Seminars in Immunology最新文献_第5页

Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases Siglecs作为治疗人类肥大细胞和/或嗜酸性粒细胞相关疾病的潜在靶点。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101799

Jeremy A. O’Sullivan , Bradford A. Youngblood , Robert P. Schleimer , Bruce S. Bochner

引用次数: 0

Unconventional protein secretion by gasdermin pores 气真皮毛孔分泌非常规蛋白质

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101811

Petr Broz

{"title":"Unconventional protein secretion by gasdermin pores","authors":"Petr Broz","doi":"10.1016/j.smim.2023.101811","DOIUrl":"10.1016/j.smim.2023.101811","url":null,"abstract":"<div><p>Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it remains one of the least understood mechanisms in cell biology, UPS plays an essential role in immunity as it controls the release of the IL-1 family of cytokines, which coordinate host defense and inflammatory responses. The unconventional secretion of IL-1β and IL-18, the two most prominent members of the IL-1 family, is initiated by inflammasome complexes – cytosolic signaling platforms that are assembled in response to infectious or noxious stimuli. Inflammasomes activate inflammatory caspases that proteolytically mature IL-1β/− 18, but also induce pyroptosis, a lytic form of cell death. Pyroptosis is caused by gasdermin-D (GSDMD), a member of the gasdermin protein family, which is activated by caspase cleavage and forms large β-barrel plasma membrane pores. This pore-forming activity is shared with other family members that are activated during infection or upon treatment with chemotherapy drugs. While the induction of cell death was assumed to be the main function of gasdermin pores, accumulating evidence suggests that they have also non-lytic functions, such as in the release of cytokines and alarmins, or in regulating ion fluxes. This has raised the possibility that gasdermin pores are one of the main mediators of UPS. Here, I summarize and discuss new insights into gasdermin activation and pore formation, how gasdermin pores achieve selective cargo release, and how gasdermin pore formation and ninjurin-1-driven plasma membrane rupture are executed and regulated.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101811"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pyroptosis in defense against intracellular bacteria 防止细胞内细菌的Pyroptosis。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101805

Lupeng Li , Mary S. Dickinson , Jörn Coers , Edward A. Miao

引用次数: 1

Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire 心血管疾病中的Pyroposis：在火上抽吸gasdermin。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101809

Timur O. Yarovinsky , Meiling Su , Chaofei Chen , Yaozu Xiang , Wai Ho Tang , John Hwa

{"title":"Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire","authors":"Timur O. Yarovinsky , Meiling Su , Chaofei Chen , Yaozu Xiang , Wai Ho Tang , John Hwa","doi":"10.1016/j.smim.2023.101809","DOIUrl":"10.1016/j.smim.2023.101809","url":null,"abstract":"<div><p>Pyroptosis is a form of programmed cell death associated with activation of inflammasomes and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the plasma membrane), and selective release of proinflammatory mediators. Induction of pyroptosis results in amplification of inflammation, contributing to the pathogenesis of chronic cardiovascular diseases such as atherosclerosis and diabetic cardiomyopathy, and acute cardiovascular events, such as thrombosis and myocardial infarction. While engagement of pyroptosis during sepsis-induced cardiomyopathy and septic shock is expected and well documented, we are just beginning to understand pyroptosis involvement in the pathogenesis of cardiovascular diseases with less defined inflammatory components, such as atrial fibrillation. Due to the danger that pyroptosis represents to cells within the cardiovascular system and the whole organism, multiple levels of pyroptosis regulation have evolved. Those include regulation of inflammasome priming, post-translational modifications of gasdermins, and cellular mechanisms for pore removal. While pyroptosis in macrophages is well characterized as a dramatic pro-inflammatory process, pyroptosis in other cell types within the cardiovascular system displays variable pathways and consequences. Furthermore, different cells and organs engage in local and distant crosstalk and exchange of pyroptosis triggers (oxidized mitochondrial DNA), mediators (IL-1β, S100A8/A9) and antagonists (IL-9). Development of genetic tools, such as Gasdermin D knockout animals, and small molecule inhibitors of pyroptosis will not only help us fully understand the role of pyroptosis in cardiovascular diseases but may result in novel therapeutic approaches inhibiting inflammation and progression of chronic cardiovascular diseases to reduce morbidity and mortality from acute cardiovascular events.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101809"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10169066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pyroptosis modulation by bacterial effector proteins 细菌效应蛋白对热亡的调节

