Seminars in Immunology最新文献

Diabetes and immunity: Decoding immunometabolism for precision intervention. 糖尿病与免疫：解码免疫代谢以实现精准干预。

IF 11.5 2区医学

Seminars in Immunology Pub Date : 2026-09-03 DOI: 10.1016/j.smim.2026.102058

Delia Goletti, Hardy Kornfeld, Catherine W M Ong

引用次数: 0

IL-1-mediated cancer-adapted hematopoiesis in aging and clonal hematopoiesis il -1介导的癌症适应性造血在衰老和克隆造血中的作用。

IF 11.5 2区医学

Seminars in Immunology Pub Date : 2026-09-01 Epub Date: 2026-08-25 DOI: 10.1016/j.smim.2026.102055

Francisco Caiado, Nagihan G. Gonullu, Markus G. Manz

{"title":"IL-1-mediated cancer-adapted hematopoiesis in aging and clonal hematopoiesis","authors":"Francisco Caiado, Nagihan G. Gonullu, Markus G. Manz","doi":"10.1016/j.smim.2026.102055","DOIUrl":"10.1016/j.smim.2026.102055","url":null,"abstract":"<div><div>A defining and evolutionary-selected feature of hematopoiesis is its capacity to adapt to organismal cellular needs. This demand-adapted hematopoiesis relies on a complex peripheric immune system capable of sensing minute amounts of damage and pathogen molecular patterns and trigger an inflammation-based reaction that sets the organism on alert. At a receiver-end of this response are bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) which rapidly sense inflammatory messages and engage in differentiating divisions to replenish the consumed innate immune cells, bringing the organism back into homeostasis. Cancer can elicit such systemic inflammatory-immune response, possibly as an initial attempt to contain tumor progression, which pushes HSPC differentiation towards myeloid cells production (myelopoiesis) in a process here termed cancer-adapted hematopoiesis (CAH). CAH leads to proliferation and mobilization of HSPCs, causing extramedullary hematopoiesis (EMH) and increased myelopoietic output that, due to its accelerated nature, generates immature myeloid cells with immunosuppressive functions that support tumor progression, generally termed myeloid-derived suppressor cells (MDSC). While multiple inflammatory pathways are implicated in CAH, here we focus on the impact of IL-1 pathway, which is a well-established modulator of HSPC biology in contexts of sterile inflammation, infection and myeloablation. We present evidence for the IL-1 pathway as a central driver of CAH acting both as a direct and indirect agent between tumors and HSPCs. Moreover, we highlight recent models on how IL-1-mediated CAH is impacted by age and clonal disorders of the hematopoietic system, further highlighting its pathological and thus targetable role in cancer progression.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"83 ","pages":"Article 102055"},"PeriodicalIF":11.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food antigen-driven immune disorders: From tolerance breakdown to precision therapeutics. 食物抗原驱动的免疫紊乱：从耐受性破坏到精确治疗。

IF 11.5 2区医学

Seminars in Immunology Pub Date : 2026-08-25 DOI: 10.1016/j.smim.2026.102057

Esko Kemppainen, Katri Lindfors

引用次数: 0

Complement in tumor immunology: From a circulating cascade to a therapeutic target in the tumor microenvironment. 肿瘤免疫学中的补体：从循环级联到肿瘤微环境中的治疗靶点。

IF 11.5 2区医学

Seminars in Immunology Pub Date : 2026-08-22 DOI: 10.1016/j.smim.2026.102056

Lubka T Roumenina

引用次数: 0

Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity. 树突状细胞介导的抗癌免疫中的蛋白酪氨酸激酶。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2026-06-05 DOI: 10.1016/j.smim.2026.102037

Misha Mao, Liwei Zhao, Guido Kroemer, Oliver Kepp, Peng Liu

{"title":"Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity.","authors":"Misha Mao, Liwei Zhao, Guido Kroemer, Oliver Kepp, Peng Liu","doi":"10.1016/j.smim.2026.102037","DOIUrl":"https://doi.org/10.1016/j.smim.2026.102037","url":null,"abstract":"<p><p>Dendritic cells (DCs), the most proficient antigen-presenting cells, bridge innate and adaptive immunity and are critical for anti-cancer immune surveillance. Their function is precisely regulated by protein tyrosine kinases (PTKs), which integrate signals from external stimuli and internal cellular stress to control DC maturation, migration, and antigen presentation. This review systematically synthesizes current knowledge on PTK roles in DC-mediated anti-tumor immunity, with a focused analysis of their differential expression and function across human and mouse DC subsets-including conventional (cDC1, cDC2), plasmacytoid (pDC), and monocyte-derived DCs. We highlight how specific PTK families (e.g., TAM, PDGFR, SRC, JAK) translate pathogen- and damage-associated signals into tailored immune responses. Furthermore, we discuss the dual impact of clinically approved PTK inhibitors on DC function, which can either enhance or suppress anti-tumor immunity depending on context. Finally, we evaluate translational strategies that combine PTK-targeted agents with DC-based vaccines or immune checkpoint blockade, offering a rationale for exploiting PTK-DC crosstalk to develop more effective combinatorial immunotherapies.</p>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"83 ","pages":"102037"},"PeriodicalIF":7.8,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to the special issue: TH9 cells in diseases 特刊导论：TH9细胞在疾病中的作用。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2026-06-01 Epub Date: 2026-05-25 DOI: 10.1016/j.smim.2026.102036

