水通道蛋白4抗体血清阳性视神经脊髓炎谱系障碍背后的免疫学过程

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2025-03-27 DOI:10.1016/j.smim.2025.101945

Monika Bradl , Qian Yu , Yoshiki Takai

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引用次数: 0

摘要

自从在视神经脊髓炎患者的血清中发现致病性水通道蛋白4特异性抗体以来，目前关于临床观察和诊断，以及潜在病理和由此产生的治疗的知识已经在优秀的综述和主要出版物中提出。然而，为了进一步开发治疗这种疾病的新策略，迫切需要了解与致病性抗体形成相关的免疫过程，以及在患者中观察到的异常免疫反应。在这篇综述中，我们将重点介绍和评价这些过程的重要研究。

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The immunological processes behind aquaporin 4-antibody seropositive neuromyelitis optica spectrum disorders

Ever since the discovery of pathogenic aquaporin 4-specific antibodies in the serum of patients with neuromyelitis optica spectrum disorders current knowledge about clinical observations and diagnosis, and about the underlying pathology and resulting therapies have been put forward in excellent reviews and primary publications. However, in order to further develop novel strategies for the treatment of this disease, there is an urgent need to understand the immunological processes associated with the formation of the pathogenic antibodies, and with aberrant immune responses observed in affected patients. In this review, we will highlight and evaluate important studies on these processes.

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.