Seminars in Immunology最新文献_第8页

Proteostasis in T cell aging T细胞老化中的蛋白质停滞

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-12 DOI: 10.1016/j.smim.2023.101838

A. Elisabeth Gressler , Houfu Leng , Heidi Zinecker , Anna Katharina Simon

引用次数: 0

Epigenetic and transcriptional control of gasdermins 气胚乳的表观遗传和转录调控

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-11 DOI: 10.1016/j.smim.2023.101841

Cristhian Cadena, Opher S. Kornfeld, Bettina L. Lee, Nobuhiko Kayagaki

{"title":"Epigenetic and transcriptional control of gasdermins","authors":"Cristhian Cadena, Opher S. Kornfeld, Bettina L. Lee, Nobuhiko Kayagaki","doi":"10.1016/j.smim.2023.101841","DOIUrl":"10.1016/j.smim.2023.101841","url":null,"abstract":"<div><p>Cells undergo an inflammatory programmed lytic cell death called ‘pyroptosis’ (with the Greek roots ‘fiery’), often featuring morphological hallmarks such as large ballooning protrusions and subsequent bursting. Originally described as a caspase-1-dependent cell death in response to bacterial infection, pyroptosis has since been re-defined in 2018 as a cell death dependent on plasma membrane pores by a gasdermin (GSDM) family member <span>[1]</span>, <span>[2]</span>. GSDMs form pores in the plasma membrane as well as organelle membranes, thereby initiating membrane destruction and the rapid and lytic demise of a cell. The gasdermin family plays a profound role in the execution of pyroptosis in the context of infection, inflammation, tumor pathogenesis, and anti-tumor therapy. More recently, cell-death-independent functions for some of the GSDMs have been proposed. Therefore, a comprehensive understanding of gasdermin gene regulation, including mechanisms in both homeostatic conditions and during inflammation, is essential. In this review, we will summarize the role of gasdermins in pyroptosis and focus our discussion on the transcriptional and epigenetic mechanisms controlling the expression of GSDMs.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101841"},"PeriodicalIF":7.8,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10597273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammasomes as regulators of non-infectious disease 炎症小体作为非传染性疾病的调节因子。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101815

Daniel Okin , Jonathan C. Kagan

引用次数: 1

Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging 异常衰老:γδ T细胞、iNKT细胞和MAIT细胞参与衰老

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101816

Ayako Kurioka , Paul Klenerman

引用次数: 3

Introduction to the Special Issue: The Immunopeptidome 特刊简介:免疫肽穹窿

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101798

Étienne Caron, Claude Perreault

引用次数: 0

Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases Siglecs作为治疗人类肥大细胞和/或嗜酸性粒细胞相关疾病的潜在靶点。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101799

Jeremy A. O’Sullivan , Bradford A. Youngblood , Robert P. Schleimer , Bruce S. Bochner

引用次数: 0

Unconventional protein secretion by gasdermin pores 气真皮毛孔分泌非常规蛋白质

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101811

Petr Broz

{"title":"Unconventional protein secretion by gasdermin pores","authors":"Petr Broz","doi":"10.1016/j.smim.2023.101811","DOIUrl":"10.1016/j.smim.2023.101811","url":null,"abstract":"<div><p>Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it remains one of the least understood mechanisms in cell biology, UPS plays an essential role in immunity as it controls the release of the IL-1 family of cytokines, which coordinate host defense and inflammatory responses. The unconventional secretion of IL-1β and IL-18, the two most prominent members of the IL-1 family, is initiated by inflammasome complexes – cytosolic signaling platforms that are assembled in response to infectious or noxious stimuli. Inflammasomes activate inflammatory caspases that proteolytically mature IL-1β/− 18, but also induce pyroptosis, a lytic form of cell death. Pyroptosis is caused by gasdermin-D (GSDMD), a member of the gasdermin protein family, which is activated by caspase cleavage and forms large β-barrel plasma membrane pores. This pore-forming activity is shared with other family members that are activated during infection or upon treatment with chemotherapy drugs. While the induction of cell death was assumed to be the main function of gasdermin pores, accumulating evidence suggests that they have also non-lytic functions, such as in the release of cytokines and alarmins, or in regulating ion fluxes. This has raised the possibility that gasdermin pores are one of the main mediators of UPS. Here, I summarize and discuss new insights into gasdermin activation and pore formation, how gasdermin pores achieve selective cargo release, and how gasdermin pore formation and ninjurin-1-driven plasma membrane rupture are executed and regulated.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101811"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pyroptosis in defense against intracellular bacteria 防止细胞内细菌的Pyroptosis。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101805

