Neuroimmune interactions between itch neurons and skin microbes

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2025-03-08 DOI:10.1016/j.smim.2025.101933

Sharan Kumar Balaji , Waris Muhammad Khuwaja , Md Liakat Hossain , Luchiano Giovanni Benjamin Fernando, Xintong Dong

引用次数: 0

Abstract

Itch is an unpleasant sensation that is encoded by specific sensory neurons called pruriceptors. Itch is associated with almost all skin diseases. Recent studies revealed that many itchy skin diseases are associated with microbiome dysbiosis. Pathogenic microbes secrete proteases and toxins to invade skin cells. Some microbial products can directly activate sensory neurons, while others activate the mammalian immune system and indirectly cause itch. In this review, we summarize the current knowledge on microbe-immune-neuron crosstalks and discuss their relevance in itchy skin diseases.

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瘙痒神经元和皮肤微生物之间的神经免疫相互作用

痒是一种不愉快的感觉，是由一种叫做瘙痒感受器的特殊感觉神经元编码的。几乎所有的皮肤病都与瘙痒有关。最近的研究表明，许多皮肤瘙痒性疾病与微生物群失调有关。病原微生物分泌蛋白酶和毒素侵入皮肤细胞。一些微生物产物可以直接激活感觉神经元，而另一些则可以激活哺乳动物的免疫系统，间接引起瘙痒。本文综述了微生物-免疫-神经元串扰的最新研究进展，并讨论了它们在皮肤瘙痒性疾病中的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.