Non-invasive cardiac output monitoring in neonates: From technologic promise to clinical practice.","authors":"Lizelle van Wyk, Silvia Martini","doi":"10.1016/j.siny.2026.101772","DOIUrl":"https://doi.org/10.1016/j.siny.2026.101772","url":null,"abstract":"<p><p>Due to the clinical importance of early detection of hemodynamic compromise and the limitations of transthoracic echocardiography (TTE) as an intermittent, operator-dependent assessment, the introduction of non-invasive cardiac output monitoring (NICOM) in the neonatal population has generated considerable interest. Electrical biosensing technology (EBT), one type of NICOM modality, offers non-invasive, continuous, bedside assessment of multiple hemodynamic parameters, yet its clinical utility is limited by variable accuracy and precision, lack of interchangeability with TTE and limited trending studies. Despite this, EBT is progressively being used in research and even clinical domains. Advancing continuous EBT-enabled cardiac output monitoring from technologic promise to clinical accountability requires specific neonatal-based refinements of the technology and a strategic shift in research emphasis, moving from method-comparison studies to rigorously designed, outcome-based trials, in order to determine whether EBT-informed management can meaningfully improve neonatal morbidity and mortality.</p>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":" ","pages":"101772"},"PeriodicalIF":2.9,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing research and development to innovate neonatology and improve newborn health 加强研究开发,创新新生儿科学,提高新生儿健康水平。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-06-01 Epub Date: 2026-04-16 DOI: 10.1016/j.siny.2026.101735
Daniele De Luca , Roberta Onesimo , Alexandra Benachi , Satoshi Kusuda , Elizabeth Foglia , Ola Saugstad , Steven Abman
{"title":"Enhancing research and development to innovate neonatology and improve newborn health","authors":"Daniele De Luca ,&nbsp;Roberta Onesimo ,&nbsp;Alexandra Benachi ,&nbsp;Satoshi Kusuda ,&nbsp;Elizabeth Foglia ,&nbsp;Ola Saugstad ,&nbsp;Steven Abman","doi":"10.1016/j.siny.2026.101735","DOIUrl":"10.1016/j.siny.2026.101735","url":null,"abstract":"<div><div>Neonatology suffers from a chronic lack of innovation, and several neonatal disorders still lack appropriate diagnostic or therapeutic tools. Here, we expand on the recent analysis of this situation by the Lancet Child and Adolescent Commission for the Future of Neonatology, highlighting the similarities between adult and neonatal critical care, the need for greater interdisciplinary collaboration, and the importance of clearly defining neonatology as a distinct specialty. We also discuss the peculiarities of medical devices. We analyse the rarity of neonatal malformative and non-malformative disorders and diseases in light of the opportunities related to the definition of rare disease. We provide a culture-based definition of neonatology and advocate for creating a separate residency program, discussing its benefits in both developed and low-middle-income countries.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 3","pages":"Article 101735"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From constraints to solutions: leveraging low-cost, scalable simulation for safer neonatal resuscitation 从限制到解决方案:利用低成本,可扩展的模拟更安全的新生儿复苏。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-06-01 Epub Date: 2026-04-14 DOI: 10.1016/j.siny.2026.101736
Juin Yee Kong , Nicole K. Yamada
{"title":"From constraints to solutions: leveraging low-cost, scalable simulation for safer neonatal resuscitation","authors":"Juin Yee Kong ,&nbsp;Nicole K. Yamada","doi":"10.1016/j.siny.2026.101736","DOIUrl":"10.1016/j.siny.2026.101736","url":null,"abstract":"<div><div>Neonatal mortality remains a major global health challenge, disproportionately affecting low-resource settings where access to timely and effective resuscitation is limited. Simulation-based training provides a safe and effective method to develop and sustain the cognitive, technical, and behavioural skills essential for neonatal resuscitation, while improving teamwork, confidence, and patient safety. Despite established evidence of its effectiveness in enhancing these skills, widespread implementation of simulation-based training remains limited in resource-constrained settings due to financial, infrastructural, human resource and organizational barriers. This review proposes simulation as a patient safety intervention that supports the shift from traditional error-focused to system resilience approaches. Scalable innovations including low-cost manikins, in situ simulation, telesimulation, and structured debriefing offer practical and sustainable solutions. Future research linking simulation-based training to measurable improvements in neonatal outcomes is essential to inform policy, guide investment, and promote global health equity.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 3","pages":"Article 101736"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The future neonatologist 未来的新生儿学家。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-06-01 Epub Date: 2026-04-21 DOI: 10.1016/j.siny.2026.101740
Josef Neu
{"title":"The future neonatologist","authors":"Josef Neu","doi":"10.1016/j.siny.2026.101740","DOIUrl":"10.1016/j.siny.2026.101740","url":null,"abstract":"<div><div>The field of Neonatal Intensive Care is rapidly changing. Technological innovations are emerging rapidly, and family-centered and holistic approaches need to keep pace. Promising areas include artificial intelligence, multiomic integrations for description and understanding of pathogenic processes using systems biology. This review will discuss where we have been, our status and the future of neonatal intensive care. Topics to be addressed include some of the most significant future technical innovations, how these might improve global health and equity, the training of the future neonatologist and ethical and financial decisions that will need to be made as we progress.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 3","pages":"Article 101740"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benefits of neonatal resuscitation training in high- and low-resource settings 高资源和低资源环境下新生儿复苏训练的益处。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-06-01 Epub Date: 2026-04-22 DOI: 10.1016/j.siny.2026.101739
