Seminars in Immunology最新文献_第10页

Exploiting antifungal immunity in the clinical context 在临床环境中开发抗真菌免疫

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101752

Michail S. Lionakis

引用次数: 3

Future indications and clinical management for fecal microbiota transplantation (FMT) in immuno-oncology 免疫肿瘤学中粪便微生物群移植(FMT)的未来适应症和临床管理

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101754

Rahima Jamal , Meriem Messaoudene , Marina de Figuieredo , Bertrand Routy

{"title":"Future indications and clinical management for fecal microbiota transplantation (FMT) in immuno-oncology","authors":"Rahima Jamal , Meriem Messaoudene , Marina de Figuieredo , Bertrand Routy","doi":"10.1016/j.smim.2023.101754","DOIUrl":"10.1016/j.smim.2023.101754","url":null,"abstract":"<div><p>The gut microbiota has rapidly emerged as one of the “hallmarks of cancers” and a key contributor to cancer immunotherapy. Metagenomics profiling has established the link between microbiota compositions and immune checkpoint inhibitors response and toxicity, while murine experiments demonstrating the synergistic benefits of microbiota modification with immune checkpoint inhibitors (ICIs) pave a clear path for translation. Fecal microbiota transplantation (FMT) is one of the most effective treatments for patients with <em>Clostridioides difficile,</em> but its utility in other disease contexts has been limited. Nonetheless, promising data from the first trials combining FMT with ICIs have provided strong clinical rationale to pursue this strategy as a novel therapeutic avenue. In addition to the safety considerations surrounding new and emerging pathogens potentially transmissible by FMT, several other challenges must be overcome in order to validate the use of FMT as a therapeutic option in oncology. In this review, we will explore how the lessons learned from FMT in other specialties will help shape the design and development of FMT in the immuno-oncology arena.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101754"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A major mechanism for immunomodulation: Dietary fibres and acid metabolites 免疫调节的主要机制:膳食纤维和酸代谢物

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101737

Liang Xie , Md Jahangir Alam , Francine Z. Marques , Charles R. Mackay

{"title":"A major mechanism for immunomodulation: Dietary fibres and acid metabolites","authors":"Liang Xie , Md Jahangir Alam , Francine Z. Marques , Charles R. Mackay","doi":"10.1016/j.smim.2023.101737","DOIUrl":"10.1016/j.smim.2023.101737","url":null,"abstract":"<div><p>Diet and the gut microbiota have a profound influence on physiology and health, however, mechanisms are still emerging. Here we outline several pathways that gut microbiota products, particularly short-chain fatty acids (SCFAs), use to maintain gut and immune homeostasis. Dietary fibre is fermented by the gut microbiota in the colon, and large quantities of SCFAs such as acetate, propionate, and butyrate are produced. Dietary fibre and SCFAs enhance epithelial integrity and thereby limit systemic endotoxemia. Moreover, SCFAs inhibit histone deacetylases (HDAC), and thereby affect gene transcription. SCFAs also bind to ‘metabolite-sensing’ G-protein coupled receptors (GPCRs) such as GPR43, which promotes immune homeostasis. The enormous amounts of SCFAs produced in the colon are sufficient to lower pH, which affects the function of proton sensors such as GPR65 expressed on the gut epithelium and immune cells. GPR65 is an anti-inflammatory Gα<sub>s</sub>-coupled receptor, which leads to the inhibition of inflammatory cytokines. The importance of GPR65 in inflammatory diseases is underscored by genetics associated with the missense variant I231L (rs3742704), which is associated with human inflammatory bowel disease, atopic dermatitis, and asthma. There is enormous scope to manipulate these pathways using specialized diets that release very high amounts of specific SCFAs in the gut, and we believe that therapies that rely on chemically modified foods is a promising approach. Such an approach includes high SCFA-producing diets, which we have shown to decrease numerous inflammatory western diseases in mouse models. These diets operate at many levels - increased gut integrity, changes to the gut microbiome, and promotion of immune homeostasis, which represents a new and highly promising way to prevent or treat human disease.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"66 ","pages":"Article 101737"},"PeriodicalIF":7.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9551158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Immunity to fungi in the lung 对肺部真菌的免疫力

