Sleep Medicine Reviews最新文献_第2页

Mechanistic links between obstructive sleep apnea, cellular senescence and aging: The role of cardiometabolic dysfunction 阻塞性睡眠呼吸暂停、细胞衰老和衰老之间的机制联系：心脏代谢功能障碍的作用。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-18 DOI: 10.1016/j.smrv.2025.102170

Sarfraz Ahmed , David Gozal , Abdelnaby Khalyfa

引用次数: 0

The dual-process model: Unlocking the potential of auditory stimulation to modulate brain oscillations during sleep 双过程模型：释放听觉刺激在睡眠中调节大脑振荡的潜力。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-17 DOI: 10.1016/j.smrv.2025.102177

Sara Fattinger , Sven Leach , Reto Huber

{"title":"The dual-process model: Unlocking the potential of auditory stimulation to modulate brain oscillations during sleep","authors":"Sara Fattinger , Sven Leach , Reto Huber","doi":"10.1016/j.smrv.2025.102177","DOIUrl":"10.1016/j.smrv.2025.102177","url":null,"abstract":"<div><div>Slow waves and spindles, key electrophysiological markers of non-rapid eye movement (NREM) sleep, are thought to play a causal role in sustaining brain functions. While their association with these functions has been recognized for decades, the underlying mechanisms remain elusive. Emerging evidence suggests that their functional role is defined not only by individual oscillations but also by the interplay of spatiotemporal neuronal synchronization. Recent studies modulating NREM sleep oscillations through auditory input have demonstrated direct behavioral effects, enabling new diagnostic and therapeutic tools for psychiatric and neurological disorders. However, clinical translation remains limited due to an incomplete understanding of the neuronal mechanisms. Here, we propose a new conceptual framework for auditory stimulation during NREM sleep, outlining how key stimulation parameters influence the spatiotemporal coordination of network activities underlying specific oscillations. This framework provides a foundation for interpreting the effects of auditory stimulation, formulating hypotheses on neuronal mechanisms, and identifying which synchronization processes to target for specific functions. Such foundational understanding is a prerequisite for establishing the causal role of distinct synchronization processes of NREM sleep oscillations in driving diverse brain functions - a critical step toward effectively applying and clinically translating brain stimulation techniques beyond auditory stimulation during NREM sleep.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102177"},"PeriodicalIF":9.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of mandibular advancement appliances with varying designs in the management of obstructive sleep apnea in children: A systematic review and meta-analysis 不同设计的下颌推进矫治器治疗儿童阻塞性睡眠呼吸暂停的疗效：一项系统回顾和荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-15 DOI: 10.1016/j.smrv.2025.102165

Hui Chen , Junyan Gao , Jianwei Liu , Ghizlane Aarab , Shaohua Ge , Frank Lobbezoo , Nelly Huynh , Carlos Flores Mir

{"title":"Efficacy of mandibular advancement appliances with varying designs in the management of obstructive sleep apnea in children: A systematic review and meta-analysis","authors":"Hui Chen , Junyan Gao , Jianwei Liu , Ghizlane Aarab , Shaohua Ge , Frank Lobbezoo , Nelly Huynh , Carlos Flores Mir","doi":"10.1016/j.smrv.2025.102165","DOIUrl":"10.1016/j.smrv.2025.102165","url":null,"abstract":"<div><div>Various designs of mandibular advancement appliances (MAAs) have been proposed for managing obstructive sleep apnea (OSA) in children. However, the difference in efficacy between various MAA designs remain unclear. A deeper understanding of the effectiveness of various MAA designs could help refine their design and improve treatment outcomes. This systematic review evaluates the efficacy of different available MAA designs. PubMed, EMBASE, and the Cochrane Library were searched for eligible studies published up to January 2025. A total of 1098 studies were initially identified, from which three randomized controlled trials (RCTs) and five Non-RCTs assessing the efficacy of MAAs in pediatric OSA patients were included. The results showed that MAAs were associated with increased minimal oxygen saturation (SpO<sub>2</sub>) (CI: 17.67 to −0.82, p=0.03) and mean SpO<sub>2</sub> (CI: 1.07 to −0.09, p=0.02) in pediatric OSA patients. The Twin-block appliance did not significantly reduce the apnea-hypopnea index (AHI) (CI: 0.11 to 8.63, p=0.06), while the Mono-block appliance was found to reduce AHI significantly (CI:2.21 to 6.79, p=0.0001). Additionally, unlike the Twin-block appliance, the Mono-block appliance improved both minimal and mean SpO<sub>2</sub>. With limitation of selected studies, the impact of MAA design on pediatric OSA varied. However, it cannot be concluded that one specific MAA design is superior to others for managing pediatric OSA.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102165"},"PeriodicalIF":9.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central disorders of hypersomnolence – A narrative review on current and potential biomarkers 嗜睡中枢性疾病-当前和潜在生物标志物的叙述性回顾