Lionel Apetoh

引用次数: 0

The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives 拉丁美洲和加勒比地区的免疫系统：从当地角度了解疾病和多样性。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2026-06-01 Epub Date: 2026-05-29 DOI: 10.1016/j.smim.2026.102035

Ileana Licona-Limón , José Luis Maravillas-Montero , Maria Carolina Amezcua Vesely , Paula Licona-Limón

{"title":"The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives","authors":"Ileana Licona-Limón , José Luis Maravillas-Montero , Maria Carolina Amezcua Vesely , Paula Licona-Limón","doi":"10.1016/j.smim.2026.102035","DOIUrl":"10.1016/j.smim.2026.102035","url":null,"abstract":"<div><div>Latin America and the Caribbean host one of the world’s most complex intersections of ancestry, pathogen exposure, and environmental change, generating an immunological landscape that cannot be fully understood through frameworks derived from high-income regions. The region’s immune profiles reflect the legacy of colonization, population collapse, forced migration and admixture, together with more recent transformations driven by urbanization, dietary change, pollution and shifts in microbial exposure. These factors contribute to variability in immune responsiveness, susceptibility to infection and immune mediated and metabolic diseases. In this review, we aim to integrate insights from population genomics, infectious disease epidemiology, environmental immunology and social determinants of health to examine how these processes contribute to immune variation across LAC. We highlight how ancestry associated immunogenetic variation, in interaction with environmental and socioeconomic context, may contribute to heterogeneity in host-pathogen interactions, inflammation regulation and vaccine responses. We further discuss how persistent infectious exposures coexist with rising non-communicable diseases, generating distinct immunological trajectories. Understanding immunity in LAC may provide a framework for developing context specific interventions while offering broader insight into how ancestry, environment and social conditions shape human immune adaptation.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"82 ","pages":"Article 102035"},"PeriodicalIF":7.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotransmitters: Key regulators of the tumor immune microenvironment 神经递质：肿瘤免疫微环境的关键调节因子

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.smim.2026.102015

Liubo Zhang , Wei Jing , Yunbo Li , Yu Ping , Yi Zhang

{"title":"Neurotransmitters: Key regulators of the tumor immune microenvironment","authors":"Liubo Zhang , Wei Jing , Yunbo Li , Yu Ping , Yi Zhang","doi":"10.1016/j.smim.2026.102015","DOIUrl":"10.1016/j.smim.2026.102015","url":null,"abstract":"<div><div>Recent studies have revealed that neurotransmitters, as a class of important signaling molecules, have functional roles that extend beyond the traditional nervous system and play critical regulatory functions in the tumor immune microenvironment. Research has demonstrated that various classical neurotransmitters and their receptors are widely expressed in tumor tissues. Through complex receptor-mediated signaling networks, neurotransmitters dynamically regulate the functions of diverse cell types, including tumor cells and immune cells, thereby influencing tumor progression. Based on these discoveries, significant progress has been made in developing innovative drugs targeting neurotransmitter-receptor axes. Multiple agents, such as N-methyl-<span>D</span>-aspartate receptor (NMDAR), γ-aminobutyric acid-A (GABA-A) agonists, and dopamine receptor antagonists, have demonstrated promising antitumor effects in both preclinical studies and clinical trials. This review systematically summarizes the multidimensional regulatory mechanisms of neurotransmitters in tumor immunity and comprehensively discusses recent advances in neurotransmitter-targeted therapies. These findings not only provide a theoretical foundation for developing novel immunotherapeutic strategies based on neurotransmitter modulation but also open new research perspectives for understanding the emerging field of \"neuro-immune-tumor\" crosstalk.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"81 ","pages":"Article 102015"},"PeriodicalIF":7.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse IL-9-secreting T helper cells direct responses in the allergic lung 多种il -9分泌T辅助细胞直接反应过敏性肺

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI: 10.1016/j.smim.2026.102014

Kaitlyn G. Jackson, Mark H. Kaplan

{"title":"Diverse IL-9-secreting T helper cells direct responses in the allergic lung","authors":"Kaitlyn G. Jackson, Mark H. Kaplan","doi":"10.1016/j.smim.2026.102014","DOIUrl":"10.1016/j.smim.2026.102014","url":null,"abstract":"<div><div>IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease. IL-9 has increasingly been linked to asthma severity in patients. Early studies primarily focused on the differentiation of \"classical\" Th9 cells, which express IL-9 but not other type II cytokines. Recent research has identified additional populations of IL-9-secreting CD4<sup>+</sup> T cells, including Th2-allergic (Th2A) cells and resident memory Th9 (Th9rm) cells. Despite IL-9 induction in classical Th9 effector cells being transient, Th2A and memory populations generate a recall IL-9 response upon repeated allergen exposure. Additionally, cytokine-driven bystander activation may prolong IL-9 production in various CD4<sup>+</sup> T cell subsets. This review evaluates the transcriptional, metabolic, and cytokine-mediated signals that regulate the effector function of IL-9-secreting CD4<sup>+</sup> T cell subsets in models of acute, chronic, and intermittent allergic airway disease. Given the heterogeneity of asthma phenotypes, identifying endotypes characterized by high levels of Th9 cells or IL-9 may improve therapeutic precision in asthma treatment.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"81 ","pages":"Article 102014"},"PeriodicalIF":7.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting immune heterogeneity in liver metastases through in vivo genetic engineering 通过体内基因工程靶向肝转移的免疫异质性。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1016/j.smim.2025.102012

Giovanna Giacca, Mario Leonardo Squadrito

引用次数: 0