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101728

Lena J. Heung , Darin L. Wiesner , Keyi Wang , Amariliz Rivera , Tobias M. Hohl

{"title":"Immunity to fungi in the lung","authors":"Lena J. Heung , Darin L. Wiesner , Keyi Wang , Amariliz Rivera , Tobias M. Hohl","doi":"10.1016/j.smim.2023.101728","DOIUrl":"10.1016/j.smim.2023.101728","url":null,"abstract":"<div><p>The respiratory tree maintains sterilizing immunity against human fungal pathogens. Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal pathogens that form small airborne conidia. In addition, pathogenic yeasts, exemplified by encapsulated <em>Cryptococcus</em> species, and <em>Pneumocystis</em> pose significant fungal threats to the lung. Classically, fungal pneumonia occurs in immune compromised individuals, specifically in patients with HIV/AIDS, in patients with hematologic malignancies, in organ transplant recipients, and in patients treated with corticosteroids and targeted biologics that impair fungal immune surveillance in the lung. The emergence of fungal co-infections during severe influenza and COVID-19 underscores the impairment of fungus-specific host defense pathways in the lung by respiratory viruses and by medical therapies to treat viral infections. Beyond life-threatening invasive syndromes, fungal antigen exposure can exacerbate allergenic disease in the lung. In this review, we discuss emerging principles of lung-specific antifungal immunity, integrate the contributions and cooperation of lung epithelial, innate immune, and adaptive immune cells to mucosal barrier immunity, and highlight the pathogenesis of fungal-associated allergenic disease. Improved understanding of fungus-specific immunity in the respiratory tree has paved the way to develop improved diagnostic, pre-emptive, therapeutic, and vaccine approaches for fungal diseases of the lung.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"66 ","pages":"Article 101728"},"PeriodicalIF":7.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148604/pdf/nihms-1894370.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10488828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example 用质谱法鉴定自身免疫性疾病中的新抗原:1型糖尿病的例子

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101730

Cheryl F. Lichti, Xiaoxiao Wan

引用次数: 4

The impact of immunopeptidomics: From basic research to clinical implementation 免疫肽组学的影响:从基础研究到临床应用

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101727

Ilja E. Shapiro , Michal Bassani-Sternberg

{"title":"The impact of immunopeptidomics: From basic research to clinical implementation","authors":"Ilja E. Shapiro , Michal Bassani-Sternberg","doi":"10.1016/j.smim.2023.101727","DOIUrl":"10.1016/j.smim.2023.101727","url":null,"abstract":"<div><p>The immunopeptidome is the set of peptides presented by the major histocompatibility complex (MHC) molecules, in humans also known as the human leukocyte antigen (HLA), on the surface of cells that mediate T-cell immunosurveillance. The immunopeptidome is a sampling of the cellular proteome and hence it contains information about the health state of cells. The peptide repertoire is influenced by intra- and extra-cellular perturbations - such as in the case of drug exposure, infection, or oncogenic transformation. Immunopeptidomics is the bioanalytical method by which the presented peptides are extracted from biological samples and analyzed by high-performance liquid chromatography coupled to tandem mass spectrometry (MS), resulting in a deep qualitative and quantitative snapshot of the immunopeptidome. In this review, we discuss published immunopeptidomics studies from recent years, grouped into three main domains: i) basic, ii) pre-clinical and iii) clinical research and applications. We review selected fundamental immunopeptidomics studies on the antigen processing and presentation machinery, on HLA restriction and studies that advanced our understanding of various diseases, and how exploration of the antigenic landscape allowed immune targeting at the pre-clinical stage, paving the way to pioneering exploratory clinical trials where immunopeptidomics is directly implemented in the conception of innovative treatments for cancer patients.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"66 ","pages":"Article 101727"},"PeriodicalIF":7.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Immunity to fungi: Editorial overview 对真菌的免疫:编辑综述

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101734

Janet A. Willment, Gordon D. Brown

引用次数: 0

Correcting inborn errors of immunity: From viral mediated gene addition to gene editing 纠正先天免疫错误:从病毒介导的基因添加到基因编辑

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101731

Maria Carmina Castiello , Samuele Ferrari , Anna Villa

{"title":"Correcting inborn errors of immunity: From viral mediated gene addition to gene editing","authors":"Maria Carmina Castiello , Samuele Ferrari , Anna Villa","doi":"10.1016/j.smim.2023.101731","DOIUrl":"10.1016/j.smim.2023.101731","url":null,"abstract":"<div><p>Allogeneic hematopoietic stem cell transplantation is an effective treatment to cure inborn errors of immunity. Remarkable progress has been achieved thanks to the development and optimization of effective combination of advanced conditioning regimens and use of immunoablative/suppressive agents preventing rejection as well as graft versus host disease. Despite these tremendous advances, autologous hematopoietic stem/progenitor cell therapy based on <em>ex vivo</em> gene addition exploiting integrating γ-retro- or lenti-viral vectors, has demonstrated to be an innovative and safe therapeutic strategy providing proof of correction without the complications of the allogeneic approach. The recent advent of targeted gene editing able to precisely correct genomic variants in an intended locus of the genome, by introducing deletions, insertions, nucleotide substitutions or introducing a corrective cassette, is emerging in the clinical setting, further extending the therapeutic armamentarium and offering a cure to inherited immune defects not approachable by conventional gene addition. In this review, we will analyze the current state-of-the art of conventional gene therapy and innovative protocols of genome editing in various primary immunodeficiencies, describing preclinical models and clinical data obtained from different trials, highlighting potential advantages and limits of gene correction.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"66 ","pages":"Article 101731"},"PeriodicalIF":7.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10294838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Different routes of MHC-I delivery to phagosomes and their consequences to CD8 T cell immunity MHC-I向吞噬体传递的不同途径及其对CD8 T细胞免疫的影响

