肿瘤免疫逃避中的补体调节。

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2024-11-01 DOI:10.1016/j.smim.2024.101912

Guijun Liu , Xuxiao He , Gaoxiang Zhao , Zhimin Lu

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引用次数: 0

摘要

补体系统在先天性免疫反应和适应性免疫反应中都发挥着至关重要的作用，有助于消灭微生物等病原体和包括癌细胞在内的受损细胞。补体系统受到严格调控，并与细胞介导免疫相结合。在肿瘤微环境中，补体系统通过依赖或独立于补体激活的途径，在肿瘤和免疫细胞中发挥免疫和非免疫功能，从而促进免疫逃避和肿瘤进展。

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Complement regulation in tumor immune evasion

The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with cell-mediated immunity. In the tumor microenvironment, the complement system performs both immune and nonimmune functions in tumor and immune cells through pathways that depend on or are independent of complement activation, thereby promoting immune evasion and tumor progression.

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.