Seminars in Immunology最新文献_第10页

Harnessing the power of oncolytic virotherapy and tertiary lymphoid structures to amplify antitumor immune responses in cancer patients 利用溶瘤病毒疗法和三级淋巴样结构的力量来增强癌症患者的抗肿瘤免疫反应

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101796

Ana Houel , Johann Foloppe , Marie-Caroline Dieu-Nosjean

{"title":"Harnessing the power of oncolytic virotherapy and tertiary lymphoid structures to amplify antitumor immune responses in cancer patients","authors":"Ana Houel , Johann Foloppe , Marie-Caroline Dieu-Nosjean","doi":"10.1016/j.smim.2023.101796","DOIUrl":"10.1016/j.smim.2023.101796","url":null,"abstract":"<div><p>Tertiary lymphoid structures (TLS) are ectopic aggregates of immune cells that develop in non-lymphoid tissues under persistent inflammation. Since their presence has been associated with a better prognosis in cancer patients, modulating TLS formation is being part of new challenges in immunotherapy. Although mechanisms underlying TLS genesis are still not fully understood, different strategies have been developed in preclinical models to induce their formation and ultimately enhance antitumor responses. Herein, we will discuss a new approach that would consist in using oncolytic viruses (OV). These viruses have the unique feature to preferentially infect, replicate in and kill cancer cells. Their immunoadjuvant property, their use as a vector of therapeutic molecules and their selectivity for cancer cells, make them an attractive strategy to induce TLS in the tumor microenvironment. This review will examine the current knowledge about TLS neogenesis, approaches for inducing them, and relevance of using OV for this purpose, especially in combination with immunotherapy such as immune checkpoint blockade.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101796"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10537765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria during T cell aging T细胞老化过程中的线粒体

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101808

Jose Ignacio Escrig-Larena , Sandra Delgado-Pulido , María Mittelbrunn

引用次数: 2

The gut mucus network: A dynamic liaison between microbes and the immune system 肠道粘液网络:微生物和免疫系统之间的动态联系

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101807

Rain Inaba, Sara Vujakovic, Kirk Bergstrom

引用次数: 2

Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination T卵泡辅助细胞的年龄依赖性变化影响疫苗的体液免疫反应

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101801

Michelle A. Linterman

引用次数: 1

Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions 数量和几率：TCR的曲目大小及其年龄变化对T细胞功能的影响。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101810

Nan-ping Weng

引用次数: 1

Thymus aging and immune reconstitution, progresses and challenges 胸腺老化与免疫重建、进展与挑战

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-31 DOI: 10.1016/j.smim.2023.101837

Yue Ru Li , Juan Carlos Zúñiga-Pflücker

{"title":"Thymus aging and immune reconstitution, progresses and challenges","authors":"Yue Ru Li , Juan Carlos Zúñiga-Pflücker","doi":"10.1016/j.smim.2023.101837","DOIUrl":"10.1016/j.smim.2023.101837","url":null,"abstract":"<div><p>Thymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent features of thymic involution include: (i) epithelial structure disruption, (ii) adipogenesis, and (iii) thymocyte development arrest. There is a sex disparity in thymus aging. It is a multifactorial process controlled and regulated by a series of molecules, including the transcription factor FOXN1, fibroblast and keratinocyte growth factors (FGF and KGF, respectively), sex steroids, Notch signaling, WNT signaling, and microRNAs. Nevertheless, there is still no satisfactory evolutionary or physiological explanation for age-associated thymic involution, and understanding the precise mechanism(s) for thymus aging remains challenging. Sustained thymic regeneration has yet to be achieved by sex steroid ablation. Recent preclinical studies indicate that long-term thymic reconstitution can be achieved via adoptive transfer of <em>in vitro</em>-generated progenitor T (proT) cells, and improvements in the methods for the generation of human proT cells make this an attractive approach. Future clinical applications may rely on new applications integrating proT cells, cytokine support and sex-steroid inhibition treatments.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101837"},"PeriodicalIF":7.8,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The paradox of aging: Aging-related shifts in T cell function and metabolism 衰老的悖论:与衰老相关的T细胞功能和代谢的变化

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-31 DOI: 10.1016/j.smim.2023.101834

