Sleep Medicine Reviews最新文献

Erratum to "The development quality of generic sleep questionnaires: A systematic review and call for action" [Sleep Med Rev 90 102362]. “通用睡眠问卷的开发质量：系统回顾和行动呼吁”的勘误[睡眠医学Rev 90 102362]。

IF 11.6 1区医学

Sleep Medicine Reviews Pub Date : 2026-10-15 DOI: 10.1016/j.smrv.2026.102388

Elke Veirman, Marie De Bruecker, An Mariman, Dirk A Pevernagie, Katrien Hertegonne, Fré A Bauters, Geert Crombez, Dimitri M L Van Ryckeghem

引用次数: 0

Corrigendum to "Actigraphy-based sleep outcomes in substance use disorders: A systematic review and meta-analysis" [Sleep Med Rev 88, 102297]. “基于活动记录仪的物质使用障碍的睡眠结果：系统回顾和荟萃分析”的更正[睡眠医学Rev 88, 102297]。

IF 11.6 1区医学

Sleep Medicine Reviews Pub Date : 2026-10-14 DOI: 10.1016/j.smrv.2026.102381

Alisson M Paredes Naveda, Henrique Nunes Pereira Oliva, Alejandra Pulido-Saavedra, Delaram J Ghadimi, James T Lemmon, Peter T Morgan, Marc N Potenza, Gustavo A Angarita

引用次数: 0

Insomnia as risk factor for brain, mental and general health consequences: an umbrella systematic review. 失眠是大脑、精神和一般健康后果的风险因素：一项综合性系统综述。

IF 11.6 1区医学

Sleep Medicine Reviews Pub Date : 2026-09-07 DOI: 10.1016/j.smrv.2026.102372

Luca Vignatelli, Maurizio A Leone, Elisabetta Pupillo, Stefan Seidel, Ulf Kallweit, Natalia Colorado Prieto, Maria Lolich, Marina Tüzün, Claudio L A Bassetti

{"title":"Insomnia as risk factor for brain, mental and general health consequences: an umbrella systematic review.","authors":"Luca Vignatelli, Maurizio A Leone, Elisabetta Pupillo, Stefan Seidel, Ulf Kallweit, Natalia Colorado Prieto, Maria Lolich, Marina Tüzün, Claudio L A Bassetti","doi":"10.1016/j.smrv.2026.102372","DOIUrl":"https://doi.org/10.1016/j.smrv.2026.102372","url":null,"abstract":"<p><p>Sleep quality is a determinant of health, and insomnia could be a risk factor for brain health. We searched MEDLINE and EMBASE (last search August 2025) to identify systematic reviews with meta-analysis (SMRAs) that evaluated insomnia as a predictive factor of dementia, stroke, depression, suicide, death, occupational injuries, and hospitalization. Sixteen SMRA were included, and three additional original systematic reviews were conducted for stroke, occupational injuries and hospitalization, as no published SMRAs were found on these topics. SRMAs consistently identified insomnia as a predictor of dementia, depression, suicide, while death was not associated with this disorder. Our two original SMRAs revealed that insomnia is a predictor of stroke (9 studies, 1,343,164 participants, HR = 1.26, 95%CI 1.05-1.53) and hospitalization for any reason (5 studies, 517,620 participants, OR = 1.28, 95%CI 1.14-1.43). With regard to occupational injuries, it was not possible to perform a meta-analysis of the results of the two studies retrieved (143,942 participants). Although an association was found with unintentional fatal injuries and with commuting injuries, data should be considered insufficient to draw a conclusion on this outcome. This work contributes to better defining the association between insomnia and the key descriptors of brain health and possible links to general health.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":" ","pages":"102372"},"PeriodicalIF":11.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phasic activities in the human body during REM sleep Part 2: Autonomic activity and general discussion. 快速眼动睡眠期间人体的相活动。第2部分：自主神经活动和一般讨论。

