Seminars in Immunology最新文献_第3页

Interferon regulatory factor 3 beyond innate immunity: Regulation in obesity and metabolic disorders 先天免疫之外的干扰素调节因子3：肥胖和代谢紊乱的调节

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-03-28 DOI: 10.1016/j.smim.2025.101948

Heng Li , Yongliang Zhang , Hong Yong Peh

{"title":"Interferon regulatory factor 3 beyond innate immunity: Regulation in obesity and metabolic disorders","authors":"Heng Li , Yongliang Zhang , Hong Yong Peh","doi":"10.1016/j.smim.2025.101948","DOIUrl":"10.1016/j.smim.2025.101948","url":null,"abstract":"<div><div>Interferon regulatory factor 3 (IRF3) is a transcription factor known primarily for its role in antiviral immunity via regulation of type I interferons (IFNs). Recent research has broadened its significance to encompass metabolic disorders, particularly obesity and diabetes. Obesity is characterized by chronic low-grade inflammation, insulin resistance, and metabolic dysfunction, all of which are increasingly found to be associated with immune signaling pathways. IRF3 has emerged as an important regulator in the development of obesity and type 2 diabetes (T2D), predominantly through its regulation of inflammatory cytokines production in various cells in adipose tissue. In obese individuals, IRF3 is activated in the adipocytes and adipose tissue macrophages, to promote the expression of inflammatory cytokines, thereby contributing to chronic inflammation and exacerbating insulin resistance. Moreover, IRF3 has been linked to mitochondrial dysfunction in hepatic disorders, further amplifying metabolic stress and imbalances associated with obesity. The growing evidence suggests that IRF3 is an important mediator in both immune and metabolic pathways, highlighting its potential as a target for the development of therapeutic interventions for obesity-related inflammation and metabolic dysfunction.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101948"},"PeriodicalIF":7.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immunological processes behind aquaporin 4-antibody seropositive neuromyelitis optica spectrum disorders 水通道蛋白4抗体血清阳性视神经脊髓炎谱系障碍背后的免疫学过程

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-03-27 DOI: 10.1016/j.smim.2025.101945

Monika Bradl , Qian Yu , Yoshiki Takai

引用次数: 0

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Insights into pathogenesis and biomarkers of prognosis 髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）：发病机制和预后生物标志物的见解

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-03-14 DOI: 10.1016/j.smim.2025.101944

Jane Andersen , Fabienne Brilot

{"title":"Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Insights into pathogenesis and biomarkers of prognosis","authors":"Jane Andersen , Fabienne Brilot","doi":"10.1016/j.smim.2025.101944","DOIUrl":"10.1016/j.smim.2025.101944","url":null,"abstract":"<div><div>MOG antibody-associated disease (MOGAD), an inflammatory demyelinating pathology, is typically associated with the clinical phenotypes acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), or transverse myelitis (TM). The mainstay of diagnosis is detection of antibodies targeting oligodendrocyte-expressed MOG (MOG-IgG). MOG-IgG-mediated demyelination occurs via complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), enhanced cognate T-cell CNS infiltration and activation, and oligodendrocyte cytoskeleton disruption, but the exact role of the immune system in MOGAD is still poorly understood. The disease course is either monophasic or relapsing, with relapsing course affecting approximately two-thirds of individuals. Neurological disability accumulates with relapse and may manifest as visual, motor, sensory, and cognitive deficits. Thus, accurate disease course prediction is of paramount importance. Prognostic biomarkers, implemented at a global scale, have the potential to guide timely therapeutic decisions to limit relapse-associated disability accrual while simultaneously avoiding unnecessary immunosuppression in monophasic individuals. This review explores recent insights in the understanding of MOGAD pathogenesis as well as advances in prognostic biomarkers of relapsing course and disease activity.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101944"},"PeriodicalIF":7.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential immune responses behind different celiac disease manifestations 不同乳糜泻表现背后的免疫反应差异

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-03-13 DOI: 10.1016/j.smim.2025.101941

