Seminars in Immunology最新文献_第10页

Western diet influences on microbiome and carcinogenesis 西方饮食对微生物群和癌变的影响

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101756

Rachel Newsome , Ye Yang , Christian Jobin

引用次数: 1

Genetics of Inborn Errors of Immunity in highly consanguineous Middle Eastern and North African populations 高度同源的中东和北非人群先天性免疫错误的遗传学研究

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101763

Hamoud Al-Mousa , Mohamed-Ridha Barbouche

{"title":"Genetics of Inborn Errors of Immunity in highly consanguineous Middle Eastern and North African populations","authors":"Hamoud Al-Mousa , Mohamed-Ridha Barbouche","doi":"10.1016/j.smim.2023.101763","DOIUrl":"10.1016/j.smim.2023.101763","url":null,"abstract":"<div><p>Consanguineous marriages in Middle Eastern and North African (MENA) countries are deeply-rooted tradition and highly prevalent resulting into increased prevalence of autosomal recessive diseases including Inborn Errors of Immunity (IEIs). Molecular genetic testing is an important diagnostic tool for IEIs since it provides a definite diagnosis, genotype-phenotype correlation, and guide therapy. In this review, we will discuss the current state and challenges of genomic and variome studies in MENA region populations, as well as the importance of funding advanced genome projects. In addition, we will review the MENA underlying molecular genetic defects of over 2457 patients published with the common IEIs, where autosomal recessive mode of inheritance accounts for 76% of cases with increased prevalence of combined immunodeficiency diseases (50%). The efforts made in the last three decades in terms of international collaboration and of in situ capacity building in MENA region countries led to the discovery of more than 150 novel genes involved in IEIs. Expanding sequencing studies within the MENA will undoubtedly be a unique asset for the IEI genetics which can advance research, and support precise genomic diagnostics and therapeutics.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101763"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunity to pathogenic fungi in the eye 对眼部病原真菌的免疫力。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101753

Serena Abbondante , Sixto M. Leal , Heather L. Clark , Bridget Ratitong , Yan Sun , Li-Jun Ma , Eric Pearlman

引用次数: 1

The biogenesis of the immunopeptidome 免疫肽穹窿的生物发生

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101766

Arie Admon

{"title":"The biogenesis of the immunopeptidome","authors":"Arie Admon","doi":"10.1016/j.smim.2023.101766","DOIUrl":"10.1016/j.smim.2023.101766","url":null,"abstract":"<div><p>The immunopeptidome is the repertoire of peptides bound and presented by the MHC class I, class II, and non-classical molecules. The peptides are produced by the degradation of most cellular proteins, and in some cases, peptides are produced from extracellular proteins taken up by the cells. This review attempts to first describe some of its known and well-accepted concepts, and next, raise some questions about a few of the established dogmas in this field: The production of novel peptides by splicing is questioned, suggesting here that spliced peptides are extremely rare, if existent at all. The degree of the contribution to the immunopeptidome by degradation of cellular protein by the proteasome is doubted, therefore this review attempts to explain why it is likely that this contribution to the immunopeptidome is possibly overstated. The contribution of defective ribosome products (DRiPs) and non-canonical peptides to the immunopeptidome is noted and methods are suggested to quantify them. In addition, the common misconception that the MHC class II peptidome is mostly derived from extracellular proteins is noted, and corrected. It is stressed that the confirmation of sequence assignments of non-canonical and spliced peptides should rely on targeted mass spectrometry using spiking-in of heavy isotope-labeled peptides. Finally, the new methodologies and modern instrumentation currently available for high throughput kinetics and quantitative immunopeptidomics are described. These advanced methods open up new possibilities for utilizing the big data generated and taking a fresh look at the established dogmas and reevaluating them critically.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101766"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9914955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma 气候变化和相关空气污染对免疫系统的影响导致过敏性疾病和哮喘的机制

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101765

Vanitha Sampath , Juan Aguilera , Mary Prunicki , Kari C. Nadeau

引用次数: 1

Viral- and tumor-reactive natural killer cells 病毒和肿瘤反应性自然杀伤细胞

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101749

Jianhua Yu , Michael A. Caligiuri

{"title":"Viral- and tumor-reactive natural killer cells","authors":"Jianhua Yu , Michael A. Caligiuri","doi":"10.1016/j.smim.2023.101749","DOIUrl":"10.1016/j.smim.2023.101749","url":null,"abstract":"<div><p>When we can understand what natural killer (NK) cells recognize during an encounter with an infectious pathogen or a tumor cell, and when we can understand how the NK cell responds to that encounter, we can then begin to understand the role of NK cells in human health and how to improve upon their role for the prevention and treatment of human disease. In the quest to understand how these cells function in antiviral and antitumoral immunity, there have been previously described mechanisms established for NK cells to participate in clearing viral infections and tumors, including classical NK cell antibody dependent cellular cytotoxicity (ADCC) as well as recognition and elimination of transformed malignant cells through direct ligand interactions. However, it is now clear that there are additional mechanisms by which NK cells can participate in these critical immune tasks. Here we review two recently described types of NK cell recognition and response: the first is to primary infection with herpes virus, recognized and responded to by non-specific Fc bridged cellular cytotoxicity (FcBCC), and the second describes a novel phenotypic and functional response when a subset of NK cells recognize myeloid leukemia.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101749"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

TREM2: A new player in the tumor microenvironment TREM2:肿瘤微环境中的新参与者

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101739

Martina Molgora, Yizhou A. Liu, Marco Colonna, Marina Cella

引用次数: 3

Cross-presentation by the others 其他人的交叉陈述

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101764

François-Xavier Mauvais , Peter van Endert

{"title":"Cross-presentation by the others","authors":"François-Xavier Mauvais , Peter van Endert","doi":"10.1016/j.smim.2023.101764","DOIUrl":"10.1016/j.smim.2023.101764","url":null,"abstract":"<div><p>The critical role of conventional dendritic cells in physiological cross-priming of immune responses to tumors and pathogens is widely documented and beyond doubt. However, there is ample evidence that a wide range of other cell types can also acquire the capacity to cross-present. These include not only other myeloid cells such as plasmacytoid dendritic cells, macrophages and neutrophils, but also lymphoid populations, endothelial and epithelial cells and stromal cells including fibroblasts. The aim of this review is to provide an overview of the relevant literature that analyzes each report cited for the antigens and readouts used, mechanistic insight and <em>in vivo</em> experimentation addressing physiological relevance. As this analysis shows, many reports rely on the exceptionally sensitive recognition of an ovalbumin peptide by a transgenic T cell receptor, with results that therefore cannot always be extrapolated to physiological settings. Mechanistic studies remain basic in most cases but reveal that the cytosolic pathway is dominant across many cell types, while vacuolar processing is most encountered in macrophages. Studies addressing physiological relevance rigorously remain exceptional but suggest that cross-presentation by non-dendritic cells may have significant impact in anti-tumor immunity and autoimmunity.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101764"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9536696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Microbial metabolites and immunotherapy: Basic rationale and clinical indications 微生物代谢物和免疫治疗:基本原理和临床适应症

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101755

Larisa V. Kovtonyuk, Kathy D. McCoy

引用次数: 2

Introduction to the Special Issue: Nutrition, microbiota and immunity 特刊导言:营养、微生物群与免疫

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101767

Laurence Zitvogel , Guido Kroemer

引用次数: 0