IF 11.6 1区医学

Sleep Medicine Reviews Pub Date : 2026-08-26 DOI: 10.1016/j.smrv.2026.102353

Dulce Neutel, Pauline Testard, Victoria Vernier, Federica Sanapo, Isabelle Arnulf, Benjamin J B Bréant

{"title":"Phasic activities in the human body during REM sleep Part 2: Autonomic activity and general discussion.","authors":"Dulce Neutel, Pauline Testard, Victoria Vernier, Federica Sanapo, Isabelle Arnulf, Benjamin J B Bréant","doi":"10.1016/j.smrv.2026.102353","DOIUrl":"https://doi.org/10.1016/j.smrv.2026.102353","url":null,"abstract":"<p><p>Numerous brief events, known as phasic activities, have been observed in terms of rapid eye movements (REMs), muscle activity, and autonomic nervous system activity during REM sleep. This occurs against the backdrop of sustained muscle atonia and vagal tone. The first part of this review was dedicated to REMs and skeletal muscle phasic activities. The second part, here, provides a list of phasic autonomic changes in the human body. Considerably stronger evidence exists for pupillary, respiratory, cardiovascular, and reproductive phasic activity than for gastrointestinal and urinary phasic activity. In addition to tonic miosis of the pupil, brief mydriasis occurs during REM sleep. The cardiovascular system exhibits phasic events such as spikes in blood pressure, tachycardia, and vasoconstriction alongside REMs. Phasic bradycardia episodes also occur during REM sleep without REMs. The respiratory system exhibits rapid and shallow breathing, as well as transient phasic hypoventilation, alongside REMs. The rate of spontaneous contractions in the esophagus and stomach increased during REM sleep compared to NREM sleep. In the reproductive system, phasic activity has been observed in the penis (although tonic activity is predominant), vagina and uterus during REM sleep. The review also examines how REMs, muscle twitches and autonomic phasic activities cluster together.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":" ","pages":"102353"},"PeriodicalIF":11.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phasic activities in the human body during REM sleep Part 1: Rapid eye movements and phasic muscle activity. 快速眼动睡眠期间人体的相活动第1部分：快速眼动和相肌活动。

IF 11.6 1区医学

Sleep Medicine Reviews Pub Date : 2026-08-01 DOI: 10.1016/j.smrv.2026.102348

Dulce Neutel, Pauline Testard, Victoria Vernier, Federica Sanapo, Isabelle Arnulf, Benjamin J B Bréant

{"title":"Phasic activities in the human body during REM sleep Part 1: Rapid eye movements and phasic muscle activity.","authors":"Dulce Neutel, Pauline Testard, Victoria Vernier, Federica Sanapo, Isabelle Arnulf, Benjamin J B Bréant","doi":"10.1016/j.smrv.2026.102348","DOIUrl":"https://doi.org/10.1016/j.smrv.2026.102348","url":null,"abstract":"<p><p>REM sleep is a state in which powerful inhibitory and excitatory mechanisms coexist. Numerous short-lived activities, known as phasic events, occur against a backdrop of sustained muscle atonia and vagal tone during REM sleep. Pioneering research in this area dates back to 1953, with renewed interest periodically emerging in the context of diseases such as depression, erectile dysfunction, sleep-related breathing disorders, and REM sleep behavior disorder. This review in two parts provides a comprehensive list of these phasic activities in the human body. The first part of the review describes rapid eye movements and muscle twitches in the striated muscles of the face, pharynx, larynx, neck and torso, and the limbs. It describes their putative functions. These activities can result in brief movements such as tympanic movements (middle ear muscle activity) and facial expressions. Phasic activities such as middle ear muscle activity, swallowing, smiling and head jerks occur more frequently during REM sleep than NREM sleep; however, rhythmic masticatory muscle activity occurs less frequently during REM sleep than NREM sleep. While some phasic activities occur alongside rapid eye movements, this is not always the case. This calls into question the definition of phasic and tonic REM sleep as distinct sub-phases.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":" ","pages":"102348"},"PeriodicalIF":11.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The misclassification of periodic limb movement disorder: A systematic review applying research diagnostic criteria. 周期性肢体运动障碍的错误分类：应用研究诊断标准的系统综述。

