Seminars in Immunology最新文献_第5页

To die or not to die: Gasdermins in intestinal health and disease 死还是不死肠道健康和疾病中的气敏物质

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-01-16 DOI: 10.1016/j.smim.2024.101865

Zhaoyu Lin , Qianyue Chen , Hai-Bin Ruan

{"title":"To die or not to die: Gasdermins in intestinal health and disease","authors":"Zhaoyu Lin , Qianyue Chen , Hai-Bin Ruan","doi":"10.1016/j.smim.2024.101865","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101865","url":null,"abstract":"<div><p><span><span>Intestinal homeostasis<span> is achieved by the balance among intestinal epithelium, </span></span>immune cells<span><span><span>, and gut microbiota. Gasdermins (GSDMs), a family of membrane pore forming proteins, can trigger rapid inflammatory </span>cell death<span> in the gut, mainly pyroptosis and </span></span>NETosis<span><span>. Importantly, there is increasing literature on the non-cell lytic roles of GSDMs in intestinal homeostasis and disease. While GSDMA is low and PJVK is not expressed in the gut, high GSDMB and GSDMC expression is found almost restrictively in intestinal epithelial cells. Conversely, GSDMD and GSDME show more ubiquitous expression among various cell types in the gut. The N-terminal region of GSDMs can be liberated for pore formation by an array of proteases in response to pathogen- and danger-associated signals, but it is not fully understood what cell type-specific mechanisms activate intestinal GSDMs. The host relies on GSDMs for </span>pathogen defense, tissue tolerance, and cancerous cell death; however, pro-inflammatory milieu caused by pyroptosis and excessive </span></span></span>cytokine release<span><span> may favor the development and progression of inflammatory bowel disease and cancer. Therefore, a thorough understanding of spatiotemporal mechanisms that control gasdermin expression, activation, and function is essential for the development of future therapeutics for </span>intestinal disorders.</span></p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"71 ","pages":"Article 101865"},"PeriodicalIF":7.8,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139480018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases 肠肝轴：慢性肝病的病理生理学概念和医学视角

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-01-13 DOI: 10.1016/j.smim.2023.101859

Susana G. Rodrigues , Schalk van der Merwe , Aleksander Krag , Reiner Wiest

引用次数: 0

Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy 树突状细胞的抗原交叉呈递:癌症免疫治疗的关键轴

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-29 DOI: 10.1016/j.smim.2023.101848

Christine Moussion, Lélia Delamarre

引用次数: 0

Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis 中性粒细胞的调节性细胞死亡：从细胞凋亡到NETosis和Pyroposis。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 DOI: 10.1016/j.smim.2023.101849

Léonie Dejas , Karin Santoni , Etienne Meunier , Mohamed Lamkanfi

引用次数: 0

Introduction to the special issue: Antigen cross-presentation 特刊简介：抗原交叉展示。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 DOI: 10.1016/j.smim.2023.101850

Peter van Endert

引用次数: 0

Regulatory T cells in allergic inflammation 过敏性炎症中的调节性T细胞。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-12 DOI: 10.1016/j.smim.2023.101847

Mehdi Benamar , Qian Chen , Monica Martinez-Blanco , Talal A. Chatila

引用次数: 0

Chemical modulation of gasdermin D activity: Therapeutic implications and consequences gasdermin D活性的化学调节：治疗意义和后果。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-08 DOI: 10.1016/j.smim.2023.101845

Bowen Zhou, Derek W. Abbott

引用次数: 0

The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions 上皮屏障：过敏性、自身免疫性、代谢性疾病和慢性神经精神疾病的途径。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-04 DOI: 10.1016/j.smim.2023.101846

Duygu Yazici , Ismail Ogulur , Yagiz Pat , Huseyn Babayev , Elena Barletta , Sena Ardicli , Manal Bel imam , Mengting Huang , Jana Koch , Manru Li , Debbie Maurer , Urszula Radzikowska , Pattraporn Satitsuksanoa , Stephan R. Schneider , Na Sun , Stephan Traidl , Alexandra Wallimann , Sebastian Wawrocki , Damir Zhakparov , Danielle Fehr , Cezmi A. Akdis

{"title":"The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions","authors":"Duygu Yazici , Ismail Ogulur , Yagiz Pat , Huseyn Babayev , Elena Barletta , Sena Ardicli , Manal Bel imam , Mengting Huang , Jana Koch , Manru Li , Debbie Maurer , Urszula Radzikowska , Pattraporn Satitsuksanoa , Stephan R. Schneider , Na Sun , Stephan Traidl , Alexandra Wallimann , Sebastian Wawrocki , Damir Zhakparov , Danielle Fehr , Cezmi A. Akdis","doi":"10.1016/j.smim.2023.101846","DOIUrl":"10.1016/j.smim.2023.101846","url":null,"abstract":"<div><p>Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing to the current pandemic in allergic, autoimmune and metabolic diseases. The \"Epithelial Barrier Theory\" postulates that these diseases are exacerbated by persistent periepithelial inflammation (epithelitis) triggered by exposure to a wide range of epithelial barrier-damaging substances as well as genetic susceptibility. The epithelial barrier serves as the body's primary physical, chemical, and immunological barrier against external stimuli. A leaky epithelial barrier facilitates the translocation of the microbiome from the surface of the afflicted tissues to interepithelial and even deeper subepithelial locations. In turn, opportunistic bacterial colonization, microbiota dysbiosis, local inflammation and impaired tissue regeneration and remodelling follow. Migration of inflammatory cells to susceptible tissues contributes to damage and inflammation, initiating and aggravating many chronic inflammatory diseases. The objective of this review is to highlight and evaluate recent studies on epithelial physiology and its role in the pathogenesis of chronic diseases in light of the epithelial barrier theory.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101846"},"PeriodicalIF":7.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The noncanonical inflammasome-induced pyroptosis and septic shock 非典型炎症小体可诱发pyroptosis和感染性休克。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-29 DOI: 10.1016/j.smim.2023.101844

Junru Wu , Jingjing Cai , Yiting Tang , Ben Lu

{"title":"The noncanonical inflammasome-induced pyroptosis and septic shock","authors":"Junru Wu , Jingjing Cai , Yiting Tang , Ben Lu","doi":"10.1016/j.smim.2023.101844","DOIUrl":"10.1016/j.smim.2023.101844","url":null,"abstract":"<div><p>Sepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic mode of cell death termed pyroptosis upon sensing cytosolic lipopolysaccharide (LPS). Although the consequences of activation of the canonical and non-canonical inflammasome are similar, the non-canonical inflammasome formation requires caspase-4/5/11, which enzymatically cleave the pore-forming protein gasdermin D (GSDMD) and thereby cause pyroptosis. The non-canonical inflammasome assembly triggers such inflammatory cell death by itself; or leverages a secondary activation of the canonical NLRP3 inflammasome pathway. Excessive cell death induced by oligomerization of GSDMD and NINJ1 leads to cytokine release and massive tissue damage, facilitating devastating consequences and death. This review summarized the updated mechanisms that initiate and regulate non-canonical inflammasome activation and pyroptosis and highlighted various endogenous or synthetic molecules as potential therapeutic targets for treating sepsis.</p></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101844"},"PeriodicalIF":7.8,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immunology and cell biology of T cell aging T细胞衰老的免疫学和细胞生物学。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-09-28 DOI: 10.1016/j.smim.2023.101843

Jörg J. Goronzy, Nan-ping Weng

引用次数: 0