Seminars in Immunology最新文献_第9页

Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma 气候变化和相关空气污染对免疫系统的影响导致过敏性疾病和哮喘的机制

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101765

Vanitha Sampath , Juan Aguilera , Mary Prunicki , Kari C. Nadeau

引用次数: 1

Viral- and tumor-reactive natural killer cells 病毒和肿瘤反应性自然杀伤细胞

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101749

Jianhua Yu , Michael A. Caligiuri

{"title":"Viral- and tumor-reactive natural killer cells","authors":"Jianhua Yu , Michael A. Caligiuri","doi":"10.1016/j.smim.2023.101749","DOIUrl":"10.1016/j.smim.2023.101749","url":null,"abstract":"<div><p>When we can understand what natural killer (NK) cells recognize during an encounter with an infectious pathogen or a tumor cell, and when we can understand how the NK cell responds to that encounter, we can then begin to understand the role of NK cells in human health and how to improve upon their role for the prevention and treatment of human disease. In the quest to understand how these cells function in antiviral and antitumoral immunity, there have been previously described mechanisms established for NK cells to participate in clearing viral infections and tumors, including classical NK cell antibody dependent cellular cytotoxicity (ADCC) as well as recognition and elimination of transformed malignant cells through direct ligand interactions. However, it is now clear that there are additional mechanisms by which NK cells can participate in these critical immune tasks. Here we review two recently described types of NK cell recognition and response: the first is to primary infection with herpes virus, recognized and responded to by non-specific Fc bridged cellular cytotoxicity (FcBCC), and the second describes a novel phenotypic and functional response when a subset of NK cells recognize myeloid leukemia.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101749"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

TREM2: A new player in the tumor microenvironment TREM2:肿瘤微环境中的新参与者

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101739

Martina Molgora, Yizhou A. Liu, Marco Colonna, Marina Cella

引用次数: 3

Cross-presentation by the others 其他人的交叉陈述

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101764

François-Xavier Mauvais , Peter van Endert

{"title":"Cross-presentation by the others","authors":"François-Xavier Mauvais , Peter van Endert","doi":"10.1016/j.smim.2023.101764","DOIUrl":"10.1016/j.smim.2023.101764","url":null,"abstract":"<div><p>The critical role of conventional dendritic cells in physiological cross-priming of immune responses to tumors and pathogens is widely documented and beyond doubt. However, there is ample evidence that a wide range of other cell types can also acquire the capacity to cross-present. These include not only other myeloid cells such as plasmacytoid dendritic cells, macrophages and neutrophils, but also lymphoid populations, endothelial and epithelial cells and stromal cells including fibroblasts. The aim of this review is to provide an overview of the relevant literature that analyzes each report cited for the antigens and readouts used, mechanistic insight and <em>in vivo</em> experimentation addressing physiological relevance. As this analysis shows, many reports rely on the exceptionally sensitive recognition of an ovalbumin peptide by a transgenic T cell receptor, with results that therefore cannot always be extrapolated to physiological settings. Mechanistic studies remain basic in most cases but reveal that the cytosolic pathway is dominant across many cell types, while vacuolar processing is most encountered in macrophages. Studies addressing physiological relevance rigorously remain exceptional but suggest that cross-presentation by non-dendritic cells may have significant impact in anti-tumor immunity and autoimmunity.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101764"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9536696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Microbial metabolites and immunotherapy: Basic rationale and clinical indications 微生物代谢物和免疫治疗:基本原理和临床适应症

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101755

Larisa V. Kovtonyuk, Kathy D. McCoy

引用次数: 2

Introduction to the Special Issue: Nutrition, microbiota and immunity 特刊导言:营养、微生物群与免疫

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101767

Laurence Zitvogel , Guido Kroemer

引用次数: 0

What fungal CNS infections can teach us about neuroimmunology and CNS-specific immunity 真菌性中枢神经系统感染可以教会我们神经免疫学和中枢神经系统特异性免疫

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101751

Rebecca A. Drummond

引用次数: 1

Innate immune effectors in cancer 癌症中的先天免疫效应物

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101760

Lorenzo Moretta, Paola Vacca

引用次数: 0

Chitinases and chitinase-like proteins in asthma 哮喘中的几丁质酶和几丁质酶样蛋白

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101759

Jozefien Declercq , Hamida Hammad , Bart N. Lambrecht , Ursula Smole

引用次数: 2

Integrating immunopeptidome analysis for the design and development of cancer vaccines 整合免疫肽球分析用于癌症疫苗的设计和开发

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101750

Sara Feola , Jacopo Chiaro , Vincenzo Cerullo

{"title":"Integrating immunopeptidome analysis for the design and development of cancer vaccines","authors":"Sara Feola , Jacopo Chiaro , Vincenzo Cerullo","doi":"10.1016/j.smim.2023.101750","DOIUrl":"10.1016/j.smim.2023.101750","url":null,"abstract":"<div><p>The repertoire of naturally presented peptides within the MHC (major histocompatibility complex) or HLA (human leukocyte antigens) system on the cellular surface of every mammalian cell is referred to as ligandome or immunopeptidome. This later gained momentum upon the discovery of CD8 + T cells able to recognize and kill cancer cells in an MHC-I antigen-restricted manner. Indeed, cancer immune surveillance relies on T cell recognition of MHC-I-restricted peptides, making the identification of those peptides the core for designing T cell-based cancer vaccines. Moreover, the breakthrough of antibodies targeting immune checkpoint molecules has led to a new and strong interest in discovering suitable targets for CD8 +T cells. Therapeutic cancer vaccines are designed for the artificial generation and/or stimulation of CD8 +T cells; thus, their combination with ICIs to unleash the breaks of the immune system comes as a natural consequence to enhance anti-tumor efficacy. In this context, the identification and knowledge of peptide candidates take advantage of the fast technology updates in immunopeptidome and mass spectrometric methodologies, paying the way to the rational design of vaccines for immunotherapeutic approaches. In this review, we discuss mainly the role of immunopeptidome analysis and its application for the generation of therapeutic cancer vaccines with main focus on HLA-I peptides. Here, we review cancer vaccine platforms based on two different preparation methods: pathogens (viruses and bacteria) and not (VLPs, nanoparticles, subunits vaccines) that exploit discoveries in the ligandome field to generate and/or enhance anti-tumor specific response. Finally, we discuss possible drawbacks and future challenges in the field that remain still to be addressed.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101750"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1