Esko Kemppainen, Olga Albó, Helka Kaunisto, Emilia Siukola, Katri Lindfors

{"title":"Differential immune responses behind different celiac disease manifestations","authors":"Esko Kemppainen, Olga Albó, Helka Kaunisto, Emilia Siukola, Katri Lindfors","doi":"10.1016/j.smim.2025.101941","DOIUrl":"10.1016/j.smim.2025.101941","url":null,"abstract":"<div><div>In celiac disease (CeD), dietary gluten serves as the driver for a comparatively well characterized small bowel mucosal immune response that generally results in small bowel mucosal villous atrophy and crypt hyperplasia along with a disease-specific transglutaminase 2 (TG2) targeting autoantibody response. Individuals with positive TG2 autoantibodies but normal small intestinal mucosal morphology are regarded at increased risk of developing CeD and represent patients with potential CeD. The removal of gluten from the diet leads to disappearance of the autoantibodies and normalization of the mucosal architecture in most cases. However, refractory CeD patients deviate from this dogma as they present with abnormal T cell compartment, persistent symptoms and villous atrophy despite a strict gluten-free diet. The heterogeneity of CeD presentation is further diversified by varying symptomatology. Gastrointestinal symptoms are the most canonical signs of CeD, and they include for instance diarrhea, vomiting, constipation and abdominal pain. Yet, a great portion of the patients manifest the disease at extraintestinal sites such as skin, musculoskeletal system or neuronal tissues. Beyond the involvement of various transglutaminase autoantibodies, the detailed immune mechanisms contributing to the development of these manifestations remains elusive, though. This review highlights the current understanding of the immunological differences in various manifestations of CeD. As the immunological basis of the different CeD phenotypes is at present insufficiently understood, more research on the subject is warranted before such data could be maximally applied to clinical practice.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"78 ","pages":"Article 101941"},"PeriodicalIF":7.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimmune interactions between itch neurons and skin microbes 瘙痒神经元和皮肤微生物之间的神经免疫相互作用

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-03-08 DOI: 10.1016/j.smim.2025.101933

Sharan Kumar Balaji , Waris Muhammad Khuwaja , Md Liakat Hossain , Luchiano Giovanni Benjamin Fernando, Xintong Dong

引用次数: 0

Complement regulators as novel targets for anti-cancer therapy: A comprehensive review 补体调节因子作为抗癌治疗的新靶点：综述

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-01-18 DOI: 10.1016/j.smim.2025.101931

Ruchi Saxena , Elizabeth B. Gottlin , Michael J. Campa , You-Wen He , Edward F. Patz Jr.

{"title":"Complement regulators as novel targets for anti-cancer therapy: A comprehensive review","authors":"Ruchi Saxena , Elizabeth B. Gottlin , Michael J. Campa , You-Wen He , Edward F. Patz Jr.","doi":"10.1016/j.smim.2025.101931","DOIUrl":"10.1016/j.smim.2025.101931","url":null,"abstract":"<div><div>Cancer remains a formidable global health challenge requiring the continued exploration of innovative therapeutic approaches. While traditional treatment strategies including surgery, chemotherapy, and radiation therapy have had some success, primarily in early-stage disease, the quest for more targeted, personalized, safer, and effective therapies remains an ongoing pursuit. Over the past decade, significant advances in the field of tumor immunology have dramatically shifted a focus towards immunotherapy, although the ability to harness and coopt the immune system to treat cancer is still just beginning to be realized. One important area that has yet to be fully explored is the complement system, an integral part of innate immunity that has gathered attention recently as a source of potential targets for anti-cancer therapy. The complement system has a complex and context dependent role in cancer biology in that it not only contributes to immune surveillance but also may promote tumor progression. Complement regulators, including CD46, CD55, CD59, and complement factor H, exercise defined control over complement activation, and have also been acknowledged for their role in the tumor microenvironment. This review explores the intricate role of complement regulators in cancer development and progression, examining their potential as therapeutic targets, current strategies, challenges, and the evolving landscape of clinical research.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"77 ","pages":"Article 101931"},"PeriodicalIF":7.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning from Inborn Errors of Immunity: From mechanisms to translation 从先天性免疫错误中学习：从机制到转化。

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-01-11 DOI: 10.1016/j.smim.2025.101932

Mohamed-Ridha Barbouche, Luigi D. Notarangelo

引用次数: 0

Neurogenic inflammation and itch in barrier tissues 屏障组织的神经源性炎症和瘙痒。

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-01-10 DOI: 10.1016/j.smim.2024.101928