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-15 DOI: 10.1016/j.smrv.2025.102167

Jian Eu Tai , Sheila Sivam , Angela D'Rozario , David Wang , Garry Cho , Brendon J. Yee

引用次数: 0

Cannabis and sleep architecture: A systematic review and meta-analysis 大麻和睡眠结构：系统回顾和荟萃分析。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-12 DOI: 10.1016/j.smrv.2025.102164

Rob Velzeboer , Adeeb Malas , Sabrina Wei , Renee Berger , Varinder Parmar , Wayne W.K. Lai

{"title":"Cannabis and sleep architecture: A systematic review and meta-analysis","authors":"Rob Velzeboer , Adeeb Malas , Sabrina Wei , Renee Berger , Varinder Parmar , Wayne W.K. Lai","doi":"10.1016/j.smrv.2025.102164","DOIUrl":"10.1016/j.smrv.2025.102164","url":null,"abstract":"<div><div>Cannabis use for sleep is increasingly prevalent, yet its effects on sleep architecture remain unclear. This systematic review and meta-analysis examined polysomnographic evidence on cannabis’ impact on sleep parameters. Eighteen studies were identified, with nine suitable for meta-analysis. Findings indicate that cannabis administration does not consistently alter sleep duration, latency, wake time, efficiency, or sleep staging. While early studies suggested reductions in rapid eye movement sleep, these were primarily based on small-scale trials with high tetrahydrocannabinol doses and significant methodological limitations. More recent studies using larger samples and lower therapeutic doses of tetrahydrocannabinol have reported mixed (and often no) evidence of rapid eye movement (REM) suppression, and the evidence base remains very limited. However, withdrawal from active cannabis use was consistently associated with sleep disturbances, including reduced total sleeping times and prolonged sleep onset latency, as well as REM rebounds. Variability in study outcomes highlights the influence of factors such as dosage, cannabinoid composition, prior cannabis use, and health conditions. Further research using standardised protocols and larger samples is needed to clarify the relationship between cannabis and sleep architecture and to address the discrepancies between subjective sleep improvements and objective sleep metrics.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102164"},"PeriodicalIF":9.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacotherapy for obstructive sleep apnea: a critical review of randomized placebo-controlled trials 阻塞性睡眠呼吸暂停的药物治疗：随机安慰剂对照试验的重要回顾。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-12 DOI: 10.1016/j.smrv.2025.102169

Steven Luu , Daryl Emery Chee Yeow Chan , Nathaniel S. Marshall , Craig L. Phillips , Ronald R. Grunstein , Brendon J. Yee

{"title":"Pharmacotherapy for obstructive sleep apnea: a critical review of randomized placebo-controlled trials","authors":"Steven Luu , Daryl Emery Chee Yeow Chan , Nathaniel S. Marshall , Craig L. Phillips , Ronald R. Grunstein , Brendon J. Yee","doi":"10.1016/j.smrv.2025.102169","DOIUrl":"10.1016/j.smrv.2025.102169","url":null,"abstract":"<div><div>Positive airway pressure therapy remains the gold standard treatment for obstructive sleep apnea (OSA), but challenges with adherence, acceptability, and side effects persist. Interest in pharmacological therapies has grown, culminating in the recent U.S. Food and Drug Administration approval of tirzepatide as the first pharmacotherapy for OSA. Our review critically examines the efficacy of pharmacologic treatments for OSA and highlights current limitations and future research directions.</div><div>We conducted a search of Medline and Embase for randomized controlled trials published from January 2005 to February 2025, identifying 41 studies investigating 37 different drugs or drug combinations.</div><div>Weight-loss therapies showed the most consistent and substantial improvements in OSA severity. Tirzepatide produced the largest reduction in apnea-hypopnea index and improved patient-reported outcomes and cardiometabolic risk factors. Other pharmacotherapies demonstrated modest and inconsistent effects on OSA severity, sometimes with side-effects that contradict the treatment goal to reduce daytime sleepiness.</div><div>Weight-loss agents, particularly tirzepatide, represent a promising and now clinically viable treatment option. While endotype-targeted approaches are conceptually attractive, many agents were too early in their testing/re-purposing phase to demonstrate improvements in sleepiness, quality of life or sustained reductions of OSA severity; or were insufficiently targeted at the endotype they might best treat.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102169"},"PeriodicalIF":9.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impairments of sleep loss on core executive functions: General and task-specific effects 睡眠缺失对核心执行功能的损害：一般和特定任务的影响

