Seminars in Immunology最新文献_第5页

The immunology and cell biology of T cell aging T细胞衰老的免疫学和细胞生物学。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-28 DOI: 10.1016/j.smim.2023.101843

Jörg J. Goronzy, Nan-ping Weng

引用次数: 0

Beyond youth: Understanding CAR T cell fitness in the context of immunological aging 超越年轻：在免疫衰老的背景下理解CAR T细胞的适应性。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-18 DOI: 10.1016/j.smim.2023.101840

Julia Han Noll , Bruce L. Levine , Carl H. June , Joseph A. Fraietta

{"title":"Beyond youth: Understanding CAR T cell fitness in the context of immunological aging","authors":"Julia Han Noll , Bruce L. Levine , Carl H. June , Joseph A. Fraietta","doi":"10.1016/j.smim.2023.101840","DOIUrl":"10.1016/j.smim.2023.101840","url":null,"abstract":"<div><p>Population aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune system is a critical factor in the senescence process, with cancer being a primary cause of death in elderly populations. Chimeric antigen receptor (CAR) T cell therapy, an innovative approach, has demonstrated success mainly in pediatric and young adult hematological malignancies but remains largely ineffective for diseases affecting older populations, such as late-in-life B cell malignancies and most solid tumor indications. This limitation arises because CAR T cell efficacy heavily relies on the fitness of the patient-derived starting T cell material. Numerous studies suggest that T cell senescence may be a key driver of CAR T cell deficiency. This review examines correlates and underlying factors associated with favorable CAR T cell outcomes and explores potential experimental and clinically actionable strategies for T cell rejuvenation.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101840"},"PeriodicalIF":7.8,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS 与疫苗反应性相关的基线免疫状态(BIS)和影响BIS的因素

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-15 DOI: 10.1016/j.smim.2023.101842

Djamel Nehar-Belaid , Mark Sokolowski , Sathyabaarathi Ravichandran , Jacques Banchereau , Damien Chaussabel , Duygu Ucar

{"title":"Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS","authors":"Djamel Nehar-Belaid , Mark Sokolowski , Sathyabaarathi Ravichandran , Jacques Banchereau , Damien Chaussabel , Duygu Ucar","doi":"10.1016/j.smim.2023.101842","DOIUrl":"10.1016/j.smim.2023.101842","url":null,"abstract":"<div><p>Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in single-cell biology have been instrumental in uncovering pre-vaccination immune cell types and genomic features (i.e., the baseline immune state, BIS) that have been associated with vaccine responsiveness. Here, we review clinical factors that shape the BIS, and the characteristics of the BIS associated with responsiveness to frequently studied vaccines (i.e., influenza, COVID-19, bacterial pneumonia, malaria). Finally, we discuss potential strategies to enhance vaccine responsiveness in high-risk groups, focusing specifically on older adults.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101842"},"PeriodicalIF":7.8,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better safe than sorry: Naive T-cell dynamics in healthy ageing 安全总比后悔好:健康衰老中的幼稚t细胞动力学

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-14 DOI: 10.1016/j.smim.2023.101839

Rob J. de Boer , Kiki Tesselaar , José A.M. Borghans

引用次数: 0

Proteostasis in T cell aging T细胞老化中的蛋白质停滞

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-12 DOI: 10.1016/j.smim.2023.101838

A. Elisabeth Gressler , Houfu Leng , Heidi Zinecker , Anna Katharina Simon

引用次数: 0

Epigenetic and transcriptional control of gasdermins 气胚乳的表观遗传和转录调控

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-11 DOI: 10.1016/j.smim.2023.101841

Cristhian Cadena, Opher S. Kornfeld, Bettina L. Lee, Nobuhiko Kayagaki

{"title":"Epigenetic and transcriptional control of gasdermins","authors":"Cristhian Cadena, Opher S. Kornfeld, Bettina L. Lee, Nobuhiko Kayagaki","doi":"10.1016/j.smim.2023.101841","DOIUrl":"10.1016/j.smim.2023.101841","url":null,"abstract":"<div><p>Cells undergo an inflammatory programmed lytic cell death called ‘pyroptosis’ (with the Greek roots ‘fiery’), often featuring morphological hallmarks such as large ballooning protrusions and subsequent bursting. Originally described as a caspase-1-dependent cell death in response to bacterial infection, pyroptosis has since been re-defined in 2018 as a cell death dependent on plasma membrane pores by a gasdermin (GSDM) family member <span>[1]</span>, <span>[2]</span>. GSDMs form pores in the plasma membrane as well as organelle membranes, thereby initiating membrane destruction and the rapid and lytic demise of a cell. The gasdermin family plays a profound role in the execution of pyroptosis in the context of infection, inflammation, tumor pathogenesis, and anti-tumor therapy. More recently, cell-death-independent functions for some of the GSDMs have been proposed. Therefore, a comprehensive understanding of gasdermin gene regulation, including mechanisms in both homeostatic conditions and during inflammation, is essential. In this review, we will summarize the role of gasdermins in pyroptosis and focus our discussion on the transcriptional and epigenetic mechanisms controlling the expression of GSDMs.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101841"},"PeriodicalIF":7.8,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10597273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammasomes as regulators of non-infectious disease 炎症小体作为非传染性疾病的调节因子。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101815

Daniel Okin , Jonathan C. Kagan