Seminars in Immunology最新文献_第10页

Systems biology of B cells in COVID-19 COVID-19 中 B 细胞的系统生物学

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-03-01 Epub Date: 2024-03-14 DOI: 10.1016/j.smim.2024.101875

Matthew C. Woodruff , Caterina E. Faliti , Ignacio Sanz

{"title":"Systems biology of B cells in COVID-19","authors":"Matthew C. Woodruff , Caterina E. Faliti , Ignacio Sanz","doi":"10.1016/j.smim.2024.101875","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101875","url":null,"abstract":"<div><p>The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both cellular and serologic investigation have resulted in an increasingly detailed mapping of the coordinated effector, memory, and antibody secreting cell responses that underpin the development of humoral immunity in response to primary viral infection. Further, the rapid development and deployment of effective vaccines has allowed for the assessment of developing memory responses across a wide variety of immune contexts, including in patients with compromised immune function. The result has been a period of rapid gains in the understanding of B cell biology unrestricted to the study of COVID-19. Here, we outline the systems-level technologies that have been routinely implemented in these investigations throughout the pandemic, and discuss how their use has led to clear and applicable gains in pursuance of the amelioration of human infectious disease and beyond.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"72 ","pages":"Article 101875"},"PeriodicalIF":7.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond I型和III型干扰素：从基础生物学和遗传学到 COVID-19 及其后的临床开发

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-03-01 Epub Date: 2024-01-24 DOI: 10.1016/j.smim.2024.101863

Evangelos Andreakos, COVID Human Genetic Effort

{"title":"Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond","authors":"Evangelos Andreakos, COVID Human Genetic Effort","doi":"10.1016/j.smim.2024.101863","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101863","url":null,"abstract":"<div><p><span>Type I and type III interferons (IFNs) constitute a key antiviral defense systems of the body, inducing viral resistance to cells and mediating diverse innate and adaptive immune functions. Defective type I and type III </span>IFN<span> responses have recently emerged as the 'Achilles heel' in COVID-19, with such patients developing severe disease and exhibiting a high risk for critical pneumonia and death. Here, we review the biology of type I and type III IFNs, their similarities and important functional differences, and their roles in SARS-CoV-2 infection. We also appraise the various mechanisms proposed to drive defective IFN responses in COVID-19 with particular emphasis to the ability of SARS-CoV-2 to suppress IFN production<span><span> and activities, the genetic factors involved and the presence of autoantibodies neutralizing IFNs and accounting for a large proportion of individuals with severe COVID-19. Finally, we discuss the long history of the type I IFN therapeutics for the </span>treatment of viral diseases<span>, cancer and multiple sclerosis, the various efforts to use them in respiratory infections, and the newly emerging type III IFN therapeutics, with emphasis to the more recent studies on COVID-19 and their potential use as broad spectrum antivirals for future epidemics or pandemics.</span></span></span></p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"72 ","pages":"Article 101863"},"PeriodicalIF":7.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to the special issue: B cells in cancer immunosurveillance 特刊简介：癌症免疫监视中的 B 细胞

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.1016/j.smim.2024.101866

Jose R. Conejo-Garcia, Paulo C. Rodriguez

引用次数: 0

Systems analysis of innate and adaptive immunity in Long COVID Long COVID先天性免疫和适应性免疫的系统分析

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-03-01 Epub Date: 2024-03-08 DOI: 10.1016/j.smim.2024.101873

Michael J. Peluso , Mohamed Abdel-Mohsen , Timothy J. Henrich , Nadia R. Roan

{"title":"Systems analysis of innate and adaptive immunity in Long COVID","authors":"Michael J. Peluso , Mohamed Abdel-Mohsen , Timothy J. Henrich , Nadia R. Roan","doi":"10.1016/j.smim.2024.101873","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101873","url":null,"abstract":"<div><p>Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the management of Long COVID (LC), an infection-associated chronic condition that has been estimated to affect 5–20% of individuals following SARS-CoV-2 infection, remains challenging due to our limited understanding of its mechanisms. Although LC is a heterogeneous disease that is likely to have several subtypes, immune system disturbances appear common across many cases. The extent to which these immune perturbations contribute to LC symptoms, however, is not entirely clear. Recent advancements in multi-omics technologies, capable of detailed, cell-level analysis, have provided valuable insights into the immune perturbations associated with LC. Although these studies are largely descriptive in nature, they are the crucial first step towards a deeper understanding of the condition and the immune system’s role in its development, progression, and resolution. In this review, we summarize the current understanding of immune perturbations in LC, covering both innate and adaptive immune responses, and the cytokines and analytes involved. We explore whether these findings support or challenge the primary hypotheses about LC’s underlying mechanisms. We also discuss the crosstalk between various immune system components and how it can be disrupted in LC. Finally, we emphasize the need for more tissue- and subtype-focused analyses of LC, and for enhanced collaborative efforts to analyze common specimens from large cohorts, including those undergoing therapeutic interventions. These collective efforts are vital to unravel the fundaments of this new disease, and could also shed light on the prevention and treatment of the larger family of chronic illnesses linked to other microbial infections.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"72 ","pages":"Article 101873"},"PeriodicalIF":7.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140062908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases 肠肝轴：慢性肝病的病理生理学概念和医学视角

