Sleep Medicine Reviews最新文献_第2页

What is the prevalence of sleep disturbances among people with Huntington disease and pre-manifest genetic expansion carriers? A systematic review and meta-analysis 睡眠障碍在亨廷顿病患者和先兆基因扩增携带者中的患病率是多少？系统回顾和荟萃分析。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-02-17 DOI: 10.1016/j.smrv.2026.102258

Natasha J. Sneddon , Angela L. D'Rozario , Armando Teixeira-Pinto , Clement T. Loy

{"title":"What is the prevalence of sleep disturbances among people with Huntington disease and pre-manifest genetic expansion carriers? A systematic review and meta-analysis","authors":"Natasha J. Sneddon , Angela L. D'Rozario , Armando Teixeira-Pinto , Clement T. Loy","doi":"10.1016/j.smrv.2026.102258","DOIUrl":"10.1016/j.smrv.2026.102258","url":null,"abstract":"<div><div>Anecdotally, sleep disturbances are common among manifest and pre-manifest Huntington disease genetic expansion carriers (HDGECs), but their prevalence has not been systematically studied. To address this gap, we systematically searched MEDLINE, EMBASE, PsychINFO, CINAHL-Plus, and PubMed (inception to October 2025), using exploded headings and text-words based on sleep-related terms intersected with “Huntington disease”. We meta-analysed data where four or more studies used the same measure. 28 articles were included, with study design including case-series and case-control studies (sample sizes 6-14,791). Measures of sleep disturbances were objective (n = 10), including polysomnography (n = 8) or circadian biomarkers (n = 2), or subjective (n = 20); with studies including multiple measures or heterogenous populations. Meta-analysed prevalence of objectively-measured sleep disturbances include: 35% for periodic limb movements (PLM index>15/hour), 3% for REM sleep behaviour disorder, 5% for REM sleep without atonia, and 9% for sleep-disordered breathing (AHI>5/hour); and of self-reported measures: 29% for use of sleep medications, 59% for poor sleep quality (Pittsburgh sleep quality index), and 15% for excessive daytime sleepiness (Epworth sleepiness scale). Periodic limb movements during sleep, use of sleep medications, and poor sleep quality were prevalent. Further research is crucial for characterising changes in sleep which may inform sleep interventions improving quality of life among HDGECs.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102258"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacologic treatment data from chronic insomnia studies and the application to individuals with acute insomnia, a narrative review 慢性失眠研究的药物治疗数据及其在急性失眠患者中的应用，综述。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.smrv.2026.102246

Andrew Krystal , Ruth Benca , William V. McCall , Michael L. Perlis , Nathaniel F. Watson , John W. Winkelman , Matt Fisher , Charles M. Morin

{"title":"Pharmacologic treatment data from chronic insomnia studies and the application to individuals with acute insomnia, a narrative review","authors":"Andrew Krystal , Ruth Benca , William V. McCall , Michael L. Perlis , Nathaniel F. Watson , John W. Winkelman , Matt Fisher , Charles M. Morin","doi":"10.1016/j.smrv.2026.102246","DOIUrl":"10.1016/j.smrv.2026.102246","url":null,"abstract":"<div><div>A variety of pharmacologic treatments are approved for insomnia, encompassing a range of mechanisms of action, including some treatments with published data in models of acute insomnia. However, most studies are conducted in individuals with chronic insomnia. Thus, it is unclear whether data from studies in individuals with chronic insomnia apply to individuals with acute insomnia symptoms. In this review, we discuss the generalizability of pharmacologic treatment data from chronic insomnia studies to individuals experiencing acute insomnia. Data from chronic insomnia treatment trials can be generalized to those with acute insomnia based on 1) the pathophysiology and evolution of insomnia and 2) data indicating medications effective for chronic insomnia are also effective for acute/induced insomnia. The pharmacologic management of acute insomnia should be based on a careful benefit-risk evaluation of each treatment option, data for acute insomnia or acute relief of chronic insomnia symptoms, and clinical practice guideline considerations. Given the limitations of available self-treatment options for acute insomnia symptoms, proven pharmacologic approaches are needed. Based on the available information, and the indications outlined in the United States (US) prescribing information, certain pharmacologic treatments are reasonable recommendations for treatment of acute insomnia.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102246"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants and interrelations of exercise effects on sleep quality: A multimethod meta-analysis 运动对睡眠质量影响的决定因素和相互关系：一项多方法荟萃分析。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.smrv.2026.102239

