Sleep Medicine Reviews最新文献

Positive airway pressure therapies improve sleep architecture in patients with chronic hypercapnic respiratory failure: A systematic review and meta-analysis 气道正压治疗改善慢性高碳酸血症性呼吸衰竭患者的睡眠结构：一项系统回顾和荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-10-03 DOI: 10.1016/j.smrv.2025.102168

Pierre Tankéré , Léa Razakamanantsoa , Charles Khouri , Maxime Patout , Emeric Stauffer , Sebastien Baillieul , Thierry Petitjean , Jean Louis Pépin , Renaud Tamisier , Laure Peter Derex

{"title":"Positive airway pressure therapies improve sleep architecture in patients with chronic hypercapnic respiratory failure: A systematic review and meta-analysis","authors":"Pierre Tankéré , Léa Razakamanantsoa , Charles Khouri , Maxime Patout , Emeric Stauffer , Sebastien Baillieul , Thierry Petitjean , Jean Louis Pépin , Renaud Tamisier , Laure Peter Derex","doi":"10.1016/j.smrv.2025.102168","DOIUrl":"10.1016/j.smrv.2025.102168","url":null,"abstract":"<div><div>Positive airway pressure therapies (PAP) are the standard of care for chronic hypercapnic respiratory failure (CHRF), and include continuous positive airway pressure (CPAP) and non-invasive ventilation (NIV) for obesity hypoventilation syndrome (OHS), and NIV for chronic obstructive pulmonary disease (COPD) and neuromuscular disease (NMD). The effects of PAP on sleep reflect a balance between correcting CHRF-induced sleep disturbances and the potential for therapy itself to disrupt sleep. Given the critical role of sleep in overall health, there are relevant concerns about the effects of PAP usage on sleep architecture. We performed a systematic review and meta-analysis of polysomnographic parameters, using a random-effects model for quantitative analyses. Forty studies were included (n = 1099; 438 OHS, 350 NMD, 175 COPD, 136 unspecified CHRF; 58 % male, age 56.6 ± 8.9 years, body mass index 36.5 ± 11.3 kg/m<sup>2</sup>, arterial carbon dioxide pressure 51.8 ± 5.0 mmHg). Significant improvements (estimate [confidence interval]) in sleep efficiency (+6.30 [3.00, 9.60]%), slow-wave sleep (+4.74 [3.08, 6.41]%), rapid-eye-movement sleep (+4.39 [2.84, 5.94]%), arousal index (−12.97 [–19.65, −6.28]/h), and apnea-hypopnea index (−15.13 [–22.34, −7.92]/h) were seen during PAP. Overall, PAP improved sleep architecture in CHRF. The prognostic significance of these changes warrants further investigation.</div></div><div><h3>Trial registration</h3><div>PROSPERO (CRD42023495516)</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102168"},"PeriodicalIF":9.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botulinum toxin therapy for neurological disorders: Serendipitous benefits on sleep quality and underlying mechanisms 肉毒杆菌毒素治疗神经系统疾病：对睡眠质量的偶然益处及其潜在机制

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-10-01 DOI: 10.1016/j.smrv.2025.102181

Guiying Kuang , Qinwei Yu , Danfang Yu , Long Liu , Xinyu Hu , Hanshu Liu , Xinyi Wang , Jingwen Li , Jinsha Huang , Tao Wang , Allison J. Cash , Zhicheng Lin , Nian Xiong

{"title":"Botulinum toxin therapy for neurological disorders: Serendipitous benefits on sleep quality and underlying mechanisms","authors":"Guiying Kuang , Qinwei Yu , Danfang Yu , Long Liu , Xinyu Hu , Hanshu Liu , Xinyi Wang , Jingwen Li , Jinsha Huang , Tao Wang , Allison J. Cash , Zhicheng Lin , Nian Xiong","doi":"10.1016/j.smrv.2025.102181","DOIUrl":"10.1016/j.smrv.2025.102181","url":null,"abstract":"<div><div>Botulinum toxin (BoNT) remains the gold standard treatment for focal and segmental dystonia and is widely used in managing hyperkinetic disorders, chronic pain, and glandular hypersecretion. Extensive clinical trials demonstrate that BoNT effectively ameliorates both the core symptoms of these neurological conditions and their frequently associated comorbidities, including depression, anxiety, and diminished quality of life. Notably, many BoNT-treated neurological disorders co-occur with sleep disturbances, yet sleep outcomes remain underexplored. This review synthesizes current evidence on sleep outcomes following BoNT treatment of both established neurological indications (e.g., neuropathic pain, chronic migraine, dystonia, spasticity, sialorrhea, hemifacial spasm, bladder dysfunction) and primary sleep disorders (e.g., restless legs syndrome, sleep bruxism, insomnia). As a result, BoNT treatment improves sleep outcomes across both categories, potentially through mechanisms involving modulation of vasomotor tone, hormonal secretion, neural activity, mood, and pain perception. However, larger, rigorously designed randomized controlled trials are essential to definitively confirm these therapeutic effects and elucidate the underlying neurobiological mechanisms.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102181"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A paediatric group neglected in research: A systematic review on the sleep patterns, chronotype, latitude and ethnicity. 在研究中被忽视的儿科群体：一项关于睡眠模式、生物钟、纬度和种族的系统综述。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.smrv.2025.102143

