Seminars in Immunology最新文献_第9页

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-28 DOI: 10.1016/j.smim.2023.101833

Junwei Hou , Tiansheng Li , Jung-Mao Hsu , Xin Zhang , Mien-Chie Hung

{"title":"Gasdermins and cancers","authors":"Junwei Hou , Tiansheng Li , Jung-Mao Hsu , Xin Zhang , Mien-Chie Hung","doi":"10.1016/j.smim.2023.101833","DOIUrl":"10.1016/j.smim.2023.101833","url":null,"abstract":"<div><p>The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes. One example is the discovery of gasdermin-mediated cancer cell pyroptosis (CCP) which has become an important and frontier field in oncology. Recent studies have shown that CCP induction can heat tumor microenvironment (TME) and thereby elicit the robust anti-tumor immunity to suppress tumor growth. As a newly discovered form of tumor cell death, CCP offers promising opportunities for improving tumor treatment and developing new drugs. Nevertheless, the research on CCP is still in its infancy, and the molecular mechanisms underlying the expression, regulation and activation of gasdermins are not yet fully understood. In this review, we summarize the recent progress of gasdermin research in cancer area, and propose that the anti-tumor effect of immune cell pyroptosis (ICP) and CCP depends on their duration, intensity, and the type of cells undergoing pyroptosis within TME.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101833"},"PeriodicalIF":7.8,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enteric neuro-immune interactions in intestinal health and disease 肠道健康和疾病中的肠道神经免疫相互作用

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-25 DOI: 10.1016/j.smim.2023.101819

Lies van Baarle, Michelle Stakenborg, Gianluca Matteoli

引用次数: 0

Accumulation of immune-suppressive CD4 + T cells in aging – tempering inflammaging at the expense of immunity 免疫抑制性CD4+T细胞在衰老中的积累——以牺牲免疫力为代价的炎症调节。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-24 DOI: 10.1016/j.smim.2023.101836

Alyssa L. Thomas , Alzbeta Godarova , Joseph A. Wayman , Emily R. Miraldi , David A. Hildeman , Claire A. Chougnet

{"title":"Accumulation of immune-suppressive CD4 + T cells in aging – tempering inflammaging at the expense of immunity","authors":"Alyssa L. Thomas , Alzbeta Godarova , Joseph A. Wayman , Emily R. Miraldi , David A. Hildeman , Claire A. Chougnet","doi":"10.1016/j.smim.2023.101836","DOIUrl":"10.1016/j.smim.2023.101836","url":null,"abstract":"<div><p>The 'immune risk profile' has been shown to predict mortality in the elderly, highlighting the need to better understand age-related immune dysfunction. While aging leads to many defects affecting all arms of the immune system, this review is focused on the accrual of immuno-suppressive CD4 + T cell populations, including FoxP3 + regulatory T cells, and subsets of IL-10-producing T follicular helper cells. New data suggest that such accumulations constitute feedback mechanisms to temper the ongoing progressive low-grade inflammation that develops with age, the so-called “inflammaging”, and by doing so, how they have the potential to promote healthier aging. However, they also impair effector immune responses, notably to infections, or vaccines. These studies also reinforce the idea that the aged immune system should not be considered as a poorly functional version of the young one, but more as a dynamic system in which CD4 + T cells, and other immune/non-immune subsets, differentiate, interact with their milieu and function differently than in young hosts. A better understanding of these unique interactions is thus needed to improve effector immune responses in the elderly, while keeping inflammaging under control.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101836"},"PeriodicalIF":7.8,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of caspase-8 in inflammatory signalling and pyroptotic cell death caspase-8在炎症信号传导和焦亡细胞死亡中的作用

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-23 DOI: 10.1016/j.smim.2023.101832

Jiyi Pang , James E. Vince

{"title":"The role of caspase-8 in inflammatory signalling and pyroptotic cell death","authors":"Jiyi Pang , James E. Vince","doi":"10.1016/j.smim.2023.101832","DOIUrl":"10.1016/j.smim.2023.101832","url":null,"abstract":"<div><p>The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8, a cysteine-aspartic acid protease typically associated with activating caspase-3 and − 7 to induce apoptosis. However, recent research has revealed that caspase-8 also plays a role in regulating the lytic gasdermin cell death machinery, contributing to pyroptosis and immune responses in contexts such as infection, autoinflammation, and T-cell signalling. In mice, loss of caspase-8 results in embryonic lethality from unrestrained necroptotic killing, while in humans caspase-8 deficiency can lead to an autoimmune lymphoproliferative syndrome, immunodeficiency, inflammatory bowel disease or, when it can’t cleave its substrate RIPK1, early onset periodic fevers. This review focuses on non-canonical caspase-8 signalling that drives immune responses, including its regulation of inflammatory gene transcription, activation within inflammasome complexes, and roles in pyroptotic cell death. Ultimately, a deeper understanding of caspase-8 function will aid in determining whether, and when, targeting caspase-8 pathways could be therapeutically beneficial in human diseases.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101832"},"PeriodicalIF":7.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10074141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T cell control of inflammaging T细胞控制炎症

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-21 DOI: 10.1016/j.smim.2023.101818

