Seminars in Immunology最新文献

Harnessing complement biomarkers for precision cancer care 利用补体生物标志物进行精准癌症治疗

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-05-15 DOI: 10.1016/j.smim.2025.101963

Houcine Hamidi , Idris Boudhabhay , Marie-Agnes Dragon-Durey

{"title":"Harnessing complement biomarkers for precision cancer care","authors":"Houcine Hamidi , Idris Boudhabhay , Marie-Agnes Dragon-Durey","doi":"10.1016/j.smim.2025.101963","DOIUrl":"10.1016/j.smim.2025.101963","url":null,"abstract":"<div><div>The tumor microenvironment (TME) consists of various immune and non-immune cells, along with proteins from different origins, and plays a crucial role in tumor development, treatment response, and patient prognosis. Complement system is a key player in the TME. It is a proteolytic cascade that generates cleavage fragments capable to activate cells through specific receptors or deposit on cells and tissues. This review summarizes current data on the complement system as a potential biomarker in cancer. Transcriptomic analyses have classified tumors based on the impact of complement gene expression on prognosis. Immunostaining provides insights into the expression and deposition of complement proteins and fragments in tumors and TME cells. In body fluids such as blood, measuring complement activation fragments and detecting anti-complement autoantibodies have identified non-invasive biomarkers relevant to certain cancer types. With the rise of complement-targeting therapies and new tools for analyzing the complement system in tumors and body fluids, it is time to define its role in cancer management. This includes its potential for cancer detection, staging, and potentially for treatment monitoring.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101963"},"PeriodicalIF":7.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches 通过假设驱动和假设生成方法揭示1型发作性睡病的病理生理学

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-05-14 DOI: 10.1016/j.smim.2025.101962

Sean A. Freeman , Ikram Ayoub , Yves Dauvilliers , Roland S. Liblau

{"title":"Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches","authors":"Sean A. Freeman , Ikram Ayoub , Yves Dauvilliers , Roland S. Liblau","doi":"10.1016/j.smim.2025.101962","DOIUrl":"10.1016/j.smim.2025.101962","url":null,"abstract":"<div><div>Narcolepsy type 1 (NT1) is a chronic orphan neurological sleep disorder characterized by the loss of hypocretin-producing neurons in the lateral hypothalamus, which play a crucial role in wakefulness. Given the genetic association with the <em>HLA-DQB1 * 06:02</em> allele and environmental links with the 2009 influenza pandemic, many lines of evidence point towards an immune mechanism, notably autoimmunity, underlying the disease pathophysiology. Autoreactive T cells are found in the blood of NT1 patients, and mouse models demonstrate their migratory capacity and contribution in the selective destruction of hypocretin-producing neurons. However, direct evidence for their role in human NT1 pathophysiology remains elusive. In complementing these findings, hypothesis-generating approaches—including multiparametric immune profiling, transcriptomic sequencing and large-scale proteomic of blood and cerebrospinal fluid—have uncovered promising new avenues into the immune system’s involvement in NT1. In this review, we explore the mechanisms driving NT1 pathogenesis, emphasizing both hypothesis-driven and hypothesis-generating approaches, and discuss potential future directions that could pave the way for targeted immunotherapies.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101962"},"PeriodicalIF":7.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual- and population-associated heterogeneity in vaccine-induced immune responses. The impact of inflammatory status and diabetic comorbidity 疫苗诱导免疫反应的个体和群体相关异质性。炎症状态和糖尿病合并症的影响

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-05-09 DOI: 10.1016/j.smim.2025.101964

Simone A. Joosten

引用次数: 0

Global aspects of celiac disease and food allergy 乳糜泻和食物过敏的全球视角

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-28 DOI: 10.1016/j.smim.2025.101961

Samagra Agrawal, Govind K. Makharia

引用次数: 0

The pathogenesis of neurological immune-related adverse events following immune checkpoint inhibitor therapy 免疫检查点抑制剂治疗后神经免疫相关不良事件的发病机制

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-27 DOI: 10.1016/j.smim.2025.101956