Zhide Liang , Shiao Zhao , Shudong Tian , Chuanzhi Wang , Meng Zhang , Kai Xu , Mingyue Yin , Sanfan Ng , Ziheng Ning

{"title":"Determinants and interrelations of exercise effects on sleep quality: A multimethod meta-analysis","authors":"Zhide Liang , Shiao Zhao , Shudong Tian , Chuanzhi Wang , Meng Zhang , Kai Xu , Mingyue Yin , Sanfan Ng , Ziheng Ning","doi":"10.1016/j.smrv.2026.102239","DOIUrl":"10.1016/j.smrv.2026.102239","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review and Bayesian meta-analysis examined determinants of exercise effects on subjective sleep quality.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, Cochrane Library, Web of Science, Scopus and CINAHL from inception to August 2025 for randomised controlled trials in adults (≥18 years) comparing exercise with non-exercise controls. Two reviewers independently assessed risk of bias (RoB 2). Bayesian multilevel models, MetaForest and structural equation modelling estimated pooled effects and moderators, expressed as standardised mean differences (Hedges’ g).</div></div><div><h3>Results</h3><div>Two hundred trials (n = 23,523) were included. Compared with active controls, qigong, walking and high-intensity interval training showed the largest benefits. In 20 trials reporting objective sleep efficiency, exercise produced a small but significant improvement, consistent with subjective outcomes. Baseline sleep quality (assessed with Pittsburgh Sleep Quality Index) and population type were the main determinants of response. Populations with poorer baseline sleep quality were much more likely to achieve a clinically important improvement than good sleepers. Intervention duration showed a U-shaped association with benefit, peaking at 25 weeks. Certainty of evidence was very low.</div></div><div><h3>Conclusion</h3><div>Exercise improves subjective sleep quality in a benefit-on-demand pattern, supporting prioritisation of approximately 25-week programmes for adults with moderate-to-severe sleep problems while acknowledging very low certainty.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102239"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring the invisible: Anosognosia and the paradox of sleep assessment in early Huntington's disease 测量看不见的：病感失认症和早期亨廷顿病睡眠评估的悖论。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-02-18 DOI: 10.1016/j.smrv.2026.102262

Mariana Moysés-Oliveira , Sergio Tufik

引用次数: 0

What is the nature of sleep and circadian rhythm health on gastrointestinal microbiota? A systematic review of studies in humans 睡眠和昼夜节律健康对胃肠道微生物群的影响是什么？对人类研究的系统回顾。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-02-17 DOI: 10.1016/j.smrv.2026.102256

Magdalena Olson , Dana Withrow , Megan Koelbel , Grace Southworth , Anh Phan , Kenneth P. Wright Jr. , Corrie M. Whisner , Megan E. Petrov