Kylie M. Quinn , Daniela M. Vicencio , Nicole L. La Gruta

{"title":"The paradox of aging: Aging-related shifts in T cell function and metabolism","authors":"Kylie M. Quinn , Daniela M. Vicencio , Nicole L. La Gruta","doi":"10.1016/j.smim.2023.101834","DOIUrl":"10.1016/j.smim.2023.101834","url":null,"abstract":"<div><p>T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent T cells, severe dysfunction in memory phenotype T cells in particular, and elevated levels of inflammatory cytokines, or ‘inflammaging’. Here, we review our current understanding of the phenotypic and functional changes that occur with aging in T cells, and how they relate to metabolic changes in the steady state and after T cell activation. We discuss the apparent contradictions in the aging T cell phenotype - where enhanced differentiation states and metabolic profiles in the steady state can correspond to a diminished capacity to adapt metabolically and functionally after T cell activation. Finally, we discuss key recent studies that indicate the enormous potential for aged T cell metabolism to induce systemic inflammaging and organism-wide multimorbidity, resulting in premature death.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101834"},"PeriodicalIF":7.8,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging 次级淋巴器官组织紊乱和趋化因子分泌失调是免疫衰老的关键因素

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-29 DOI: 10.1016/j.smim.2023.101835

Sandip Ashok Sonar , Makiko Watanabe , Janko Ž. Nikolich

{"title":"Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging","authors":"Sandip Ashok Sonar , Makiko Watanabe , Janko Ž. Nikolich","doi":"10.1016/j.smim.2023.101835","DOIUrl":"10.1016/j.smim.2023.101835","url":null,"abstract":"<div><p>Aging is characterized by progressive loss of organ and tissue function, and the immune system is no exception to that inevitable principle. Of all the age-related changes in the body, reduction of the size of, and naïve T (Tn) cell output from, the thymus occurs earliest, being prominent already before or by the time of puberty. Therefore, to preserve immunity against new infections, over much of their lives, vertebrates dominantly rely on peripheral maintenance of the Tn cell pool in the secondary lymphoid organs (SLO). However, SLO structure and function subsequently also deteriorate with aging. Several recent studies have made a convincing case that this deterioration is of major importance to the erosion of protective immunity in the last third of life. Specifically, the SLO were found to accumulate multiple degenerative changes with aging. Importantly, the results from adoptive transfer and parabiosis studies teach us that the old microenvironment is the limiting factor for protective immunity in old mice. In this review, we discuss the extent, mechanisms, and potential role of stromal cell aging in the age-related alteration of T cell homeostatic maintenance and immune function decline. We use that discussion to frame the potential strategies to correct the SLO stromal aging defects - in the context of other immune rejuvenation approaches, - to improve functional immune responses and protective immunity in older adults.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101835"},"PeriodicalIF":7.8,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T cell control of SARS-CoV-2: When, which, and where? T细胞控制SARS-CoV-2的时间、方式和地点?

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-29 DOI: 10.1016/j.smim.2023.101828

Mariana O. Diniz, Mala K. Maini, Leo Swadling

引用次数: 0

Gasdermins and cancers Gasdermins和癌症

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-28 DOI: 10.1016/j.smim.2023.101833

Junwei Hou , Tiansheng Li , Jung-Mao Hsu , Xin Zhang , Mien-Chie Hung

{"title":"Gasdermins and cancers","authors":"Junwei Hou , Tiansheng Li , Jung-Mao Hsu , Xin Zhang , Mien-Chie Hung","doi":"10.1016/j.smim.2023.101833","DOIUrl":"10.1016/j.smim.2023.101833","url":null,"abstract":"<div><p>The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes. One example is the discovery of gasdermin-mediated cancer cell pyroptosis (CCP) which has become an important and frontier field in oncology. Recent studies have shown that CCP induction can heat tumor microenvironment (TME) and thereby elicit the robust anti-tumor immunity to suppress tumor growth. As a newly discovered form of tumor cell death, CCP offers promising opportunities for improving tumor treatment and developing new drugs. Nevertheless, the research on CCP is still in its infancy, and the molecular mechanisms underlying the expression, regulation and activation of gasdermins are not yet fully understood. In this review, we summarize the recent progress of gasdermin research in cancer area, and propose that the anti-tumor effect of immune cell pyroptosis (ICP) and CCP depends on their duration, intensity, and the type of cells undergoing pyroptosis within TME.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101833"},"PeriodicalIF":7.8,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0