Irina Shchukina, Pavla Bohacova, Maxim N. Artyomov

引用次数: 0

Aging of lymphoid stromal architecture impacts immune responses 淋巴基质结构老化影响免疫反应

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-10 DOI: 10.1016/j.smim.2023.101817

Jessica N. Lancaster

{"title":"Aging of lymphoid stromal architecture impacts immune responses","authors":"Jessica N. Lancaster","doi":"10.1016/j.smim.2023.101817","DOIUrl":"10.1016/j.smim.2023.101817","url":null,"abstract":"<div><p>The secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport, and provide chemokine and cytokine signals that are essential for immune homeostasis. Mechanisms that drive SLO development have been described, but their roles in SLO maintenance with advanced age are unknown. Disorganization of the fibroblasts of the T cell and B cell zones may reduce the maintenance of naïve lymphocytes and delay immune activation. Reduced lymphatic transport efficiency with age can also delay the onset of the adaptive immune response. This review focuses on recent studies that describe age-associated changes to the stroma of the lymph nodes and spleen. We also review recent investigations into stromal cell biology, which include high-dimensional analysis of the stromal cell transcriptome and viscoelastic testing of lymph node mechanical properties, as they constitute an important framework for understanding aging of the lymphoid tissues.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101817"},"PeriodicalIF":7.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9972826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice 上皮炎性小体、气真皮和粘膜炎症——沙门氏菌和志贺氏菌感染小鼠的经验教训

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-08-08 DOI: 10.1016/j.smim.2023.101812

Ersin Gül , Stefan A. Fattinger , Mikael E. Sellin , Wolf-Dietrich Hardt

{"title":"Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice","authors":"Ersin Gül , Stefan A. Fattinger , Mikael E. Sellin , Wolf-Dietrich Hardt","doi":"10.1016/j.smim.2023.101812","DOIUrl":"10.1016/j.smim.2023.101812","url":null,"abstract":"<div><p>Besides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The membrane permeabilization, a hallmark of pyroptosis, is caused by the pore-forming proteins called gasdermins (GSDMs). Recent work has revealed that NAIP/NLRC4-dependent extrusion of infected IECs can, however, also be executed in the absence of GSDMD. In fact, several reports highlighted that various cell death pathways (e.g., pyroptosis or apoptosis) and unique mechanisms specific to particular infection models and stages of gut infection are in action during epithelial inflammasome defense against intestinal pathogens. Here, we summarize the current knowledge regarding the underlying mechanisms and speculate on the putative functions of the epithelial inflammasome activation and cell death, with a particular emphasis on mouse infection models for two prominent enterobacterial pathogens, <em>Salmonella</em> Typhimurium and <em>Shigella flexneri</em>.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101812"},"PeriodicalIF":7.8,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systems analysis of human innate immunity in COVID-19 COVID-19人群先天免疫系统分析

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101778

Sophie Müller , Joachim L. Schultze

{"title":"Systems analysis of human innate immunity in COVID-19","authors":"Sophie Müller , Joachim L. Schultze","doi":"10.1016/j.smim.2023.101778","DOIUrl":"10.1016/j.smim.2023.101778","url":null,"abstract":"<div><p>Recent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics (SCMO) technologies and that these technologies are perfectly suited to dissect pathophysiological processes in a new disease such as COVID-19, triggered by SARS-CoV-2 infection. Systems level interrogation not only revealed the different disease endotypes, highlighted the differential dynamics in context of disease severity, and pointed towards global immune deviation across the different arms of the immune system, but was already instrumental to better define long COVID phenotypes, suggest promising biomarkers for disease and therapy outcome predictions and explains treatment responses for the widely used corticosteroids. As we identified SCMO to be the most informative technologies in the vest to better understand COVID-19, we propose to routinely include such single cell level analysis in all future clinical trials and cohorts addressing diseases with an immunological component.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"68 ","pages":"Article 101778"},"PeriodicalIF":7.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9650720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease 从阿米什农场灰尘到细菌裂解物:防止过敏性疾病的漫长而曲折的道路

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101779

Donata Vercelli

{"title":"From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease","authors":"Donata Vercelli","doi":"10.1016/j.smim.2023.101779","DOIUrl":"10.1016/j.smim.2023.101779","url":null,"abstract":"<div><p>Allergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the “farm effect”, the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathways. Farm exposure also promotes timely maturation of the gut microbiome, which mediates a proportion of the protection conferred by the farm effect.</p><p>Current research seeks to identify allergy-protective compounds from traditional farm environments, but standardization and regulation of such substances will likely prove challenging. On the other hand, studies in mouse models show that administration of standardized, pharmacological-grade lysates of human airway bacteria abrogates allergic lung inflammation by acting on multiple innate immune targets, including the airway epithelium/IL-33/ILC2 axis and dendritic cells whose <em>Myd88/Trif</em>-dependent tolerogenic reprogramming is sufficient for asthma protection in adoptive transfer models. To the extent that these bacterial lysates mimic the protective effects of natural exposure to microbe-rich environments, these agents might provide an effective tool for prevention of allergic disease.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"68 ","pages":"Article 101779"},"PeriodicalIF":7.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9765880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pyroptosis: A road to next-generation cancer immunotherapy Pyroptosis：通往下一代癌症免疫疗法的道路

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101782

Yiliang Fang , Yaxing Tang , Bo Huang

引用次数: 4