Amy Mackay, Waldemar A. Carlo
{"title":"Benefits of neonatal resuscitation training in high- and low-resource settings","authors":"Amy Mackay,&nbsp;Waldemar A. Carlo","doi":"10.1016/j.siny.2026.101739","DOIUrl":"10.1016/j.siny.2026.101739","url":null,"abstract":"<div><div>Globally, around 1.9 million stillbirths occur each year, and around 2.3 million newborns die in the first 28 days after birth each year. Many of these deaths are preventable. The burden of stillbirths is likely even higher, as many are unreported. A disproportionate number of fresh stillbirths and neonatal deaths occur in low-resource settings. About 1 million neonatal deaths occur in the first 24 h after birth, with preterm birth and birth asphyxia/intrapartum-related death being the leading causes. For newborns who have difficulty establishing effective breathing at birth, prompt and effective resuscitation is usually lifesaving. Training providers in high- and low-resource settings have been instrumental in equipping healthcare professionals to support a newborn's breathing at birth and continued care in the first month after birth to mitigate stillbirths and neonatal deaths. This review focuses on educational programs in both high- and low-resource settings designed to enable providers to perform timely and effective neonatal resuscitation and early newborn care. The highest level of available evidence that investigates the effects of these programs on provider knowledge and skills, as well as neonatal mortality and stillbirths, will be discussed. Where strong evidence may be lacking, it will be reviewed. Current complementary interventions to neonatal resuscitation training programs that are being researched will be addressed.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 3","pages":"Article 101739"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological safety in healthcare – helping everyone to speak up 医疗保健中的心理安全——帮助每个人畅所欲言。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-06-01 Epub Date: 2026-04-17 DOI: 10.1016/j.siny.2026.101738
Sanjay Patole
{"title":"Psychological safety in healthcare – helping everyone to speak up","authors":"Sanjay Patole","doi":"10.1016/j.siny.2026.101738","DOIUrl":"10.1016/j.siny.2026.101738","url":null,"abstract":"<div><div>Psychological safety is important for excellence in team performance. Team performance is compromised when team members fear the consequences of speaking up to raise concerns about wrongdoing or an individual.</div><div>Consistent delivery of safe and the best quality of care is the prime responsibility of healthcare teams. Those involved in neonatal intensive care are not an exception. The importance of psychological safety in healthcare cannot be overemphasised considering the unique nature and complexity of this industry. It is also important for teaching hospitals with added responsibility for high-quality training, education and research. The issue of psychological safety is more relevant for healthcare organizations considering their strict hierarchy where careers depend on performance appraisals. Facilitating a culture of psychological safety is the responsibility of everyone holding a leadership role in an organization.</div><div>We briefly review the history of psychological safety, the reasons why it matters in healthcare, impact on all stakeholders when it is missing, tools for assessing its presence and balance in a team, and the role of leaders at all levels in facilitating a culture of psychological safety in an organization. The barriers and facilitators of psychological safety and key issues about the phenomenon of whistleblowing are discussed.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 3","pages":"Article 101738"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International collaborations in neonatal and fetal medicine — Low-and-middle income countries have the patients and high-income countries have the technology: Consensus, conundrums and controversies 新生儿和胎儿医学的国际合作——中低收入国家有患者,高收入国家有技术:共识、难题和争议。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-06-01 Epub Date: 2026-04-13 DOI: 10.1016/j.siny.2026.101737
Sourabh Dutta
{"title":"International collaborations in neonatal and fetal medicine — Low-and-middle income countries have the patients and high-income countries have the technology: Consensus, conundrums and controversies","authors":"Sourabh Dutta","doi":"10.1016/j.siny.2026.101737","DOIUrl":"10.1016/j.siny.2026.101737","url":null,"abstract":"<div><div>International collaborations between investigators in low-and-middle-income countries (LMICs) and high-income countries (HICs) in neonatal and fetal medicine have expanded over the past decade. This narrative review documents a rise in HIC–LMIC publications since 2014, with a plateau and transient dip during the COVID-19 pandemic. It analyses leadership, patient recruitment, and how HIC-based technologies and laboratory platforms shape research agendas. Many influential trials are conceived and sponsored by HIC institutions, with recruitment concentrated in LMICs because of higher disease burden, larger eligible populations and lower costs. Meanwhile, LMIC centers report growing readiness to support randomized controlled trials, and LMIC-conceived, led and completed multicentre studies are increasingly reported. Ongoing concerns include misalignment between donor priorities and national agendas, inequities in authorship and leadership, and ethical challenges related to standards of care, post-trial access, consent and compensation. The review compares regulatory, consent and insurance processes in India and the United States, and highlights enabling factors such as harmonised guidelines, global registries, political goodwill and professional networks. It anticipates a doubling of HIC–LMIC collaborative studies over the next decade, rapid growth of South–South partnerships, and gradual, though incomplete, correction of authorship and leadership imbalances in global neonatal and fetal medicine.