Sleep Medicine Reviews最新文献

{"title":"Central disorders of hypersomnolence – A narrative review on current and potential biomarkers","authors":"Jian Eu Tai ,&nbsp;Sheila Sivam ,&nbsp;Angela D'Rozario ,&nbsp;David Wang ,&nbsp;Garry Cho ,&nbsp;Brendon J. Yee","doi":"10.1016/j.smrv.2025.102167","DOIUrl":"10.1016/j.smrv.2025.102167","url":null,"abstract":"<div><div>Central disorders of hypersomnolence are currently diagnosed in clinical practice from overnight polysomnography and multiple sleep latency test (MSLT). Cerebrospinal fluid (CSF) orexin levels are also a useful confirmatory test for type 1 narcolepsy. The diagnosis and differentiation of disorders of hypersomnolence remain limited by the lack of repeatability of MSLT and the absence of any known biomarkers for type 2 narcolepsy (NT2) and idiopathic hypersomnolence (IH). There remains limited understanding of the pathophysiology and neural pathways involved in NT2 and IH. In this narrative review, we explore the research on serum and CSF testing, neuroimaging, polysomnography and other modalities in improving the sensitivity and specificity of diagnosing these disorders.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102167"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex nocturnal behaviour – issues with expert evidence and the duty to the court","authors":"Ian Morrison ,&nbsp;Renata L. Riha ,&nbsp;John M.M. Rumbold","doi":"10.1016/j.smrv.2025.102162","DOIUrl":"10.1016/j.smrv.2025.102162","url":null,"abstract":"<div><div>Motor behaviour during the sleep period has several possible causes. In this review paper, we discuss the typical features of slow wave sleep parasomnias and nocturnal dissociation to illustrate the difficulties when evaluating complex sleep behaviours. These two categories of disorders illustrate issues around criminal responsibility and social control measures, in particular. One such concern is that slow wave sleep parasomnias may be considered ‘not legally insane’ by medical sleep experts which may be contrary to the relevant law in the jurisdiction. Nocturnal dissociative behaviour, by contrast, clearly involves mental health issues. There are implications for the criminal justice system when the disorders that cause complex nocturnal behaviour entail a continuing risk of harm to others. This means that the insanity verdict or equivalent may be appropriate to ensure supervision and restrictions to protect the public. The options for disposal are discussed, alongside the implications for expert witnesses.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102162"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of traumatic brain injury on sleep and associated neuroimaging changes: A systematic review","authors":"Jacob S. Shaw ,&nbsp;Kaylee Woodard ,&nbsp;Akshay Krieg ,&nbsp;Barry R. Bryant ,&nbsp;Sabrina Kentis ,&nbsp;Aaron I. Esagoff ,&nbsp;Anne Reisch ,&nbsp;Rachel M. Salas ,&nbsp;Matthew E. Peters ,&nbsp;Michael J.C. Bray","doi":"10.1016/j.smrv.2025.102155","DOIUrl":"10.1016/j.smrv.2025.102155","url":null,"abstract":"<div><div>Sleep disturbances are among the most common neuropsychiatric symptoms following traumatic brain injury (TBI). However, no review has sought to identify the major neuroimaging correlates of post-TBI sleep disturbances across multiple imaging modalities. This systematic review aimed to describe post-TBI neuroimaging changes associated with self-reported and objective markers of sleep disturbance using computed tomography (CT), magnetic resonance imaging (MRI), and quantitative electroencephalography (qEEG). 21 studies were included in this review, comprising the data of 3176 individual with TBI and 396 individuals without TBI. While acute intracranial abnormalities on CT were not reliable predictors of self-reported symptoms of insomnia, measures of axonal integrity on diffusion tensor imaging (DTI), particularly involving cortico-subcortical white matter tracts such as the uncinate fasciculus, were highly associated with self-reported sleep disturbance. Individuals with TBI were also found to have decreased delta power and increased beta power on qEEG during sleep, providing preliminary support for the functional role of the hypothalamus in the pathogenesis of post-TBI sleep disturbance. Key study limitations include small sample sizes and heterogeneity of TBI severity and chronicity. Functional neuroimaging studies are needed that elucidate which alterations in white matter connectivity may be most implicated in the neurocircuitry of post-TBI sleep disturbance.