Sleep Medicine Reviews最新文献

Sleep abnormalities in bipolar disorders across mood phases: A systematic review and meta-analysis 双相情感障碍情绪阶段的睡眠异常：一项系统回顾和荟萃分析

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-07-17 DOI: 10.1016/j.smrv.2025.102137

Mattia Marchetti , Ahmad Mayeli , Claudio Sanguineti , Francesco L. Donati , Omeed Chaichian , Allison Kim , Katerina Piskun , Armando D'Agostino , Nicholas Meyer , James D. Wilson , Paolo Fusar-Poli , Mary L. Phillips , Fabio Ferrarelli

{"title":"Sleep abnormalities in bipolar disorders across mood phases: A systematic review and meta-analysis","authors":"Mattia Marchetti , Ahmad Mayeli , Claudio Sanguineti , Francesco L. Donati , Omeed Chaichian , Allison Kim , Katerina Piskun , Armando D'Agostino , Nicholas Meyer , James D. Wilson , Paolo Fusar-Poli , Mary L. Phillips , Fabio Ferrarelli","doi":"10.1016/j.smrv.2025.102137","DOIUrl":"10.1016/j.smrv.2025.102137","url":null,"abstract":"<div><div>Sleep abnormalities are core features of bipolar disorders (BD), but they have not been thoroughly examined across mood phases. This meta-analysis investigated sleep disturbance prevalence and sleep characteristics differences in BD across mood phases. A systematic search through September 2024 identified 44 studies (7614 BD cases, 3164 controls), including 11 prevalence and 34 case-control studies. Poor sleep quality prevalence was 52% during euthymia, and insomnia prevalence was 63% during the depressive phase. Individuals with euthymic BD reported worse sleep quality and objectively measured longer total sleep time and sleep onset latency than controls. Depressive phase BD showed higher rapid eye movement percentages, while manic/mixed phase exhibited shorter total sleep time, lower sleep efficiency, and longer sleep onset latency. During euthymia, BD demonstrated greater variability in sleep duration and continuity, and more prominent sleep differences when assessed with sleep diary versus objective sleep measures, highlighting the importance of integrating objective assessments and patient-reported outcomes. Overall, these findings indicate that poor sleep quality and insomnia are highly prevalent in BD, and that some sleep parameter differences are present during euthymia, while others occur during depressive and manic phases, emphasizing the need for sleep assessments and tailored management throughout the course of BD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102137"},"PeriodicalIF":11.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REM sleep in schizophrenia: a systematic review and meta-analysis 精神分裂症的快速眼动睡眠：系统回顾和荟萃分析

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-07-15 DOI: 10.1016/j.smrv.2025.102134

Dario Morra, Giuseppe Barbato

{"title":"REM sleep in schizophrenia: a systematic review and meta-analysis","authors":"Dario Morra, Giuseppe Barbato","doi":"10.1016/j.smrv.2025.102134","DOIUrl":"10.1016/j.smrv.2025.102134","url":null,"abstract":"<div><div>A systematic review and meta-analysis of REM studies in schizophrenia were conducted using published articles researched in major databases within the period from January 1, 1955, to March 15, 2025. REM sleep parameters such as REM time, REM percentage, REM latency and REM density of drug-naive, drug-free and treated schizophrenic patients were analyzed and, where available, compared with case-control data of healthy controls and depressed patients. One hundred ninety studies were identified in the systematic review. Ninety-two case-control studies with 1845 schizophrenic patients, 1269 healthy controls and 262 depressed patients were included in the meta-analyses. The primary outcome was the standard mean difference. Data were fitted with a random-effects model. Publication bias assessment was checked by Egger's Regression and funnel plot asymmetry. Compared to healthy controls, REM time and REM latency were found respectively reduced and shortened in both drug-naive and drug-free schizophrenics, while REM density was found increased in drug-free and treated schizophrenics. No significant difference, compared to healthy control, emerged for REM percentages either in drug-naive, drug-free and treated schizophrenics. Reduced REM latency in drug-free and drug-naive schizophrenics was like that of depressed patients. Antipsychotic treatment appeared to have a normalizing effect on REM time and REM latency but not on REM density: increased density in both drug-free and treated schizophrenics suggest that this variable might be controlled by different mechanisms and/or neurotransmitters than those controlling REM occurrence.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102134"},"PeriodicalIF":11.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on “Insomnia and emotion dysregulation: A meta-analytical perspective integrating regulatory strategies and dispositional difficulties” “失眠与情绪失调：整合调节策略和处置困难的元分析视角”评论

