Seminars in Immunology最新文献_第7页

Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis 中性粒细胞的调节性细胞死亡：从细胞凋亡到NETosis和Pyroposis。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 DOI: 10.1016/j.smim.2023.101849

Léonie Dejas , Karin Santoni , Etienne Meunier , Mohamed Lamkanfi

引用次数: 0

Introduction to the special issue: Antigen cross-presentation 特刊简介：抗原交叉展示。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 DOI: 10.1016/j.smim.2023.101850

Peter van Endert

引用次数: 0

Regulatory T cells in allergic inflammation 过敏性炎症中的调节性T细胞。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-12 DOI: 10.1016/j.smim.2023.101847

Mehdi Benamar , Qian Chen , Monica Martinez-Blanco , Talal A. Chatila

引用次数: 0

Chemical modulation of gasdermin D activity: Therapeutic implications and consequences gasdermin D活性的化学调节：治疗意义和后果。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-08 DOI: 10.1016/j.smim.2023.101845

Bowen Zhou, Derek W. Abbott

引用次数: 0

The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions 上皮屏障：过敏性、自身免疫性、代谢性疾病和慢性神经精神疾病的途径。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-04 DOI: 10.1016/j.smim.2023.101846

Duygu Yazici , Ismail Ogulur , Yagiz Pat , Huseyn Babayev , Elena Barletta , Sena Ardicli , Manal Bel imam , Mengting Huang , Jana Koch , Manru Li , Debbie Maurer , Urszula Radzikowska , Pattraporn Satitsuksanoa , Stephan R. Schneider , Na Sun , Stephan Traidl , Alexandra Wallimann , Sebastian Wawrocki , Damir Zhakparov , Danielle Fehr , Cezmi A. Akdis

{"title":"The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions","authors":"Duygu Yazici , Ismail Ogulur , Yagiz Pat , Huseyn Babayev , Elena Barletta , Sena Ardicli , Manal Bel imam , Mengting Huang , Jana Koch , Manru Li , Debbie Maurer , Urszula Radzikowska , Pattraporn Satitsuksanoa , Stephan R. Schneider , Na Sun , Stephan Traidl , Alexandra Wallimann , Sebastian Wawrocki , Damir Zhakparov , Danielle Fehr , Cezmi A. Akdis","doi":"10.1016/j.smim.2023.101846","DOIUrl":"10.1016/j.smim.2023.101846","url":null,"abstract":"<div><p>Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing to the current pandemic in allergic, autoimmune and metabolic diseases. The \"Epithelial Barrier Theory\" postulates that these diseases are exacerbated by persistent periepithelial inflammation (epithelitis) triggered by exposure to a wide range of epithelial barrier-damaging substances as well as genetic susceptibility. The epithelial barrier serves as the body's primary physical, chemical, and immunological barrier against external stimuli. A leaky epithelial barrier facilitates the translocation of the microbiome from the surface of the afflicted tissues to interepithelial and even deeper subepithelial locations. In turn, opportunistic bacterial colonization, microbiota dysbiosis, local inflammation and impaired tissue regeneration and remodelling follow. Migration of inflammatory cells to susceptible tissues contributes to damage and inflammation, initiating and aggravating many chronic inflammatory diseases. The objective of this review is to highlight and evaluate recent studies on epithelial physiology and its role in the pathogenesis of chronic diseases in light of the epithelial barrier theory.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101846"},"PeriodicalIF":7.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The noncanonical inflammasome-induced pyroptosis and septic shock 非典型炎症小体可诱发pyroptosis和感染性休克。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-29 DOI: 10.1016/j.smim.2023.101844