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 3","pages":"Article 101737"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical tensions in decisions about treatment for babies born at the borderline of viability: Discussion and consensus 关于在生存能力边缘出生的婴儿的治疗决策中的伦理紧张:讨论和共识。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-04-01 Epub Date: 2026-03-04 DOI: 10.1016/j.siny.2026.101715
David L. Weisoly , Mathew A. Rysavy , Joseph Kaempf , Robert Ursprung , John Lantos
{"title":"Ethical tensions in decisions about treatment for babies born at the borderline of viability: Discussion and consensus","authors":"David L. Weisoly ,&nbsp;Mathew A. Rysavy ,&nbsp;Joseph Kaempf ,&nbsp;Robert Ursprung ,&nbsp;John Lantos","doi":"10.1016/j.siny.2026.101715","DOIUrl":"10.1016/j.siny.2026.101715","url":null,"abstract":"","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 2","pages":"Article 101715"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An emerging consensus about treatment of the tiniest babies 关于如何对待最小婴儿的共识正在形成。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1016/j.siny.2026.101712
John D. Lantos
{"title":"An emerging consensus about treatment of the tiniest babies","authors":"John D. Lantos","doi":"10.1016/j.siny.2026.101712","DOIUrl":"10.1016/j.siny.2026.101712","url":null,"abstract":"<div><div>Over the past three decades, a broad consensus has emerged that decisions about life-sustaining treatment for extremely premature infants should be grounded in shared decision-making (SDM) between clinicians and parents. This consensus is endorsed by professional societies, bioethics commissions, and parents of babies in the neonatal intensive care unit. Despite this robust consensus, there is evidence that SDM is not always practiced. The evidence comes from observations of actual studies in which there is substantial practice variation that seems unlikely to reflect individualized decisions. In this paper, I examine the sources of that variation and argue that current SDM frameworks rest on an overly simplistic assumption that outcomes are stable, objective, unambiguous, and communicated clearly. In reality, prognostic data for survival and neurodevelopmental impairment are deeply contingent on treatment practices, prenatal management, institutional culture, and reporting conventions. These ambiguities complicate counseling, obscure value-laden judgments, and contribute to moral distress among clinicians. Moreover, parental preferences are heterogeneous and often reflect attitudes about disabilities that are different from the attitudes of health professionals. I propose a more dynamic model of SDM that acknowledges emotional complexity, evolving prognostic clarity, and the need for iterative decision-making over time. Rather than centering decisions on a single variable such as gestational age, this approach emphasizes individualized assessment, a trial of therapy when appropriate, and longitudinal conversations grounded in trust, empathy, and responsiveness to changing clinical realities. As neonatology continues to push the boundaries of viability—and as emerging technologies reshape the therapeutic landscape—ethical deliberation must keep pace. Clinicians and parents alike must navigate persistent uncertainty with humility, attentiveness to suffering, and a shared commitment to doing what is best for each infant and family.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 2","pages":"Article 101712"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The case for improving care for patients and families affected by birth at <25 weeks’ gestation 改善对受妊娠<25周分娩影响的患者和家庭的护理的案例。
IF 2.8 3区 医学
Seminars in Fetal & Neonatal Medicine Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1016/j.siny.2026.101713
Matthew A. Rysavy
{"title":"The case for improving care for patients and families affected by birth at <25 weeks’ gestation","authors":"Matthew A. Rysavy","doi":"10.1016/j.siny.2026.101713","DOIUrl":"10.1016/j.siny.2026.101713","url":null,"abstract":"<div><div>The medical management of infants born before 25 weeks' gestation is among the most controversial and challenging areas of perinatology. Despite remarkable advances in neonatal intensive care over the past half century, substantial variability in clinical care and outcomes persists. Infants born at 22-24 weeks' gestation account for approximately 1 in 5 infant deaths in the United States, 1 in 50 neonatal intensive care admissions, and 1 in 3 newborn ventilator-days in United States tertiary centers—yet they are poorly represented in clinical trials and little evidence exists to guide safe and effective care. Drawing from international experience and emerging data, we propose three strategies to improve the care of these patients and their families: (1) identifying the unique physiological characteristics of infants &lt;25 weeks’ gestation that require specialized approaches; (2) generating evidence to inform care through collaborative networks; and (3) systematically partnering with families and former patients to guide care and research.</div></div>","PeriodicalId":49547,"journal":{"name":"Seminars in Fetal & Neonatal Medicine","volume":"31 2","pages":"Article 101713"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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