The association between obstructive sleep apnea and osteoporosis: A systematic review and meta-analysis

IF 11.2 1区 医学 Q1 CLINICAL NEUROLOGY
Yong Hoe Chan , Chong Boon Teo , Joshua K. Tay , Crystal S. Cheong
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Abstract

Obstructive sleep apnea (OSA) is a sleep disorder with well-known metabolic consequences. The relationship between OSA and bone health, especially osteoporosis, remains poorly understood. Given that both OSA and osteoporosis are highly prevalent chronic conditions with significant public health implications, this study aims to investigate the association of OSA with bone health and osteoporosis. A systematic search of PubMed, Embase and Cochrane Library was conducted from inception to November 22, 2022. Fifteen studies comprising 158,273 individuals were included. The presence of OSA correlated negatively with bone mineral density on meta-analysis (pooled correlation = -0.30; 95 % CI, -0.42 to -0.17; N = 8). Individuals with OSA had poorer bone mineral density scores (mean difference = -0.58, 95 % CI, -1.15 to -0.01; N = 8), and significantly higher risk of developing osteoporosis (adjusted odds ratio = 2.18; 95 % CI, 1.14 to 4.16; N = 4). Notably, both body mass index (BMI) and age were not significant effect modulators in the correlation of OSA and bone density. These findings suggest that OSA is associated with diminished bone health, and it is severity-dependent. Further studies are required to determine if treatment of OSA may have the potential to mitigate these risks.

阻塞性睡眠呼吸暂停与骨质疏松症之间的关系:系统回顾与荟萃分析
阻塞性睡眠呼吸暂停(OSA)是一种睡眠障碍,其代谢后果众所周知。人们对 OSA 与骨骼健康(尤其是骨质疏松症)之间的关系仍然知之甚少。鉴于 OSA 和骨质疏松症都是对公众健康有重大影响的高发慢性疾病,本研究旨在调查 OSA 与骨骼健康和骨质疏松症的关系。从开始到 2022 年 11 月 22 日,对 PubMed、Embase 和 Cochrane 图书馆进行了系统检索。共纳入 15 项研究,涉及 158,273 人。根据荟萃分析,存在 OSA 与骨矿物质密度呈负相关(汇总相关性 = -0.30;95 % CI,-0.42 至 -0.17;N = 8)。患有 OSA 的个体骨矿物质密度评分较低(平均差异 = -0.58,95 % CI,-1.15 至 -0.01;N = 8),患骨质疏松症的风险明显更高(调整后的几率比 = 2.18;95 % CI,1.14 至 4.16;N = 4)。值得注意的是,体重指数(BMI)和年龄对 OSA 和骨密度的相关性没有明显的调节作用。这些研究结果表明,OSA 与骨骼健康的减弱有关,而且与严重程度有关。要确定治疗 OSA 是否有可能减轻这些风险,还需要进一步的研究。
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来源期刊
Sleep Medicine Reviews
Sleep Medicine Reviews 医学-临床神经学
CiteScore
20.10
自引率
3.80%
发文量
107
期刊介绍: Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.
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