Sialic acid and Siglec receptors in tumor immunity and immunotherapy

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2024-07-01 DOI:10.1016/j.smim.2024.101893

引用次数: 0

Abstract

Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in recent years, providing new and potentially curative options for patients with even advanced disease. However, only a minority of patients achieve long-lasting remissions, and resistance to immune checkpoint inhibition is common. Recently, the sialic acid-Siglec axis has been proposed as a new immune checkpoint that could overcome resistance to current immunotherapy options. In this review, we summarize the current preclinical knowledge about the role of the sialic acid-Siglec interaction in immune suppression in cancer and discuss potential approaches to block this inhibitory pathway to enhance anti-cancer immunity.

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肿瘤免疫和免疫疗法中的 Sialic acid 和 Siglec 受体。

近年来，包括免疫检查点抑制在内的免疫疗法改变了癌症疗法，为晚期患者提供了新的甚至可能治愈的选择。然而，只有少数患者能获得长期缓解，而且对免疫检查点抑制剂的耐药性也很常见。最近，人们提出了一种新的免疫检查点--sialic acid-Siglec 轴，它可以克服目前免疫疗法的抗药性。在这篇综述中，我们总结了目前临床前关于sialic acid-Siglec相互作用在癌症免疫抑制中作用的知识，并讨论了阻断这一抑制途径以增强抗癌免疫力的潜在方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.