Seminars in Immunology最新文献_第3页

Toolkit for mapping the clonal landscape of tumor-infiltrating B cells 绘制肿瘤浸润 B 细胞克隆图谱的工具包

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-01-31 DOI: 10.1016/j.smim.2024.101864

E.O. Serebrovskaya , E.A. Bryushkova , D.K. Lukyanov , N.V. Mushenkova , D.M. Chudakov , M.A. Turchaninova

{"title":"Toolkit for mapping the clonal landscape of tumor-infiltrating B cells","authors":"E.O. Serebrovskaya , E.A. Bryushkova , D.K. Lukyanov , N.V. Mushenkova , D.M. Chudakov , M.A. Turchaninova","doi":"10.1016/j.smim.2024.101864","DOIUrl":"10.1016/j.smim.2024.101864","url":null,"abstract":"<div>Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern these roles, which are cumulatively defined by B cell clonal functional programs, specificities of their B cell receptors, specificities and isotypes of the antibodies they produce, and their spatial interactions within the tumor environment. Comprehensive analysis of these characteristics of clonal B cell populations is now becoming feasible with the development of a whole arsenal of advanced technical approaches, which include (1) methods of single-cell and spatial transcriptomics, genomics, and proteomics; (2) methods of massive identification of B cell specificities; (3) methods of deep error-free profiling of B cell receptor repertoires. Here we overview existing techniques, summarize their current application for B cells studies and propose promising future directions in advancing B cells exploration.</div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"72 ","pages":"Article 101864"},"PeriodicalIF":7.8,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139648542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond I型和III型干扰素：从基础生物学和遗传学到 COVID-19 及其后的临床开发

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-01-24 DOI: 10.1016/j.smim.2024.101863

Evangelos Andreakos, COVID Human Genetic Effort

{"title":"Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond","authors":"Evangelos Andreakos, COVID Human Genetic Effort","doi":"10.1016/j.smim.2024.101863","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101863","url":null,"abstract":"<div>Type I and type III interferons (IFNs) constitute a key antiviral defense systems of the body, inducing viral resistance to cells and mediating diverse innate and adaptive immune functions. Defective type I and type III IFN responses have recently emerged as the 'Achilles heel' in COVID-19, with such patients developing severe disease and exhibiting a high risk for critical pneumonia and death. Here, we review the biology of type I and type III IFNs, their similarities and important functional differences, and their roles in SARS-CoV-2 infection. We also appraise the various mechanisms proposed to drive defective IFN responses in COVID-19 with particular emphasis to the ability of SARS-CoV-2 to suppress IFN production and activities, the genetic factors involved and the presence of autoantibodies neutralizing IFNs and accounting for a large proportion of individuals with severe COVID-19. Finally, we discuss the long history of the type I IFN therapeutics for the treatment of viral diseases, cancer and multiple sclerosis, the various efforts to use them in respiratory infections, and the newly emerging type III IFN therapeutics, with emphasis to the more recent studies on COVID-19 and their potential use as broad spectrum antivirals for future epidemics or pandemics.</div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"72 ","pages":"Article 101863"},"PeriodicalIF":7.8,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To die or not to die: Gasdermins in intestinal health and disease 死还是不死肠道健康和疾病中的气敏物质

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-01-16 DOI: 10.1016/j.smim.2024.101865

Zhaoyu Lin , Qianyue Chen , Hai-Bin Ruan

{"title":"To die or not to die: Gasdermins in intestinal health and disease","authors":"Zhaoyu Lin , Qianyue Chen , Hai-Bin Ruan","doi":"10.1016/j.smim.2024.101865","DOIUrl":"https://doi.org/10.1016/j.smim.2024.101865","url":null,"abstract":"<div>Intestinal homeostasis is achieved by the balance among intestinal epithelium, immune cells, and gut microbiota. Gasdermins (GSDMs), a family of membrane pore forming proteins, can trigger rapid inflammatory cell death in the gut, mainly pyroptosis and NETosis. Importantly, there is increasing literature on the non-cell lytic roles of GSDMs in intestinal homeostasis and disease. While GSDMA is low and PJVK is not expressed in the gut, high GSDMB and GSDMC expression is found almost restrictively in intestinal epithelial cells. Conversely, GSDMD and GSDME show more ubiquitous expression among various cell types in the gut. The N-terminal region of GSDMs can be liberated for pore formation by an array of proteases in response to pathogen- and danger-associated signals, but it is not fully understood what cell type-specific mechanisms activate intestinal GSDMs. The host relies on GSDMs for pathogen defense, tissue tolerance, and cancerous cell death; however, pro-inflammatory milieu caused by pyroptosis and excessive cytokine release may favor the development and progression of inflammatory bowel disease and cancer. Therefore, a thorough understanding of spatiotemporal mechanisms that control gasdermin expression, activation, and function is essential for the development of future therapeutics for intestinal disorders.</div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"71 ","pages":"Article 101865"},"PeriodicalIF":7.8,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139480018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases 肠肝轴：慢性肝病的病理生理学概念和医学视角