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102155"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission, treatment response, and treatment adherence across the delivery methods of cognitive behavioral therapy for insomnia: A systematic review and meta-analysis of randomized controlled trials","authors":"Yuta Takano ,&nbsp;Isa Okajima ,&nbsp;Masumi Osao ,&nbsp;Rui Ibata ,&nbsp;Naho Machida ,&nbsp;Koyo Higami ,&nbsp;Shunsuke Takagi ,&nbsp;Yuichi Inoue","doi":"10.1016/j.smrv.2025.102204","DOIUrl":"10.1016/j.smrv.2025.102204","url":null,"abstract":"<div><div>This study aimed to clarify the clinically meaningful outcomes and treatment adherence across different delivery methods of cognitive behavioral therapy for insomnia (CBT-I). CBT-I was defined as incorporating both sleep restriction and stimulus control techniques. This study included individual, group, fully automated Internet-based, and supported Internet-based formats. Remission from insomnia increased significantly across all delivery methods compared with the control group (individual: <em>k</em> = 36, <em>n</em> = 1696, odds ratio [OR] = 8.36; group: <em>k</em> = 22, <em>n</em> = 2356, OR = 4.65; fully automated Internet-based: <em>k</em> = 50, <em>n</em> = 15590, OR = 3.87; supported Internet-based: <em>k</em> = 19, <em>n</em> = 1759, OR = 8.35). After adjusting for comorbidities and types of control group, meta-regression analysis showed that the individual and supported Internet-based formats were significantly associated with higher odds of remission from insomnia compared with the fully automated Internet-based format. The completion rate for all sessions was significantly higher in the individual format (<em>k</em> = 8, 83.8%) than in the Internet-based formats (supported Internet-based: <em>k</em> = 15, 70.7%; fully automated Internet-based: <em>k</em> = 26, 58.4%). CBT-I is robustly effective in managing insomnia, although relatively lower treatment adherence continues to be a major challenge for Internet-based CBT-I.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102204"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative adverse events in patients with obstructive sleep apnea undergoing ambulatory ENT surgery: A systematic review and meta-analysis","authors":"Felicia Ceban ,&nbsp;Andy Cui ,&nbsp;Aparna Saripella ,&nbsp;Subin Park ,&nbsp;Felix Hu ,&nbsp;Nethmi Rajapakse ,&nbsp;Ellene Yan ,&nbsp;Marina Englesakis ,&nbsp;Michael J. Hutz ,&nbsp;Basem Abdelmalak ,&nbsp;Frances Chung","doi":"10.1016/j.smrv.2025.102194","DOIUrl":"10.1016/j.smrv.2025.102194","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with obstructive sleep apnea (OSA) may be at increased risk for adverse events during ambulatory otorhinolaryngologic (ear, nose, and throat, [ENT]) surgery. There remains a gap in the literature quantifying these risks. This systematic review and meta-analysis aimed to evaluate the incidence of perioperative complications among patients with OSA undergoing ambulatory ENT surgeries.</div></div><div><h3>Methods</h3><div>We systematically searched five databases from inception until February 2024 for studies on adult OSA patients undergoing ambulatory ENT surgeries. Primary outcomes included rates of composite adverse events, same-day admissions, emergency department (ED) visits, and readmissions. Meta-analysis, sensitivity analyses, and meta-regression were performed.</div></div><div><h3>Results</h3><div>Sixteen studies (5453 patients) were included. The pooled incidence of composite adverse events was 10 % (95 % CI 7–14 %), with 12 % requiring same-day admission, 7 % presenting to the ED, and a 3 % readmission rate. Adverse events were mostly bleeding, pain, and dehydration. Expansion sphincter pharyngoplasty and other combined/multi-level procedures were generally associated with the most complications.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that ENT procedures may be safely performed in ambulatory settings in appropriately selected patients with OSA. Improved patient selection and perioperative management may reduce complications, and careful risk stratification remains essential, particularly for combined/multi-level airway surgeries.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102194"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of cannabinoids on subjective sleep quality in people with and without insomnia or poor sleep: A systematic review and meta-analysis of randomised studies","authors":"Giovanna Hanike Santos da Silva ,&nbsp;Eduardo Cerchi Barbosa ,&nbsp;Fernanda Ribeiro de Lima ,&nbsp;Douglas Carneiro Barroso ,&nbsp;Loyná Euá Flores E. Paez ,&nbsp;Felipe Bandeira de Melo Guimarães ,&nbsp;Saulo Bernardo Lança ,&nbsp;Stephanie Brito Ceolin de Faria ,&nbsp;Arthur Bezerra Cavalcanti Petrucci ,&nbsp;Alicja Garbacka ,&nbsp;Jennifer H. Walsh","doi":"10.1016/j.smrv.2025.102156","DOIUrl":"10.1016/j.smrv.2025.102156","url":null,"abstract":"<div><h3>Study objectives</h3><div>This systematic review and meta-analysis assessed the efficacy of cannabinoids compared to placebo for improving sleep quality.</div></div><div><h3>Methods</h3><div>Searches were conducted in MEDLINE, Embase, and Cochrane databases for randomised controlled trials comparing cannabinoids vs. placebo for improving sleep quality in adults with or without insomnia or poor sleep. The primary outcome was self-reported sleep quality (PROMIS, PSQI, LSEQ, Sleep Diary). Secondary outcomes included actigraphy parameters, anxiety (GAD-7, STAI-T), well-being (WHO-5 index), and insomnia severity (ISI). Additional analyses focused on sleep quality in (1) participants with insomnia or poor sleep, and (2) cannabidiol (CBD) vs. non-CBD interventions. Statistical analysis was performed using RevMan 5.4.1, with p &lt; 0.05 considered significant.