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-07-01 DOI: 10.1016/j.smrv.2025.102124

Xinrui Ma , Jing Liu , Xicai Liang , Ziyin Cui

引用次数: 0

Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential 褪黑素：超越昼夜节律调节-探索其多种生理作用和治疗潜力

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-26 DOI: 10.1016/j.smrv.2025.102123

Min Jia , Anbang Luo , Minhui Wei , Yali Zhang , Tong Wu , Ning Chen

{"title":"Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential","authors":"Min Jia , Anbang Luo , Minhui Wei , Yali Zhang , Tong Wu , Ning Chen","doi":"10.1016/j.smrv.2025.102123","DOIUrl":"10.1016/j.smrv.2025.102123","url":null,"abstract":"<div><div>As an indoleamine with a long evolutionary history, melatonin's physiological functions have evolved from its initial role in regulating skin pigmentation in fish and amphibians to encompass a broad spectrum of critical physiological regulatory functions. In mammals, melatonin primarily serves to regulate the circadian rhythm system, which is essential for maintaining the sleep-wake cycle. Abnormal melatonin secretion has been strongly associated with the development of sleep disorders, which are recognized as significant risk factors for various chronic diseases. This article aims to comprehensively examine the diverse physiological functions of melatonin beyond its role in regulating circadian rhythms and the sleep-wake cycle, while analyzing its mechanisms of action in modulating oxidative stress, anti-inflammatory responses, and mitochondrial function. Furthermore, this article evaluates the multifaceted effects of melatonin on energy metabolism, bone metabolism, nervous system regulation, and cardiovascular health at pharmacological doses, highlighting its importance in managing sleep disorders. By synthesizing current research findings, this article provides an objective assessment of the scientific foundation for melatonin's role in enhancing sleep quality and promoting overall health, while emphasizing the need to distinguish between its physiological and pharmacological effects.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"82 ","pages":"Article 102123"},"PeriodicalIF":11.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of the global prevalence and burden of insomnia: a systematic literature review-based analysis 失眠症全球患病率和负担的估计：基于文献综述的系统分析

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-25 DOI: 10.1016/j.smrv.2025.102121

Adam V. Benjafield , Fatima H Sert Kuniyoshi , Atul Malhotra , Jennifer L. Martin , Charles M. Morin , Leonie F. Maurer , Peter A. Cistulli , Jean-Louis Pépin , Emerson M. Wickwire , on behalf of the medXcloud group

{"title":"Estimation of the global prevalence and burden of insomnia: a systematic literature review-based analysis","authors":"Adam V. Benjafield , Fatima H Sert Kuniyoshi , Atul Malhotra , Jennifer L. Martin , Charles M. Morin , Leonie F. Maurer , Peter A. Cistulli , Jean-Louis Pépin , Emerson M. Wickwire , on behalf of the medXcloud group","doi":"10.1016/j.smrv.2025.102121","DOIUrl":"10.1016/j.smrv.2025.102121","url":null,"abstract":"<div><div>Insomnia is common, is associated with major adverse medical and mental health outcomes, has a negative impact on quality of life, and has significant economic consequences. However, little is known about the global insomnia burden. This systematic review estimated the global prevalence of insomnia in adults. PubMed and Embase were searched (terms “insomnia,” “prevalence,” and “general population”) to identify relevant peer-reviewed studies (final search 2–3 Sep 2024). Included studies had the highest data quality and lowest risk of bias, and reported clinically relevant insomnia prevalence in the general population. Insomnia prevalence estimates were applied to United Nations (UN) population data using a country-specific study (if available) or the highest-quality study (if no country-specific study). Of 1651 potential records, 18 studies (262,582 participants) were included. Thirty-one of 237 UN/World Bank-recognized countries/territories had a suitable nation-specific adult insomnia prevalence estimate. 852,325,091 adults (95 % confidence interval 830,354,161–874,309,252) were estimated to have insomnia (global prevalence: 16.2 %) and 414,967,941 were estimated to have severe insomnia (7.9 %). Insomnia and severe insomnia were more prevalent in females versus males across all age groups. The high global prevalence of insomnia disorder reinforces the need for comprehensive public health and clinical sleep health initiatives worldwide.</div></div><div><h3>Registration</h3><div>PROSPERO: CRD42024581410.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"82 ","pages":"Article 102121"},"PeriodicalIF":11.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-25 DOI: 10.1016/j.smrv.2025.102122