IF 11.6 1区医学

Sleep Medicine Reviews Pub Date : 2026-06-10 DOI: 10.1016/j.smrv.2026.102322

S Fulda, J Haba-Rubio, M Manconi, R Rijsman, L M Trotti, A M Williams, J W Winkelman

{"title":"The misclassification of periodic limb movement disorder: A systematic review applying research diagnostic criteria.","authors":"S Fulda, J Haba-Rubio, M Manconi, R Rijsman, L M Trotti, A M Williams, J W Winkelman","doi":"10.1016/j.smrv.2026.102322","DOIUrl":"https://doi.org/10.1016/j.smrv.2026.102322","url":null,"abstract":"<p><p>Periodic limb movement disorder (PLMD) has been reported in the scientific literature for more than three decades. However, its diagnostic criteria have changed substantially over time, complicating cross-study comparisons and weakening the evidence base. In a companion paper, we proposed research diagnostic criteria (RDC) for PLMD in adults to operationalize current ICSD-3TR elements and support transparent classification in research settings. We systematically searched PubMed, Scopus, and Google Scholar from inception through April 2025 using predefined PLMD-related terms. We then applied modified RDC to classify PLMD status across all eligible published samples. More than half of the reviewed samples (55.6% of 180 samples from 149 studies) were incompatible with a PLMD diagnosis under contemporary standards, most often because of exclusionary comorbidities such as restless legs syndrome or untreated sleep-related breathing disorders. A further 28.3% could not be classified because critical diagnostic information was missing. Only 29 samples (16.1%) met criteria for possible or probable PLMD, and only four (2.2%) approached definite PLMD. These findings show that the diagnosis of PLMD has been applied inconsistently across diagnostic eras, resulting in widespread misclassification under current criteria. Clear diagnostic criteria and reporting standards are needed to build a reliable evidence base and advance PLMD research.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":" ","pages":"102322"},"PeriodicalIF":11.6,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between gut microbiota and insomnia: A systematic review and meta-analysis 肠道微生物群与失眠之间的关系：一项系统综述和荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1016/j.smrv.2026.102236

Shucheng Chen , Han Li , Meng Ning , Branda Yee Man Yu , Shirong Wu , Wai-yin Cheng , Yamin Li , Wing Fai Yeung

{"title":"The association between gut microbiota and insomnia: A systematic review and meta-analysis","authors":"Shucheng Chen , Han Li , Meng Ning , Branda Yee Man Yu , Shirong Wu , Wai-yin Cheng , Yamin Li , Wing Fai Yeung","doi":"10.1016/j.smrv.2026.102236","DOIUrl":"10.1016/j.smrv.2026.102236","url":null,"abstract":"<div><div>Emerging evidence suggests interactions between gut microbiota and sleep regulation, but specific associations with insomnia remain unclear. This systematic review evaluated alterations in gut microbiota in patients with insomnia compared with healthy controls. A systematic literature search was performed on eight databases from inception to June 2025. Case-control, cohort, and cross-sectional studies examining gut microbiota in adults with insomnia versus healthy controls were included. Fourteen studies encompassing 9036 participants (58.4 % female) were included. Alpha diversity was reduced in patients with insomnia in most of the included studies, among which observed species significantly decreased (SMD: 0.90, 95 % CI: 1.39, −0.40, k = 5). Beta diversity analysis revealed a consistently distinct microbial community structure between individuals with insomnia and healthy controls. Taxonomically, insomnia correlated with shifted Firmicutes-to-Bacteroidetes ratios. Meta-analyses revealed alterations in key genera, including significantly decreased <em>Faecalibacterium</em> and <em>Lachnospira</em>, and significantly increased <em>Blautia</em> and <em>Eubacterium hallii</em>. Changes in gut microbiota were also correlated with inflammatory markers and metabolic disturbances. In summary, gut microbiota dysbiosis was associated with insomnia and characterized by reduced microbial diversity and altered bacterial composition. These findings suggest potential applications for microbial biomarkers in insomnia diagnosis and subtyping, and the development of personalized microbiota-targeted interventions.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102236"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OSA in the aging population: Diagnostic and therapeutic considerations 老年人群中的阻塞性睡眠呼吸暂停：诊断和治疗考虑。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.smrv.2026.102247