Sandra Figueiredo, Genta Kulari, Ana Gomes

{"title":"A paediatric group neglected in research: A systematic review on the sleep patterns, chronotype, latitude and ethnicity.","authors":"Sandra Figueiredo, Genta Kulari, Ana Gomes","doi":"10.1016/j.smrv.2025.102143","DOIUrl":"10.1016/j.smrv.2025.102143","url":null,"abstract":"<p><p>This study presents a systematic review design aiming to explore how chronotype features are assessed in school-aged children (ages 4-11) and how chronotype is related to sleep habits, household dynamics, ethnicity, and geographical latitude. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-one studies were identified as eligible and reviewed by three independent researchers. The main findings indicate that chronotype is often under-assessed in school-aged children, with both professionals and parents reporting limited knowledge of children's sleep patterns. Additionally, there is a lack of information in the literature regarding how chronotype, sleep patterns, and vigilance are influenced by latitude and sociocultural factors. Most research on the relationship among the aforementioned variables is focused on adults rather than children. Furthermore, the methods for measuring sleep quality and chronotype were found to be inconsistent, with chronotype and sleep quality often used interchangeably. Based on these findings, further research is needed to explore how chronotype, sleep habits, and cultural or latitudinal factors might predict mental health and cognitive development in children. In terms of practical implications, there is an urgent need for re-education of parents on establishing healthy sleep and wake routines for their children.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"102143"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological impact on sleep architecture and polysomnographic measures in Restless Legs Syndrome: A systematic review. 药物对不宁腿综合征患者睡眠结构和多导睡眠图测量的影响：一项系统综述。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.smrv.2025.102147

Maria P Mogavero, Elias G Karroum, Giuseppe Lanza, Elena Antelmi, Oliviero Bruni, Rosalia Silvestri, Sara Marelli, Alessandra Castelnuovo, Luigi Ferini-Strambi, Raffaele Ferri

{"title":"Pharmacological impact on sleep architecture and polysomnographic measures in Restless Legs Syndrome: A systematic review.","authors":"Maria P Mogavero, Elias G Karroum, Giuseppe Lanza, Elena Antelmi, Oliviero Bruni, Rosalia Silvestri, Sara Marelli, Alessandra Castelnuovo, Luigi Ferini-Strambi, Raffaele Ferri","doi":"10.1016/j.smrv.2025.102147","DOIUrl":"10.1016/j.smrv.2025.102147","url":null,"abstract":"<p><p>Restless Legs Syndrome (RLS) is a sensorimotor disorder with diverse clinical manifestations that significantly impact sleep and quality of life, particularly among women. Polysomnography (PSG) plays a key role in evaluating motor features of RLS, such as periodic leg movements during sleep (PLMS). This review examines the effects of pharmacological treatments on PSG parameters and sleep architecture in RLS. Dopamine agonists are the most studied, consistently reducing PLMS but offering limited improvements in sleep structure and carrying risks of augmentation with long-term use. In contrast, alpha-2-delta ligands (e.g., pregabalin, gabapentin) improve sleep efficiency and reduce wakefulness, particularly benefiting patients with sensory symptoms or insomnia. Research on opioids and intravenous iron remains limited, though both show potential: opioids may reduce PLMS and improve sleep but raise respiratory safety concerns, while intravenous iron has shown efficacy, especially in pregnant women and children. We also conducted a meta-analysis assessing treatment effects of dopamine agonists on total sleep time, wakefulness after sleep onset, and sleep stage percentages (N1, N2, N3, REM). Given the heterogeneity of RLS and variable treatment responses across age and sex, future research should prioritize individualized therapeutic strategies and further investigate underexplored options to support precision medicine in RLS.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"102147"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of sleep duration on daytime sleepiness in children: A meta-analysis 睡眠时间对儿童日间嗜睡的影响：一项荟萃分析。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-10-01 DOI: 10.1016/j.smrv.2025.102180

Anosha Altaf, Jayne Spiller

{"title":"Impact of sleep duration on daytime sleepiness in children: A meta-analysis","authors":"Anosha Altaf, Jayne Spiller","doi":"10.1016/j.smrv.2025.102180","DOIUrl":"10.1016/j.smrv.2025.102180","url":null,"abstract":"<div><div>Whilst previous reviews have identified that shorter sleep duration is associated with poorer cognition in children, it is not known whether short sleep duration increases daytime sleepiness compared with sufficient or extended sleep. A systematic search of the literature identified 17 studies to be included in the meta-analysis. When excluding two sleep deprivation studies, short sleep duration was associated with higher daytime sleepiness compared with sufficient or extended sleep duration, standardised mean difference: 0.74 (95 % CI 0.45; 1.02). There was substantial variation in the extent of sleep restriction in the short sleep duration group compared to the sufficient/extended group. This was a significant moderator, accounting for 7 % of the effect size. As the effect size was lower for children compared to adolescents, it suggests that adolescents are particularly vulnerable to the effects of short sleep. For individual studies, the standardised mean difference had wide confidence intervals, suggesting that there are substantial inter-individual differences in response to short sleep duration compared to sufficient sleep duration. Further research is needed to identify whether daytime sleepiness mediates the relationship between sleep duration and cognitive outcomes.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102180"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the obstructive sleep apnea and restless legs syndrome comorbidity (Co-ROSA): A systematic review 探讨阻塞性睡眠呼吸暂停和不宁腿综合征共病（Co-ROSA）：一项系统综述。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-30 DOI: 10.1016/j.smrv.2025.102178