Valentina Poletti , Sandra Hackethal , Anna Castelnovo , Silvia Riccardi , Eleonora Volpato , Mauro Manconi

{"title":"Sleep-related breathing disorders during pregnancy: A systematic review and meta-analysis","authors":"Valentina Poletti , Sandra Hackethal , Anna Castelnovo , Silvia Riccardi , Eleonora Volpato , Mauro Manconi","doi":"10.1016/j.smrv.2025.102122","DOIUrl":"10.1016/j.smrv.2025.102122","url":null,"abstract":"<div><div>This systematic review analyzed 37 studies on sleep-disordered breathing during pregnancy, involving over 7000 women, predominantly pregnant, with a subgroup of non-pregnant controls. Most studies were conducted in the United States, using in-laboratory polysomnography and focusing on the third trimester. The meta-analysis estimated a prevalence of nearly 20 %, although results showed considerable heterogeneity, reflecting variations in study methodologies, diagnostic criteria, and sample characteristics.</div><div>Sleep-disordered breathing was generally mild, with body mass index identified as the main risk factor, while age did not appear to significantly influence prevalence. Monitoring body mass index throughout pregnancy and screening for sleep-disordered breathing in women with gestational diabetes or hypertensive disorders is crucial, as these conditions are associated with higher prevalence.</div><div>Findings highlight the need for future studies to adhere to standardized guidelines, use objective diagnostic tools, and include larger, well-characterized samples of normal pregnancies. Comparative studies with matched non-pregnant controls by body mass index and age, longitudinal cohort designs, and interventional trials using continuous positive airway pressure for moderate-to-severe obstructive sleep apnea are essential to enhance understanding and improve maternal-fetal outcomes.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"82 ","pages":"Article 102122"},"PeriodicalIF":11.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive brain stimulation to enhance sleep quality and architecture in Parkinson's disease: A systematic review and Bayesian network meta-analysis 非侵入性脑刺激提高帕金森病睡眠质量和结构：系统综述和贝叶斯网络荟萃分析

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-19 DOI: 10.1016/j.smrv.2025.102117

Jacopo Cristini , Almudena Medina-Rincon , Anke Van Roy , Freddie Seo , Kevin Moncion , Julie Carrier , Caroline Paquette , Alain Dagher , Simon Steib , Marc Roig