</div></div><div><h3>Results</h3><div>Six trials (1077 patients) were included. Cannabinoids significantly improved sleep quality compared to placebo [SMD 0.53; 95 % CI 0.03–1.02; p = 0.04; I2 = 88 %], particularly in those with insomnia or poor sleep [SMD 0.60; 95 % CI 0.09–1.11; p = 0.02; I2 = 89 %]. Non-CBD cannabinoids demonstrated greater efficacy [SMD 0.82; 95 % CI 0.24–1.40; p = 0.005], whereas CBD-only therapies showed no significant effect [SMD 0.13; 95 % CI -0.38-0.65; p = 0.61].</div></div><div><h3>Conclusion</h3><div>Cannabinoids, particularly non-CBD formulations, improve sleep quality, justifying further investigation as therapeutic options for insomnia or poor sleep.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102156"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should you get MAD with kids?","authors":"David Gozal","doi":"10.1016/j.smrv.2025.102191","DOIUrl":"10.1016/j.smrv.2025.102191","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102191"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep regularity as an important component of sleep hygiene: a systematic review","authors":"Alexandros Kalkanis ,&nbsp;Dierik Lenkens ,&nbsp;Paschalis Steiropoulos ,&nbsp;Dries Testelmans","doi":"10.1016/j.smrv.2025.102203","DOIUrl":"10.1016/j.smrv.2025.102203","url":null,"abstract":"<div><h3>Background</h3><div>Beyond sleep duration and efficiency, the day-to-day regularity of bed- and wake-times is increasingly recognized as a distinct dimension of sleep health. Whether irregular schedules independently predict adverse health outcomes remains unclear.</div></div><div><h3>Objective</h3><div>To synthesize evidence on the association between objectively or diary-quantified sleep regularity and mental, cardiometabolic, inflammatory, cognitive, lifestyle, sleep-disorder, and mortality outcomes in adults.</div></div><div><h3>Methods</h3><div>A protocol registered with PROSPERO (CRD420251101936) guided the review. MEDLINE (PubMed), Cochrane Library, PsycINFO, and Google Scholar were searched from inception to July 1, 2025 using a comprehensive strategy incorporating validated regularity metrics (Sleep Regularity Index, interdaily stability, composite phase deviation, social jetlag, night-to-night standard deviations). After duplicate removal, 3140 unique records underwent title/abstract screening; 147 full texts were reviewed. Risk of bias was appraised with the Newcastle–Ottawa Scale. Heterogeneity of metrics and outcomes precluded meta-analysis; evidence was synthesized narratively following SWiM guidelines and graded with van Tulder's best-evidence taxonomy.</div></div><div><h3>Results</h3><div>Fifty-nine primary studies met all criteria. Consistent, moderate-certainty evidence linked greater sleep-timing irregularity to higher depressive and anxiety symptoms, elevated body mass index, insulin resistance, hypertension, and incident cardiovascular events. Limited but directionally uniform evidence indicated higher inflammatory markers and poorer lifestyle indices in irregular sleepers. Prospective biobank data associated low Sleep Regularity Index with smaller hippocampal volume and a 26–53 % increase in dementia risk. Five low-bias cohorts showed 20–88 % higher all-cause mortality for the least regular sleepers, independent of sleep duration and quality. Mechanistic pathways implicated circadian misalignment, autonomic imbalance, and systemic inflammation.</div></div><div><h3>Conclusions</h3><div>Across diverse populations and measurement approaches, unstable sleep timing consistently portends poorer mental, metabolic, vascular, cognitive, and survival outcomes. Because sleep regularity is modifiable and objectively trackable with wearables, schedule stabilization merits elevation to a core public-health recommendation and a priority target for randomized intervention trials.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102203"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forecasting the burden of insomnia: A call to action","authors":"Wenxin Bao,&nbsp;Rong Ren,&nbsp;Xiangdong Tang,&nbsp;Ye Zhang","doi":"10.1016/j.smrv.2025.102211","DOIUrl":"10.1016/j.smrv.2025.102211","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102211"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal sleep disorders during pregnancy: Potential threats to offspring metabolism and possible interventions","authors":"Haiyan Chen,&nbsp;Yaolin Ren,&nbsp;Yuan Zeng,&nbsp;Yifan Wu,&nbsp;Jie Yu,&nbsp;Qian Zhang,&nbsp;Xinhua Xiao","doi":"10.1016/j.smrv.2025.102188","DOIUrl":"10.1016/j.smrv.2025.102188","url":null,"abstract":"<div><div>The uterine microenvironment exerts a significant and lasting influence on metabolic health later in life. The incidence of sleep disorders during pregnancy is high. Sleep disorders not only increase the risk of maternal complications during pregnancy but also may lead to increased susceptibility to metabolic diseases in offspring during adulthood by influencing the fetal development environment. In this review, we explored the effects of maternal sleep disorders during pregnancy on the metabolic health of offspring, the potential mechanisms, and intervention measures, with the aim of providing more scientific guidance for pregnancy care and promoting the health of mothers and offspring.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102188"},"PeriodicalIF":9.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}