Seminars in Immunology最新文献_第8页

Systems analysis of human innate immunity in COVID-19 COVID-19人群先天免疫系统分析

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101778

Sophie Müller , Joachim L. Schultze

{"title":"Systems analysis of human innate immunity in COVID-19","authors":"Sophie Müller , Joachim L. Schultze","doi":"10.1016/j.smim.2023.101778","DOIUrl":"10.1016/j.smim.2023.101778","url":null,"abstract":"<div><p>Recent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics (SCMO) technologies and that these technologies are perfectly suited to dissect pathophysiological processes in a new disease such as COVID-19, triggered by SARS-CoV-2 infection. Systems level interrogation not only revealed the different disease endotypes, highlighted the differential dynamics in context of disease severity, and pointed towards global immune deviation across the different arms of the immune system, but was already instrumental to better define long COVID phenotypes, suggest promising biomarkers for disease and therapy outcome predictions and explains treatment responses for the widely used corticosteroids. As we identified SCMO to be the most informative technologies in the vest to better understand COVID-19, we propose to routinely include such single cell level analysis in all future clinical trials and cohorts addressing diseases with an immunological component.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"68 ","pages":"Article 101778"},"PeriodicalIF":7.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9650720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease 从阿米什农场灰尘到细菌裂解物:防止过敏性疾病的漫长而曲折的道路

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101779

Donata Vercelli

{"title":"From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease","authors":"Donata Vercelli","doi":"10.1016/j.smim.2023.101779","DOIUrl":"10.1016/j.smim.2023.101779","url":null,"abstract":"<div><p>Allergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the “farm effect”, the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathways. Farm exposure also promotes timely maturation of the gut microbiome, which mediates a proportion of the protection conferred by the farm effect.</p><p>Current research seeks to identify allergy-protective compounds from traditional farm environments, but standardization and regulation of such substances will likely prove challenging. On the other hand, studies in mouse models show that administration of standardized, pharmacological-grade lysates of human airway bacteria abrogates allergic lung inflammation by acting on multiple innate immune targets, including the airway epithelium/IL-33/ILC2 axis and dendritic cells whose <em>Myd88/Trif</em>-dependent tolerogenic reprogramming is sufficient for asthma protection in adoptive transfer models. To the extent that these bacterial lysates mimic the protective effects of natural exposure to microbe-rich environments, these agents might provide an effective tool for prevention of allergic disease.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"68 ","pages":"Article 101779"},"PeriodicalIF":7.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9765880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pyroptosis: A road to next-generation cancer immunotherapy Pyroptosis：通往下一代癌症免疫疗法的道路

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101782

Yiliang Fang , Yaxing Tang , Bo Huang

引用次数: 4

How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses MHC I类配体的质谱分析如何提高了我们对病毒免疫反应的理解

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101780

Nicola Ternette , Eleni Adamopoulou , Anthony W. Purcell

引用次数: 1

Targeting dendritic cells to advance cross-presentation and vaccination outcomes 靶向树突状细胞以促进交叉呈递和疫苗接种结果

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-07-01 DOI: 10.1016/j.smim.2023.101762

Christophe Macri , Devi Jenika , Cassandra Ouslinis, Justine D. Mintern

引用次数: 5

Immunoglobulins at the interface of the gut mycobiota and anti-fungal immunity 肠道菌群界面的免疫球蛋白与抗真菌免疫

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101757

Itai Doron , Takato Kusakabe , Iliyan D. Iliev

引用次数: 1

Western diet influences on microbiome and carcinogenesis 西方饮食对微生物群和癌变的影响

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101756

Rachel Newsome , Ye Yang , Christian Jobin

引用次数: 1

Genetics of Inborn Errors of Immunity in highly consanguineous Middle Eastern and North African populations 高度同源的中东和北非人群先天性免疫错误的遗传学研究

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101763

Hamoud Al-Mousa , Mohamed-Ridha Barbouche

{"title":"Genetics of Inborn Errors of Immunity in highly consanguineous Middle Eastern and North African populations","authors":"Hamoud Al-Mousa , Mohamed-Ridha Barbouche","doi":"10.1016/j.smim.2023.101763","DOIUrl":"10.1016/j.smim.2023.101763","url":null,"abstract":"<div><p>Consanguineous marriages in Middle Eastern and North African (MENA) countries are deeply-rooted tradition and highly prevalent resulting into increased prevalence of autosomal recessive diseases including Inborn Errors of Immunity (IEIs). Molecular genetic testing is an important diagnostic tool for IEIs since it provides a definite diagnosis, genotype-phenotype correlation, and guide therapy. In this review, we will discuss the current state and challenges of genomic and variome studies in MENA region populations, as well as the importance of funding advanced genome projects. In addition, we will review the MENA underlying molecular genetic defects of over 2457 patients published with the common IEIs, where autosomal recessive mode of inheritance accounts for 76% of cases with increased prevalence of combined immunodeficiency diseases (50%). The efforts made in the last three decades in terms of international collaboration and of in situ capacity building in MENA region countries led to the discovery of more than 150 novel genes involved in IEIs. Expanding sequencing studies within the MENA will undoubtedly be a unique asset for the IEI genetics which can advance research, and support precise genomic diagnostics and therapeutics.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101763"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunity to pathogenic fungi in the eye 对眼部病原真菌的免疫力。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101753

Serena Abbondante , Sixto M. Leal , Heather L. Clark , Bridget Ratitong , Yan Sun , Li-Jun Ma , Eric Pearlman

引用次数: 1

The biogenesis of the immunopeptidome 免疫肽穹窿的生物发生

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-05-01 DOI: 10.1016/j.smim.2023.101766

Arie Admon

{"title":"The biogenesis of the immunopeptidome","authors":"Arie Admon","doi":"10.1016/j.smim.2023.101766","DOIUrl":"10.1016/j.smim.2023.101766","url":null,"abstract":"<div><p>The immunopeptidome is the repertoire of peptides bound and presented by the MHC class I, class II, and non-classical molecules. The peptides are produced by the degradation of most cellular proteins, and in some cases, peptides are produced from extracellular proteins taken up by the cells. This review attempts to first describe some of its known and well-accepted concepts, and next, raise some questions about a few of the established dogmas in this field: The production of novel peptides by splicing is questioned, suggesting here that spliced peptides are extremely rare, if existent at all. The degree of the contribution to the immunopeptidome by degradation of cellular protein by the proteasome is doubted, therefore this review attempts to explain why it is likely that this contribution to the immunopeptidome is possibly overstated. The contribution of defective ribosome products (DRiPs) and non-canonical peptides to the immunopeptidome is noted and methods are suggested to quantify them. In addition, the common misconception that the MHC class II peptidome is mostly derived from extracellular proteins is noted, and corrected. It is stressed that the confirmation of sequence assignments of non-canonical and spliced peptides should rely on targeted mass spectrometry using spiking-in of heavy isotope-labeled peptides. Finally, the new methodologies and modern instrumentation currently available for high throughput kinetics and quantitative immunopeptidomics are described. These advanced methods open up new possibilities for utilizing the big data generated and taking a fresh look at the established dogmas and reevaluating them critically.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"67 ","pages":"Article 101766"},"PeriodicalIF":7.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9914955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5