Rebecca Liu , Dean R. Buttaci , Caroline L. Sokol

引用次数: 0

Celiac disease, non-celiac wheat sensitivity, wheat allergy – clinical and diagnostic aspects 乳糜泻，非乳糜小麦敏感性，小麦过敏-临床和诊断方面。

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-01-09 DOI: 10.1016/j.smim.2025.101930

Ketil Størdal , Kalle Kurppa

{"title":"Celiac disease, non-celiac wheat sensitivity, wheat allergy – clinical and diagnostic aspects","authors":"Ketil Størdal , Kalle Kurppa","doi":"10.1016/j.smim.2025.101930","DOIUrl":"10.1016/j.smim.2025.101930","url":null,"abstract":"<div><div>In recent years, wheat- and gluten-free diets have increased in demand due to reported increases in various conditions reported to be driven by ingredients of these food products. Celiac disease, wheat allergy and non-celiac wheat sensitivity constitute the three main categories of wheat-related disorders. Celiac disease is a well-characterized immune-mediated disease caused by immune reaction against specific gliadin epitopes, the main protein in wheat. Screening studies of samples collected over time bring evidence that there is a true increase in prevalence not only driven by increased testing activity. Clinical presentation of CeD is diverse and there is an increased risk of autoimmune co-morbidities. Wheat allergy consists of IgE- and non-IgE-mediated reactions, driven by Th2-cells directing eosinophil and basophil responses. Rapid IgE-mediated reactions are characterized by specific IgE antibodies in conjunction with symptoms originating especially from the respiratory and gastrointestinal tract. There is an increased risk of other allergies and the majority recover during adolescence. Non-IgE-mediated wheat allergy is a less-well defined condition, which is often diagnostically challenging due to a longer interval between exposure and symptoms and lack of non-invasive biomarkers. In this condition, wheat as a trigger needs to be established by exclusion followed by dietary challenge. Non-celiac wheat sensitivity, despite being the most recently recognized, has the highest reported prevalence among the three wheat-related entities. It remains, however, particularly poorly characterized due to unclear pathophysiology and lack of diagnostic markers. This narrative review will scrutinize the shared and distinct clinical features of the three wheat-related conditions, focusing on epidemiology, clinical presentation, co-morbidities, diagnosis, treatment and prognosis.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"77 ","pages":"Article 101930"},"PeriodicalIF":7.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironment 超常：肿瘤微环境中补体系统和细胞外基质的相互作用。

IF 7.4 2区医学

Seminars in Immunology Pub Date : 2025-01-09 DOI: 10.1016/j.smim.2025.101929

Andrea Balduit , Chiara Agostinis , Roberta Bulla

{"title":"Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironment","authors":"Andrea Balduit , Chiara Agostinis , Roberta Bulla","doi":"10.1016/j.smim.2025.101929","DOIUrl":"10.1016/j.smim.2025.101929","url":null,"abstract":"<div><div>Ground-breaking awareness has been reached about the intricate and dynamic connection between developing tumors and the host immune system. Being a powerful arm of innate immunity and a functional bridge with adaptive immunity, the complement system (C) has also emerged as a pivotal player in the tumor microenvironment (TME). Its “double-edged sword” role in cancer can find an explanation in the controversial relationship between C capability to mediate tumor cell cytolysis or, conversely, to sustain chronic inflammation and tumor progression by enhancing cell invasion, angiogenesis, and metastasis to distant organs. However, comprehensive knowledge about the actual role of C in cancer progression is impaired by several limitations of the currently available studies.</div><div>In the current review, we aim to bring a fresh eye to the controversial role of C in cancer by analyzing the interplay between C and extracellular matrix (ECM) components as potential orchestrators of the TME. The interaction of C components with specific ECM components can determine C activation or inhibition and promote specific non-canonical functions, which can, in the tumor context, favor or limit progression based on the cancer setting. An in-depth and tumor-specific characterization of TME composition in terms of C components and ECM proteins could be essential to determine their potential interactions and become a key element for improving drug development, prognosis, and therapy response prediction in solid tumors.</div></div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"77 ","pages":"Article 101929"},"PeriodicalIF":7.4,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0