Jonathan Tam , Diego Garcia Borreguero , Lourdes M. DelRosso

{"title":"Exploring the obstructive sleep apnea and restless legs syndrome comorbidity (Co-ROSA): A systematic review","authors":"Jonathan Tam , Diego Garcia Borreguero , Lourdes M. DelRosso","doi":"10.1016/j.smrv.2025.102178","DOIUrl":"10.1016/j.smrv.2025.102178","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically evaluate the prevalence, clinical profiles, and treatment outcomes in patients with comorbid RLS and OSA and to assess the impact of OSA therapy on RLS symptoms.</div></div><div><h3>Methods</h3><div>We conducted a systematic review of observational studies indexed in MedLine, PubMed, and EMBASE through August 2025. The review followed PRISMA guidelines and was registered in PROSPERO. The Inclusion criteria were studies reporting original data on adult patients with comorbid RLS and OSA, including clinical features and treatment outcomes. Study quality was assessed using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.</div></div><div><h3>Results</h3><div>Ten studies were included, comprising over 3000 participants. The prevalence of RLS among patients with OSA ranged from 10 % to 30 %. Comorbidity was associated with increased rates of insomnia, fatigue, depression, and reduced response to OSA therapy. In multiple studies, CPAP treatment led to improvement in RLS symptoms, including reduced medication use in over 70 % of patients in some cohorts. However, therapeutic response was variable, with some patients exhibiting persistent or CPAP-emergent periodic limb movements. The quality of the studies included was mainly fair, with two rated as good.</div></div><div><h3>Conclusions</h3><div>Comorbid RLS and OSA represent a clinically distinct phenotype characterized by a greater symptom burden and more complex treatment trajectories. CPAP may offer therapeutic benefit for RLS in many patients.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102178"},"PeriodicalIF":9.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward deeper understanding of maternal sleep during pregnancy and childhood health 更深入地了解母亲在怀孕期间的睡眠和儿童健康。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-29 DOI: 10.1016/j.smrv.2025.102183

Ye Zhang , Zidi Ning , Jiajun Yuan , Shenghui Li

引用次数: 0

Complex nocturnal behaviour – issues with expert evidence and the duty to the court 复杂的夜间行为——与专家证据和法庭责任有关的问题

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-29 DOI: 10.1016/j.smrv.2025.102162

Ian Morrison , Renata L. Riha , John M.M. Rumbold

引用次数: 0

Sleep abnormalities in mouse models of depression: a systematic review 抑郁症小鼠模型中的睡眠异常：一项系统综述

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-27 DOI: 10.1016/j.smrv.2025.102179

Alberto Potenzieri , Andrea Escelsior , Gianluca Serafini , Antonio Uccelli , Antoine Adamantidis , Lino Nobili

{"title":"Sleep abnormalities in mouse models of depression: a systematic review","authors":"Alberto Potenzieri , Andrea Escelsior , Gianluca Serafini , Antonio Uccelli , Antoine Adamantidis , Lino Nobili","doi":"10.1016/j.smrv.2025.102179","DOIUrl":"10.1016/j.smrv.2025.102179","url":null,"abstract":"<div><div>Sleep disturbances are highly prevalent in people with major depressive disorder (MDD) and contribute to a vicious cycle that exacerbates both conditions. Electroencephalographic (EEG)-based sleep features of people with MDD are well described in systematic reviews and meta-analyses. However, sleep abnormalities in mouse models of MDD remain poorly characterized. We conducted a systematic review to evaluate the face validity of mouse models of MDD in relation to sleep alterations. Among the 22 articles we identified, the most consistently represented features of sleep disturbances in mouse models were increased rapid eye movement (REM) sleep and non-REM (NREM) sleep fragmentation. A blunted response to sleep deprivation was reported but only in a few studies and requires further investigation. Data regarding delta and theta power were limited and showed heterogeneous results. By providing a comprehensive summary of all mouse models in the field, our study serves as a resource to confirm the utility of animal models and guide researchers in studying sleep alterations in MDD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102179"},"PeriodicalIF":9.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype and circadian epidemiology 时间型和昼夜流行病学

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-27 DOI: 10.1016/j.smrv.2025.102182

Erren Thomas C, Morfeld Peter, Lewis Philip

引用次数: 0