Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2023-11-01 DOI:10.1016/j.smim.2023.101849

Léonie Dejas , Karin Santoni , Etienne Meunier , Mohamed Lamkanfi

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引用次数: 0

Abstract

Neutrophils are among the most abundant immune cells, representing about 50%− 70% of all circulating leukocytes in humans. Neutrophils rapidly infiltrate inflamed tissues and play an essential role in host defense against infections. They exert microbicidal activity through a variety of specialized effector mechanisms, including phagocytosis, production of reactive oxygen species, degranulation and release of secretory vesicles containing broad-spectrum antimicrobial factors. In addition to their homeostatic turnover by apoptosis, recent studies have revealed the mechanisms by which neutrophils undergo various forms of regulated cell death. In this review, we will discuss the different modes of regulated cell death that have been described in neutrophils, with a particular emphasis on the current understanding of neutrophil pyroptosis and its role in infections and autoinflammation.

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中性粒细胞的调节性细胞死亡：从细胞凋亡到NETosis和Pyroposis。

中性粒细胞是最丰富的免疫细胞之一，约占人类所有循环白细胞的50%-70%。中性粒细胞迅速浸润发炎组织，在宿主防御感染中发挥重要作用。它们通过多种特殊的效应机制发挥杀微生物活性，包括吞噬作用、活性氧的产生、脱颗粒和释放含有广谱抗菌因子的分泌囊泡。除了通过细胞凋亡进行稳态转换外，最近的研究还揭示了中性粒细胞经历各种形式的调节细胞死亡的机制。在这篇综述中，我们将讨论中性粒细胞中所描述的不同调节细胞死亡模式，特别强调目前对中性粒细胞焦下垂及其在感染和自身炎症中的作用的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.