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101804

Qiyao Chai , Zehui Lei , Cui Hua Liu

{"title":"Pyroptosis modulation by bacterial effector proteins","authors":"Qiyao Chai , Zehui Lei , Cui Hua Liu","doi":"10.1016/j.smim.2023.101804","DOIUrl":"10.1016/j.smim.2023.101804","url":null,"abstract":"<div><p>Pyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the pore-forming proteins named gasdermins, and is intricately orchestrated by diverse regulatory factors in mammalian hosts to exert a prompt immune response against infections. However, growing evidence suggests that bacterial pathogens have evolved to regulate host pyroptosis for evading immune clearance and establishing progressive infection. In this review, we highlight current understandings of the functional role and regulatory network of pyroptosis in host antibacterial immunity. Thereafter, we further discuss the latest advances elucidating the mechanisms by which bacterial pathogens modulate pyroptosis through adopting their effector proteins to drive infections. A better understanding of regulatory mechanisms underlying pyroptosis at the interface of host-bacterial interactions will shed new light on the pathogenesis of infectious diseases and contribute to the development of promising therapeutic strategies against bacterial pathogens.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101804"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The gut-brain vascular axis in neuroinflammation 神经性炎症中的肠-脑血管轴

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101802

Sara Carloni , Maria Rescigno

{"title":"The gut-brain vascular axis in neuroinflammation","authors":"Sara Carloni , Maria Rescigno","doi":"10.1016/j.smim.2023.101802","DOIUrl":"10.1016/j.smim.2023.101802","url":null,"abstract":"<div><p>The multifaceted microbiota characterizing our gut plays a crucial role in maintaining immune, metabolic and tissue homeostasis of the intestine as well as of distal organs, including the central nervous system. Microbial dysbiosis is reported in several inflammatory intestinal diseases characterized by the impairment of the gut epithelial and vascular barriers, defined as leaky gut, and it is reported as a potential danger condition associated with the development of metabolic, inflammatory and neurodegenerative diseases. Recently, we pointed out the strict connection between the gut and the brain via a novel vascular axis. Here we want to deepen our knowledge on the gut-brain axis, with particular emphasis on the connection between microbial dysbiosis, leaky gut, cerebral and gut vascular barriers, and neurodegenerative diseases. The firm association between microbial dysbiosis and impairment of the vascular gut-brain axis will be summarized in the context of protection, amelioration or boosting of Alzheimer, Parkinson, Major depressive and Anxiety disorders. Understanding the relationship between disease pathophysiology, mucosal barrier function and host-microbe interaction will foster the use of the microbiome as biomarker for health and disease as well as a target for therapeutic and nutritional advances.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101802"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Immune responses to SARS-CoV-2 infection and vaccination in children 儿童对SARS-CoV-2感染的免疫反应和疫苗接种

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101794

Petter Brodin

引用次数: 0

Pyroptosis-induced inflammation and tissue damage 焦热引起的炎症和组织损伤

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101781

Swathy O. Vasudevan , Bharat Behl , Vijay A. Rathinam

引用次数: 1

T cell fate decisions during memory cell generation with aging 记忆细胞衰老过程中的T细胞命运决定。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101800

Ines Sturmlechner , Abhinav Jain , Yunmei Mu , Cornelia M. Weyand , Jörg J. Goronzy

{"title":"T cell fate decisions during memory cell generation with aging","authors":"Ines Sturmlechner , Abhinav Jain , Yunmei Mu , Cornelia M. Weyand , Jörg J. Goronzy","doi":"10.1016/j.smim.2023.101800","DOIUrl":"10.1016/j.smim.2023.101800","url":null,"abstract":"<div><p>The defense against infectious diseases, either through natural immunity or after vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T cells are at the center of memory T cell generation during primary responses. Upon activation, they undergo a complex, highly regulated differentiation process towards different functional states. Naïve T cells maintained into older age have undergone epigenetic adaptations that influence their fate decisions during differentiation. We review age-sensitive, molecular pathways and gene regulatory networks that bias naïve T cell differentiation towards effector cell generation at the expense of memory and Tfh cells. As a result, T cell differentiation in older adults is associated with release of bioactive waste products into the microenvironment, higher stress sensitivity as well as skewing towards pro-inflammatory signatures and shorter life spans. These maladaptations not only contribute to poor vaccine responses in older adults but also fuel a more inflammatory state.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101800"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10169088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

T follicular helper cells in cancer, tertiary lymphoid structures, and beyond T滤泡辅助细胞在癌症，三级淋巴结构，及其他

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-01 DOI: 10.1016/j.smim.2023.101797

Can Cui , Joseph Craft , Nikhil S. Joshi

{"title":"T follicular helper cells in cancer, tertiary lymphoid structures, and beyond","authors":"Can Cui , Joseph Craft , Nikhil S. Joshi","doi":"10.1016/j.smim.2023.101797","DOIUrl":"10.1016/j.smim.2023.101797","url":null,"abstract":"<div><p>With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular helper (TFH) cells and B cells in cancer, highlighting the important role of their crosstalk and interactions with other immune cell components in the tumor microenvironment. These interactions also occur in tumor-associated tertiary lymphoid structures (TLS), which resemble secondary lymphoid organs (SLOs) with orchestrated vascular, chemokine, and cellular infrastructures that support the developmental pathways of functional immune cells. In this review, we discuss recent breakthroughs on TFH biology and T cell-B cell interactions in tumor immunology, and their potential as novel therapeutic targets to advance cancer treatment.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"69 ","pages":"Article 101797"},"PeriodicalIF":7.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0