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2023.101713

J. Magarian Blander

{"title":"Different routes of MHC-I delivery to phagosomes and their consequences to CD8 T cell immunity","authors":"J. Magarian Blander","doi":"10.1016/j.smim.2023.101713","DOIUrl":"10.1016/j.smim.2023.101713","url":null,"abstract":"<div><p>Dendritic cells (DCs) present internalized antigens to CD8 T cells through cross-presentation by major histocompatibility complex class I (MHC-I) molecules. While conventional cDC1 excel at cross-presentation, cDC2 can be licensed to cross-present during infection by signals from inflammatory receptors, most prominently Toll-like receptors (TLRs). At the core of the regulation of cross-presentation by TLRs is the control of subcellular MHC-I traffic. Within DCs, MHC-I are enriched within endosomal recycling compartments (ERC) and traffic to microbe-carrying phagosomes under the control of phagosome-compartmentalized TLR signals to favor CD8 T cell cross-priming to microbial antigens. Viral blockade of the transporter associated with antigen processing (TAP), known to inhibit the classic MHC-I presentation of cytoplasmic protein-derived peptides, depletes the ERC stores of MHC-I to simultaneously also block TLR-regulated cross-presentation. DCs counter this impairment in the two major pathways of MHC-I presentation to CD8 T cells by mobilizing noncanonical cross-presentation, which delivers MHC-I to phagosomes from a new location in the ER-Golgi intermediate compartment (ERGIC) where MHC-I abnormally accumulate upon TAP blockade. Noncanonical cross-presentation thus rescues MHC-I presentation and cross-primes TAP-independent CD8 T cells best-matched against target cells infected with immune evasive viruses. Because noncanonical cross-presentation relies on a phagosome delivery route of MHC-I that is not under TLR control, it risks potential cross-presentation of self-antigens during infection. Here I review these findings to illustrate how the subcellular route of MHC-I to phagosomes critically impacts the regulation of cross-presentation and the nature of the CD8 T cell response to infection and cancer. I highlight important and novel implications to CD8 T cell vaccines and immunotherapy.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"66 ","pages":"Article 101713"},"PeriodicalIF":7.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Contemplating immunopeptidomes to better predict them 观察免疫多肽以更好地预测它们

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-03-01 DOI: 10.1016/j.smim.2022.101708

David Gfeller , Yan Liu , Julien Racle

{"title":"Contemplating immunopeptidomes to better predict them","authors":"David Gfeller , Yan Liu , Julien Racle","doi":"10.1016/j.smim.2022.101708","DOIUrl":"10.1016/j.smim.2022.101708","url":null,"abstract":"<div><p>The identification of T-cell epitopes is key for a complete molecular understanding of immune recognition mechanisms in infectious diseases, autoimmunity and cancer. T-cell epitopes further provide targets for personalized vaccines and T-cell therapy, with several therapeutic applications in cancer immunotherapy and elsewhere. T-cell epitopes consist of short peptides displayed on Major Histocompatibility Complex (MHC) molecules. The recent advances in mass spectrometry (MS) based technologies to profile the ensemble of peptides displayed on MHC molecules – the so-called immunopeptidome – had a major impact on our understanding of antigen presentation and MHC ligands. On the one hand, these techniques enabled researchers to directly identify hundreds of thousands of peptides presented on MHC molecules, including some that elicited T-cell recognition. On the other hand, the data collected in these experiments revealed fundamental properties of antigen presentation pathways and significantly improved our ability to predict naturally presented MHC ligands and T-cell epitopes across the wide spectrum of MHC alleles found in human and other organisms. Here we review recent computational developments to analyze experimentally determined immunopeptidomes and harness these data to improve our understanding of antigen presentation and MHC binding specificities, as well as our ability to predict MHC ligands. We further discuss the strengths and limitations of the latest approaches to move beyond predictions of antigen presentation and tackle the challenges of predicting TCR recognition and immunogenicity.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"66 ","pages":"Article 101708"},"PeriodicalIF":7.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9196834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5