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-11 DOI: 10.1016/j.smrv.2025.102163

Yixuan Cao , Tian Xie , Ning Ma

{"title":"The impairments of sleep loss on core executive functions: General and task-specific effects","authors":"Yixuan Cao , Tian Xie , Ning Ma","doi":"10.1016/j.smrv.2025.102163","DOIUrl":"10.1016/j.smrv.2025.102163","url":null,"abstract":"<div><div>This meta-analysis quantified the impact of sleep loss (including both total sleep deprivation and partial sleep restriction) on core components of executive function: working memory, inhibitory control, and cognitive flexibility. A systematic search of Scopus, Web of Science, and PubMed identified 79 relevant publications. Using random-effects models, pooled effect sizes for reaction time and accuracy metrics were estimated separately within each task category. All reaction time metrics, except for cognitive flexibility, increased significantly following sleep loss, with medium to near-large effect sizes. Analysis of accuracy metrics revealed medium to large effect sizes on task-switching and task-repeat performance of cognitive flexibility, as well as on working memory maintenance, whereas a small effect size was observed on resolving interference inhibition. These findings highlight pervasive damage to all executive function components and suggest that the impaired common factor of executive functions may underpin sleep loss–related deterioration. Furthermore, the discrepancies between reaction time and accuracy effect sizes indicate opposite speed-accuracy trade-offs following sleep loss between interference inhibition and cognitive flexibility. This study provides essential evidence for understanding how sleep loss affects different components of executive function, emphasizing the importance of exploring sleep loss–related impairments from a comprehensive perspective.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102163"},"PeriodicalIF":9.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of mandibular advancement devices on pediatric obstructive sleep apnea: An umbrella review 下颌推进装置对儿童阻塞性睡眠呼吸暂停的影响：综述

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-11 DOI: 10.1016/j.smrv.2025.102166

Yaqi Li , Tingting Zhao , Lizhuo Lin , Jingyuan Zhang , Sunliu Liu , Yueyi Wu , Carlos Flores-Mir , Fang Hua , Hong He

{"title":"The effects of mandibular advancement devices on pediatric obstructive sleep apnea: An umbrella review","authors":"Yaqi Li , Tingting Zhao , Lizhuo Lin , Jingyuan Zhang , Sunliu Liu , Yueyi Wu , Carlos Flores-Mir , Fang Hua , Hong He","doi":"10.1016/j.smrv.2025.102166","DOIUrl":"10.1016/j.smrv.2025.102166","url":null,"abstract":"<div><div>This umbrella review evaluated the effects of mandibular advancement devices (MADs) on pediatric obstructive sleep apnea (PedOSA). We searched six databases for systematic reviews published up to June 2025, that included children with polysomnography (PSG)-diagnosed OSA managed with MADs. The primary outcome was the change in the apnea-hypopnea index (AHI). Secondary outcomes included oxygen saturation and skeletal/dental changes. Twelve systematic reviews, including 7 meta-analyses, were included. Management with MADs resulted in a reduction in AHI and a slight improvement in sagittal mandibular position. However, significant heterogeneity was observed due to variations in device designs, treatment duration, and patient characteristics. Most findings were based on before-after studies, with limited randomized controlled trials, reducing the robustness of the results. The methodological quality of the included systematic reviews, assessed using AMSTAR 2, was predominantly low or critically low, indicating significant flaws. A corrected covered area (CCA) analysis revealed substantial overlap (20.7 %) in primary studies. While MADs show promise as an adjunctive therapy for PedOSA management in indicated cases, the low methodological quality of the included systematic reviews limits the strength of the evidence. High-quality primary studies and systematic reviews are needed to confirm the impact of MADs in PedOSA management and guide clinical practice.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102166"},"PeriodicalIF":9.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of traumatic brain injury on sleep and associated neuroimaging changes: A systematic review 外伤性脑损伤对睡眠和相关神经影像学改变的影响：系统综述。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-11 DOI: 10.1016/j.smrv.2025.102155