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2024-01-13 DOI: 10.1016/j.smim.2023.101859

Susana G. Rodrigues , Schalk van der Merwe , Aleksander Krag , Reiner Wiest

引用次数: 0

Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy 树突状细胞的抗原交叉呈递:癌症免疫治疗的关键轴

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-29 DOI: 10.1016/j.smim.2023.101848

Christine Moussion, Lélia Delamarre

引用次数: 0

Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis 中性粒细胞的调节性细胞死亡：从细胞凋亡到NETosis和Pyroposis。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 DOI: 10.1016/j.smim.2023.101849

Léonie Dejas , Karin Santoni , Etienne Meunier , Mohamed Lamkanfi

引用次数: 0

Introduction to the special issue: Antigen cross-presentation 特刊简介：抗原交叉展示。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-11-01 DOI: 10.1016/j.smim.2023.101850

Peter van Endert

引用次数: 0

Regulatory T cells in allergic inflammation 过敏性炎症中的调节性T细胞。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-12 DOI: 10.1016/j.smim.2023.101847

Mehdi Benamar , Qian Chen , Monica Martinez-Blanco , Talal A. Chatila

引用次数: 0

Chemical modulation of gasdermin D activity: Therapeutic implications and consequences gasdermin D活性的化学调节：治疗意义和后果。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-08 DOI: 10.1016/j.smim.2023.101845

Bowen Zhou, Derek W. Abbott

引用次数: 0

The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions 上皮屏障：过敏性、自身免疫性、代谢性疾病和慢性神经精神疾病的途径。

IF 7.8 2区医学

Seminars in Immunology Pub Date : 2023-10-04 DOI: 10.1016/j.smim.2023.101846

Duygu Yazici , Ismail Ogulur , Yagiz Pat , Huseyn Babayev , Elena Barletta , Sena Ardicli , Manal Bel imam , Mengting Huang , Jana Koch , Manru Li , Debbie Maurer , Urszula Radzikowska , Pattraporn Satitsuksanoa , Stephan R. Schneider , Na Sun , Stephan Traidl , Alexandra Wallimann , Sebastian Wawrocki , Damir Zhakparov , Danielle Fehr , Cezmi A. Akdis

{"title":"The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions","authors":"Duygu Yazici , Ismail Ogulur , Yagiz Pat , Huseyn Babayev , Elena Barletta , Sena Ardicli , Manal Bel imam , Mengting Huang , Jana Koch , Manru Li , Debbie Maurer , Urszula Radzikowska , Pattraporn Satitsuksanoa , Stephan R. Schneider , Na Sun , Stephan Traidl , Alexandra Wallimann , Sebastian Wawrocki , Damir Zhakparov , Danielle Fehr , Cezmi A. Akdis","doi":"10.1016/j.smim.2023.101846","DOIUrl":"10.1016/j.smim.2023.101846","url":null,"abstract":"<div>Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing to the current pandemic in allergic, autoimmune and metabolic diseases. The \"Epithelial Barrier Theory\" postulates that these diseases are exacerbated by persistent periepithelial inflammation (epithelitis) triggered by exposure to a wide range of epithelial barrier-damaging substances as well as genetic susceptibility. The epithelial barrier serves as the body's primary physical, chemical, and immunological barrier against external stimuli. A leaky epithelial barrier facilitates the translocation of the microbiome from the surface of the afflicted tissues to interepithelial and even deeper subepithelial locations. In turn, opportunistic bacterial colonization, microbiota dysbiosis, local inflammation and impaired tissue regeneration and remodelling follow. Migration of inflammatory cells to susceptible tissues contributes to damage and inflammation, initiating and aggravating many chronic inflammatory diseases. The objective of this review is to highlight and evaluate recent studies on epithelial physiology and its role in the pathogenesis of chronic diseases in light of the epithelial barrier theory.</div>","PeriodicalId":49546,"journal":{"name":"Seminars in Immunology","volume":"70 ","pages":"Article 101846"},"PeriodicalIF":7.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0