{"title":"What is the nature of sleep and circadian rhythm health on gastrointestinal microbiota? A systematic review of studies in humans","authors":"Magdalena Olson , Dana Withrow , Megan Koelbel , Grace Southworth , Anh Phan , Kenneth P. Wright Jr. , Corrie M. Whisner , Megan E. Petrov","doi":"10.1016/j.smrv.2026.102256","DOIUrl":"10.1016/j.smrv.2026.102256","url":null,"abstract":"<div><div>This systematic review synthesized findings from 41 human studies across the lifespan published between 2016 and 2025 examining associations of multidimensional sleep and circadian rhythm health with the gut microbiome (GM). The studies include experimental and observational designs of generally healthy participants, measuring sleep and circadian dimensions such as duration, quality, insomnia, and circadian disruptions (e.g., shift work). Results suggest sleep truncation, disturbances, and circadian misalignment may be linked to GM composition and function, though results were mixed on microbial diversity. The heterogeneous evidence suggests that the microbial family <em>Oscillospiraceae/Ruminococcaceae</em> is often associated with sleep and circadian metrics, warranting rigorous inquiry of taxa within this family. Functional outputs of the GM were infrequently assessed, but when measured, identified functions in amino acid and fatty acid metabolism, and vitamin, hormone/neurotransmitter, phosphate, short-chain fatty acid, and bile acid pathways. Inconsistencies in findings may reflect differing analytical methods, participants’ age, health status, and lifestyle (e.g., diet, physical activity). Future investigations should prioritize longitudinal and experimental, multi-omics studies to clarify causal pathways and assess interventions, especially in populations with sleep disruption. Findings underscore the potential for sleep and circadian interventions to support GM balance and improve health outcomes.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102256"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between sleep duration and fluid biomarkers of Alzheimer's disease: A systematic review 睡眠时间与阿尔茨海默病液体生物标志物之间的关系：一项系统综述

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.smrv.2026.102242

Vanessa M. Young , Joy Zeynoun , Agustin Ruiz Laza , Arash Salardini , Christopher R. Frei , Christine Gaspard , Tiffany Kautz , Thiago Macedo e Cordeiro , Matthew P. Pase , Jonathan Gelfond , Jayandra Jung Himali , Antonio L. Teixeira , Sudha Seshadri , Andrée-Ann Baril

{"title":"Association between sleep duration and fluid biomarkers of Alzheimer's disease: A systematic review","authors":"Vanessa M. Young , Joy Zeynoun , Agustin Ruiz Laza , Arash Salardini , Christopher R. Frei , Christine Gaspard , Tiffany Kautz , Thiago Macedo e Cordeiro , Matthew P. Pase , Jonathan Gelfond , Jayandra Jung Himali , Antonio L. Teixeira , Sudha Seshadri , Andrée-Ann Baril","doi":"10.1016/j.smrv.2026.102242","DOIUrl":"10.1016/j.smrv.2026.102242","url":null,"abstract":"<div><div>This systematic review (PROSPERO CRD420246206360) investigated relationships between self-reported or objective sleep duration and fluid biomarkers of Alzheimer's disease pathology and neurodegeneration: cerebrospinal fluid or blood Aβ, p-tau181, t-tau, NfL and GFAP. We searched PubMed, SCOPUS, and CINAHL from inception to September 2024. Twenty studies (n = 12,445) met inclusion criteria (13 cerebrospinal fluid biomarkers [n = 2836]; 7 blood biomarkers [n = 9609]). Study quality was assessed using Newcastle-Ottawa scales. Whereas many studies did not report any associations, some trends emerged: short sleep duration was associated with higher cerebrospinal fluid t-tau and p-tau181 and lower cerebrospinal fluid or blood Aβ42 across multiple studies. Longer sleep duration showed more variable associations, with some suggesting either worse or better biomarker profiles (e.g., higher and lower fluid t-tau, p-tau181, or Aβ42). Two studies investigating non-linear relationships identified U-shaped associations, suggesting both short (≤5–6 h) and long (≥8 h) sleep durations are associated with altered biomarker profiles. The predominantly cross-sectional and high heterogeneity of the available evidence, as well as the relatively small number of studies by individual biomarker (especially for NfL and GFAP) limit conclusions about sleep-biomarker relationships. Future research should investigate emerging blood-based biomarkers and explore temporal associations between sleep duration and Alzheimer's disease biomarker changes.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102242"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep well, feel well and vice versa? A meta-analysis of daily bidirectional within-person associations between sleep and affect 睡得好，感觉好，反之亦然？一项关于睡眠和情绪之间日常双向关系的元分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-04-01 Epub Date: 2026-01-16 DOI: 10.1016/j.smrv.2026.102232