Lupeng Li , Mary S. Dickinson , Jörn Coers , Edward A. Miao

引用次数: 1

Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire 心血管疾病中的Pyroposis：在火上抽吸gasdermin。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101809

Timur O. Yarovinsky , Meiling Su , Chaofei Chen , Yaozu Xiang , Wai Ho Tang , John Hwa

{"title":"Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire","authors":"Timur O. Yarovinsky , Meiling Su , Chaofei Chen , Yaozu Xiang , Wai Ho Tang , John Hwa","doi":"10.1016/j.smim.2023.101809","DOIUrl":"10.1016/j.smim.2023.101809","url":null,"abstract":"<div><p>Pyroptosis is a form of programmed cell death associated with activation of inflammasomes and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the plasma membrane), and selective release of proinflammatory mediators. Induction of pyroptosis results in amplification of inflammation, contributing to the pathogenesis of chronic cardiovascular diseases such as atherosclerosis and diabetic cardiomyopathy, and acute cardiovascular events, such as thrombosis and myocardial infarction. While engagement of pyroptosis during sepsis-induced cardiomyopathy and septic shock is expected and well documented, we are just beginning to understand pyroptosis involvement in the pathogenesis of cardiovascular diseases with less defined inflammatory components, such as atrial fibrillation. Due to the danger that pyroptosis represents to cells within the cardiovascular system and the whole organism, multiple levels of pyroptosis regulation have evolved. Those include regulation of inflammasome priming, post-translational modifications of gasdermins, and cellular mechanisms for pore removal. While pyroptosis in macrophages is well characterized as a dramatic pro-inflammatory process, pyroptosis in other cell types within the cardiovascular system displays variable pathways and consequences. Furthermore, different cells and organs engage in local and distant crosstalk and exchange of pyroptosis triggers (oxidized mitochondrial DNA), mediators (IL-1β, S100A8/A9) and antagonists (IL-9). Development of genetic tools, such as Gasdermin D knockout animals, and small molecule inhibitors of pyroptosis will not only help us fully understand the role of pyroptosis in cardiovascular diseases but may result in novel therapeutic approaches inhibiting inflammation and progression of chronic cardiovascular diseases to reduce morbidity and mortality from acute cardiovascular events.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101809"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10169066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pyroptosis modulation by bacterial effector proteins 细菌效应蛋白对热亡的调节

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101804

Qiyao Chai , Zehui Lei , Cui Hua Liu

{"title":"Pyroptosis modulation by bacterial effector proteins","authors":"Qiyao Chai , Zehui Lei , Cui Hua Liu","doi":"10.1016/j.smim.2023.101804","DOIUrl":"10.1016/j.smim.2023.101804","url":null,"abstract":"<div><p>Pyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the pore-forming proteins named gasdermins, and is intricately orchestrated by diverse regulatory factors in mammalian hosts to exert a prompt immune response against infections. However, growing evidence suggests that bacterial pathogens have evolved to regulate host pyroptosis for evading immune clearance and establishing progressive infection. In this review, we highlight current understandings of the functional role and regulatory network of pyroptosis in host antibacterial immunity. Thereafter, we further discuss the latest advances elucidating the mechanisms by which bacterial pathogens modulate pyroptosis through adopting their effector proteins to drive infections. A better understanding of regulatory mechanisms underlying pyroptosis at the interface of host-bacterial interactions will shed new light on the pathogenesis of infectious diseases and contribute to the development of promising therapeutic strategies against bacterial pathogens.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101804"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1