Complement and the hallmarks of cancer

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2025-04-02 DOI:10.1016/j.smim.2025.101950

Mikel Rezola Artero , Andrea Minery , Leon Nedelcev , Maria Radanova , Lubka T. Roumenina

引用次数: 0

Abstract

The hallmarks of cancer are a set of traits that normal cells acquire during their transformation into malignancy. Among the biological processes influencing these hallmarks, the innate immune complement system plays a critical role. It can operate canonically—in blood and tissues—via phagocytosis, inflammation, and complement-dependent cytotoxicity, similar to its roles against invading pathogens. Additionally, it functions non-canonically by modulating the behavior of cells within the tumor microenvironment and their intracellular landscape which regulates cell fate. These mechanisms contribute to the complex and context-dependent roles of complement in both tumor growth and antitumor immunity, shaped by the characteristics of the dynamic tumor microenvironment. This review analyses the multifaceted interplay between complement proteins and cancer hallmarks, positioning this system as a target to cancer therapy.

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补体和癌症的标志

癌症的特征是正常细胞在向恶性肿瘤转化过程中获得的一系列特征。在影响这些特征的生物过程中，先天免疫补体系统起着至关重要的作用。它可以在血液和组织中正常运作，通过吞噬、炎症和补体依赖性细胞毒性，类似于它抵抗入侵病原体的作用。此外，它通过调节肿瘤微环境中细胞的行为和调节细胞命运的细胞内景观而发挥非典型的作用。这些机制有助于补体在肿瘤生长和抗肿瘤免疫中的复杂和情境依赖性作用，由动态肿瘤微环境的特征决定。这篇综述分析了补体蛋白与癌症标志物之间多方面的相互作用，将该系统定位为癌症治疗的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.