Matthew Bourke , Zoe Harrison , Sally Staton , Kalina Rossa , Simon Smith

{"title":"Sleep well, feel well and vice versa? A meta-analysis of daily bidirectional within-person associations between sleep and affect","authors":"Matthew Bourke , Zoe Harrison , Sally Staton , Kalina Rossa , Simon Smith","doi":"10.1016/j.smrv.2026.102232","DOIUrl":"10.1016/j.smrv.2026.102232","url":null,"abstract":"<div><div>This meta-analysis examines the bidirectional within-person association between sleep and affect using data from 118 studies. Focusing on intensive longitudinal designs such as daily diaries and ecological momentary assessments, this meta-analysis examines how daily variations in sleep, measured via subjective and objective methods, are associated with fluctuations in positive and negative affect. Results show small-to-moderate within-person correlations, with better subjective sleep quality and longer sleep duration predicting improved next-day affect. Conversely, more positive affect and less negative affect during the day were modestly associated with better subjective sleep quality but not total sleep time. The within-person correlations were generally stronger when aspects of sleep were self-reported rather than objectively measured, highlighting the importance of perceived sleep experiences. These findings were largely consistent across age groups and health status, suggesting that the relationship between sleep and affect may be universal. Overall, this study underscores the psychological significance of everyday sleep-affect dynamics.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"86 ","pages":"Article 102232"},"PeriodicalIF":9.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insomnia among hospitalized inpatients: A systematic review and network meta-analysis 住院患者失眠：系统回顾与网络荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102210

Dario Bottignole , Giulia Balella , Matteo Minetti , Luca Gambolò , Francesco Rausa , Giorgio Ughetti , Andrea Melpignano , Marcello Giuseppe Maggio , Liborio Parrino , Carlotta Mutti

{"title":"Insomnia among hospitalized inpatients: A systematic review and network meta-analysis","authors":"Dario Bottignole , Giulia Balella , Matteo Minetti , Luca Gambolò , Francesco Rausa , Giorgio Ughetti , Andrea Melpignano , Marcello Giuseppe Maggio , Liborio Parrino , Carlotta Mutti","doi":"10.1016/j.smrv.2025.102210","DOIUrl":"10.1016/j.smrv.2025.102210","url":null,"abstract":"<div><div>Insomnia affects up to 50% of hospitalized patients and is strongly associated with longer hospital stays and higher mortality rates, especially among vulnerable individuals. Despite its prevalence, it's often overlooked in clinical practice and research. Our systematic review analyzed and compared pharmacological interventions for insomnia in hospitalized patients. We searched five major databases for randomized controlled trials published before January 2024. A total of 29 trials (1913 patients, mean age 58.4 ± 9.66) were finally included. Different drug classes were evaluated, including benzodiazepines, Z-drugs, melatonin receptor agonists, antidepressants, antihistamines, alpha-2 adrenergic agonists, and dietary supplements. We conducted a network meta-analysis on drugs' efficacy across subjective sleep quality, sleep latency, total sleep duration, and nocturnal awakenings. Notably, only a minority of studies focused on fragile populations, such as geriatric and critically ill patients. Results are also discussed according to potential moderating factors (i.e., gender, age, admission setting). Our review provides a framework for the pharmacologic treatment of insomnia disorder in inpatients. Differences in study methodologies limit the generalizability of findings, highlighting the urgent need for standardized research to fill existing gaps. We therefore propose a concise protocol to guide the design of future studies on this clinically important topic.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102210"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging artificial intelligence and sleep medicine: current evidence, open challenges, and future directions 连接人工智能和睡眠医学：目前的证据、公开的挑战和未来的方向

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-18 DOI: 10.1016/j.smrv.2026.102237

Hanwen Bi , Wen Liu , Masoud Tahmasian

引用次数: 0

Implementing strategies to address the global burden of insomnia 实施解决全球失眠负担的战略

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102209

Adam V. Benjafield , Emerson M. Wickwire

引用次数: 0