Magdalena Lerch , Sudarshini Ramanathan

{"title":"The pathogenesis of neurological immune-related adverse events following immune checkpoint inhibitor therapy","authors":"Magdalena Lerch , Sudarshini Ramanathan","doi":"10.1016/j.smim.2025.101956","DOIUrl":"10.1016/j.smim.2025.101956","url":null,"abstract":"<div><div>Cancer is a leading cause of morbidity and mortality worldwide. The development of immune checkpoint inhibitors (ICI) has revolutionised cancer therapy, and patients who were previously incurable can now have excellent responses. These therapies work by blocking inhibitory immune pathways, like cytotoxic T lymphocyte-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), its ligand PD-L1, and lymphocyte activation gene 3 (LAG-3); which leads to increased anti-tumour immune responses. However, their use can lead to the development of immune-related adverse events (irAEs), which may result in severe disability, interruption of cancer therapy, and even death. Neurological autoimmune sequelae occur in 1–10 % of patients treated with ICIs and can be fatal. They encompass a broad spectrum of diseases, may affect the central and the peripheral nervous system, and include syndromes like encephalitis, cerebellitis, neuropathy, and myositis. In some cases, neurological irAEs can be associated with autoantibodies recognising neuronal or glial targets. In this review, we first describe the key targets in ICI therapy, followed by a formulation of irAEs and their clinical presentations, where we focus on neurological syndromes. We comprehensively formulate the current literature evaluating cell surface and intracellular autoantibodies, cytokines, chemokines, leukocyte patterns, other blood derived biomarkers, and immunogenetic profiles; and highlight their impact on our understanding of the pathogenesis of neurological irAEs. Finally, we describe therapeutic pathways and patient outcomes, and provide an overview on future aspects of ICI cancer therapy.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101956"},"PeriodicalIF":7.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetylation and deacetylation dynamics in stress response to cancer and infections 对癌症和感染的应激反应中的乙酰化和去乙酰化动力学

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-26 DOI: 10.1016/j.smim.2025.101957

Lili Li , Yanqiong Zeng , Genhong Cheng , Heng Yang

{"title":"Acetylation and deacetylation dynamics in stress response to cancer and infections","authors":"Lili Li , Yanqiong Zeng , Genhong Cheng , Heng Yang","doi":"10.1016/j.smim.2025.101957","DOIUrl":"10.1016/j.smim.2025.101957","url":null,"abstract":"<div><div>In response to stress stimuli, cells have evolved various mechanisms to integrate internal and external signals to achieve dynamic homeostasis. Lysine acetyltransferase (KATs) and deacetyltransferase (KDACs) are the key modulators of epigenetic modifications, enabling cells to modulate cellular responses through the acetylation and deacetylation of both histone and nonhistone proteins. Understanding the signaling pathways involved in cellular stress response, along with the roles of KATs and KDACs may pave the way for the development of novel therapeutic strategies. This review discusses the molecular mechanisms of acetylation and deacetylation in stress responses related to tumorigenesis, viral and bacterial infections. In tumorigenesis section, we focused on the tumor cells’ intrinsic and external molecules and signaling pathways regulated by acetylation and deacetylation modification. In viral and bacterial infections, we summarized the update research on acetylation and deacetylation modification in viral and bacterial infections, which systematical introduction on this topic is not too much. Additionally, we provide an overview of current therapeutic interventions and clinical trials involving KAT and KDAC inhibitors in the treatment of cancer, as well as viral and bacterial infection-related diseases.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101957"},"PeriodicalIF":7.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune therapies in coeliac disease and food allergies: Advances, challenges, and opportunities 乳糜泻和食物过敏的免疫治疗：进展、挑战和机遇

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-23 DOI: 10.1016/j.smim.2025.101960

Dianne E. Campbell , Sam Mehr , Olivia G. Moscatelli , Robert P. Anderson , Jason A. Tye-Din