{"title":"Non-invasive brain stimulation to enhance sleep quality and architecture in Parkinson's disease: A systematic review and Bayesian network meta-analysis","authors":"Jacopo Cristini , Almudena Medina-Rincon , Anke Van Roy , Freddie Seo , Kevin Moncion , Julie Carrier , Caroline Paquette , Alain Dagher , Simon Steib , Marc Roig","doi":"10.1016/j.smrv.2025.102117","DOIUrl":"10.1016/j.smrv.2025.102117","url":null,"abstract":"<div><div>Individuals with Parkinson's disease (PD) suffer from sleep disorders and maladaptive alterations in sleep architecture. These disorders, which increase in frequency and severity as the disease progresses, are multifactorial and clinically relevant. Sleep problems drastically reduce quality of life in these patients and are associated with faster cognitive and motor decline. Standard treatments for managing sleep disorders, which mainly include cognitive behavioral therapy and pharmacotherapy, have provided inconsistent results. Non-invasive brain stimulation (NIBS) has been proposed as another potential strategy for improving sleep quality in PD. We conducted a systematic review and Bayesian network meta-analysis (NMA) following the grading of recommendations, assessment, development, and evaluation (GRADE), to determine whether NIBS improves sleep quality and architecture in PD. Evidence from twenty-four studies, including 792 individuals with PD in the early-to-severe disease stages, was summarized. Our NMA indicated that low-frequency repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex (rTMS; 0.54, 95 %CrI: 0.13,0.93; moderate certainty) may ameliorate subjective sleep quality compared to a control condition. Our review further suggested that rTMS may enhance objective sleep quality and sleep architecture. Our findings, which should be interpreted cautiously due to a high risk of bias, are examined in the context of sleep disorders in PD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"82 ","pages":"Article 102117"},"PeriodicalIF":11.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microsleep episodes and wakefulness, the daytime job of sleep-wake medicine 微睡眠发作和觉醒，这是睡眠-觉醒医学白天的工作

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-19 DOI: 10.1016/j.smrv.2025.102120

David R. Schreier

引用次数: 0

Efficacy of incretin-based therapies in obesity-related obstructive sleep apnea: a systematic review and meta-analysis of randomized controlled trials 基于肠促胰岛素治疗肥胖相关阻塞性睡眠呼吸暂停的疗效：随机对照试验的系统回顾和荟萃分析

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-17 DOI: 10.1016/j.smrv.2025.102119

Anna Bardóczi , Zsombor Zoltán Matics , Caner Turan , Bence Szabó , Zsolt Molnár , Péter Hegyi , Veronika Müller , Gábor Horváth

{"title":"Efficacy of incretin-based therapies in obesity-related obstructive sleep apnea: a systematic review and meta-analysis of randomized controlled trials","authors":"Anna Bardóczi , Zsombor Zoltán Matics , Caner Turan , Bence Szabó , Zsolt Molnár , Péter Hegyi , Veronika Müller , Gábor Horváth","doi":"10.1016/j.smrv.2025.102119","DOIUrl":"10.1016/j.smrv.2025.102119","url":null,"abstract":"<div><div>The primary etiologic risk factor for obstructive sleep apnea (OSA) is obesity. As incretin-based therapies, specifically glucagon-like peptide 1 (GLP-1) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonists, have shown promising outcomes in obesity management, these medications have generated interest in OSA therapy. To investigate their efficacy in OSA, we performed a systematic literature search following PRISMA and Cochrane Handbook guidelines for studies reporting apnea-hypopnea index (AHI) and incretin-based therapy in patients with OSA. Only randomized controlled trials were eligible for inclusion. Our literature search identified 813 publications, and 5 articles met the inclusion criteria. Collectively, the studies enrolled 1024 patients, lasted ≥12 weeks with liraglutide or tirzepatide, and resulted in significant reductions in body weight and/or body mass index. Incretin-based therapies were also associated with AHI reduction, with a mean change of −14.45 events/h (95 % CI: 25.90 to −2.99, p < 0.001). By pooling data of 5 RCTs in a pairwise meta-analysis, incretin-based therapies showed a greater effect on AHI than usual care, with a mean difference of −11.61 events/h (95 % CI: 22.91 to −0.31, p = 0.046). Our analysis demonstrates that weight reduction through incretin-based therapies improves AHI in OSA. Incretin-based therapies have the potential to treat sleep-disordered breathing in OSA patients with excess weight.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"82 ","pages":"Article 102119"},"PeriodicalIF":11.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Don't forget sleep! Bridging the gap between periodontal and brain health 别忘了睡觉！弥合牙周和大脑健康之间的差距

IF 11.2 1区医学

Sleep Medicine Reviews Pub Date : 2025-06-16 DOI: 10.1016/j.smrv.2025.102118

Maria Clotilde Carra (Prof.)

引用次数: 0