Junru Wu , Jingjing Cai , Yiting Tang , Ben Lu

{"title":"The noncanonical inflammasome-induced pyroptosis and septic shock","authors":"Junru Wu , Jingjing Cai , Yiting Tang , Ben Lu","doi":"10.1016/j.smim.2023.101844","DOIUrl":"10.1016/j.smim.2023.101844","url":null,"abstract":"<div><p>Sepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic mode of cell death termed pyroptosis upon sensing cytosolic lipopolysaccharide (LPS). Although the consequences of activation of the canonical and non-canonical inflammasome are similar, the non-canonical inflammasome formation requires caspase-4/5/11, which enzymatically cleave the pore-forming protein gasdermin D (GSDMD) and thereby cause pyroptosis. The non-canonical inflammasome assembly triggers such inflammatory cell death by itself; or leverages a secondary activation of the canonical NLRP3 inflammasome pathway. Excessive cell death induced by oligomerization of GSDMD and NINJ1 leads to cytokine release and massive tissue damage, facilitating devastating consequences and death. This review summarized the updated mechanisms that initiate and regulate non-canonical inflammasome activation and pyroptosis and highlighted various endogenous or synthetic molecules as potential therapeutic targets for treating sepsis.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101844"},"PeriodicalIF":7.8,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immunology and cell biology of T cell aging T细胞衰老的免疫学和细胞生物学。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-28 DOI: 10.1016/j.smim.2023.101843

Jörg J. Goronzy, Nan-ping Weng

引用次数: 0

Beyond youth: Understanding CAR T cell fitness in the context of immunological aging 超越年轻：在免疫衰老的背景下理解CAR T细胞的适应性。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-18 DOI: 10.1016/j.smim.2023.101840

Julia Han Noll , Bruce L. Levine , Carl H. June , Joseph A. Fraietta

{"title":"Beyond youth: Understanding CAR T cell fitness in the context of immunological aging","authors":"Julia Han Noll , Bruce L. Levine , Carl H. June , Joseph A. Fraietta","doi":"10.1016/j.smim.2023.101840","DOIUrl":"10.1016/j.smim.2023.101840","url":null,"abstract":"<div><p>Population aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune system is a critical factor in the senescence process, with cancer being a primary cause of death in elderly populations. Chimeric antigen receptor (CAR) T cell therapy, an innovative approach, has demonstrated success mainly in pediatric and young adult hematological malignancies but remains largely ineffective for diseases affecting older populations, such as late-in-life B cell malignancies and most solid tumor indications. This limitation arises because CAR T cell efficacy heavily relies on the fitness of the patient-derived starting T cell material. Numerous studies suggest that T cell senescence may be a key driver of CAR T cell deficiency. This review examines correlates and underlying factors associated with favorable CAR T cell outcomes and explores potential experimental and clinically actionable strategies for T cell rejuvenation.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101840"},"PeriodicalIF":7.8,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS 与疫苗反应性相关的基线免疫状态(BIS)和影响BIS的因素

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-15 DOI: 10.1016/j.smim.2023.101842

Djamel Nehar-Belaid , Mark Sokolowski , Sathyabaarathi Ravichandran , Jacques Banchereau , Damien Chaussabel , Duygu Ucar

{"title":"Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS","authors":"Djamel Nehar-Belaid , Mark Sokolowski , Sathyabaarathi Ravichandran , Jacques Banchereau , Damien Chaussabel , Duygu Ucar","doi":"10.1016/j.smim.2023.101842","DOIUrl":"10.1016/j.smim.2023.101842","url":null,"abstract":"<div><p>Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in single-cell biology have been instrumental in uncovering pre-vaccination immune cell types and genomic features (i.e., the baseline immune state, BIS) that have been associated with vaccine responsiveness. Here, we review clinical factors that shape the BIS, and the characteristics of the BIS associated with responsiveness to frequently studied vaccines (i.e., influenza, COVID-19, bacterial pneumonia, malaria). Finally, we discuss potential strategies to enhance vaccine responsiveness in high-risk groups, focusing specifically on older adults.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101842"},"PeriodicalIF":7.8,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better safe than sorry: Naive T-cell dynamics in healthy ageing 安全总比后悔好:健康衰老中的幼稚t细胞动力学

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-14 DOI: 10.1016/j.smim.2023.101839

Rob J. de Boer , Kiki Tesselaar , José A.M. Borghans

引用次数: 0