{"title":"Immune therapies in coeliac disease and food allergies: Advances, challenges, and opportunities","authors":"Dianne E. Campbell , Sam Mehr , Olivia G. Moscatelli , Robert P. Anderson , Jason A. Tye-Din","doi":"10.1016/j.smim.2025.101960","DOIUrl":"10.1016/j.smim.2025.101960","url":null,"abstract":"<div><div>Coeliac disease and food allergy management primarily relies on the strict avoidance of dietary antigens. This approach is challenging to maintain in real-world settings and in food allergy carries the risk of life-threatening anaphylaxis. Despite their distinct pathogenesis, both disorders are driven by maladaptive responses to dietary proteins, creating opportunities for shared treatment strategies. In food allergy, desensitisation therapies such as oral, sublingual, and epicutaneous immunotherapy are well-established, complemented by biologics like omalizumab and dupilumab. However, the induction of sustained tolerance remains challenging. In contrast, therapeutic advancements for coeliac disease are still in their early stages. Current efforts focus on gluten detoxification or modification, immune blockade or modulation, tolerogenic approaches, and barrier restoration. Emerging therapies, including JAK and BTK inhibitors and microbiome-targeted interventions, support further targeted treatment options for both conditions. Biomarkers tracking gluten-specific T cells have emerged as valuable tools for immunomonitoring and symptom assessment in coeliac disease, although standardisation of patient-reported outcome measures and gluten challenge protocols is still needed. Food allergy trials are reliant on double-blind placebo-controlled food challenges to measure allergen reactivity, but these are time-consuming, carry risks, and underscore the need for surrogate biomarkers. The successful development of immune-targeted therapies will require building an immune toolset to optimally assess systemic responses to antigens in both conditions. Clinically, this could lead to better outcomes for patients who might otherwise remain undiagnosed or untreated due to the absence of significant enteropathy or allergen-specific symptoms.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101960"},"PeriodicalIF":7.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune dysregulation of diabetes in tuberculosis 糖尿病在肺结核中的免疫失调

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-22 DOI: 10.1016/j.smim.2025.101959

Pei Min Thong , Yi Hao Wong , Hardy Kornfeld , Delia Goletti , Catherine W.M. Ong

引用次数: 0

From immunobiology to intervention: Pathophysiology of autoimmune encephalitis 从免疫生物学到干预：自身免疫性脑炎的病理生理学

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-22 DOI: 10.1016/j.smim.2025.101955

Marie A. Homeyer , Alice Falck , Lucie Y. Li , Harald Prüss

{"title":"From immunobiology to intervention: Pathophysiology of autoimmune encephalitis","authors":"Marie A. Homeyer , Alice Falck , Lucie Y. Li , Harald Prüss","doi":"10.1016/j.smim.2025.101955","DOIUrl":"10.1016/j.smim.2025.101955","url":null,"abstract":"<div><div>Autoimmune encephalitides (AEs) are neurological disorders caused by autoantibodies against neuronal and glial surface proteins. Nearly 20 years after their discovery, AE have evolved from being frequently misdiagnosed and untreated to a growing group of increasingly well-characterized conditions where patients benefit from targeted therapeutic strategies. This narrative review provides an immunological perspective on AE, focusing on NMDAR, CASPR2 and LGI1 encephalitis as the three most common forms of AE associated with anti-neuronal surface autoantibodies. We examine the autoreactive B cell subsets, the tolerance checkpoints that may fail, and the known triggers and predispositions contributing to disease. In addition, we discuss the roles of other immune cells, including T cells and microglia, in the pathogenesis of AE. By analyzing therapeutic strategies and treatment responses we draw insights into AE pathophysiology. Written at a time of transformative therapeutic advancements through cell therapies this work underscores the synergy between detailed immunological research and the development of innovative therapies.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101955"},"PeriodicalIF":7.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoplasmic reticulum stress: A key player in immune cell regulation and autoimmune disorders 内质网应激：免疫细胞调节和自身免疫性疾病的关键参与者

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-04-22 DOI: 10.1016/j.smim.2025.101954

Marion Moreews, Mikael C.I. Karlsson

{"title":"Endoplasmic reticulum stress: A key player in immune cell regulation and autoimmune disorders","authors":"Marion Moreews, Mikael C.I. Karlsson","doi":"10.1016/j.smim.2025.101954","DOIUrl":"10.1016/j.smim.2025.101954","url":null,"abstract":"<div><div>The endoplasmic reticulum (ER) is a large organelle, found in all eukaryotes, that is essential for normal cellular function. This function encompasses protein folding and quality control, post-translational modifications, lipid regulation, and the storage of intracellular calcium, among others. These diverse processes are essential for maintaining proteome stability. Therefore, a robust surveillance system is established under stress to ensure cell homeostasis. Sources of stress can originate from the cellular environment, including nutrient deprivation, hypoxia, and low pH, as well as from endogenous signals within the cell, such as metabolic challenges and increased demands for protein production. When cellular homeostasis is altered by one of these triggers, ER primary functions are altered which leads to the accumulation of misfolded proteins. These impaired proteins trigger the activation of the Unfolded Protein Response (UPR) pathway. This response aims at reducing ER stress by implementing the induction of complex programs to restore cell homeostasis. However, extended ER stress can modify the UPR response, shifting its signals from promoting survival to triggering pathways that reprogram or eliminate affected cells.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101954"},"PeriodicalIF":7.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0