Jacob S. Shaw , Kaylee Woodard , Akshay Krieg , Barry R. Bryant , Sabrina Kentis , Aaron I. Esagoff , Anne Reisch , Rachel M. Salas , Matthew E. Peters , Michael J.C. Bray

{"title":"The impact of traumatic brain injury on sleep and associated neuroimaging changes: A systematic review","authors":"Jacob S. Shaw , Kaylee Woodard , Akshay Krieg , Barry R. Bryant , Sabrina Kentis , Aaron I. Esagoff , Anne Reisch , Rachel M. Salas , Matthew E. Peters , Michael J.C. Bray","doi":"10.1016/j.smrv.2025.102155","DOIUrl":"10.1016/j.smrv.2025.102155","url":null,"abstract":"<div><div>Sleep disturbances are among the most common neuropsychiatric symptoms following traumatic brain injury (TBI). However, no review has sought to identify the major neuroimaging correlates of post-TBI sleep disturbances across multiple imaging modalities. This systematic review aimed to describe post-TBI neuroimaging changes associated with self-reported and objective markers of sleep disturbance using computed tomography (CT), magnetic resonance imaging (MRI), and quantitative electroencephalography (qEEG). 21 studies were included in this review, comprising the data of 3176 individual with TBI and 396 individuals without TBI. While acute intracranial abnormalities on CT were not reliable predictors of self-reported symptoms of insomnia, measures of axonal integrity on diffusion tensor imaging (DTI), particularly involving cortico-subcortical white matter tracts such as the uncinate fasciculus, were highly associated with self-reported sleep disturbance. Individuals with TBI were also found to have decreased delta power and increased beta power on qEEG during sleep, providing preliminary support for the functional role of the hypothalamus in the pathogenesis of post-TBI sleep disturbance. Key study limitations include small sample sizes and heterogeneity of TBI severity and chronicity. Functional neuroimaging studies are needed that elucidate which alterations in white matter connectivity may be most implicated in the neurocircuitry of post-TBI sleep disturbance.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102155"},"PeriodicalIF":9.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonobvious connections between napping and stroke: a systematic review and meta-analysis 午睡和中风之间不明显的联系：一项系统回顾和荟萃分析。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2025-09-06 DOI: 10.1016/j.smrv.2025.102157

Radosław Kaźmierski , Szymon Jurga , Izabela Wojtasz , Joanna Kostanek , Maria Łukasik , Cezary Watala

{"title":"Nonobvious connections between napping and stroke: a systematic review and meta-analysis","authors":"Radosław Kaźmierski , Szymon Jurga , Izabela Wojtasz , Joanna Kostanek , Maria Łukasik , Cezary Watala","doi":"10.1016/j.smrv.2025.102157","DOIUrl":"10.1016/j.smrv.2025.102157","url":null,"abstract":"<div><div>We present a meta-analysis and systematic review of research on the relationships between various aspects of naps and stroke risk. Two searches were conducted: a bibliographic search in four electronic databases for published articles that considered associations between the duration of napping and stroke risk versus a reference group (who did not nap) (n = 13) from inception up to July 15, 2024. The second search analyzed different features of napping (e.g., frequency, mild or severe napping, planned or unplanned, etc.) and stroke risk (n = 7). We found that the studies were very methodologically heterogeneous. Several publications reported more than one effect size. These differences allowed us to build models that describe the associations between napping and stroke. We used a funnel plot to estimate publication bias and employed a model of random effects for the analysis. The duration of naps was significantly associated with stroke risk; naps of 1–30 min had an odds ratio (OR) of 1.27, whereas naps >90 min had an OR of 1.79. Mutated forest plots were used to visualize the overall effects. We describe the pathomechanisms associated with an increased risk of hypertension and diabetes, mild inflammation, and other risk factors for stroke.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"84 ","pages":"Article 102157"},"PeriodicalIF":9.7,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0