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-02-01 Epub Date: 2024-01-13 DOI: 10.1016/j.smim.2023.101859

Susana G. Rodrigues , Schalk van der Merwe , Aleksander Krag , Reiner Wiest

引用次数: 0

Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy 树突状细胞的抗原交叉呈递:癌症免疫治疗的关键轴

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-02-01 Epub Date: 2023-11-29 DOI: 10.1016/j.smim.2023.101848

Christine Moussion, Lélia Delamarre

引用次数: 0

To die or not to die: Gasdermins in intestinal health and disease 死还是不死肠道健康和疾病中的气敏物质

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI: 10.1016/j.smim.2024.101865

Zhaoyu Lin , Qianyue Chen , Hai-Bin Ruan

{"title":"To die or not to die: Gasdermins in intestinal health and disease","authors":"Zhaoyu Lin , Qianyue Chen , Hai-Bin Ruan","doi":"10.1016/j.smim.2024.101865","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101865","url":null,"abstract":"<div><p><span><span>Intestinal homeostasis<span> is achieved by the balance among intestinal epithelium, </span></span>immune cells<span><span><span>, and gut microbiota. Gasdermins (GSDMs), a family of membrane pore forming proteins, can trigger rapid inflammatory </span>cell death<span> in the gut, mainly pyroptosis and </span></span>NETosis<span><span>. Importantly, there is increasing literature on the non-cell lytic roles of GSDMs in intestinal homeostasis and disease. While GSDMA is low and PJVK is not expressed in the gut, high GSDMB and GSDMC expression is found almost restrictively in intestinal epithelial cells. Conversely, GSDMD and GSDME show more ubiquitous expression among various cell types in the gut. The N-terminal region of GSDMs can be liberated for pore formation by an array of proteases in response to pathogen- and danger-associated signals, but it is not fully understood what cell type-specific mechanisms activate intestinal GSDMs. The host relies on GSDMs for </span>pathogen defense, tissue tolerance, and cancerous cell death; however, pro-inflammatory milieu caused by pyroptosis and excessive </span></span></span>cytokine release<span><span> may favor the development and progression of inflammatory bowel disease and cancer. Therefore, a thorough understanding of spatiotemporal mechanisms that control gasdermin expression, activation, and function is essential for the development of future therapeutics for </span>intestinal disorders.</span></p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"71 ","pages":"Article 101865"},"PeriodicalIF":7.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139480018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice 上皮炎性小体、气真皮和粘膜炎症——沙门氏菌和志贺氏菌感染小鼠的经验教训

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 Epub Date: 2023-08-08 DOI: 10.1016/j.smim.2023.101812

Ersin Gül , Stefan A. Fattinger , Mikael E. Sellin , Wolf-Dietrich Hardt

{"title":"Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice","authors":"Ersin Gül , Stefan A. Fattinger , Mikael E. Sellin , Wolf-Dietrich Hardt","doi":"10.1016/j.smim.2023.101812","DOIUrl":"10.1016/j.smim.2023.101812","url":null,"abstract":"<div><p>Besides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The membrane permeabilization, a hallmark of pyroptosis, is caused by the pore-forming proteins called gasdermins (GSDMs). Recent work has revealed that NAIP/NLRC4-dependent extrusion of infected IECs can, however, also be executed in the absence of GSDMD. In fact, several reports highlighted that various cell death pathways (e.g., pyroptosis or apoptosis) and unique mechanisms specific to particular infection models and stages of gut infection are in action during epithelial inflammasome defense against intestinal pathogens. Here, we summarize the current knowledge regarding the underlying mechanisms and speculate on the putative functions of the epithelial inflammasome activation and cell death, with a particular emphasis on mouse infection models for two prominent enterobacterial pathogens, <em>Salmonella</em> Typhimurium and <em>Shigella flexneri</em>.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101812"},"PeriodicalIF":7.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better safe than sorry: Naive T-cell dynamics in healthy ageing 安全总比后悔好:健康衰老中的幼稚t细胞动力学

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 Epub Date: 2023-09-14 DOI: 10.1016/j.smim.2023.101839

Rob J. de Boer , Kiki Tesselaar , José A.M. Borghans

引用次数: 0

Chemical modulation of gasdermin D activity: Therapeutic implications and consequences gasdermin D活性的化学调节：治疗意义和后果。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 Epub Date: 2023-10-08 DOI: 10.1016/j.smim.2023.101845

Bowen Zhou, Derek W. Abbott

引用次数: 0