早期生命微生物组对儿童特应性和哮喘发展的贡献

IF 7.4 2区 医学 Q1 IMMUNOLOGY
Holly Steininger , Jacqueline Moltzau-Anderson , Susan V. Lynch
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引用次数: 1

摘要

在工业化国家,特应性变态反应和哮喘的迅速增加,导致人们发现了促进这些疾病的早期环境因素,并促使人们研究这种暴露如何介导儿童疾病发展的轨迹。在过去的十年里,人类微生物组已成为人类健康的关键决定因素。这在很大程度上是由于人们越来越重视微生物调节和训练宿主免疫力的无数非互斥机制。微生物组,特别是早期的微生物组,是由外在和内在因素形成的,包括许多已知会影响过敏和哮喘风险的暴露。这导致了一个普遍的假设,即这种暴露通过改变在这一关键发育时期形成免疫功能的微生物群的功能和代谢生产力,介导其对儿童特应性和哮喘的影响。从产前到儿童期,在基因和分子水平上研究人类微生物组的能力具有明确的临床结果,为确定特应性和哮喘结果的早期生活和代际决定因素提供了前所未有的机会。此外,这些研究提供了一个综合的微生物组研究框架,可应用于其他慢性炎症疾病。这篇综述试图捕捉该领域的关键研究,这些研究为儿童特应性和哮喘的发育起源提供了见解,为儿童适应不良免疫和慢性炎症疾病的微生物介质提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contributions of the early-life microbiome to childhood atopy and asthma development

The rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation for the myriad of non-mutually exclusive mechanisms by which microbes tune and train host immunity. Microbiomes, particularly those in early life, are shaped by extrinsic and intrinsic factors, including many of the exposures known to influence allergy and asthma risk. This has led to the over-arching hypothesis that such exposures mediate their effect on childhood atopy and asthma by altering the functions and metabolic productivity of microbiomes that shape immune function during this critical developmental period. The capacity to study microbiomes at the genetic and molecular level in humans from the pre-natal period into childhood with well-defined clinical outcomes, offers an unprecedented opportunity to identify early-life and inter-generational determinants of atopy and asthma outcomes. Moreover, such studies provide an integrative microbiome research framework that can be applied to other chronic inflammatory conditions. This review attempts to capture key studies in the field that offer insights into the developmental origins of childhood atopy and asthma, providing novel insights into microbial mediators of maladaptive immunity and chronic inflammatory disease in childhood.

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来源期刊
Seminars in Immunology
Seminars in Immunology 医学-免疫学
CiteScore
11.40
自引率
1.30%
发文量
50
审稿时长
89 days
期刊介绍: Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.
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