Martino F. Pengo , Miguel Angel Martinez Garcia , Michael V. Vitiello , David Gozal

{"title":"OSA in the aging population: Diagnostic and therapeutic considerations","authors":"Martino F. Pengo , Miguel Angel Martinez Garcia , Michael V. Vitiello , David Gozal","doi":"10.1016/j.smrv.2026.102247","DOIUrl":"10.1016/j.smrv.2026.102247","url":null,"abstract":"<div><div>The extremely high prevalence of obstructive sleep apnea (OSA) in the elderly population approaches 50 % and is even higher among individuals older than 80 years, posing substantial challenges in defining an appropriate risk–benefit balance for OSA treatment in this age group. A major barrier to the formulation of coherent, evidence-based recommendations lies in the marked limitations of the available evidence, which is often derived from observational or post hoc analyses, affected by substantial heterogeneity, or based on small samples that lack adequate statistical power to detect clinically meaningful outcomes. Moreover, older adults—particularly the very old and those with multimorbidity or frailty—are systematically underrepresented in randomized controlled trials, further limiting the generalizability of existing findings. In this review, we synthesize the scarce and methodologically heterogeneous evidence on the impact of OSA in older adults, highlight conflicting results supporting either treatment or non-treatment in this population, and delineate the key unresolved clinical and research questions that must be addressed before robust consensus guidelines and informed healthcare policies can be developed.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102247"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining circadian health: Conceptual framework and development of a circadian health index 定义昼夜健康：昼夜健康指数的概念框架和发展。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1016/j.smrv.2026.102244

Julien Coelho , Jean-Arthur Micoulaud-Franchi , Pierre-Alexis Geoffroy , Pierre Philip , Jacques Taillard , Patrice Bourgin

{"title":"Defining circadian health: Conceptual framework and development of a circadian health index","authors":"Julien Coelho , Jean-Arthur Micoulaud-Franchi , Pierre-Alexis Geoffroy , Pierre Philip , Jacques Taillard , Patrice Bourgin","doi":"10.1016/j.smrv.2026.102244","DOIUrl":"10.1016/j.smrv.2026.102244","url":null,"abstract":"<div><div>Circadian rhythms are key determinants of physical and mental health at the nexus of physiology and behavior. Classically, endogenous circadian rhythms are characterized according to three principal dimensions: circadian phase, amplitude and stability. From a behavioral perspective, the timing and regularity of nychthemeral behaviors represent two additional dimensions, and we propose as a sixth dimension the sleep complaints arising from a circadian disruption due to a mismatch between circadian physiology and nycthemeral behaviors. This article reviews each of these dimensions and examines their interactions, along with their effects on sleep and health. On this basis, we propose an integrated definition of circadian health. We then review both, objective (melatonin, temperature, actimetry) and subjective (sleep diaries, self-report questionnaires) tools for assessing each of the circadian health dimensions. Finally, we propose a novel tool aimed at assessing those circadian health dimensions as well as the computation of a composite index to quantify circadian health, along with a graphical representation to visualize it. While further validation is still needed, this proposal will help clinicians and researchers better decipher circadian rhythms and their impact on mental and physical health and may offer new opportunities for public health promotion in both general and clinical populations.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102244"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision sleep medicine for the aging population: Moving from device-centered to person-centered care 针对老龄化人口的精准睡眠医学：从以设备为中心转向以人为中心的护理。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1016/j.smrv.2026.102261

Ronaldo Piovezan MD, PhD

引用次数: 0