胃肠道(GI)-肺-脑轴。

IF 2.9 3区医学 Q1 PEDIATRICS

Seminars in Fetal & Neonatal Medicine Pub Date : 2025-04-09 DOI:10.1016/j.siny.2025.101639

Catalina Bazacliu, Juan Carlos Roig, Josef Neu

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引用次数: 0

摘要

胃肠道-肺-脑轴是连接胃肠道、中枢神经系统和呼吸系统的通讯网络。这条轴在早产儿中尤为重要，因为他们的免疫和神经系统正在快速发育，因此容易受到胃肠道和肺部微生物群的影响，而胃肠道和肺部微生物群是这条轴的关键介质。这种通讯网络通过神经、激素和免疫调节途径连接起来，所有这些途径在疾病发病和健康中都是关键的。在这里，我们简要介绍了这个轴，以及影响这个系统的相互作用机制和扰动，以及它们在健康和疾病中所起的作用。

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Gastrointestinal (GI)-lung-brain axis

The GI tract-lung-brain axis refers to the communication network linking the gastrointestinal tract, central nervous system, and respiratory system. This axis is particularly significant in preterm neonates because their immune and nervous systems are undergoing rapid development and thus are susceptible to various conditions influenced by GI tract and lung microbiota that are key mediators in this axis. This communication network is connected via neural, hormonal, and immunological regulatory pathways, all of which are pivotal in disease pathogenesis and health. Here we provide a brief introduction to this axis along with interactive mechanisms and perturbations that can affect this system and the roles they play in health and disease.

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来源期刊

Seminars in Fetal & Neonatal Medicine 医学-小儿科

CiteScore

6.40

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Fetal & Neonatal Medicine (formerly Seminars in Neonatology) is a bi-monthly journal which publishes topic-based issues, including current ''Hot Topics'' on the latest advances in fetal and neonatal medicine. The Journal is of interest to obstetricians and maternal-fetal medicine specialists. The Journal commissions review-based content covering current clinical opinion on the care and treatment of the pregnant patient and the neonate and draws on the necessary specialist knowledge, including that of the pediatric pulmonologist, the pediatric infectious disease specialist, the surgeon, as well as the general pediatrician and obstetrician. Each topic-based issue is edited by an authority in their field and contains 8-10 articles. Seminars in Fetal & Neonatal Medicine provides: • Coverage of major developments in neonatal care; • Value to practising neonatologists, consultant and trainee pediatricians, obstetricians, midwives and fetal medicine specialists wishing to extend their knowledge in this field; • Up-to-date information in an attractive and relevant format.