Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2023-09-01 DOI:10.1016/j.smim.2023.101810

Nan-ping Weng

引用次数: 1

Abstract

A vast array of αβ T cell receptors (TCRs) is generated during T cell development in the thymus through V(D)J recombination, which involves the rearrangement of multiple V, D, and J genes and the pairing of α and β chains. These diverse TCRs provide protection to the human body against a multitude of foreign pathogens and internal cancer cells. The entirety of TCRs present in an individual's T cells is referred to as the TCR repertoire. Despite an estimated 4 × 10¹¹ T cells in the adult human body, the lower bound estimate for the TCR repertoire is 3.8 × 10⁸. While the number of circulating T cells may slightly decrease with age, the changes in the diversity of the TCR repertoire is more apparent. Here, I review recent advancements in TCR repertoire studies, the methods used to measure it, how richness and diversity change as humans age, and some of the known consequences associated with these changes.

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数量和几率：TCR的曲目大小及其年龄变化对T细胞功能的影响。

在胸腺T细胞发育过程中，通过V（D）J重组产生了大量的αβT细胞受体（TCRs），该重组涉及多个V、D和J基因的重排以及α链和β链的配对。这些不同的TCR为人体提供保护，使其免受多种外来病原体和内部癌症细胞的侵害。存在于个体T细胞中的全部TCR被称为TCR库。尽管成年人体中估计有4×1011个T细胞，但TCR库的下限估计为3.8×108。虽然循环T细胞的数量可能会随着年龄的增长而略有减少，但TCR库多样性的变化更为明显。在这里，我回顾了TCR曲目研究的最新进展，用于测量它的方法，丰富性和多样性如何随着人类年龄的增长而变化，以及与这些变化相关的一些已知后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.